8 research outputs found
Spiral Chain O4 Form of Dense Oxygen
Oxygen is in many ways a unique element: the only known diatomic molecular
magnet and the capability of stabilization of the hitherto unexpected O8
cluster structure in its solid form at high pressure. Molecular dissociations
upon compression as one of the fundamental problems were reported for other
diatomic solids (e.g., H2, I2, Br2, and N2), but it remains elusive for solid
oxygen, making oxygen an intractable system. We here report the theoretical
prediction on the dissociation of molecular oxygen into a polymeric spiral
chain O4 structure (\theta-O4) by using first-principles calypso method on
crystal structure prediction. The \theta-O4 stabilizes above 2 TPa and has been
observed as the third high pressure phase of sulfur (S-III). We find that the
molecular O8 phase remains extremely stable in a large pressure range of 0.008
- 2 TPa, whose breakdown is driven by the pressure-induced instability of a
transverse acoustic phonon mode at zone boundary, leading to the ultimate
formation of \theta-O4. Remarkably, stabilization of \theta-O4 turns oxygen
from a superconductor into an insulator with a wide band gap (approximately 5.9
eV) originating from the sp3-like hybridized orbitals of oxygen and the
localization of valence electrons. (This is a pre-print version of the
following article: Li Zhu et al, Spiral chain O4 form of dense oxygen, Proc.
Natl. Acad. Sci. U.S.A. (2011), doi: 10.1073/pnas.1119375109, which has been
published online at http://www.pnas.org/content/early/2011/12/27/1119375109 .)Comment: 13 apages, 3 figure
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Edoxaban versus warfarin in patients with atrial fibrillation
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125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)