610 research outputs found
Novel Quenched Disorder Fixed Point in a Two-Temperature Lattice Gas
We investigate the effects of quenched randomness on the universal properties
of a two-temperature lattice gas. The disorder modifies the dynamical
transition rates of the system in an anisotropic fashion, giving rise to a new
fixed point. We determine the associated scaling form of the structure factor,
quoting critical exponents to two-loop order in an expansion around the upper
critical dimension d. The close relationship with another quenched
disorder fixed point, discovered recently in this model, is discussed.Comment: 11 pages, no figures, RevTe
Review of the k-Body Embedded Ensembles of Gaussian Random Matrices
The embedded ensembles were introduced by Mon and French as physically more
plausible stochastic models of many--body systems governed by one--and
two--body interactions than provided by standard random--matrix theory. We
review several approaches aimed at determining the spectral density, the
spectral fluctuation properties, and the ergodic properties of these ensembles:
moments methods, numerical simulations, the replica trick, the eigenvector
decomposition of the matrix of second moments and supersymmetry, the binary
correlation approximation, and the study of correlations between matrix
elements.Comment: Final version. 29 pages, 4 ps figures, uses iopart.st
The latencies of correct and incorrect responses in discrimination and detection tasks: Their interpretation in terms of a model based on simple counting
The limits of prior entry: Nonsensitivity of temporal order judgments to selective preparation affecting choice reaction time
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.
BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.
METHODS: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis.
RESULTS: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P  =  5.71 × 10(-7)). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P  =  2.18 × 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively.
CONCLUSIONS: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function
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