299 research outputs found
Domain wall structure in magnetic bilayers with perpendicular anisotropy
We study the magnetic domain wall structure in magnetic bilayers (two
ultrathin ferromagnetic layers separated by a non magnetic spacer) with
perpendicular magnetization. Combining magnetic force and ballistic electron
emission microscopies, we are able to reveal the details of the magnetic
structure of the wall with a high spatial accuracy. In these layers, we show
that the classical Bloch wall observed in single layers transforms into
superposed N\'eel walls due to the magnetic coupling between the ferromagnetic
layers. Quantitative agreement with micromagnetic calculations is achieved.Comment: Author adresses AB, SR, JM and AT: Laboratoire de Physique des
Solides, CNRS, Universit\'e Paris Sud, UMR 8502, 91405 Orsay Cedex, France ML
: Laboratoire PMTM, Institut Galil\'ee, CNRS, Universit\'e Paris-13, UPR
9001, 93430 Villetaneuse, Franc
Structure and diversity of shallow soft-bottom benthic macrofauna in the Gulf of Lions (NW Mediterranean).
14 páginas, 10 figuras, 4 tablas.Samples of soft-sediment macrobenthos from
92 sites between 10 and 50 m depth were used to assess (1)
the main soft-bottom macrofauna communities in the Gulf
of Lions, (2) the different components of the diversity of
benthic macrofauna in this area, and (3) the relevance of
the use of major taxonomic groups as surrogates for the
analysis of the structure and diversity of total macrofauna.
Three main communities were identified by cluster analysis
and associated procedures. These communities corresponded well to the assemblages recently identified on the
basis of polychaete composition. The a-diversity indices
were in accordance with those reported for similar communities in the Mediterranean. Conversely, the b-diversity
value was higher than the few other data available in the
literature for marine soft-bottom macrofauna. The total
number of species in the studied area estimated by the
‘‘total species accumulation curve’’ (TS) method was
2,319, which was only 10% higher than the number
obtained by extrapolation of the species–area curve. The
similarity matrix based on polychaetes correlated best with
the one based on total macrofauna. Polychaetes and crustaceans were also the best surrogates of total macrofauna
when assessing a-diversity (except in the case of D*).
Conversely, molluscs were the best surrogates of total
macrofauna b-diversity. Our results show that the choice of
an optimal surrogate for total benthic macrofauna depends
on the characteristic of the benthic macrofauna to be
studied. Moreover, this choice is also dependent on the
environment to be studiedThis work is part of the PhD thesis of Ce´line
Labrune. It was carried out within the EC Network of Excellence
MARBEF. Ce´line Labrune was supported by the SYSCOLAG project
run by the Re´gion Languedoc-Roussillon.Peer reviewe
Role of environmental factors for the vertical distribution (0–1000 m) of marine bacterial communities in the NW Mediterranean Sea
Bacterioplankton plays a central role in energy and matter fluxes in the sea, yet the factors that constrain its variation in marine systems are still poorly understood. Here we use the explanatory power of direct multivariate gradient analysis to evaluate the driving forces exerted by environmental parameters on bacterial community distribution in the water column. We gathered and analysed data from a one month sampling period from the surface to 1000 m depth at the JGOFS-DYFAMED station (NW Mediterranean Sea). This station is characterized by very poor horizontal advection currents which makes it an ideal model to test hypotheses on the causes of vertical stratification of bacterial communities. Capillary electrophoresis single strand conformation polymorphism (CE-SSCP) fingerprinting profiles analyzed using multivariate statistical methods demonstrated a vertical zonation of bacterial assemblages in three layers, above, in or just below the chlorophyll maximum and deeper, that remained stable during the entire sampling period. Through the use of direct gradient multivariate ordination analyses we demonstrate that a complex array of biogeochemical parameters is the driving force behind bacterial community structure shifts in the water column. Physico-chemical parameters such as phosphate, nitrate, salinity and to a lesser extent temperature, oxygen, dissolved organic carbon and photosynthetically active radiation acted in synergy to explain bacterial assemblages changes with depth. Analysis of lipid biomarkers of organic matter sources and fates suggested that bacterial community structure in the surface layers was in part explained by lipids of chloroplast origin. Further detailed analysis of pigment-based phytoplankton diversity gave evidence of a compartmentalized influence of several phytoplankton groups on bacterial community structure in the first 150 m depth
Induced Anisotropies in NiCo Obliquely Deposited Films and Their effect on Magnetic Domains
English Article: Oblique and in-plane anisotropies in obliquely evaporated NiCo thin films were investigated in order to understand their origin. All the compositions studied clearly show the effect of columnar grain morphology coupled with some intrinsic factors such as magnetostriction and crystallinity. Energy calculations are undertaken to explain the effect of
Low Temperature Plasma Synthesis of Nanocrystals and their Application to the Growth of Crystalline Silicon and Germanium Thin Films
International audienceWe summarize our research studies on the synthesis of silicon and germanium nanocrystals and their application to the growth of a variety of thin films, spanning the range from fully disordered amorphous up to fully ordered crystalline. All these films are deposited in a standard radio-frequency glow discharge system at low temperature (~200 °C). We show how the plasma synthesis of silicon nanocrystals, initially a side effect of powder formation, has become over the years an exciting field of research which has opened the way to new opportunities in the field of materials deposition and their application to optoelectronic devices. Our results suggest that epitaxy requires the melting/amorphization of the nanocrystals upon impact on the substrate, the subsequent epitaxial growth being favored on (100) c-Si substrates. As a consequence, the control of the impact energy is a critical aspect of the growth which will require new strategies such as the use of tailored voltage waveforms
Temperature-dependent interface magnetism and magnetization reversal in Co/Pt multilayers
We report on the temperature dependence of the magnetic properties and interface magnetism of Co/Pt multilayers. The magnetic properties including magnetization and anisotropy change substantially as the temperature varies from 300 to 10 K for samples with Co layer thickness in the range from 3 to 7 Å. The interface anisotropy of about 0.38 erg/cm2 is nearly independent of temperature. The magnetization reversal is dominated by domain wall motion for the thinner Co layers and dominated by nucleation for the thicker Co layers
Galactokinase deficiency:lessons from the GalNet registry
PURPOSE
Galactokinase (GALK1) deficiency is a rare hereditary galactose metabolism disorder. Beyond cataract, the phenotypic spectrum is questionable. Data from affected patients included in the Galactosemias Network registry were collected to better characterize the phenotype.
METHODS
Observational study collecting medical data of 53 not previously reported GALK1 deficient patients from 17 centers in 11 countries from December 2014 to April 2020.
RESULTS
Neonatal or childhood cataract was reported in 15 and 4 patients respectively. The occurrence of neonatal hypoglycemia and infection were comparable with the general population, whereas bleeding diathesis (8.1% versus 2.17-5.9%) and encephalopathy (3.9% versus 0.3%) were reported more often. Elevated transaminases were seen in 25.5%. Cognitive delay was reported in 5 patients. Urinary galactitol was elevated in all patients at diagnosis; five showed unexpected Gal-1-P increase. Most patients showed enzyme activities ≤1%. Eleven different genotypes were described, including six unpublished variants. The majority was homozygous for NM_000154.1:c.82C>A (p.Pro28Thr). Thirty-five patients were diagnosed following newborn screening, which was clearly beneficial.
CONCLUSION
The phenotype of GALK1 deficiency may include neonatal elevation of transaminases, bleeding diathesis, and encephalopathy in addition to cataract. Potential complications beyond the neonatal period are not systematically surveyed and a better delineation is needed
Characterization of silicon heterojunctions for solar cells
Conductive-probe atomic force microscopy (CP-AFM) measurements reveal the existence of a conductive channel at the interface between p-type hydrogenated amorphous silicon (a-Si:H) and n-type crystalline silicon (c-Si) as well as at the interface between n-type a-Si:H and p-type c-Si. This is in good agreement with planar conductance measurements that show a large interface conductance. It is demonstrated that these features are related to the existence of a strong inversion layer of holes at the c-Si surface of (p) a-Si:H/(n) c-Si structures, and to a strong inversion layer of electrons at the c-Si surface of (n) a-Si:H/(p) c-Si heterojunctions. These are intimately related to the band offsets, which allows us to determine these parameters with good precision
Long-term (1998–2010) large-scale comparison of the ecological quality status of gulf of lions (NW Mediterranean) benthic habitats
12 páginas, 4 tablas, 8 figuras.A comprehensive Mediterranean data set has been used to address 3 questions associated with the use of sensitivity/tolerance
based biotic indices to infer the Ecological Quality status (EcoQs) of benthic habitats. Our results
showed: (1) a significant effect of the reference database on derived sensitivity/tolerance measure (ES500.05) as
well as associated Benthic Quality Index values and derived EcoQs; (2) a lack of correlation neither between BQI
and AZTI Marine Biotic Index values nor between BQI and Multivariate-AZTI Marine Biotic Index values; (3) a lack
of correlation between the values of the Benthic Habitat Quality Index (index derived from Sediment Profile Imagery)
and those of either of the 3 tested biotic indices; and (4) a general agreement between the 3 tested biotic
indices in describing the lack of global trend for the EcoQs of the Gulf of Lions despite the occurrence of significant
changes in benthic macrofauna composition between 1998 and 2010.This study has been carried out with financial support from the French National
Research Agency (ANR) in the frame of the Investments for the future
Programme, within the Cluster of Excellence COTE (ANR-10-LABX-45).Peer reviewe
The natural history of classic galactosemia: lessons from the GalNet registry.
BACKGROUND
Classic galactosemia is a rare inborn error of carbohydrate metabolism, caused by a severe deficiency of the enzyme galactose-1-phosphate uridylyltransferase (GALT). A galactose-restricted diet has proven to be very effective to treat the neonatal life-threatening manifestations and has been the cornerstone of treatment for this severe disease. However, burdensome complications occur despite a lifelong diet. For rare diseases, a patient disease specific registry is fundamental to monitor the lifespan pathology and to evaluate the safety and efficacy of potential therapies. In 2014, the international Galactosemias Network (GalNet) developed a web-based patient registry for this disease, the GalNet Registry. The aim was to delineate the natural history of classic galactosemia based on a large dataset of patients.
METHODS
Observational data derived from 15 countries and 32 centers including 509 patients were acquired between December 2014 and July 2018.
RESULTS
Most affected patients experienced neonatal manifestations (79.8%) and despite following a diet developed brain impairments (85.0%), primary ovarian insufficiency (79.7%) and a diminished bone mineral density (26.5%). Newborn screening, age at onset of dietary treatment, strictness of the galactose-restricted diet, p.Gln188Arg mutation and GALT enzyme activity influenced the clinical picture. Detection by newborn screening and commencement of diet in the first week of life were associated with a more favorable outcome. A homozygous p.Gln188Arg mutation, GALT enzyme activity of ≤ 1% and strict galactose restriction were associated with a less favorable outcome.
CONCLUSION
This study describes the natural history of classic galactosemia based on the hitherto largest data set
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