High resolution 3-D temperature and salinity fields derived from in situ and satellite observations

This paper describes an observation-based approach that efficiently combines the main components of the global ocean observing system using statistical methods. Accurate but sparse in situ temperature and salinity profiles (mainly from Argo for the last 10 yr) are merged with the lower accuracy but high-resolution synthetic data derived from satellite altimeter and sea surface temperature observations to provide global 3-D temperature and salinity fields at high temporal and spatial resolution. The first step of the method consists in deriving synthetic temperature fields from altimeter and sea surface temperature observations, and salinity fields from altimeter observations, through multiple/simple linear regression methods. The second step of the method consists in combining the synthetic fields with in situ temperature and salinity profiles using an optimal interpolation method. Results show the revolutionary nature of the Argo observing system. Argo observations now allow a global description of the statistical relationships that exist between surface and subsurface fields needed for step 1 of the method, and can constrain the large-scale temperature and mainly salinity fields during step 2 of the method. Compared to the use of climatological estimates, results indicate that up to 50% of the variance of the temperature fields can be reconstructed from altimeter and sea surface temperature observations and a statistical method. For salinity, only about 20 to 30% of the signal can be reconstructed from altimeter observations, making the in situ observing system essential for salinity estimates. The in situ observations (step 2 of the method) further reduce the differences between the gridded products and the observations by up to 20% for the temperature field in the mixed layer, and the main contribution is for salinity and the near surface layer with an improvement up to 30%. Compared to estimates derived using in situ observations only, the merged fields provide a better reconstruction of the high resolution temperature and salinity fields. This also holds for the large-scale and low-frequency fields thanks to a better reduction of the aliasing due to the mesoscale variability. Contribution of the merged fields is then illustrated to describe qualitatively the temperature variability patterns for the period from 1993 to 2009

Contribution of future wide-swath altimetry missions to ocean analysis and forecasting

The impact of forthcoming wide-swath altimetry missions on the ocean analysis and forecasting system was investigated by means of OSSEs (observing system simulation experiments). These experiments were performed with a regional data assimilation system, implemented in the Iberian–Biscay–Ireland (IBI) region, at 1∕12° resolution using simulated observations derived from a fully eddy-resolving free simulation at 1∕36° resolution over the same region. The objective of the experiments was to assess the ability of different satellite constellations to constrain the ocean analyses and forecasts, considering both along-track altimeters and future wide-swath missions; consequently, the capability of the data assimilation techniques used in the Mercator Ocean operational system to effectively combine the different kinds of measurements was also investigated. These assessments were carried out as part of a European Space Agency (ESA) study on the potential role of wide-swath altimetry in future versions of the European Union Copernicus programme. The impact of future wide-swath altimetry data is evident for investigating the reliability of sea level values in OSSEs. The most significant results were obtained when looking at the sensitivity of the system to wide-swath instrumental error: considering a constellation of three nadir and two accurate (small instrumental error) wide-swath altimeters, the error in ocean analysis was reduced by up to 50&thinsp;% compared to conventional altimeters. Investigating the impact of the repetitivity of the future measurements, the results showed that two wide-swath missions had a major impact on sea-level forecasting – increasing the accuracy over the entire time window of the 5-day forecasts – compared with a single wide-swath instrument. A spectral analysis underlined that the contributions of wide-swath altimetry data observed in ocean analyses and forecast statistics were mainly due to the more accurate resolution, compared with along-track data, of ocean variability at spatial scales smaller than 100&thinsp;km. Considering the ocean currents, the results confirmed that the information provided by wide-swath measurements at the surface is propagated down the water column and has a considerable impact (30&thinsp;%) on ocean currents (up to a depth of 300&thinsp;m), compared with the present constellation of altimeters. The ocean analysis and forecasting systems used here are those currently used by the Copernicus Marine Environment and Monitoring Service (CMEMS) to provide operational services and ocean reanalysis. The results obtained in the OSSEs considering along-track altimeters were consistent with those derived from real data (observing system experiments, OSEs). OSSEs can also be used to assess the potential of new observing systems, and in this study the results showed that future constellations of altimeters will have a major impact on constraining the CMEMS ocean analysis and forecasting systems and their applications.</p

A micropillar for cavity optomechanics

We present a new micromechanical resonator designed for cavity optomechanics. We have used a micropillar geometry to obtain a high-frequency mechanical resonance with a low effective mass and a very high quality factor. We have coated a 60-$\mu$m diameter low-loss dielectric mirror on top of the pillar and are planning to use this micromirror as part of a high-finesse Fabry-Perot cavity, to laser cool the resonator down to its quantum ground state and to monitor its quantum position fluctuations by quantum-limited optical interferometry

Free-space cavity optomechanics in a cryogenic environment

International audienceWe present a free-space optomechanical system operating in the 1-K range. The device is made ofa high mechanical quality factor micropillar with a high-reflectivity optical coating atop, combinedwith an ultra-small radius-of-curvature coupling mirror to form a high-finesse Fabry-Perot cavityembedded in a dilution refrigerator. The cavity environment as well as the cryostat have beendesigned to ensure low vibrations and to preserve micron-level alignment from room temperatur

Estimates of North Atlantic ventilation and mode water formation for winters 2002–06

Author Posting. © American Meteorological Society, 2009. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 39 (2009): 2600-2617, doi:10.1175/2009JPO3930.1.Lagrangian estimates for ventilation rates in the Gulf Stream Extension using Argo and World Ocean Circulation Experiment/Atlantic Climate and Circulation Experiment (WOCE/ACCE) float data, scatterometer (QuikSCAT) wind stress satellite observations, and altimetric [Archiving, Validation, and Interpretation of Satellite Oceanographic data (AVISO)] sea surface height (SSH) satellite observations from 2002 to 2006 are presented. Satellite winds and estimates of surface geostrophic currents allow the inclusion of the effects of currents on wind stress as well as their impact on the Ekman pumping. The presence of large surface geostrophic currents decreases the total Ekman pumping, contributing up to 20% where the Gulf Stream makes its two sharpest turns, and increases the total Ekman pumping by 10% or less everywhere else. The ageostrophic currents may be as large as 15% of the geostrophic currents, but only in proximity of the Gulf Stream. Using currents and mixed layer depths (MLDs) that are either climatological or vary from year to year, obducted water tends to originate along the Gulf Stream, while subducted water tends to originate to its south. However, using time-varying MLDs for each year, subduction varies significantly, sometimes oppositely from obduction. The 18° Water (EDW) subducts in different locations and is distributed differently each year but tends to be located in the Sargasso Sea. Vertical pumping is the only dominant factor in ventilation closer to the coast where MLDs are shallower and lighter parcels are subducted. Vertical pumping contributes up to 20% of the several hundreds of ventilated meters per year around the Gulf Stream and less elsewhere. Using a temperature- or density-based criterion for estimating the MLDs, especially along the coasts and north of 45°N, obduction estimates differ by up to 25%. The horizontal and temporal structure of the MLDs is the primary factor that controls the tens of sverdrups of ventilation (and a few sverdrups of EDW subduction)

New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study

Objectives: Orthostatic hypotension (OH) is a key feature of multiple system atrophy (MSA), a fatal progressive neurodegenerative disorder associated with autonomic failure, parkinsonism and ataxia. This study aims (1) to determine the clinical spectrum of OH in a large European cohort of patients with MSA and (2) to investigate whether a prolonged postural challenge increases the sensitivity to detect OH in MSA. Methods: Assessment of OH during a 10 min orthostatic test in 349 patients with MSA from seven centres of the European MSA-Study Group (age: 63.6±8.8 years; disease duration: 4.2±2.6 years). Assessment of a possible relationship between OH and MSA subtype (P with predominant parkinsonism or C with predominant cerebellar ataxia), Unified MSA Rating Scale (UMSARS) scores and drug intake. Results: 187 patients (54%) had moderate (>20 mm Hg (systolic blood pressure (SBP)) and/or >10 mm Hg (diastolic blood pressure (DBP)) or severe OH (>30 mm Hg (SBP) and/or >15 mm Hg (DBP)) within 3 min and 250 patients (72%) within 10 min. OH magnitude was significantly associated with disease severity (UMSARS I, II and IV), orthostatic symptoms (UMSARS I) and supine hypertension. OH severity was not associated with MSA subtype. Drug intake did not differ according to OH magnitude except for antihypertensive drugs being less frequently, and antihypotensive drugs more frequently, prescribed in severe OH. Conclusions: This is the largest study of OH in patients with MSA. Our data suggest that the sensitivity to pick up OH increases substantially by a prolonged 10 min orthostatic challenge. These results will help to improve OH management and the design of future clinical trials.Fil: Pavy Le Traon, Anne. University Hospital of Toulouse; Francia. Inserm; FranciaFil: Piedvache, A.. Université Paul Sabatier; FranciaFil: Pérez Lloret, Santiago. University Hospital of Toulouse; Francia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Calandra Buonara, G.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; ItaliaFil: Cochen De Cock, V.. University Hospital of Toulouse; Francia. University of Montpellier; FranciaFil: Colosimo, C.. Sapienza Università di Roma; ItaliaFil: Cortelli, P.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; ItaliaFil: Debs, R.. University Hospital of Toulouse; FranciaFil: Duerr, S.. Universidad de Innsbruck; AustriaFil: Fanciulli, A.. Universidad de Innsbruck; AustriaFil: Foubert Samier, A.. Centre Hospitalier Universitaire de Bordeaux; Francia. Universite de Bordeaux; FranciaFil: Gerdelat, Angela. University Hospital of Toulouse; FranciaFil: Gurevich, T.. Tel-Aviv University; IsraelFil: Krismer, F.. Universidad de Innsbruck; AustriaFil: Poewe, W.. Universidad de Innsbruck; AustriaFil: Tison, Francois. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; FranciaFil: Tranchant, C.. University Hospital Hautepierre; FranciaFil: Wenning, G.. Universidad de Innsbruck; AustriaFil: Meissner, Wassilios G.. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; FranciaFil: Rascol, Olivier. University Hospital of Toulouse; Franci

Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

Several studies have confirmed the α-synuclein real-time quaking-induced conversion (RT-QuIC) assay to have high sensitivity and specificity for Parkinson's disease. However, whether the assay can be used as a robust, quantitative measure to monitor disease progression, stratify different synucleinopathies and predict disease conversion in patients with idiopathic REM sleep behaviour disorder remains undetermined. The aim of this study was to assess the diagnostic value of CSF α-synuclein RT-QuIC quantitative parameters in regard to disease progression, stratification and conversion in synucleinopathies. We performed α-synuclein RT-QuIC in the CSF samples from 74 Parkinson's disease, 24 multiple system atrophy and 45 idiopathic REM sleep behaviour disorder patients alongside 55 healthy controls, analysing quantitative assay parameters in relation to clinical data. α-Synuclein RT-QuIC showed 89% sensitivity and 96% specificity for Parkinson's disease. There was no correlation between RT-QuIC quantitative parameters and Parkinson's disease clinical scores (e.g. Unified Parkinson's Disease Rating Scale motor), but RT-QuIC positivity and some quantitative parameters (e.g. Vmax) differed across the different phenotype clusters. RT-QuIC parameters also added value alongside standard clinical data in diagnosing Parkinson's disease. The sensitivity in multiple system atrophy was 75%, and CSF samples showed longer T50 and lower Vmax compared to Parkinson's disease. All RT-QuIC parameters correlated with worse clinical progression of multiple system atrophy (e.g. change in Unified Multiple System Atrophy Rating Scale). The overall sensitivity in idiopathic REM sleep behaviour disorder was 64%. In three of the four longitudinally followed idiopathic REM sleep behaviour disorder cohorts, we found around 90% sensitivity, but in one sample (DeNoPa) diagnosing idiopathic REM sleep behaviour disorder earlier from the community cases, this was much lower at 39%. During follow-up, 14 of 45 (31%) idiopathic REM sleep behaviour disorder patients converted to synucleinopathy with 9/14 (64%) of convertors showing baseline RT-QuIC positivity. In summary, our results showed that α-synuclein RT-QuIC adds value in diagnosing Parkinson's disease and may provide a way to distinguish variations within Parkinson's disease phenotype. However, the quantitative parameters did not correlate with disease severity in Parkinson's disease. The assay distinguished multiple system atrophy patients from Parkinson's disease patients and in contrast to Parkinson's disease, the quantitative parameters correlated with disease progression of multiple system atrophy. Our results also provided further evidence for α-synuclein RT-QuIC having potential as an early biomarker detecting synucleinopathy in idiopathic REM sleep behaviour disorder patients prior to conversion. Further analysis of longitudinally followed idiopathic REM sleep behaviour disorder patients is needed to better understand the relationship between α-synuclein RT-QuIC signature and the progression from prodromal to different synucleinopathies

The Oceanic Variability Spectrum and Transport Trends

Oceanic meridional transports evaluated over the width of the Pacific Ocean from altimetric observations become incoherent surprisingly rapidly with meridional separation. Even with 15 years of data, surface slopes show no significant coherence beyond 5◦ of latitude separation at any frequency. An analysis of the frequency/zonal-wavenumber spectral density shows a broad continuum of motions at all time and space scales, with a significant excess of energy along a “non-dispersive” line extending between the simple barotropic and first baroclinic mode Rossby waves. It is speculated that much of that excess energy lies with coupled barotropic and first mode Rossby waves. The statistical significance of apparent oceanic transport trends depends upon the existence of a reliable frequency/wavenumber spectrum and for which only a few observational elements now exist.Jet Propulsion Laboratory (U.S.).United States. National Aeronautics and Space Administration (Jason-1 program)National Oceanographic Partnership Program (U.S.