Discrete Symmetries of Off-Shell Electromagnetism

We discuss the discrete symmetries of the Stueckelberg-Schrodinger relativistic quantum theory and its associated 5D local gauge theory, a dynamical description of particle/antiparticle interactions, with monotonically increasing Poincare-invariant parameter. In this framework, worldlines are traced out through the parameterized evolution of spacetime events, advancing or retreating with respect to the laboratory clock, with negative energy trajectories appearing as antiparticles when the observer describes the evolution using the laboratory clock. The associated gauge theory describes local interactions between events (correlated by the invariant parameter) mediated by five off-shell gauge fields. These gauge fields are shown to transform tensorially under under space and time reflections, unlike the standard Maxwell fields, and the interacting quantum theory therefore remains manifestly Lorentz covariant. Charge conjugation symmetry in the quantum theory is achieved by simultaneous reflection of the sense of evolution and the fifth scalar field. Applying this procedure to the classical gauge theory leads to a purely classical manifestation of charge conjugation, placing the CPT symmetries on the same footing in the classical and quantum domains. In the resulting picture, interactions do not distinguish between particle and antiparticle trajectories -- charge conjugation merely describes the interpretation of observed negative energy trajectories according to the laboratory clock.Comment: 26 page

Duality in Off-Shell Electromagnetism

In this paper, we examine the Dirac monopole in the framework of Off-Shell Electromagnetism, the five dimensional U(1) gauge theory associated with Stueckelberg-Schrodinger relativistic quantum theory. After reviewing the Dirac model in four dimensions, we show that the structure of the five dimensional theory prevents a natural generalization of the Dirac monopole, since the theory is not symmetric under duality transformations. It is shown that the duality symmetry can be restored by generalizing the electromagnetic field strength to an element of a Clifford algebra. Nevertheless, the generalized framework does not permit us to recover the phenomenological (or conventional) absence of magnetic monopoles.Comment: 18 page

Modeling of predictive human movement coordination patterns for applications in computer graphics

The planning of human body movements is highly predictive. Within a sequence of actions, the anticipation of a final task goal modulates the individual actions within the overall pattern of motion. An example is a sequence of steps, which is coordinated with the grasping of an object at the end of the step sequence. Opposed to this property of natural human movements, real-time animation systems in computer graphics often model complex activities by a sequential concatenation of individual pre-stored movements, where only the movement before accomplishing the goal is adapted. We present a learning-based technique that models the highly adaptive predictive movement coordination in humans, illustrated for the example of the coordination of walking and reaching. The proposed system for the real-time synthesis of human movements models complex activities by a sequential concatenation of movements, which are approximated by the superposition of kinematic primitives that have been learned from trajectory data by anechoic demixing, using a step-wise regression approach. The kinematic primitives are then approximated by stable solutions of nonlinear dynamical systems (dynamic primitives) that can be embedded in control architectures. We present a control architecture that generates highly adaptive predictive full-body movements for reaching while walking with highly human-like appearance. We demonstrate that the generated behavior is highly robust, even in presence of strong perturbations that require the insertion of additional steps online in order to accomplish the desired task

Short oestrous cycles in sheep during anoestrus involve defects in progesterone biosynthesis and luteal neovascularisation

Anoestrous ewes can be induced to ovulate by the socio-sexual, 'ram effect'. However, in some ewes the induced ovulation is followed by an abnormally short luteal phase causing a so called, "short cycle". The defect responsible for this luteal dysfunction has not been identified. In this experiment we investigated ovarian and uterine factors implicated in male-induced short cycles in anoestrus ewes using a combined endocrine and molecular strategy. Prior to ovulation, we were able to detect a moderate loss of thecal expression of steroid acute regulatory protein (STAR) in ewes that had not received progesterone priming (which prevents short cycles). At and following ovulation we were able to identify significant loss of expression of genes coding key proteins involved in the biosynthesis of progesterone (STAR, CYP11A1, HSD3B) as well as genes coding proteins critical for vascular development during early luteal development (VEGFA, VEGFR2) suggesting dysfunction in at least two pathways critical for normal luteal function. Furthermore, these changes were associated with a significant reduction of progesterone production and luteal weight. Additionally, we cast doubt on the proposed uterine-mediated effect of prostaglandin F2α as a cause of short cycles by demonstrating both the dysregulation of luteal expression of the PGF receptor, which mediates the luteal effects of PGF2α, and by finding no significant changes in the circulating concentrations of PGFM, the principal metabolite of PGF2α in ewes with short cycles. This study is the first of its kind to examine concurrently, the endocrine and molecular events in the follicular and early luteal stages of the short cycle

Large Scale Traces of Solar System Cold Dust on CMB Anisotropies

We explore the microwave anisotropies at large angular scales produced by the emission from cold and large dust grains, expected to exist in the outer parts of the Solar System, using a simple toy model for this diuse emission. Its amplitude is constrained in the Far-IR by the COBE data and is compatible with simulations found in the literature. We analyze the templates derived after subtracting our model from the WMAP ILC 7 yr maps and investigate on the cosmological implications of such a possible foreground. The anomalies related to the low quadrupole of the angular power spectrum, the two-point correlation function, the parity and the excess of signal found in the ecliptic plane are significantly alleviated. An impact of this foreground for some cosmological parameters characterizing the spectrum of primordial density perturbations, relevant for on-going and future CMB anisotropy experiments, is found.Comment: Issue 2.0, Accepted for pub. in MNRAS, Apr 8th, 2011, (sub. Oct 4th, 2010); 10 pages, 6 Figures, 1 table; pdflatex with mn2e, AMS, natbib, txfonts, graphic

Where do Children Travel to and What Local Opportunities Are Available? The Relationship Between Neighborhood Destinations and Children’s Independent Mobility

Associations between access to local destinations and children’s independent mobility (IM) were examined. In 2007, 10- to 12-year-olds (n = 1,480) and their parents (n = 1,314) completed a survey. Children marked on a map the destinations they walked or cycled to (n = 1,132), and the availability of local destinations was assessed using Geographic Information Systems. More independently mobile children traveled to local destinations than other children. The odds of IM more than halved in both boys and girls whose parents reported living on a busy road (boys, OR = 0.48; girls, OR = 0.36) and in boys who lived near shopping centers (OR = 0.18) or community services (OR = 0.25). Conversely, the odds of IM more than doubled in girls living in neighborhoods with well-connected low-traffic streets (OR = 2.32) and increased in boys with access to local recreational (OR = 1.67) and retail (OR = 1.42) destinations. Creating safe and accessible places and routes may facilitate children’s IM, partly by shaping parent’s and children’s feelings of safety while enhancing their confidence in the child’s ability to use active modes without an adult

How improving access times had unforeseen consequences: a case study in a Dutch hospital

OBJECTIVES: To investigate the consequences of increasing capacity to reduce access times, and to explore how patient waiting times and use of physical capacity were influenced by variability. DESIGN: A retrospective case study that combines both primary and secondary data. Secondary data were retrieved from a hospital database to establish inflow and outflow of patients, utilisation of resources and available capacity, realised acc

Kiwi Forego Vision in the Guidance of Their Nocturnal Activities

BACKGROUND: In vision, there is a trade-off between sensitivity and resolution, and any eye which maximises information gain at low light levels needs to be large. This imposes exacting constraints upon vision in nocturnal flying birds. Eyes are essentially heavy, fluid-filled chambers, and in flying birds their increased size is countered by selection for both reduced body mass and the distribution of mass towards the body core. Freed from these mass constraints, it would be predicted that in flightless birds nocturnality should favour the evolution of large eyes and reliance upon visual cues for the guidance of activity. METHODOLOGY/PRINCIPAL FINDINGS: We show that in Kiwi (Apterygidae), flightlessness and nocturnality have, in fact, resulted in the opposite outcome. Kiwi show minimal reliance upon vision indicated by eye structure, visual field topography, and brain structures, and increased reliance upon tactile and olfactory information. CONCLUSIONS/SIGNIFICANCE: This lack of reliance upon vision and increased reliance upon tactile and olfactory information in Kiwi is markedly similar to the situation in nocturnal mammals that exploit the forest floor. That Kiwi and mammals evolved to exploit these habitats quite independently provides evidence for convergent evolution in their sensory capacities that are tuned to a common set of perceptual challenges found in forest floor habitats at night and which cannot be met by the vertebrate visual system. We propose that the Kiwi visual system has undergone adaptive regressive evolution driven by the trade-off between the relatively low rate of gain of visual information that is possible at low light levels, and the metabolic costs of extracting that information

Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas denitrificans

Author Posting. © American Society for Microbiology, 2008. This article is posted here by permission of American Society for Microbiology for personal use, not for redistribution. The definitive version was published in Applied and Environmental Microbiology 74 (2008): 1145-1156, doi:10.1128/AEM.01844-07.Sulfur-oxidizing epsilonproteobacteria are common in a variety of sulfidogenic environments. These autotrophic and mixotrophic sulfur-oxidizing bacteria are believed to contribute substantially to the oxidative portion of the global sulfur cycle. In order to better understand the ecology and roles of sulfur-oxidizing epsilonproteobacteria, in particular those of the widespread genus Sulfurimonas, in biogeochemical cycles, the genome of Sulfurimonas denitrificans DSM1251 was sequenced. This genome has many features, including a larger size (2.2 Mbp), that suggest a greater degree of metabolic versatility or responsiveness to the environment than seen for most of the other sequenced epsilonproteobacteria. A branched electron transport chain is apparent, with genes encoding complexes for the oxidation of hydrogen, reduced sulfur compounds, and formate and the reduction of nitrate and oxygen. Genes are present for a complete, autotrophic reductive citric acid cycle. Many genes are present that could facilitate growth in the spatially and temporally heterogeneous sediment habitat from where Sulfurimonas denitrificans was originally isolated. Many resistance-nodulation-development family transporter genes (10 total) are present; of these, several are predicted to encode heavy metal efflux transporters. An elaborate arsenal of sensory and regulatory protein-encoding genes is in place, as are genes necessary to prevent and respond to oxidative stress.This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory, University of California, under contract W-7405-ENG-48. Genome closure was funded in part by a USF Innovative Teaching Grant (K.M.S.). S.M.S. received partial support through a fellowship from the Hanse Wissenschaftskolleg in Delmenhorst, Germany (http://www.h-w-k.de), and NSF grant OCE-0452333. K.M.S. is grateful for support from NSF grant MCB-0643713. M.H. was supported by a WHOI postdoctoral scholarship. M.G.K. was supported in part by incentive funds provided by the UofL-EVPR office, the KY Science and Engineering Foundation (KSEF-787-RDE-007), and the National Science Foundation (EF-0412129)