Cosmic-Ray Production and the Role of Supernovae in NGC 6946

We present a study of 35 radio-selected supernova remnant (SNR) candidates in the nearby spiral galaxy NGC 6946. In this study, an optically selected sample of 27 SNRs from Matonick & Fesen is compared to our sample of radio-selected SNRs. The optically selected SNRs are found to have almost no overlap with the radio-selected sample. This dichotomy is further enhanced by the observation that the optically selected SNRs favor the interarm regions, while the radio-emitting SNRs lie predominately on the spiral arms in or near regions of high star formation. The separation of the two samples of SNRs is discussed in terms of selection effects and differences in cosmic-ray production. The optical sample of SNRs is probably biased toward those SNRs located in areas of NGC 6946 where the confusion of Hα emission by H II regions is relatively low and the SNRs are easier to identify by their emission-line signatures. The radio-selected sample is also subject to selection biases such that these SNRs favor the arms. However, the absence of radio emission from the optically selected, largely interarm SNRs and the relatively large number of radio-detected SNRs in the arms require additional explanation. The properties of the radio-selected SNRs are discussed in the context of diffusive shock acceleration theory. We find that the theory can account for the range in radio flux densities and the nondetection of the optically selected SNRs. The differences in the radio properties between the arm and interarm population of SNRs can be explained by differences in the average gas densities and magnetic fields since the latter affect both the cosmic-ray yield and the radio properties of the SNRs. The possibility that the arm and interarm SNRs arise from different stellar populations is also addressed

Radio emission from SNe and young SNRs

Study of radio supernovae (RSNe), the earliest stages of supernova remnant (SNR) formation, over the past 20 years includes two dozen detected objects and more than 100 upper limits. From this work we are able to identify classes of radio properties, demonstrate conformance to and deviations from existing models, estimate the density and structure of the circumstellar material and, by inference, the evolution of the presupernova stellar wind, and reveal the last stages of stellar evolution before explosion. It is also possible to detect ionized hydrogen along the line of sight, to demonstrate binary properties of the stellar system, and to show clumpiness of the circumstellar material. More speculatively, it may be possible to provide distance estimates to RSNe

VLA Observations of J1228+441, a Luminous Supernova Remnant in NGC 4449

The luminous, oxygen-rich supernova remnant, J1228+441, is located in the irregular galaxy NGC 4449 and has been observed at radio wavelengths for thirty years. An analysis of recent VLA observations of NGC 4449, combined with VLA archive data and previously published VLA and WSRT observations, yields light curves at 6 and 20 cm from 1972 to 2002. The light curves at all radio frequencies exhibit a marked decline in radio emission, confirming past findings. This paper presents and discusses the radio light curves and spectral index, alpha, variations from 1972 to 2002 where nu propto nu^(-alpha) and compares J1228+441 with other radio supernovae. The spectral index of J1228+441 appears to have steepened in the last five years at higher frequencies from alpha=0.64 +- 0.02 in 1996 to alpha=1.01 +- 0.02 in 2001-2002.Comment: aastex, 19 pages, 6 figures, to be published in A

An X-ray, Optical and Radio Search for Supernova Remnants in the Nearby Sculptor Group Sd Galaxy NGC 7793

We present a multi-wavelength study of the properties of supernova remnants (SNRs) in the nearby Sculptor Group Sd galaxy NGC 7793. Using our own Very Large Array radio observations at 6 and 20 cm, as well as archived ROSAT X-ray data, previously published optical results and our own H-alpha image, we have searched for X-ray and radio counterparts to previously known optically-identified SNRs and for new previously unidentified SNRs at these two wavelength regimes. Only two of the 28 optically-identified SNRs are detected at another wavelength. The most noteworthy source in our study is N7793-S26, which is the only SNR that is detected at all three wavelengths. It features a long (approximately 450 pc) filamentary morphology that is clearly seen in both the optical and radio images. N7793-S26's radio luminosity exceeds that of the Galactic SNR Cas A, and based on equipartition calculations we determine that an energy of at least 10^52 ergs is required to maintain this source. A second optically identified SNR, N7793-S11, has detectable radio emission but is not detected in the X-ray. Complementary X-ray and radio searches for SNRs have yielded five new candidate radio SNRs, to be added to the 28 SNRs in this galaxy that have already been detected by optical methods. We find that the density of the ambient interstellar medium (ISM) surrounding these SNRs significantly impacts the spectral characteristics of SNRs in this galaxy, consistent with surveys of the SNR populations in other galaxies.Comment: 32 pages, 25 figures, to appear in the Astrophysical Journal (February 2002

Chandra and Very Large Array Observations of the Nearby Sd Galaxy NGC 45

We present an analysis of high angular resolution observations made in the X-ray and the radio with the Chandra X-ray Observatory and the Karl Jansky Very Large Array (VLA), respectively, of the nearby spiral galaxy NGC 45. This galaxy is the third that we have considered in a study of the supernova remnant (SNR) populations of nearby spiral galaxies and the present work represents the first detailed analysis of the discrete X-ray and radio source populations of this galaxy. We analyzed data sets from the three pointed observations made of this galaxy with Chandra along with a merged data set obtained from combining these data sets: the total effective exposure time of the merged data set is 63515 s. A total of 25 discrete X-ray sources are found in the entire field of view of the ACIS-S3 chip, with 16 sources found within the visual extent of the galaxy. We estimate that as many as half of the sources detected in the entire field of view of the ACIS-S3 chip and seven of the sources detected in the optical extent of NGC 45 may be background sources. We analyzed the spectral properties of the discrete X-ray sources within the galaxy and conclude that the majority of these sources are X-ray binaries. We have searched for counterparts at different wavelengths to the discrete X-ray sources and we find two associations: one with a star cluster and the other with a background galaxy. We have found one source that is clearly variable within one observation and seven that are seen to vary from one observation to another. We also conduct a photometric analysis to determine the near-infrared fluxes of the discrete X-ray sources in Spitzer Infrared Array Camera channels. We constructed a cumulative luminosity function of the discrete X-ray sources seen toward NGC 45: taking into account simultaneously the luminosity function of background sources, the fitted slope of the cumulative luminosity function Γ = –1.3_(-1.6)^(+0.7) (all error bounds correspond to 90% confidence intervals). The VLA observations reveal seven discrete radio sources: we find no overlaps between these sources and the X-ray detected sources. Based on their measured spectral indices and their locations with respect to the visible extent of NGC 45, we classify one source as a candidate radio SNR associated with the galaxy and the others as likely background galaxies seen in projection toward NGC 45. Finally, we discuss the properties of a background cluster of galaxies (denoted as CXOU J001354.2–231254.7) seen in projection toward NGC 45 and detected by the Chandra observations. The fit parameters to the extracted Chandra spectra of this cluster are a column density N_H = 0.07(<0.14) × 10^(22) cm^(−2), a temperature kT = 4.22_(-1.42)^(+2.08) keV, an abundance Z = 0.30(<0.75) relative to solar and a redshift z = 0.28 ± 0.14. From the fit parameters we derive an electron number density n_e = 4(±1) × 10^(−3) cm^(−3), an unabsorbed X-ray luminosity L_(0.5-7.0keV) ~ 8.77(±0.96) × 10^(43) erg s^(−1) for the cluster and an X-ray emitting mass M = 2.32(±1.75) × 10^(12)M_☉

X-ray, Optical, and Radio Observations of the Type II Supernovae 1999em and 1998S

Observations of the Type II-P (plateau) Supernova (SN) 1999em and Type IIn (narrow emission line) SN 1998S have enabled estimation of the profile of the SN ejecta, the structure of the circumstellar medium (CSM) established by the pre-SN stellar wind, and the nature of the shock interaction. SN 1999em is the first Type II-P detected at both X-ray and radio wavelengths. The Chandra X-ray data indicate non-radiative interaction of SN ejecta with a power-law density profile (rho \propto r^{-n} with n ~ 7) with a pre-SN wind with a low mass-loss rate of ~2 \times 10^{-6} M_sun/yr for a wind velocity of 10 km/sec, in agreement with radio mass-loss rate estimates. The Chandra data show an unexpected, temporary rise in the 0.4--2.0 keV X-ray flux at ~100 days after explosion. SN 1998S, at an age of >3 years, is still bright in X-rays and is increasing in flux density at cm radio wavelengths. Spectral fits to the Chandra data show that many heavy elements (Ne, Al, Si, S, Ar, and Fe) are overabundant with respect to solar values. We compare the observed elemental abundances and abundance ratios to theoretical calculations and find that our data are consistent with a progenitor mass of approximately 15-20 M_sun if the heavy element ejecta are radially mixed out to a high velocity. If the X-ray emission is from the reverse shock wave region, the supernova density profile must be moderately flat at a velocity ~10^4 km/sec, the shock front is non-radiative at the time of the observations, and the mass-loss rate is 1-2 \times 10^{-4} M_sun/yr for a pre-supernova wind velocity of 10 km/sec. This result is also supported by modeling of the radio emission which implies that SN 1998S is surrounded by a clumpy or filamentary CSM established by a high mass-loss rate, ~2 \times 10^{-4} M_sun/yr, from the pre-supernova star.Comment: 14 pages, 10 figures, accepted by ApJ, includes new data (one new obs. each of SN 1999em and SN 1998S), expanded discussion of spectral fit

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk

Expression and function of G-protein-coupled receptorsin the male reproductive tract

This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract. The localization and differential expression of mAChR and α1-adrenoceptor subtypes in specific compartments of the efferent ductules, epididymis, vas deferens, seminal vesicle and prostate of various species indicate a role for these receptors in the modulation of luminal fluid composition and smooth muscle contraction, including effects on male fertility. Furthermore, the activation of mAChRs induces transactivation of the epidermal growth factor receptor (EGFR) and the Sertoli cell proliferation. The relaxin receptors are present in the testis, RXFP1 in elongated spermatids and Sertoli cells from rat, and RXFP2 in Leydig and germ cells from rat and human, suggesting a role for these receptors in the spermatogenic process. The localization of both receptors in the apical portion of epithelial cells and smooth muscle layers of the vas deferens suggests an involvement of these receptors in the contraction and regulation of secretion.Esta revisão enfatiza a expressão e a função dos receptores muscarínicos, adrenoceptores α1 e receptores para relaxina no sistema reprodutor masculino. A expressão dos receptores muscarínicos e adrenoceptores α1 em compartimentos específicos de dúctulos eferentes, epidídimo, ductos deferentes, vesícula seminal e próstata de várias espécies indica o envolvimento destes receptores na modulação da composição do fluido luminal e na contração do músculo liso, incluindo efeitos na fertilidade masculina. Além disso, a ativação dos receptores muscarínicos leva à transativação do receptor para o fator crescimento epidermal e proliferação das células de Sertoli. Os receptores para relaxina estão presentes no testículo, RXFP1 nas espermátides alongadas e células de Sertoli de rato e RXFP2 nas células de Leydig e germinativas de ratos e humano, sugerindo o envolvimento destes receptores no processo espermatogênico. A localização de ambos os receptores na porção apical das células epiteliais e no músculo liso dos ductos deferentes de rato sugere um papel na contração e na regulação da secreção.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FarmacologiaUNIFESP, EPM, Depto. de FarmacologiaSciEL