374 research outputs found
Magnetic fields of intermediate mass T Tauri stars
Aims. In this paper, we aim to measure the strength of the surface magnetic
fields for a sample of five intermediate mass T Tauri stars and one low mass T
Tauri star from late-F to mid-K spectral types. While magnetic fields of T
Tauri stars at the low mass range have been extensively characterized, our work
complements previous studies towards the intermediate mass range; this
complementary study is key to evaluate how magnetic fields evolve during the
transition from a convective to a radiative core.
Methods. We studied the Zeeman broadening of magnetically sensitive spectral
lines in the H-band spectra obtained with the CRIRES high-resolution
near-infrared spectrometer. These data are modelled using magnetic spectral
synthesis and model atmospheres. Additional constraints on non-magnetic line
broadening mechanisms are obtained from modelling molecular lines in the K band
or atomic lines in the optical wavelength region.
Results. We detect and measure mean surface magnetic fields for five of the
six stars in our sample: CHXR 28, COUP 107, V2062 Oph, V1149 Sco, and Par 2441.
Magnetic field strengths inferred from the most magnetically sensitive
diagnostic line range from 0.8 to 1.8 kG. We also estimate a magnetic field
strength of 1.9 kG for COUP 107 from an alternative diagnostic. The magnetic
field on YLW 19 is the weakest in our sample and is marginally detected, with a
strength of 0.8 kG.
Conclusions. We populate an uncharted area of the pre-main-sequence HR
diagram with mean magnetic field measurements from high-resolution
near-infrared spectra. Our sample of intermediate mass T Tauri stars in general
exhibits weaker magnetic fields than their lower mass counterparts. Our
measurements will be used in combination with other spectropolarimetric studies
of intermediate mass and lower mass T Tauri stars to provide input into
pre-main-sequence stellar evolutionary models.Comment: 8 pages, 8 figures, accepted for publication in Astronomy and
Astrophysic
Retrieval of the dayside atmosphere of WASP-43b with CRIRES+
Accurately estimating the C/O ratio of hot Jupiter atmospheres is a promising
pathway towards understanding planet formation and migration, as well as the
formation of clouds and the overall atmospheric composition. The atmosphere of
the hot Jupiter WASP-43b has been extensively analysed using low-resolution
observations with HST and Spitzer, but these previous observations did not
cover the K band, which hosts prominent spectral features of major
carbon-bearing species such as CO and CH. As a result, the ability to
establish precise constraints on the C/O ratio was limited. Moreover, the
planet has not been studied at high spectral resolution, which can provide
insights into the atmospheric dynamics.
In this study, we present the first high-resolution dayside spectra of
WASP-43b with the new CRIRES spectrograph. By observing the planet in the K
band, we successfully detected the presence of CO and provide evidence for the
existence of HO using the cross-correlation method. This discovery
represents the first direct detection of CO in the atmosphere of WASP-43b.
Furthermore, we retrieved the temperature-pressure profile, abundances of CO
and HO, and a super-solar C/O ratio of 0.78 by applying a Bayesian
retrieval framework to the data. Our findings also shed light on the
atmospheric characteristics of WASP-43b. We found no evidence for a cloud deck
on the dayside, and recovered a line broadening indicative of an equatorial
super-rotation corresponding to a jet with a wind speed of 5 km
s, matching the results of previous forward models and low-resolution
atmospheric retrievals for this planet.Comment: 15 pages, 14 figure
CRIRES+ detection of CO emissions lines and temperature inversions on the dayside of WASP-18b and WASP-76b
The dayside atmospheres of ultra-hot Jupiters (UHJs) are predicted to possess
temperature inversion layers with extremely high temperatures at high
altitudes. We observed the dayside thermal emission spectra of WASP-18b and
WASP-76b with the new CRIRES+ high-resolution spectrograph at near-infrared
wavelengths. Using the cross-correlation technique, we detected strong CO
emission lines in both planets, which confirms the existence of temperature
inversions on their dayside hemispheres. The two planets are the first UHJs
orbiting F-type stars with CO emission lines detected; previous detections were
mostly for UHJs orbiting A-type stars. Evidence of weak H2O emission signals is
also found for both planets. We further applied forward-model retrievals on the
detected CO lines and retrieved the temperature-pressure profiles along with
the CO volume mixing ratios. The retrieved logarithmic CO mixing ratio of
WASP-18b (-2.2) is slightly higher than the value predicted by the
self-consistent model assuming solar abundance. For WASP-76b, the retrieved CO
mixing ratio (-3.6) is broadly consistent with the value of solar abundance. In
addition, we included the equatorial rotation velocity (Veq ) in the retrieval
when analyzing the line profile broadening. The obtained Veq is 7.0 km/s for
WASP-18b and 5.2 km/s for WASP-76b, which are consistent with the tidally
locked rotational velocities.Comment: 11 pages, 12 figures; accepted for publication in A&
Mouse Retinal Development: a Dark Horse Model for Systems Biology Research
The developing retina is an excellent model to study cellular fate determination and differentiation in the context of a complex tissue. Over the last decade, many basic principles and key genes that underlie these processes have been experimentally identified. In this review, we construct network models to summarize known gene interactions that underlie determination and fundamentally affect differentiation of each retinal cell type. These networks can act as a scaffold to assemble subsequent discoveries. In addition, these summary networks provide a rational segue to systems biology approaches necessary to understand the many events leading to appropriate cellular determination and differentiation in the developing retina and other complex tissues
Monitoring the large-scale magnetic field of AD~Leo with SPIRou, ESPaDOnS and Narval. Toward a magnetic polarity reversal?
One manifestation of dynamo action on the Sun is the 22-yr magnetic cycle,
exhibiting a polarity reversal and a periodic conversion between poloidal and
toroidal fields. For M dwarfs, several authors claim evidence of activity
cycles from photometry and analyses of spectroscopic indices, but no clear
polarity reversal has been identified from spectropolarimetric observations.
Our aim is to monitor the evolution of the large-scale field of AD Leo, which
has shown hints of a secular evolution from past dedicated spectropolarimetric
campaigns. We analysed near-infrared spectropolarimetric observations of the
active M dwarf AD Leo taken with SPIRou between 2019 and 2020 and archival
optical data collected with ESPaDOnS and Narval between 2006 and 2019. We
searched for long-term variability in the longitudinal field, the width of
unpolarised Stokes profiles, the unsigned magnetic flux derived from Zeeman
broadening, and the geometry of the large-scale magnetic field using both
Zeeman-Doppler Imaging and Principal Component Analysis. We found evidence of a
long-term evolution of the magnetic field, featuring a decrease in axisymmetry
(from 99% to 60%). This is accompanied by a weakening of the longitudinal field
(-300 to -50 G) and a correlated increase in the unsigned magnetic flux (2.8 to
3.6 kG). Likewise, the width of the mean profile computed with selected
near-infrared lines manifests a long-term evolution corresponding to field
strength changes over the full time series, but does not exhibit modulation
with the stellar rotation of AD Leo in individual epochs. The large-scale
magnetic field of AD Leo manifested first hints of a polarity reversal in late
2020 in the form of a substantially increased dipole obliquity, while the
topology remained predominantly poloidal and dipolar. This suggests that
low-mass M dwarfs with a dipole-dominated magnetic field can undergo magnetic
cycles.Comment: 26 pages, 18 figures, 8 table
The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
Mutations in the MYO7A gene cause a deaf-blindness disorder, known as Usher syndrome 1B. In the retina, the majority of MYO7A is in the retinal pigmented epithelium (RPE), where many of the reactions of the visual retinoid cycle take place. We have observed that the retinas of Myo7a-mutant mice are resistant to acute light damage. In exploring the basis of this resistance, we found that Myo7a-mutant mice have lower levels of RPE65, the RPE isomerase that has a key role in the retinoid cycle. We show for the first time that RPE65 normally undergoes a light-dependent translocation to become more concentrated in the central region of the RPE cells. This translocation requires MYO7A, so that, in Myo7a-mutant mice, RPE65 is partly mislocalized in the light. RPE65 is degraded more quickly in Myo7a-mutant mice, perhaps due to its mislocalization, providing a plausible explanation for its lower levels. Following a 50–60% photobleach, Myo7a-mutant retinas exhibited increased all-trans-retinyl ester levels during the initial stages of dark recovery, consistent with a deficiency in RPE65 activity. Lastly, MYO7A and RPE65 were co-immunoprecipitated from RPE cell lysate by antibodies against either of the proteins, and the two proteins were partly colocalized, suggesting a direct or indirect interaction. Together, the results support a role for MYO7A in the translocation of RPE65, illustrating the involvement of a molecular motor in the spatiotemporal organization of the retinoid cycle in vision
Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration
Glia, the support cells of the central nervous system, have recently attracted considerable attention both as mediators of neural cell survival and as sources of neural regeneration. To further elucidate the role of glial and neural cells in neurodegeneration, we generated TrkBGFAP and TrkBc-kit knockout mice in which TrkB, a receptor for brain-derived neurotrophic factor (BDNF), is deleted in retinal glia or inner retinal neurons, respectively. Here, we show that the extent of glutamate-induced retinal degeneration was similar in these two mutant mice. Furthermore in TrkBGFAP knockout mice, BDNF did not prevent photoreceptor degeneration and failed to stimulate Müller glial cell proliferation and expression of neural markers in the degenerating retina. These results demonstrate that BDNF signalling in glia has important roles in neural protection and regeneration, particularly in conversion of Müller glia to photoreceptors. In addition, our genetic models provide a system in which glia- and neuron-specific gene functions can be tested in central nervous system tissues in vivo
℮-conome: an automated tissue counting platform of cone photoreceptors for rodent models of retinitis pigmentosa
<p>Abstract</p> <p>Background</p> <p>Retinitis pigmentosa is characterized by the sequential loss of rod and cone photoreceptors. The preservation of cones would prevent blindness due to their essential role in human vision. Rod-derived Cone Viability Factor is a thioredoxin-like protein that is secreted by rods and is involved in cone survival. To validate the activity of Rod-derived Cone Viability Factors (RdCVFs) as therapeutic agents for treating retinitis Pigmentosa, we have developed e-conome, an automated cell counting platform for retinal flat mounts of rodent models of cone degeneration. This automated quantification method allows for faster data analysis thereby accelerating translational research.</p> <p>Methods</p> <p>An inverted fluorescent microscope, motorized and coupled to a CCD camera records images of cones labeled with fluorescent peanut agglutinin lectin on flat-mounted retinas. In an average of 300 fields per retina, nine Z-planes at magnification X40 are acquired after two-stage autofocus individually for each field. The projection of the stack of 9 images is subject to a threshold, filtered to exclude aberrant images based on preset variables. The cones are identified by treating the resulting image using 13 variables empirically determined. The cone density is calculated over the 300 fields.</p> <p>Results</p> <p>The method was validated by comparison to the conventional stereological counting. The decrease in cone density in <it>rd1 </it>mouse was found to be equivalent to the decrease determined by stereological counting. We also studied the spatiotemporal pattern of the degeneration of cones in the <it>rd1 </it>mouse and show that while the reduction in cone density starts in the central part of the retina, cone degeneration progresses at the same speed over the whole retinal surface. We finally show that for mice with an inactivation of the Nucleoredoxin-like genes <it>Nxnl1 </it>or <it>Nxnl2 </it>encoding RdCVFs, the loss of cones is more pronounced in the ventral retina.</p> <p>Conclusion</p> <p>The automated platform ℮-conome used here for retinal disease is a tool that can broadly accelerate translational research for neurodegenerative diseases.</p
- …