Developing ecosystem service indicators: experiences and lessons learned from sub-global assessments and other initiatives

People depend upon ecosystems to supply a range of services necessary for their survival and well-being. Ecosystem service indicators are critical for knowing whether or not these essential services are being maintained and used in a sustainable manner, thus enabling policy makers to identify the policies and other interventions needed to better manage them. As a result, ecosystem service indicators are of increasing interest and importance to governmental and inter-governmental processes, including amongst others the Convention on Biological Diversity (CBD) and the Aichi Targets contained within its strategic plan for 2011-2020, as well as the emerging Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES). Despite this growing demand, assessing ecosystem service status and trends and developing robust indicators is o!en hindered by a lack of information and data, resulting in few available indicators. In response, the United Nations Environment Programme World Conservation Monitoring Centre (UNEP-WCMC), together with a wide range of international partners and supported by the Swedish International Biodiversity Programme (SwedBio)*, undertook a project to take stock of the key lessons that have been learnt in developing and using ecosystem service indicators in a range of assessment contexts. The project examined the methodologies, metrics and data sources employed in delivering ecosystem service indicators, so as to inform future indicator development. This report presents the principal results of this project

The cytotoxicity and synergistic potential of aspirin and aspirin analogues towards oesophageal and colorectal cancer

Background: Oesophageal cancer (OC) is a deadly cancer because of its aggressive nature with survival rates that have barely improved in decades. Epidemiologic studies have shown that low-dose daily intake of aspirin can decrease the incidence of OC. Methods: The toxicity of aspirin and aspirin derivatives to OC and a colorectal cancer (CRC) cell line were investigated in the presence and absence of platins. Results: The data in this study show the effects of a number of aspirin analogues and aspirin on OC cell lines that originally presented as squamous cell carcinoma (SSC) and adenocarcinoma (ADC). The aspirin analogues fumaryldiaspirin (PN517) and the benzoylsalicylates (PN524, PN528 and PN529), were observed to be more toxic against the OC cell lines than aspirin. Both quantitative and qualitative apoptosis experiments reveal that these compounds largely induce apoptosis, although some necrosis was evident with PN528 and PN529. Failure to recover following the treatment with these analogues emphasized that these drugs are largely cytotoxic in nature. The OE21 (SSC) and OE33 (ADC) cell lines were more sensitive to the aspirin analogues compared to the Flo-1 cell line (ADC). A non-cancerous oesophageal primary cells NOK2101, was used to determine the specificity of the aspirin analogues and cytotoxicity assays revealed that analogues PN528 and PN529 were selectively toxic to cancer cell lines, whereas PN508, PN517 and PN524 also induced cell death in NOK2101. In combination index testing synergistic interactions of the most promising compounds, including aspirin, with cisplatin, oxaliplatin and carboplatin against the OE33 cell line and the SW480 CRC cell line were investigated. Compounds PN517 and PN524, and to a lesser extent PN528, synergised with cisplatin against OE33 cells. Cisplatin and oxaliplatin synergised with aspirin and PN517 when tested against the SW480 cell line. Conclusion: These findings indicate the potential and limitations of aspirin and aspirin analogues as chemotherapeutic agents against OC and CRC when combined with platins

The Cumulative Effects of Polymorphisms in the DNA Mismatch Repair Genes and Tobacco Smoking in Oesophageal Cancer Risk

The DNA mismatch repair (MMR) enzymes repair errors in DNA that occur during normal DNA metabolism or are induced by certain cancer-contributing exposures. We assessed the association between 10 single-nucleotide polymorphisms (SNPs) in 5 MMR genes and oesophageal cancer risk in South Africans. Prior to genotyping, SNPs were selected from the HapMap database, based on their significantly different genotypic distributions between European ancestry populations and four HapMap populations of African origin. In the Mixed Ancestry group, the MSH3 rs26279 G/G versus A/A or A/G genotype was positively associated with cancer (OR = 2.71; 95% CI: 1.34–5.50). Similar associations were observed for PMS1 rs5742938 (GG versus AA or AG: OR = 1.73; 95% CI: 1.07–2.79) and MLH3 rs28756991 (AA or GA versus GG: OR = 2.07; 95% IC: 1.04–4.12). In Black individuals, however, no association between MMR polymorhisms and cancer risk was observed in individual SNP analysis. The interactions between MMR genes were evaluated using the model-based multifactor-dimensionality reduction approach, which showed a significant genetic interaction between SNPs in MSH2, MSH3 and PMS1 genes in Black and Mixed Ancestry subjects, respectively. The data also implies that pathogenesis of common polymorphisms in MMR genes is influenced by exposure to tobacco smoke. In conclusion, our findings suggest that common polymorphisms in MMR genes and/or their combined effects might be involved in the aetiology of oesophageal cancer

Towards screening Barrett’s Oesophagus: current guidelines, imaging modalities and future developments

Barrett’s oesophagus is the only known precursor to oesophageal adenocarcinoma (OAC). Although guidelines on the screening and surveillance exist in Barrett’s oesophagus, the current strategies are inadequate. Oesophagogastroduodenoscopy (OGD) is the gold standard method in screening for Barrett’s oesophagus. This invasive method is expensive with associated risks negating its use as a current screening tool for Barrett’s oesophagus. This review explores current definitions, epidemiology, biomarkers, surveillance, and screening in Barrett’s oesophagus. Imaging modalities applicable to this condition are discussed, in addition to future developments. There is an urgent need for an alternative non-invasive method of screening and/or surveillance which could be highly beneficial towards reducing waiting times, alleviating patient fears and reducing future costs in current healthcare services. Vibrational spectroscopy has been shown to be promising in categorising Barrett’s oesophagus through to high-grade dysplasia (HGD) and OAC. These techniques need further validation through multicentre trials

An assessment of soil erosion prevention by vegetation in Mediterranean Europe: Current trends of ecosystem service provision

International audienceThe concept of ecosystem services has received increased attention in recent years, and is seen as a useful construct for the development of policy relevant indicators and communication for science, policy and practice. Soil erosion is one of the main environmental problems for European Mediterranean agro-forestry systems, making soil erosion prevention a key ecosystem service to monitor and assess. Here, we present a spatially and temporally explicit assessment of the provision of soil erosion prevention by vegetation in Mediterranean Europe between 2001 and 2013, including maps of vulnerable areas. We follow a recently described conceptual framework for the mapping and assessment of regulating ecosystem services to calculate eight pro cess-based indicators, and an ecosystem service provision profile. Results show a relative increase in the effectiveness of provision of soil erosion prevention in Mediterranean Europe between 2001 and 2013. This increase is particularly noticeable between 2009 and 2013, but it does not represent a general trend across the whole Mediterranean region. Two regional examples describe contrasting trends and illustrate the need for regional assessments and policy targets. Our results demonstrate the strength of having a coherent and complementary set of indicators for regulating services to inform policy and land management decisions. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Urban morphological determinants of temperature regulating ecosystem services in two African cities

Urban green infrastructure provides important regulating ecosystem services, such as temperature and flood regulation, and thus, has the potential to increase the resilience of African cities to climate change. Differing characteristics of urban areas can be conceptualised and subsequently mapped through the idea of urban morphology types (UMTs) – classifications which combine facets of urban form and function. When mapped, UMT units provide biophysically relevant meso-scale geographical zones which can be used as the basis for understanding climate-related impacts and adaptations. For example, they support the assessment of urban temperature patterns and the temperature regulation services provided by urban green structures. UMTs have been used for assessing regulating ecosystem services in European cities but little similar knowledge is available in an African context. This paper outlines the concept of UMTs and how they were applied to two African case study cities: Addis Ababa, Ethiopia and Dar es Salaam, Tanzania. It then presents the data and methods used to understand provision of temperature regulation services across the two cities. In total, 35 detailed UMT classes were identified for Addis Ababa and 43 for Dar es Salaam. Modelled land surface temperature profiles for each of these UMTs are presented. The results demonstrate that urban morphological characteristics of UMTs, such as land surface cover proportions and associated built mass, have a much larger potential to alter neighbourhood level surface temperatures compared to projected climate changes. Land surface cover differences drive land surface temperature ranges over 25 ◦C compared to climate change projections being associated with changes of less than 1.5 ◦C. Residential UMTs account for the largest surface area of the cities, which are rapidly expanding due to population increase. Within the Residential UMTs, informal settlements and traditional housing areas are associated with the lowest land surface temperatures in Addis Ababa. These have higher proportions and better composition of green structures than other residential areas. The results have implications for planning policies in the cities. In Addis Ababa, the current urban renewal strategy to convert high density informal unplanned settlements into formal planned housing needs to explicitly account for green structure provision to avoid adverse effects on future supply of temperature regulation services. In Dar es Salaam, condominium UMTs have some of the largest proportions of green structures, and the best provision of temperature regulation services. In this case the challenge will be to maintain these into the future