329 research outputs found
An Inverse Method for Policy-Iteration Based Algorithms
We present an extension of two policy-iteration based algorithms on weighted
graphs (viz., Markov Decision Problems and Max-Plus Algebras). This extension
allows us to solve the following inverse problem: considering the weights of
the graph to be unknown constants or parameters, we suppose that a reference
instantiation of those weights is given, and we aim at computing a constraint
on the parameters under which an optimal policy for the reference instantiation
is still optimal. The original algorithm is thus guaranteed to behave well
around the reference instantiation, which provides us with some criteria of
robustness. We present an application of both methods to simple examples. A
prototype implementation has been done
Tropical Fourier-Motzkin elimination, with an application to real-time verification
We introduce a generalization of tropical polyhedra able to express both
strict and non-strict inequalities. Such inequalities are handled by means of a
semiring of germs (encoding infinitesimal perturbations). We develop a tropical
analogue of Fourier-Motzkin elimination from which we derive geometrical
properties of these polyhedra. In particular, we show that they coincide with
the tropically convex union of (non-necessarily closed) cells that are convex
both classically and tropically. We also prove that the redundant inequalities
produced when performing successive elimination steps can be dynamically
deleted by reduction to mean payoff game problems. As a complement, we provide
a coarser (polynomial time) deletion procedure which is enough to arrive at a
simply exponential bound for the total execution time. These algorithms are
illustrated by an application to real-time systems (reachability analysis of
timed automata).Comment: 29 pages, 8 figure
Contracts for Abstract Processes in Service Composition
Contracts are a well-established approach for describing and analyzing
behavioral aspects of web service compositions. The theory of contracts comes
equipped with a notion of compatibility between clients and servers that
ensures that every possible interaction between compatible clients and servers
will complete successfully. It is generally agreed that real applications often
require the ability of exposing just partial descriptions of their behaviors,
which are usually known as abstract processes. We propose a formal
characterization of abstraction as an extension of the usual symbolic
bisimulation and we recover the notion of abstraction in the context of
contracts.Comment: In Proceedings FIT 2010, arXiv:1101.426
The Serums Tool-Chain:Ensuring Security and Privacy of Medical Data in Smart Patient-Centric Healthcare Systems
Digital technology is permeating all aspects of human society and life. This leads to humans becoming highly dependent on digital devices, including upon digital: assistance, intelligence, and decisions. A major concern of this digital dependence is the lack of human oversight or intervention in many of the ways humans use this technology. This dependence and reliance on digital technology raises concerns in how humans trust such systems, and how to ensure digital technology behaves appropriately. This works considers recent developments and projects that combine digital technology and artificial intelligence with human society. The focus is on critical scenarios where failure of digital technology can lead to significant harm or even death. We explore how to build trust for users of digital technology in such scenarios and considering many different challenges for digital technology. The approaches applied and proposed here address user trust along many dimensions and aim to build collaborative and empowering use of digital technologies in critical aspects of human society
Synthesis and biological evaluation of benzodiazepines containing a pentafluorosulfanyl group
The widely used pentafluorosulfanyl group (SF5) was deployed as a bioisosteric replacement for a chloro-group in the benzodiazepine diazepam (Valiumâą). Reaction of 2-amino-5-pentafluorosulfanyl-benzophenone with chloroacetyl chloride followed by hexamethylenetetramine, in the presence of ammonia, led to 7-sulfurpentafluoro-5-phenyl-1H-benzo[1,4]diazepin-2(3H)-one (2c). The latter was able to undergo a Pd-catalysed ortho-arylation, demonstrating that these highly fluorinated benzodiazepines can be further modified to form more complicated scaffolds. The replacement of Cl by the SF5 group, led to a loss of potency for potentiating GABAA receptor activation, most likely because of a lost ligand interaction with His102 in the GABAA receptor α subunit.
Dedicated to Professor Jonathan Williams, an inspirational and humble pioneer, a colleague and mentor in chemistry
A Hierarchy of Scheduler Classes for Stochastic Automata
Stochastic automata are a formal compositional model for concurrent
stochastic timed systems, with general distributions and non-deterministic
choices. Measures of interest are defined over schedulers that resolve the
nondeterminism. In this paper we investigate the power of various theoretically
and practically motivated classes of schedulers, considering the classic
complete-information view and a restriction to non-prophetic schedulers. We
prove a hierarchy of scheduler classes w.r.t. unbounded probabilistic
reachability. We find that, unlike Markovian formalisms, stochastic automata
distinguish most classes even in this basic setting. Verification and strategy
synthesis methods thus face a tradeoff between powerful and efficient classes.
Using lightweight scheduler sampling, we explore this tradeoff and demonstrate
the concept of a useful approximative verification technique for stochastic
automata
Compared to conventional, ecological intensive management promotes beneficial proteolytic soil microbial communities for agro-ecosystem functioning under climate change-induced rain regimes
Projected climate change and rainfall variability will affect soil microbial communities, biogeochemical cycling and agriculture. Nitrogen (N) is the most limiting nutrient in agroecosystems and its cycling and availability is highly dependent on microbial driven processes. In agroecosystems, hydrolysis of organic nitrogen (N) is an important step in controlling soil N availability. We analyzed the effect of management (ecological intensive vs. conventional intensive) on N-cycling processes and involved microbial communities under climate change-induced rain regimes. Terrestrial model ecosystems originating from agroecosystems across Europe were subjected to four different rain regimes for 263 days. Using structural equation modelling we identified direct impacts of rain regimes on N-cycling processes, whereas N-related microbial communities were more resistant. In addition to rain regimes, management indirectly affected N-cycling processes via modifications of N-related microbial community composition. Ecological intensive management promoted a beneficial N-related microbial community composition involved in N-cycling processes under climate change-induced rain regimes. Exploratory analyses identified phosphorus-associated litter properties as possible drivers for the observed management effects on N-related microbial community composition. This work provides novel insights into mechanisms controlling agro-ecosystem functioning under climate change
Au-Ag template stripped pattern for scanning probe investigations of DNA arrays produced by Dip Pen Nanolithography
We report on DNA arrays produced by Dip Pen Nanolithography (DPN) on a novel
Au-Ag micro patterned template stripped surface. DNA arrays have been
investigated by atomic force microscopy (AFM) and scanning tunnelling
microscopy (STM) showing that the patterned template stripped substrate enables
easy retrieval of the DPN-functionalized zone with a standard optical
microscope permitting a multi-instrument and multi-technique local detection
and analysis. Moreover the smooth surface of the Au squares (abput 5-10
angstrom roughness) allows to be sensitive to the hybridization of the
oligonucleotide array with label-free target DNA. Our Au-Ag substrates,
combining the retrieving capabilities of the patterned surface with the
smoothness of the template stripped technique, are candidates for the
investigation of DPN nanostructures and for the development of label free
detection methods for DNA nanoarrays based on the use of scanning probes.Comment: Langmuir (accepted
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