A method for evaluating the murine pulmonary vasculature using micro-computed tomography

AbstractBackgroundSignificant mortality and morbidity are associated with alterations in the pulmonary vasculature. While techniques have been described for quantitative morphometry of whole-lung arterial trees in larger animals, no methods have been described in mice. We report a method for the quantitative assessment of murine pulmonary arterial vasculature using high-resolution computed tomography scanning.MethodsMice were harvested at 2 weeks, 4 weeks, and 3 months of age. The pulmonary artery vascular tree was pressure perfused to maximal dilation with a radio-opaque casting material with viscosity and pressure set to prevent capillary transit and venous filling. The lungs were fixed and scanned on a specimen computed tomography scanner at 8-μm resolution, and the vessels were segmented. Vessels were grouped into categories based on lumen diameter and branch generation.ResultsRobust high-resolution segmentation was achieved, permitting detailed quantitation of pulmonary vascular morphometrics. As expected, postnatal lung development was associated with progressive increase in small-vessel number and arterial branching complexity.ConclusionsThese methods for quantitative analysis of the pulmonary vasculature in postnatal and adult mice provide a useful tool for the evaluation of mouse models of disease that affect the pulmonary vasculature

The effects of r-process heating on fall-back accretion in compact object mergers

We explore the effects of r-process nucleosynthesis on fall-back accretion in neutron star(NS)-NS and black hole-NS mergers, and the resulting implications for short-duration gamma-ray bursts (GRBs). Though dynamically important, the energy released during the r-process is not yet taken into account in merger simulations. We use a nuclear reaction network to calculate the heating (due to beta-decays and nuclear fission) experienced by material on the marginally-bound orbits nominally responsible for late-time fall-back. Since matter with longer orbital periods t_orb experiences lower densities, for longer periods of time, the total r-process heating rises rapidly with t_orb, such that material with t_orb > 1 seconds can become completely unbound. Thus, r-process heating fundamentally changes the canonical prediction of an uninterrupted power-law decline in the fall-back rate dM/dt at late times. When the timescale for r-process to complete is > 1 second, the heating produces a complete cut-off in fall-back accretion after ~ 1 second; if robust, this would imply that fall-back accretion cannot explain the late-time X-ray flaring observed following some short GRBs. However, for a narrow, but physically plausible, range of parameters, fall-back accretion can resume after ~ 10 s, despite having been strongly suppressed for ~ 1-10 s after the merger. This suggests the intriguing possibility that the gap observed between the prompt and extended emission in short GRBs is a manifestation of r-process heating.Comment: 7 pages; 4 figures; submitted to MNRA

Mid-Infrared Evidence for Accelerated Evolution in Compact Group Galaxies

We find evidence for accelerated evolution in compact group galaxies from the distribution in mid-infrared colorspace of 42 galaxies from 12 Hickson Compact Groups (HCGs) compared to the the distributions of several other samples including the LVL+SINGS galaxies, interacting galaxies, and galaxies from the Coma Cluster. We find that the HCG galaxies are not uniformly distributed in colorspace, as well as quantitative evidence for a gap. Galaxies in the infall region of the Coma cluster also exhibit a non-uniform distribution and a less well defined gap, which may reflect a similarity with the compact group environment. Neither the Coma Center or interacting samples show evidence of a gap, leading us to speculate that the gap is unique to the environment of high galaxy density where gas has not been fully processed or stripped.Comment: To appear in the Proceedings of the Galaxy Wars: Stellar Populations and Star Formation in Interacting Galaxies Conferenc

Constraining The Assembly Of Normal And Compact Passively Evolving Galaxies From Redshift z=3 To The Present With CANDELS

We study the evolution of the number density, as a function of the size, of passive early-type galaxies with a wide range of stellar masses 10^10<M*/Msun<10^11.5) from z~3 to z~1, exploiting the unique dataset available in the GOODS-South field, including the recently obtained WFC3 images as a part of the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS). In particular, we select a sample of 107 massive (M*>10^10 M_sun), passive (SSFR<10^-2 Gyr^-1) and morphologically spheroidal galaxies at 1.2<z<3, taking advantage of the panchromatic dataset available for GOODS, including VLT, CFHT, Spitzer, Chandra and HST ACS+WFC3 data. We find that at 1<z<3 the passively evolving early-type galaxies are the reddest and most massive objects in the Universe, and we prove that a correlation between mass, morphology, color and star-formation activity is already in place at that epoch. We measure a significant evolution in the mass-size relation of passive early-type galaxies (ETGs) from z~3 to z~1, with galaxies growing on average by a factor of 2 in size in a 3 Gyr timescale only. We witness also an increase in the number density of passive ETGs of 50 times over the same time interval. We find that the first ETGs to form at z>2 are all compact or ultra-compact, while normal sized ETGs (meaning ETGs with sizes comparable to those of local counterparts of the same mass) are the most common ETGs only at z<1. The increase of the average size of ETGs at 0<z<1 is primarily driven by the appearance of new large ETGs rather than by the size increase of individual galaxies.Comment: 9 pages, 5 figures, submitted to Ap

The propagation of uncertainties in stellar population synthesis modeling III: model calibration, comparison, and evaluation

Stellar population synthesis (SPS) provides the link between the stellar and dust content of galaxies and their observed spectral energy distributions. In the present work we perform a comprehensive calibration of our own flexible SPS (FSPS) model against a suite of data. Several public SPS models are intercompared, including the models of Bruzual & Charlot (BC03), Maraston (M05) and FSPS. The relative strengths and weaknesses of these models are evaluated, with the following conclusions: 1) The FSPS and BC03 models compare favorably with MC data at all ages, whereas M05 colors are too red and the age-dependence is incorrect; 2) All models yield similar optical and near-IR colors for old metal-poor systems, and yet they all provide poor fits to the integrated J-K and V-K colors of both MW and M31 star clusters; 4) All models predict ugr colors too red, D4000 strengths too strong and Hdelta strengths too weak compared to massive red sequence galaxies, under the assumption that such galaxies are composed solely of old metal-rich stars; 5) FSPS and, to a lesser extent, BC03 can reproduce the optical and near-IR colors of post-starburst galaxies, while M05 cannot. Reasons for these discrepancies are explored. The failure at predicting the ugr colors, D4000, and Hdelta strengths can be explained by some combination of a minority population of metal-poor stars, young stars, blue straggler and/or blue horizontal branch stars, but not by appealing to inadequacies in either theoretical stellar atmospheres or canonical evolutionary phases (e.g., the main sequence turn-off). We emphasize that due to a lack of calibrating star cluster data in regions of the metallicity-age plane relevant for galaxies, all of these models continue to suffer from serious uncertainties that are difficult to quantify. (ABRIDGED)Comment: 26 pages, 16 figures, submitted to ApJ. The FSPS code can be downloaded at http://www.astro.princeton.edu/~cconroy/SPS

Heparin-Binding Epidermal Growth Factor-Like Growth Factor Signaling in Flow-Induced Arterial Remodeling

Heparin-binding EGF-like growth factor (HB-EGF) is activated by reduced endothelial shear stress and stimulates smooth muscle cell (SMC) proliferation in vitro. More- over, HB-EGF is augmented at sites of intimal hyperplasia and atherosclerosis— conditions favored by low/disturbed shear stress. We thus tested whether HB-EGF contributes to low Flow-Induced NUegative hypertrophic Remodeling (FINR) of mouse carotid artery. Blood flow was surgically decreased in the left and increased in the right common carotids. After 21 days, left carotid exhibited lumen narrowing, thickening of intima-media and adventitia, and increased circumference that were inhibited by ~50% in HB-EGF+/- and ~90% in HB-EGF-/- mice. FINR was also inhibited by the EGF receptor inhibitor, AG1478. In contrast, eutrophic outward remodeling of the right carotid was unaffected in HB-EGF+/- and HB-EGF-/- mice or by AG1478. FINR-induced proliferation and leukocyte accumulation were reduced in HB-EGF-/-. FINR was associated with increased: reactive oxygen species, expression of pro-HB-EGF and TACE (pro-HB-EGF sheddase), phosphorylation of EGFR and Erk1/2, and NF-κB activity. Apocynin and deletion of p47phox inhibited FINR, while deletion of HB-EGF abolished NF-κB activation in SMCs. These findings suggest that HB-EGF signaling is required for low flow-induced hypertrophic remodeling and may participate in vascular wall disease and remodeling

The Hubble Constant from Observations of the Brightest Red Giant Stars in a Virgo-Cluster Galaxy

The Virgo and Fornax clusters of galaxies play central roles in determining the Hubble constant H_0. A powerful and direct way of establishing distances for elliptical galaxies is to use the luminosities of the brightest red-giant stars (the TRGB luminosity, at M_I = -4.2). Here we report the direct observation of the TRGB stars in a dwarf elliptical galaxy in the Virgo cluster. We find its distance to be 15.7 +- 1.5 Megaparsecs, from which we estimate a Hubble constant of H_0 = 77 +- 8 km/s/Mpc. Under the assumption of a low-density Universe with the simplest cosmology, the age of the Universe is no more than 12-13 billion years.Comment: 12 pages, LaTeX, with 2 postscript figures; in press for Nature, July 199

The Shapes of Flux Domains in the Intermediate State of Type-I Superconductors

In the intermediate state of a thin type-I superconductor magnetic flux penetrates in a disordered set of highly branched and fingered macroscopic domains. To understand these shapes, we study in detail a recently proposed "current-loop" (CL) model that models the intermediate state as a collection of tense current ribbons flowing along the superconducting-normal interfaces and subject to the constraint of global flux conservation. The validity of this model is tested through a detailed reanalysis of Landau's original conformal mapping treatment of the laminar state, in which the superconductor-normal interfaces are flared within the slab, and of a closely-related straight-lamina model. A simplified dynamical model is described that elucidates the nature of possible shape instabilities of flux stripes and stripe arrays, and numerical studies of the highly nonlinear regime of those instabilities demonstrate patterns like those seen experimentally. Of particular interest is the buckling instability commonly seen in the intermediate state. The free-boundary approach further allows for a calculation of the elastic properties of the laminar state, which closely resembles that of smectic liquid crystals. We suggest several new experiments to explore of flux domain shape instabilities, including an Eckhaus instability induced by changing the out-of-plane magnetic field, and an analog of the Helfrich-Hurault instability of smectics induced by an in-plane field.Comment: 23 pages, 22 bitmapped postscript figures, RevTex 3.0, submitted to Phys. Rev. B. Higher resolution figures may be obtained by contacting the author

Population Synthesis in the Blue IV: Accurate Model Predictions for Lick Indices and UBV Colors in Single Stellar Populations

[Abridged] We present new model predictions for 16 Lick absorption line indices from Hdelta through Fe5335, and UBV colors for single stellar populations (SPs) with ages ranging between 1 and 15 Gyr, [Fe/H] ranging from -1.3 to +0.3, and variable abundance ratios. We develop a method to estimate mean ages and abundances of Fe, C, N, Mg, and Ca that explores the sensitivity of the various indices to those parameters. When applied to high-S/N Galactic cluster data, the models match the clusters' elemental abundances and ages with high precision. Analyzing stacked SDSS spectra of early-type galaxies brighter than Lstar, we find mean luminosity-weighted ages of the order of ~ 8 Gyr and iron abundances slightly below solar. Abundance ratios, [X/Fe], are higher than solar, and correlate positively with galaxy luminosity. Nitrogen is the element whose abundance correlates the most strongly with luminosity, which seems to indicate secondary enrichment. This result may impose a lower limit of 50-200 Myr to the time-scale of star formation in early-type galaxies. Unlike in the case of clusters, in galaxies bluer Balmer lines yield younger ages than Hbeta. This age discrepancy is stronger for lower luminosity galaxies. We examine four scenarios to explain this trend. The most likely is the presence of small amounts of a young/intermediate-age SP component. Two-component models provide a better match to the data when the mass fraction of the young component is a few %. This result implies that star formation has been extended in early-type galaxies, and more so in less massive galaxies, lending support to the ``downsizing'' scenario. It also implies that SP synthesis models are capable of constraining not only the mean ages of SPs in galaxies, but also their age spread.Comment: To appear in the Astrophysical Journal Supplement Series. 55 Pages, using emulateapj5.sty. Full version, containing all (enlarged) figures can be found at http://www.astro.virginia.edu/~rps7v/Models/ms.pdf . A number of useful tables in the Appendix can be obtained in advance of publication by request to the autho

Clustering and descendants of MUSYC galaxies at z<1.5

We measure the evolution of galaxy clustering out to a redshift of z~1.5 using data from two MUSYC fields, the Extended Hubble Deep Field South (EHDF-S) and the Extended Chandra Deep Field South (ECDF-S). We use photometric redshift information to calculate the projected-angular correlation function, omega(sigma), from which we infer the projected correlation function Xi(sigma). We demonstrate that this technique delivers accurate measurements of clustering even when large redshift measurement errors affect the data. To this aim we use two mock MUSYC fields extracted from a LambdaCDM simulation populated with GALFORM semi-analytic galaxies which allow us to assess the degree of accuracy of our estimates of Xi(sigma) and to identify and correct for systematic effects in our measurements. We study the evolution of clustering for volume limited subsamples of galaxies selected using their photometric redshifts and rest-frame r-band absolute magnitudes. We find that the real-space correlation length r_0 of bright galaxies, M_r<-21 (rest-frame) can be accurately recovered out to z~1.5, particularly for ECDF-S given its near-infrared photometric coverage. There is mild evidence for a luminosity dependent clustering in both fields at the low redshift samples (up to =0.57), where the correlation length is higher for brighter galaxies by up to 1Mpc/h between median rest-frame r-band absolute magnitudes of -18 to -21.5. As a result of the photometric redshift measurement, each galaxy is assigned a best-fit template; we restrict to E and E+20%Sbc types to construct subsamples of early type galaxies (ETGs). Our ETG samples show a strong increase in r_0 as the redshift increases, making it unlikely (95% level) that ETGs at median redshift z_med=1.15 are the direct progenitors of ETGs at z_med=0.37 with equivalent passively evolved luminosities. (ABRIDGED)Comment: 16 pages, 12 figures, 2 tables, accepted for publication in MNRA