122 research outputs found
Two distinct populations of Bovine IL-17+ T-cells can be induced and WC1+IL-17+γδ T-cells are effective killers of protozoan parasites
IL-17 has emerged as a key player in the immune system, exhibiting roles in protection from infectious diseases and promoting inflammation in autoimmunity. Initially thought to be CD4 T-cell-derived, the sources of IL-17 are now known to be varied and belong to both the innate and adaptive arms of the immune system. Mechanisms for inducing IL-17 production in lymphoid cells are thought to rely on appropriate antigenic stimulation in the context of TGF-β1, IL-6 and/or IL-1β. Using culture protocols adapted from human studies, we have effectively induced both bovine CD4+ and WC1+ γδ T-cells to produce IL-17 termed Th17 and γδ17 cells, respectively. The negative regulatory effect of IFN-γ on mouse and human IL-17 production can be extended to the bovine model, as addition of IFN-γ decreases IL-17 production in both cell types. Furthermore we show that infection with the protozoan Neospora caninum will induce fibroblasts to secrete pro-IL-17 factors thereby inducing a γδ17 phenotype that preferentially kills infected target cells. Our study identifies two T-cell sources of IL-17, and is the first to demonstrate a protective effect of IL-17+ T-cells in ruminants. Our findings offer further opportunities for future adjuvants or vaccines which could benefit from inducing these responses
FACTORS AFFECTING PREGNANCY RATES AFTER OVUM PICK UP-DERIVED EMBRYO TRANSFER IN LACTATING HOLSTEIN RECIPIENTS UNDER TROPICAL CONDITIONS
Serum progesterone concentration and conception rate of beef cows supplemented with ground corn after a fixed-time artificial insemination protocol
Search for neutrino counterparts to the gravitational wave sources from O3 catalogues with the ANTARES detector
Since 2015 the LIGO and Virgo interferometers have detected gravitational
waves from almost one hundred coalescences of compact objects (black holes and
neutron stars). This article presents the results of a search performed with
data from the ANTARES telescope to identify neutrino counterparts to the
gravitational wave sources detected during the third LIGO/Virgo observing run
and reported in the catalogues GWTC-2, GWTC-2.1, and GWTC-3. This search is
sensitive to all-sky neutrinos of all flavours and of energies GeV,
thanks to the inclusion of both track-like events (mainly induced by
charged-current interactions) and shower-like events (induced by other
interaction types). Neutrinos are selected if they are detected within s from the GW merger and with a reconstructed direction compatible with
its sky localisation. No significant excess is found for any of the 80 analysed
GW events, and upper limits on the neutrino emission are derived. Using the
information from the GW catalogues and assuming isotropic emission, upper
limits on the total energy and on the fraction of the total
energy budget emitted as neutrinos of
all flavours are also computed. Finally, a stacked analysis of all the 72
binary black hole mergers (respectively the 7 neutron star - black hole merger
candidates) has been performed to constrain the typical neutrino emission
within this population, leading to the limits: erg and (respectively, erg and ) for spectrum and isotropic emission.
Other assumptions including softer spectra and non-isotropic scenarios have
also been tested.Comment: 13 pages, 4 figure
Searches for neutrinos in the direction of radio-bright blazars with the ANTARES telescope
Active galaxies, especially blazars, are among the most promising neutrino
source candidates. To date, ANTARES searches for these objects considered
GeV-TeV -ray bright blazars. Here, a statistically complete
radio-bright blazar sample is used as the target for searches of origins of
neutrinos collected by the ANTARES neutrino telescope over 13 years of
operation. The hypothesis of a neutrino-blazar directional correlation is
tested by pair counting and by a complementary likelihood-based approach. The
resulting post-trial -value is ( in the two-sided
convention), possibly indicating a correlation. Additionally, a time-dependent
analysis is performed to search for temporal clustering of neutrino candidates
as a mean of detecting neutrino flares in blazars. None of the investigated
sources alone reaches a significant flare detection level. However, the
presence of 18 sources with a pre-trial significance above indicates
a ( in the two-sided convention) detection of a
time-variable neutrino flux. An \textit{a posteriori} investigation reveals an
intriguing temporal coincidence of neutrino, radio, and -ray flares of
the J0242+1101 blazar at a ( in the two-sided convention)
level. Altogether, the results presented here suggest a possible connection of
neutrino candidates detected by the ANTARES telescope with radio-bright
blazars
Implementation and first results of the KM3NeT real-time core-collapse supernova neutrino search
The authors acknowledge the financial support of the funding agencies: Agence Nationale de la Recherche (contract ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Paris ile-de-France Region, France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG, FR-18-1268), Georgia; Deutsche Forschungsgemeinschaft (DFG), Germany; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Universita e della Ricerca (MIUR), PRIN 2017 program (Grant NAT-NET 2017W4HA7S) Italy; Ministry of Higher Education Scientific Research and Professional Training, ICTP through Grant AF-13, Morocco; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; The National Science Centre, Poland (2015/18/E/ST2/00758); National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Generalitat Valenciana: Prometeo (PROMETEO/2020/019), Grisolia (ref. GRISOLIA/2018/119) and GenT (refs. CIDEGENT/2018/034, /2019/043, /2020/049) programs, Junta de Andalucia (ref. A-FQM-053-UGR18), La Caixa Foundation (ref. LCF/BQ/IN17/11620019), EU: MSC program (ref. 101025085), Spain.The KM3NeT research infrastructure is unconstruction
in the Mediterranean Sea. KM3NeT will study
atmospheric and astrophysical neutrinos with two multipurpose
neutrino detectors, ARCA and ORCA, primarily
aimed at GeV–PeV neutrinos. Thanks to the multiphotomultiplier
tube design of the digital optical modules,
KM3NeT is capable of detecting the neutrino burst from
a Galactic or near-Galactic core-collapse supernova. This potential is already exploitable with the first detection units
deployed in the sea. This paper describes the real-time implementation
of the supernova neutrino search, operating on the
two KM3NeT detectors since the first months of 2019. A
quasi-online astronomy analysis is introduced to study the
time profile of the detected neutrinos for especially significant
events. Themechanism of generation and distribution of
alerts, aswell as the integration into theSNEWSandSNEWS
2.0 global alert systems, are described. The approach for the
follow-up of external alerts with a search for a neutrino excess
in the archival data is defined. Finally, an overviewof the current
detector capabilities and a report after the first two years
of operation are given.French National Research Agency (ANR)European Commission ANR-15-CE31-0020Centre National de la Recherche Scientifique (CNRS)Commission EuropeenneInstitut Universitaire de France (IUF)LabEx UnivEarthS ANR-10-LABX-0023
ANR-18-IDEX-0001Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268German Research Foundation (DFG)Greek Ministry of Development-GSRTIstituto Nazionale di Fisica Nucleare (INFN)Ministry of Education, Universities and Research (MIUR)PRIN 2017 program, Italy NAT-NET 2017W4HA7SMinistry of Higher Education Scientific Research and Professional Training, ICTP, Morocco AF-13Netherlands Organization for Scientific Research (NWO)
Netherlands GovernmentNational Science Centre, Poland 2015/18/E/ST2/00758National Authority for Scientific Research (ANCS), RomaniaMinisterio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento PGC2018-096663-B-C41
PGC2018-096663-A-C42
PGC2018-096663-B-C43
PGC2018-096663-B-C44Generalitat Valenciana PROMETEO/2020/019Grisolia program GRISOLIA/2018/119
CIDEGENT/2018/034Junta de Andalucia A-FQM-053-UGR18La Caixa Foundation LCF/BQ/IN17/11620019EU: MSC program 101025085Paris Ile-de-France Region, FranceGenT program CIDEGENT/2018/034
CIDEGENT/2019/043
CIDEGENT/2020/04
Eficácia do tratamento Ovsynch associado à inseminação artificial prefixada em rebanhos Bos taurus e Bos indicus
Inseminação artificial em tempo fixo e diagnóstico precoce de gestação em vacas leiteiras mestiças
Les kystes ovariens dans l'espèce bovine. 1. Définitions, symptômes et diagnostic
An ovarian cyst is classically defined as a fluid-filled space larger than 24 mm, that can persist for more than 7 to 10 days in the absence of a corpus luteum. The frequenc y of this pathology is between 7 to 15%. Contrary to the follicular cyst, the luteinised follicular cyst is characterized by the presence in its periphery of a luteal tissue. The ovarian cyst is a dynamic structure. Its presence doesn't interfere with the follicular waves but can modify their characteristics. An ovarian cyst results from or induces an absence of ovulation. Ovarian cyst diagnosis and especially the differential diagnosis between follicular and luteal cysts necessarily imply the use of ultrasonography to clearly identified their diameter and thickeness. The ultrasonography sensibility is better than that of transrectal palpation. Progesteronemia interpretation supposes the preliminary definition of a threshold. Behavioural(anoestrus or nymphomany), uterine(tonicity of the uterine horns) or vaginal (mucus) abnormalities can help to direct the diagnosis.Le kyste ovarien se définit le plus souvent comme une structure liquidienne de diamètre supérieur à 24 mm de diamètre, présent durant sept à dix jours sur l'ovaire en l'absence de corps jaune. La fréquence de cette affection est comprise entre 7 et 15 %. Le kyste folliculaire lutéinisé se distingue du kyste folliculaire par la présence à sa périphérie de tissu lutéal. Le kyste ovarien est une structure dynamique. Sa présence n'empêche pas l'apparition de vagues de croissance folliculaire dont les caractéristiques sont cependant modifiées. La présence d'un kyste ovarien traduit et/ou induit l'absence d'ovulation. Le diagnostic du kyste ovarien et surtout le diagnostic différentiel entre un kyste folliculaire et un kyste folliculaire lutéinisé implique nécessairement le recours à l'échographie pour identifier correctement le diamètre et l'épaisseur du kyste ovarien. La sensibilité de l'échographie s'avère supérieure à celle du diagnostic manuel. L'interprétation de la progestéronémie suppose la définition préalable d'un seuil. Les symptômes comportementaux (nymphomanie et anoestrus), utérins (tonicité) et vaginaux (écoulement de mucus) sont de nature à orienter le diagnostic
- …