Effets du suivi zootechnique sur les performances de production et la rentabilité des élevages de bovins laitiers en périmètre irrigué au Maroc

International audienceUne démarche de " suivi - intervention " a été adoptée dans cinq exploitations agricoles, illustrant la diversité des situations d'élevage bovin laitier dans le périmètre irrigué du Tadla (Maroc). Un diagnostic initial de gestion de l'élevage (alimentation et reproduction) et de ses répercussions sur la productivité et la rentabilité des troupeaux bovins a été réalisé dans chaque étable. Des manques à gagner ayant été détectés, un appui technique en continu a été instauré. Il a consisté en l'évaluation des carences alimentaires dans les rations utilisées par les éleveurs et en leur correction par des matières premières disponibles (plus de fourrages ou recours aux concentrés). Les résultats ont montré qu'en dépit de la conjoncture climatique difficile où s'est déroulé ce travail (campagne agricole de 2006-2007 où les précipitations ont été de 200 mm par rapport à une moyenne annuelle de 300 mm sur les dix dernières années), l'encadrement alimentaire rapproché a permis de promouvoir le rendement laitier des vaches, par l'extériorisation de leur potentiel génétique. L'étude a aussi révélé que les vaches de race Holstein affichaient de meilleures réponses au rationnement alimentaire par rapport aux vaches de type croisé, en raison de leurs aptitudes laitières plus affirmées. Les résultats ont indiqué que l'appui technique permettait l'augmentation des livraisons de lait par vache et la diminution du prix de revient du lait. Étant donné le contexte actuel de désengagement prononcé des services techniques de l'Etat de l'encadrement de la production agricole, la méthode d'appui zootechnique mise à l'épreuve dans ce suivi gagnerait à être prise en main par les associations professionnelles et les coopératives de collecte du lait pour être diffusée auprès d'un effectif plus important, en vue d'en juger l'impact sur toute la filière dans le périmètre irrigué du Tadla

Genomic Organization and Expression of Iron Metabolism Genes in the Emerging Pathogenic Mold

The ubiquitous mold is increasingly recognized as an emerging pathogen, especially among patients with underlying disorders such as immunodeficiency or cystic fibrosis (CF). Indeed, it ranks the second among the filamentous fungi colonizing the respiratory tract of CF patients. However, our knowledge about virulence factors of this fungus is still limited. The role of iron-uptake systems may be critical for establishment of infections, notably in the iron-rich environment of the CF lung. Two main strategies are employed by fungi to efficiently acquire iron from their host or from their ecological niche: siderophore production and reductive iron assimilation (RIA) systems. The aim of this study was to assess the existence of orthologous genes involved in iron metabolism in the recently sequenced genome of . At first, a tBLASTn analysis using iron-related proteins as query revealed orthologs of almost all relevant loci in the genome. Whereas the genes putatively involved in RIA were randomly distributed, siderophore biosynthesis and transport genes were organized in two clusters, each containing a non-ribosomal peptide synthetase (NRPS) whose orthologs in have been described to catalyze hydroxamate siderophore synthesis. Nevertheless, comparative genomic analysis of siderophore-related clusters showed greater similarity between and phylogenetically close molds than with species. The expression level of these genes was then evaluated by exposing conidia to iron starvation and iron excess. The expression of several orthologs of genes involved in siderophore-based iron uptake or RIA was significantly induced during iron starvation, and conversely repressed in iron excess conditions. Altogether, these results indicate that possesses the genetic information required for efficient and competitive iron uptake. They also suggest an important role of the siderophore production system in iron uptake by

Rôle des coopératives dans le fonctionnement du bassin de collecte laitier du Tadla, Maroc

International audienceLe bassin de collecte laitier situé sur le périmètre du Tadla se structure autour d'une usine de transformation industrielle approvisionnée par une myriade de petits éleveurs. Cette atomisation de l'offre a rendu nécessaire la mise en place de coopératives de collecte chargées d'agréger l'offre et d'assurer la chaîne du froid au plus près des producteurs. De fait, ces coopératives jouent un rôle central d'intermédiaire dans la chaîne d'approvisionnement allant de l'eau d'irrigation à la fourniture de lait à l'usine. Cet article, tiré d'une enquête approfondie conduite sur 12 cas, présente dans une première partie les différentes fonctions assurées par les coopératives. Différentes stratégies émergent, fonction de la place tenue par l'équilibre entre volume et qualité du lait produits et la place des activités de diversification dans les performances et les revenus des cas étudiés. Leurs pratiques gestionnaires sont ensuite analysées, concernant leur gestion financière, le paiement des adhérents et leur système d'information. Une relative complexité des circuits de gestion de l'information, couplée à une multiplicité des données et supports à gérer favorisent une certaine opacité des résultats technico-économiques, dommageable à la durabilité de ces organisations. Différentes propositions de recherche et d'intervention tirées de cette analyse sont présentées en conclusion

Utiliser la modélisation pour évaluer l'impact du fonctionnement d'élevages laitiers sur l'économie et la valorisation de l'eau d'irrigation. Cas du Tadla (Maroc)

L'économie et la valorisation de l'eau d'irrigation dépendent des décisions prises par les agriculteurs en matière de choix d'assolement, de modes de conduite des systèmes de production et de stratégies de commercialisation. Si les gestionnaires de périmètre comme les opérateurs aval des filières influencent ces décisions, ils sont souvent démunis face à la diversité des contextes d'action des agriculteurs et à la complexité des réflexions prospectives à mener. Cet article présente une démarche conçue et expérimentée sur le bassin de collecte laitier du périmètre du Tadla au Maroc. Elle combine l'utilisation d'une typologie en 4 types basés sur les stratégies et les pratiques des éleveurs, et d'un outil de simulation confrontant offre et demande alimentaire sur chacun des types. L'utilisation de l'outil est illustrée sur l'exemple des petites exploitations laitières intensives. Différents systèmes fourragers sont comparés et leurs impacts sur la production laitière, la consommation et la valorisation de l'eau d'irrigation sont évalués. Il est ainsi montré que les systèmes combinant maïs ensilage et luzerne sont plus intéressants que les systèmes à base de luzerne sur tous ces plans. Les limites de la démarche touchent à la base de données nécessaire pour valider la typologie sur l'ensemble de la population des éleveurs et pour paramétrer le modèle, aux simplifications apportées à la représentation des processus de gestion et à l'ergonomie de l'application

Investigation of nosocomial pneumocystis infections: usefulness of longitudinal screening of epidemic and post-epidemic pneumocystis genotypes

BACKGROUND: Twenty-five patients, of whom 22 were renal transplant recipients, developed Pneumocystis jirovecii infections at the nephrology department of Reims University Hospital (France) from September 2008 to October 2009, whereas only four sporadic cases had been diagnosed in this department over the 14 previous years. AIM: This outbreak was investigated by analysing patient encounters and P. jirovecii types. METHODS: A transmission map was drawn up. P. jirovecii typing at DHPS, ITS and mtLSU rRNA sequences was performed in the patients of the cluster (18 patients with Pneumocystis pneumonia (PCP) and seven colonized patients), 10 unlinked control patients (six PCP patients and four colonized patients), as well as 23 other patients diagnosed with P. jirovecii (nine PCP patients and 14 colonized patients) in the same department over a three-year post-epidemic period. FINDINGS: Eleven encounters between patients harbouring the same types were observed. Three PCP patients and one colonized patient were considered as possible index cases. The most frequent types in the cluster group and the control group were identical. However, their frequency was significantly higher in the first than in the second group (P < 0.01). Identical types were also identified in the post-epidemic group, suggesting a second outbreak due to the same strain, contemporary to a disruption in prevention measures. CONCLUSIONS: These results provide additional data on the role of both PCP and colonized patients as infectious sources. Longitudinal screening of P. jirovecii types in infected patients, including colonized patients, is required in the investigation of the fungus\u27s circulation within hospitals

A sulfur-rich pi-electron acceptor derived from 5,5 '-bithiazolidinylidene: charge-transfer complex vs. charge-transfer salt

International audienceNovel pi-electron acceptors are still highly desirable for the formation of conducting salts or as n-dopable semiconductors. We describe here two synthetic approaches to substitute a dicyanovinylidene group, C=C(CN)(2) to a thioketone (C=S) in the recently described DEBTTT acceptor where DEBTTT stands for (E)-3,3'-diethyl-5,5'-bithiazolidinylidene-2,4,2',4'-tetrathione. These electron withdrawing groups enhance the electron accepting ability as demonstrated through electrochemical investigations, without hindering the formation of short intra-and intermolecular S center dot center dot center dot S contacts in the solid state. Association of this acceptor 1 with tetramethyltetrathiafulvalene (TMTTF) and decamethylferrocene (Fe(Cp*)(2)) afforded 1 : 1 adducts which were analyzed by single crystal X-ray diffraction. Combined with vibrational and magnetic properties, it appears that [TMTTF][1] behaves as a neutral charge-transfer complex while [Fe(Cp*)(2)][1] is an ionic salt. The concentration of the spin density on the exocyclic sulfur atoms in 1(-center dot) favors the setting of direct anti-ferromagnetic interactions in [Fe(Cp*)(2)][1

Type Ia Supernovae Rates and Galaxy Clustering from the CFHT Supernova Legacy Survey

The Canada-France-Hawaii Telescope Supernova Legacy Survey (SNLS) has created a large homogeneous database of intermediate redshift (0.2 < z < 1.0) type Ia supernovae (SNe Ia). The SNLS team has shown that correlations exist between SN Ia rates, properties, and host galaxy star formation rates. The SNLS SN Ia database has now been combined with a photometric redshift galaxy catalog and an optical galaxy cluster catalog to investigate the possible influence of galaxy clustering on the SN Ia rate, over and above the expected effect due to the dependence of SFR on clustering through the morphology-density relation. We identify three cluster SNe Ia, plus three additional possible cluster SNe Ia, and find the SN Ia rate per unit mass in clusters at intermediate redshifts is consistent with the rate per unit mass in field early-type galaxies and the SN Ia cluster rate from low redshift cluster targeted surveys. We also find the number of SNe Ia in cluster environments to be within a factor of two of expectations from the two component SNIa rate model.Comment: 21 pages, 2 figures, 6 tables, accepted for publication in A

Heart failure during the COVID-19 pandemic: clinical, diagnostic, management, and organizational dilemmas

The coronavirus 2019 (COVID-19) infection pandemic has affected the care of patients with heart failure (HF). Several consensus documents describe the appropriate diagnostic algorithm and treatment approach for patients with HF and associated COVID-19 infection. However, few questions about the mechanisms by which COVID can exacerbate HF in patients with high-risk (Stage B) or symptomatic HF (Stage C) remain unanswered. Therefore, the type of HF occurring during infection is poorly investigated. The diagnostic differentiation and management should be focused on the identification of the HF phenotype, underlying causes, and subsequent tailored therapy. In this framework, the relationship existing between COVID and onset of acute decompensated HF, isolated right HF, and cardiogenic shock is questioned, and the specific management is mainly based on local hospital organization rather than a standardized model. Similarly, some specific populations such as advanced HF, heart transplant, patients with left ventricular assist device (LVAD), or valve disease remain under investigated. In this systematic review, we examine recent advances regarding the relationships between HF and COVID-19 pandemic with respect to epidemiology, pathogenetic mechanisms, and differential diagnosis. Also, according to the recent HF guidelines definition, we highlight different clinical profile identification, pointing out the main concerns in understudied HF populations.© 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology

Association between canine leishmaniosis and Ehrlichia canis co-infection: a prospective case-control study

Abstract Background In the Mediterranean basin, Leishmania infantum is a major cause of disease in dogs, which are frequently co-infected with other vector-borne pathogens (VBP). However, the associations between dogs with clinical leishmaniosis (ClinL) and VBP co-infections have not been studied. We assessed the risk of VBP infections in dogs with ClinL and healthy controls. Methods We conducted a prospective case-control study of dogs with ClinL (positive qPCR and ELISA antibody for L. infantum on peripheral blood) and clinically healthy, ideally breed-, sex- and age-matched, control dogs (negative qPCR and ELISA antibody for L. infantum on peripheral blood) from Paphos, Cyprus. We obtained demographic data and all dogs underwent PCR on EDTA-blood extracted DNA for haemoplasma species, Ehrlichia/Anaplasma spp., Babesia spp., and Hepatozoon spp., with DNA sequencing to identify infecting species. We used logistic regression analysis and structural equation modelling (SEM) to evaluate the risk of VBP infections between ClinL cases and controls. Results From the 50 enrolled dogs with ClinL, DNA was detected in 24 (48%) for Hepatozoon spp., 14 (28%) for Mycoplasma haemocanis, 6 (12%) for Ehrlichia canis and 2 (4%) for Anaplasma platys. In the 92 enrolled control dogs, DNA was detected in 41 (45%) for Hepatozoon spp., 18 (20%) for M. haemocanis, 1 (1%) for E. canis and 3 (3%) for A. platys. No Babesia spp. or “Candidatus Mycoplasma haematoparvum” DNA was detected in any dog. No statistical differences were found between the ClinL and controls regarding age, sex, breed, lifestyle and use of ectoparasitic prevention. A significant association between ClinL and E. canis infection (OR = 12.4, 95% CI: 1.5–106.0, P = 0.022) was found compared to controls by multivariate logistic regression. This association was confirmed using SEM, which further identified that younger dogs were more likely to be infected with each of Hepatozoon spp. and M. haemocanis, and dogs with Hepatozoon spp. were more likely to be co-infected with M. haemocanis. Conclusions Dogs with ClinL are at a higher risk of co-infection with E. canis than clinically healthy dogs. We recommend that dogs diagnosed with ClinL should be tested for E. canis co-infection using PCR