Venturi air-jet vacuum ejectors for high-volume atmospheric sampling on aircraft platforms

Documentation of the installation and use of venturi air-jet vacuum ejectors for high-volume atmospheric sampling on aircraft platforms is presented. Information on the types of venturis that are useful for meeting the pumping requirements of atmospheric-sampling experiments is also presented. A description of the configuration and installation of the venturi system vacuum line is included with details on the modifications that were made to adapt a venturi to the NASA Electra aircraft at GSFC, Wallops Flight Facility. Flight test results are given for several venturis with emphasis on applications to the Differential Absorption Carbon Monoxide Measurement (DACOM) system at LaRC. This is a source document for atmospheric scientists interested in using the venturi systems installed on the NASA Electra or adapting the technology to other aircraft

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc

Venturi Air-Jet Vacuum Ejectors for High-Volume Atmospheric Sampling on Aircraft Platforms

This report provides documentation of the installation and use of venturi air-jet vacuum ejectors for high-volume atmospheric sampling on aircraft platforms. It contains information on the types of venturis that are useful for meeting the pumping requirements of atmosphericsampling experiments. A description of the configuration and installation of the venturi system vacuum line is included with details on the modifications that were made to adapt a venturi to the NASA Electra aircraft at Goddard Space Flight Center, Wallops Flight Facility. Flight test results are given for several venturis with emphasis on applications to the Differential Absorption Carbon Monoxide Measurement (DACOM) system at Langley Research Center. This report is a source document for atmospheric scientists interested in using the venturi systems installed on the NASA Electra or adapting the technology to other aircraft. Introduction The NASA Global Tropospheric Experiment (GTE) program includes many trace-gas-s..

Report Documentation Page

(Maximum 200 words) This report provides documentation of the installation and use of venturi air-jet vacuum ejectors for highvolume atmospheric sampling on aircraft platforms. It contains information on the types of venturis that are useful for meeting the pumping requirements of atmospheric-sampling experiments. A description of the configuration and installation of the venturi system vacuum line is included with details on the modifications that were made to adapt a venturi to the NASA Electra aircraft at Goddard Space Flight Center, Wallops Flight Facility. Flight test results are given for several venturis with emphasis on applications to the Differential Absorption Carbon Monoxide Measurement (DACOM) system at Langley Research Center. This report is a source document for atmospheric scientists interested in using the venturi systems installed on the NASA Electra or adapting the technology to other aircraft. 14. SUBJECT TERMS 15. NUMBER OF PAGES Venturi; Vacuum pump; Ejectors; A..

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection