306 research outputs found
Formation et esprit d'entreprendre chez les Ă©tudiants
Cette contribution s'attache à étudier entre esprit d'entreprendre et domaine d'études chez les étudiants français. L'esprit d'entreprendre est le substrat dans lequel peut germer l'intention qui pourra donner lieu à une création d'entreprise. Nous choisissons de l'appréhender à partir d'une grille de lecture dérivée du modÚle psychosocial du comportement planifié d'Ajzen, enrichie par des variables reflétant l'implication dans la vie associative et les opinions sur les formations à la création d'entreprise.esprit d'entreprendre ; domaine d'étude ; étudiants français
A randomized phase II study comparing two schedules of the 21-day regimen of gemcitabine and carboplatin in advanced non-small cell lung cancer
Purpose: Carboplatin area under the curve (AUC) 5 ml/min on day 1 with gemcitabine 1,250 mg/m2on day 1 and day 8 is a widely used regimen in advanced non-small cell lung cancer. Grade 3-4 thrombocytopenia and neutropenia are frequent. The aim of this study is to investigate whether toxicity of gemcitabine/carboplatin could be reduced by administering carboplatin on day 8 instead of
Ultrasonic roll bite measurements in cold rolling â Roll stress and deformation
In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip flatness defects and thickness inhomogeneity. To control the process, several online measurements are usually carried out such as the rolling load, forward slip and strip tensions at each stand. Shape defects of the strip are usually evaluated after the last stand of a rolling mill thanks to a flatness measuring roll. However, none of these measurements is made within the roll bite itself due to the harsh conditions taking place in that area.
This paper presents a sensor capable of monitoring roll deformations as well as roll radial stresses in situ and in real time. The sensor emits ultrasonic pulses that reflect from the roll surface. The time-of-flight (ToF) of the pulses is recorded during the testing.
The sensor system was incorporated into a work roll and tested on a pilot rolling mill. Measurements were taken as steel strips were rolled under different strip elongation. Roll deformation and radial stresses obtained from the experimental data are in good agreement with numerical results computed with a cold rolling model developed in non-linear Finite Element software
Interatomic potentials for atomistic simulations of the Ti-Al system
Semi-empirical interatomic potentials have been developed for Al, alpha-Ti,
and gamma-TiAl within the embedded atomic method (EAM) by fitting to a large
database of experimental as well as ab-initio data. The ab-initio calculations
were performed by the linear augmented plane wave (LAPW) method within the
density functional theory to obtain the equations of state for a number of
crystal structures of the Ti-Al system. Some of the calculated LAPW energies
were used for fitting the potentials while others for examining their quality.
The potentials correctly predict the equilibrium crystal structures of the
phases and accurately reproduce their basic lattice properties. The potentials
are applied to calculate the energies of point defects, surfaces, planar faults
in the equilibrium structures. Unlike earlier EAM potentials for the Ti-Al
system, the proposed potentials provide reasonable description of the lattice
thermal expansion, demonstrating their usefulness in the molecular dynamics or
Monte Carlo studies at high temperatures. The energy along the tetragonal
deformation path (Bain transformation) in gamma-TiAl calculated with the EAM
potential is in a fairly good agreement with LAPW calculations. Equilibrium
point defect concentrations in gamma-TiAl are studied using the EAM potential.
It is found that antisite defects strongly dominate over vacancies at all
compositions around stoichiometry, indicating that gamm-TiAl is an antisite
disorder compound in agreement with experimental data.Comment: 46 pages, 6 figures (Physical Review B, in press
K^+ production in the reaction at incident energies from 1 to 2 AGeV
Semi-inclusive triple differential multiplicity distributions of positively
charged kaons have been measured over a wide range in rapidity and transverse
mass for central collisions of Ni with Ni nuclei. The transverse
mass () spectra have been studied as a function of rapidity at a beam
energy 1.93 AGeV. The distributions of K^+ mesons are well described by a
single Boltzmann-type function. The spectral slopes are similar to that of the
protons indicating that rescattering plays a significant role in the
propagation of the kaon. Multiplicity densities have been obtained as a
function of rapidity by extrapolating the Boltzmann-type fits to the measured
distributions over the remaining phase space. The total K^+ meson yield has
been determined at beam energies of 1.06, 1.45, and 1.93 AGeV, and is presented
in comparison to existing data. The low total yield indicates that the K^+
meson can not be explained within a hadro-chemical equilibrium scenario,
therefore indicating that the yield does remain sensitive to effects related to
its production processes such as the equation of state of nuclear matter and/or
modifications to the K^+ dispersion relation.Comment: 24 pages Latex (elsart) 7 PS figures to be submitted to Nucl. Phys
The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections : current knowledge and new perspectives
ACKNOWLEDGEMENTS: We thank our friends and colleagues in the medical mycology, fungal immunology and microbiota fields for many thought-provoking discussions. FUNDING: We received funding from the European Unionâs Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie action, Innovative Training Network: FunHoMic; grant N° 812969. CdE received funding from the French Government âInvestissement dâAvenirâ program (Laboratoire dâExcellence Integrative Biology of Emerging Infectious Diseases, ANR-10-LABX-62-IBEID), the Agence Nationale de la Recherche (ERA-Net Infect-ERA, FUNCOMPATH, ANR-14-IFEC-0004), the EU Horizon2020 consortium âHost-Directed Medicine in invasive FUNgal infectionsâ - HDM-FUN (Grant Agreement 847507). SLL and CdE received funding from the Swiss National Science Foundation (Sinergia program, #CRSII5_173863). BIOASTER received funding from the French Government âInvestissement dâAvenirâ program (Grant No. ANR-10-AIRT-03). MSG was supported by a Humboldt Research Fellowship for Postdoctoral Researchers by the Alexander von Humboldt-Foundation and the Deutsche Forschungsgemeinschaft (DFG) Emmy Noether Program (project no. 434385622 / GR 5617/1-1). BH was supported by the Deutsche Forschungsgemeinschaft (DFG) project Hu 532/20-1, project C1 within the Collaborative Research Centre (CRC)/Transregio 124 FungiNet and the Balance of the Microverse Cluster under GermanyÂŽs Excellence Strategy â EXC 2051 â Project-ID 390713860, the EU Horizon2020 consortium âHost-Directed Medicine in invasive FUNgal infectionsâ - HDM-FUN (Grant Agreement 847507), the Leibniz Association Campus InfectoOptics SAS-2015-HKI-LWC and the Wellcome Trust (215599/Z/19/Z). IDJ was supported by the Deutsche orschungsgemeinschaft (DFG) project C5 within the Collaborative Research Centre (CRC)/Transregio 124 FungiNet and the Balance of the Microverse Cluster under GermanyÂŽs Excellence Strategy â EXC 2051 â Project-ID 390713860, the Leibniz Association Campus InfectoOptics SAS-2015-HKI-LWC and the Wellcome Trust (Grant 215599/Z/19/Z). CM received funding from the the Instituto de Salud Carlos III/FEDER. MGN was supported by an ERC Advanced Grant (#833247) and a Spinoza grant of the Netherlands Organization for Scientific Research. CAM was supported by EU Horizon2020 consortium âHost-Directed Medicine in invasive FUNgal infectionsâ -HDM-FUN (Grant Agreement 847507) and the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z). AWW receives core funding support from the Scottish Governmentâs Rural and Environment Science and Analytical Services (RESAS). AJPB was supported by a programme grant from the UK Medical Research Council (MR/M026663/1) and by the Medical Research Council Centre for Medical Mycology at the University of Exeter (MR/N006364/1).Peer reviewedPublisher PD
Tests of sunspot number sequences: 2. Using geomagnetic and auroral data
We compare four sunspot-number data sequences against geomagnetic and terrestrial auroral observations. The comparisons are made for the original SIDC (Solar Influences Data Center) composite of Wolf/ZĂŒrich/International sunspot number [RISNv1], the group sunspot number [RG] by Hoyt and Schatten (Solar Phys., 181, 491, 1998), the new âbackboneâ group sunspot number [RBB] by Svalgaard and Schatten (Solar Phys., doi: 10.1007/s11207-015-0815-8, 2016), and the âcorrectedâ sunspot number [RC] by Lockwood, Owens, and Barnard (J. Geophys. Res., 119, 5172, 2014). Each sunspot number is fitted with terrestrial observations, or parameters derived from terrestrial observations to be linearly proportional to sunspot number, over a 30-year calibration interval of 1982 - 2012. The fits are then used to compute test sequences, which extend further back in time and which are compared to RISNv1, RG, RBB, and RC. To study the long-term trends, comparisons are made using averages over whole solar cycles (minimum-to-minimum). The test variations are generated in four ways: i) using the IDV(1d) and IDV geomagnetic indices (for 1845 - 2013) fitted over the calibration interval using the various sunspot numbers and the phase of the solar cycle; ii) from the open solar flux (OSF) generated for 1845 - 2013 from four pairings of geomagnetic indices by Lockwood et al. (Ann. Geophys., 32, 383, 2014) and analysed using the OSF continuity model of Solanki, SchĂŒssler, and Fligge (Nature, 408, 445, 2000) which employs a constant fractional OSF loss rate; iii) the same OSF data analysed using the OSF continuity model of Owens and Lockwood (J. Geophys. Res., 117, A04102, 2012) in which the fractional loss rate varies with the tilt of the heliospheric current sheet and hence with the phase of the solar cycle; iv) the occurrence frequency of low-latitude aurora for 1780 - 1980 from the survey of Legrand and Simon (Ann. Geophys., 5, 161, 1987). For all cases, RBB exceeds the test terrestrial series by an amount that increases as one goes back in time
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