1,630 research outputs found
The formation of the eccentric-orbit millisecond pulsar J1903+0327 and the origin of single millisecond pulsars
The millisecond pulsar J1903+0327 is accompanied by an ordinary G-dwarf star
in an unusually wide (\,days) and eccentric () orbit. The standard model for producing MSPs fails to explain the
orbital characteristics of this extraordinary binary, and alternative binary
models are unable to explain the observables. We present a triple-star model
for producing MSPs in relatively wide eccentric binaries with a normal
(main-sequence) stellar companion. We start from a stable triple system
consisting of a Low-Mass X-ray Binary (LMXB) with an orbital period of at least
1 day, accompanied by a G-dwarf in a wide and possibly eccentric orbit.
Variations in the initial conditions naturally provide a satisfactory
explanation for the unexplained triple component in the eclipsing soft X-ray
transient 4U~2129+47 or the cataclysmic variable EC 19314-5915. The best
explanation for J1903, however, results from the expansion of the orbit of the
LMXB, driven by the mass transfer from the evolving donor star to its neutron
star companion, which causes the triple eventually to becomes dynamically
unstable. Using numerical computations we show that, depending on the precise
system configuration at the moment the triple becomes dynamically unstable, the
ejection of each of the three components is possible. If the donor star of the
LMXB is ejected, a system resembling J1903, will result. If the neutron star is
ejected, a single MSP results. This model therefore also provides a
straightforward mechanism for forming single MSP in the Galactic disk. We
conclude that the Galaxy contains some 30--300 binaries with characteristics
similar to J1903, and about an order of magnitude fewer single millisecond
pulsars produced with the proposed triple scenario.Comment: ApJ accepted for publicatio
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Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering
Disrupting the interaction between primase and helicase in Escherichia coli increases Okazaki fragment (OF) length due to less frequent primer synthesis. We exploited this feature to increase the amount of ssDNA at the lagging strand of the replication fork that is available for λ Red-mediated Multiplex Automatable Genome Engineering (MAGE). Supporting this concept, we demonstrate that MAGE enhancements correlate with OF length. Compared with a standard recombineering strain (EcNR2), the strain with the longest OFs displays on average 62% more alleles converted per clone, 239% more clones with 5 or more allele conversions and 38% fewer clones with 0 allele conversions in 1 cycle of co-selection MAGE (CoS-MAGE) with 10 synthetic oligonucleotides. Additionally, we demonstrate that both synthetic oligonucleotides and accessible ssDNA targets on the lagging strand of the replication fork are limiting factors for MAGE. Given this new insight, we generated a strain with reduced oligonucleotide degradation and increased genomic ssDNA availability, which displayed 111% more alleles converted per clone, 527% more clones with 5 or more allele conversions and 71% fewer clones with 0 allele conversions in 1 cycle of 10-plex CoS-MAGE. These improvements will facilitate ambitious genome engineering projects by minimizing dependence on time-consuming clonal isolation and screening
Affordable In-Space Transportation
Current and proposed launch systems will provide access to low-Earth orbit (LEO), and destinations beyond LEO, but the cost of delivering payloads will preclude the use of these services by many users. To develop and encourage revolutionary commercial utilization of geosynchronous orbit (GEO) and to provide an affordable means to continue NASA space science and exploration missions, the transportation costs to in-space destinations must be reduced. The principal objective of this study was to conceptually define three to four promising approaches to in-space transportation for delivery of satellites and other payloads, 3,000- to 10,000-lb class, to GEO destinations. This study established a methodology for evaluating in-space transportation systems based on life-cycle cost. The reusable concepts seemed to fare better in the evaluation than expendable, since a major driver in the life-cycle cost was the stage production cost
DIFFICULTĂS DE LA PARTICIPATION EN RECHERCHE- ACTION : retour d'expĂ©riences de modĂ©lisation d'accompagnement en appui Ă l'amĂ©nagement du territoire au SĂ©nĂ©gal et Ă la RĂ©union
International audienceComment aider les institutions et acteurs locaux à investir davantage les processus d'affectation des terres pour aménager leur territoire ? La décentralisation de l'aménagement du territoire engagée à la Réunion et au Sénégal est inachevée. Malgré l'arsenal législatif, les populations locales semblent peu impliquées dans les décisions les concernant en raison notamment de la difficulté à appréhender la complexité des systÚmes d'interactions entre dynamiques sociales et environnementales. Le projet Domino vise à accompagner les processus de décision en proposant aux acteurs de construire et d'explorer des scenarii prospectifs d'affectation des terres. Cette expérience de modélisation participative repose sur une dynamique partenariale complexe sur chaque terrain, source de difficultés. Conscients des dérives potentielles, nous discutons la nécessité de construire une démarche qualité de notre recherche-action. Mots clés : montage de partenariat, démarche qualité, modÚle, changement social, ComMod, interdisciplinarité, décentralisation, foncier, Sénégal, Réunio
Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane
The plasma membrane is organized into various subdomains of clustered macromolecules. Such domains include adhesive structures (cellular synapses, substrate adhesions, and cellâcell junctions) and membrane invaginations (clathrin-coated pits and caveolae), as well as less well-defined domains such as lipid rafts and lectin-glycoprotein lattices. Domains are organized by specialized scaffold proteins including the intramembranous caveolins, which stabilize lipid raft domains, and the galectins, a family of animal lectins that cross-link glycoproteins forming molecular lattices. We review evidence that these heterogeneous microdomains interact to regulate substratum adhesion and cytokine receptor dynamics at the cell surface
On the incidence of weak magnetic fields in DA white dwarfs
Context: About 10% of white dwarfs have magnetic fields with strength in the
range between about 10^5 and 3x10^8 G. It is not known whether the remaining
white dwarfs are not magnetic, or if they have a magnetic field too weak to be
detected with the techniques adopted in the large surveys. Aims. We describe
the results of the first survey specifically devised to clarify the detection
frequency of kG-level magnetic fields in cool DA white dwarfs. Methods: Using
the FORS1 instrument of the ESO VLT, we have obtained Balmer line circular
spectropolarimetric measurements of a small sample of cool (DA6 - DA8) white
dwarfs. Using FORS and UVES archive data, we have also revised numerous white
dwarf field measurements previously published in the literature. Results: We
have discovered an apparently constant longitudinal magnetic field of \sim9.5
kG in the DA6 white dwarf WD2105-820. This star is the first weak-field white
dwarf that has been observed sufficiently to roughly determine the
characteristics of its field. The available data are consistent with a simple
dipolar morphology with magnetic axis nearly parallel to the rotation axis, and
a polar strength of \simeq 56 kG. Our re-evaluation of the FORS archive data
for white dwarfs indicates that longitudinal magnetic fields weaker than 10 kG
had previously been correctly identified in at least three white dwarfs.
Conclusions: We find that the probability of detecting a field of kG strength
in a DA white dwarf is of the order of 10% for each of the cool and hot DA
stars. If there is a lower cutoff to field strength in white dwarfs, or a field
below which all white dwarfs are magnetic, the current precision of
measurements is not yet sufficient to reveal it.Comment: Accepted for publication in Astronomy & Astrophysic
Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1
Both tyrosine-phosphorylated caveolin-1 (pY14Cav1) and GlcNAc-transferase V (Mgat5) are linked with focal adhesions (FAs); however, their function in this context is unknown. Here, we show that galectin-3 binding to Mgat5-modified N-glycans functions together with pY14Cav1 to stabilize focal adhesion kinase (FAK) within FAs, and thereby promotes FA disassembly and turnover. Expression of the Mgat5/galectin lattice alone induces FAs and cell spreading. However, FAK stabilization in FAs also requires expression of pY14Cav1. In cells lacking the Mgat5/galectin lattice, pY14Cav1 is not sufficient to promote FAK stabilization, FA disassembly, and turnover. In human MDA-435 cancer cells, Cav1 expression, but not mutant Y14FCav1, stabilizes FAK exchange and stimulates de novo FA formation in protrusive cellular regions. Thus, transmembrane crosstalk between the galectin lattice and pY14Cav1 promotes FA turnover by stabilizing FAK within FAs defining previously unknown, interdependent roles for galectin-3 and pY14Cav1 in tumor cell migration
The Mid-Infrared Instrument for the James Webb Space Telescope, V: Predicted Performance of the MIRI Coronagraphs
The imaging channel on the Mid-Infrared Instrument (MIRI) is equipped with
four coronagraphs that provide high contrast imaging capabilities for studying
faint point sources and extended emission that would otherwise be overwhelmed
by a bright point-source in its vicinity. Such bright sources might include
stars that are orbited by exoplanets and circumstellar material, mass-loss
envelopes around post-main-sequence stars, the near-nuclear environments in
active galaxies, and the host galaxies of distant quasars. This paper describes
the coronagraphic observing modes of MIRI, as well as performance estimates
based on measurements of the MIRI flight model during cryo-vacuum testing. A
brief outline of coronagraphic operations is also provided. Finally, simulated
MIRI coronagraphic observations of a few astronomical targets are presented for
illustration
Search for positively charged strangelets and other related results with E864 at the AGS
We report on the latest results in the search for positively charged
strangelets from E864's 96/97 run at the AGS with sensitivity of about per central collision. This contribution also contains new results of
a search for highly charged strangelets with . Production of light
nuclei, such as and , is presented as well. Measurements of yields
of these rarely produced isotopes near midrapidity will help constrain the
production levels of strangelets via coalescence. E864 also measures antiproton
production which includes decays from antihyperons. Comparisons with antiproton
yields measured by E878 as a function of centrality indicate a large
antihyperon-to-antiproton ratio in central collisions.Comment: 8 pages, 4 figures; Talk at SQM'98, Padova, Italy (July 20-24th,
1998
Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts
Cell fusion occurs when several cells combine to form a multinuclear aggregate (syncytium). In human placenta, a syncytialized trophoblast (syncytiotrophoblast) layer forms the primary interface between maternal and fetal tissue, facilitates nutrient and gas exchange, and produces hormones vital for pregnancy. Syncytiotrophoblast development occurs by differentiation of underlying progenitor cells called cytotrophoblasts, which then fuse into the syncytiotrophoblast layer. Differentiation is associated with chromatin remodeling and specific changes in gene expression mediated, at least in part, by histone acetylation. However, the epigenetic regulation of human cytotrophoblast differentiation and fusion is poorly understood. In this study, we found that human syncytiotrophoblast development was associated with deacetylation of multiple core histone residues. Chromatin immunoprecipitation sequencing revealed chromosomal regions that exhibit dynamic alterations in histone H3 acetylation during differentiation. These include regions containing genes classically associated with cytotrophoblast differentiation (TEAD4, TP63, OVOL1, CGB), as well as near genes with novel regulatory roles in trophoblast development and function, such as LHX4 and SYDE1. Prevention of histone deacetylation using both pharmacological and genetic approaches inhibited trophoblast fusion, supporting a critical role of this process for trophoblast differentiation. Finally, we identified the histone deacetylases (HDACs) HDAC1 and HDAC2 as the critical mediators driving cytotrophoblast differentiation. Collectively, these findings provide novel insights into the epigenetic mechanisms underlying trophoblast fusion during human placental development
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