13 research outputs found
Variation in the Glucose Transporter gene <i>SLC2A2 </i>is associated with glycaemic response to metformin
- Author
- A Ait-Omar
- A Dahlin
- A Kooy
- A Schröder
- AC Pawlyk
- Adriaan Kooy
- AK Madiraju
- AL Price
- Albert Hofman
- Albert M Levin
- Alison A Motsinger-Reif
- Amanda J Bennett
- Amber A van der Heijden
- AP Morris
- B Kabakchiev
- BN Howie
- Bruno H Stricker
- Calum Sutherland
- Catherine E de Keyser
- Christopher J Groves
- CJ Bailey
- Coen D A Stehouwer
- Colin N A Palmer
- CT Pau
- D Sherifali
- Daniel M Rotroff
- EE Schadt
- Eric L Seiser
- Ewan R Pearson
- F Innocenti
- F Manz
- Federico Innocenti
- G Fanconi
- Huan-Chieh Chien
- I Postmus
- I Tkáč
- Ivan Tkáč
- J Marchini
- Janis Klovins
- John S Witte
- Joline W Beulens
- Jose C Florez
- Jozef Židzik
- K Xia
- K Zhou
- K Zhou
- K Zhou
- KA Jablonski
- Kaixin Zhou
- Kathleen A Jablonski
- Kathleen M Giacomini
- L Gong
- L Keoki Williams
- Leen M 't Hart
- Linda Zaharenko
- Ling Chen
- Lisa Logie
- LJ McCreight
- Longyang Wu
- M Hosokawa
- M van de Bunt
- Mark I McCarthy
- Martin Javorský
- Mattijs Out
- MD Fullerton
- Michael J Wagner
- Michiaki Kubo
- Monique M Hedderson
- N Soranzo
- N van Leeuwen
- Nienke van Leeuwen
- P Seyer
- R Burcelin
- R Mägi
- RA DeFronzo
- RA Miller
- RA Scott
- Roger Tavendale
- Ron H N van Schaik
- RS Hundal
- Rury R Holman
- Ruth L Coleman
- S Purcell
- Sabina Semiz
- SE Kahn
- Shiro Maeda
- SL Stocker
- Sook Wah Yee
- Tanja Dujic
- Valdis Pirags
- X Liang
- Y Banda
- Y Shu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear1. Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 × 10−14) greater metformin-induced reduction in hemoglobin A1c (HbA1c) in 10,577 participants of European ancestry. rs8192675 was the top cis expression quantitative trait locus (cis-eQTL) for SLC2A2 in 1,226 human liver samples, suggesting a key role for hepatic GLUT2 in regulation of metformin action. Among obese individuals, C-allele homozygotes at rs8192675 had a 0.33% (3.6 mmol/mol) greater absolute HbA1c reduction than T-allele homozygotes. This was about half the effect seen with the addition of a DPP-4 inhibitor, and equated to a dose difference of 550 mg of metformin, suggesting rs8192675 as a potential biomarker for stratified medicine
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
- Author
- Abecasis GR
- Abecasis GR
- Abecasis Goncalo R.
- Absher D
- Absher D
- Aherrahrou Z
- Ahmadi KR
- Alavere Helene
- Alizadeh Behrooz Z.
- Altshuler D
- Altshuler David
- Amin Najaf
- Andersen K
- Andrews JS
- Aragam J
- Arking DE
- Arnett DK
- Arora Pankaj
- Aspelund T
- Aspelund T
- Aspelund Thor
- Assime TL
- Assimes TL
- Assimes TL
- Atkinson EJ
- Attwood T
- Aulchenko YS
- Aulchenko YS
- Aulchenko YS
- Aulchenko Yurii
- Badola S
- Bakker SJ
- Ball SG
- Balmforth AJ
- Bandinelli Stefania
- Barbalic M
- Barroso In S.
- Beckmann J
- Beckmann Jacques S.
- Beilby John P.
- Bekaert S
- Belz S
- Benjamin E
- Benjamin EJ
- Benjamin EJ
- Bergman Richard N.
- Bergmann Sven
- Bickel C
- Bilo HJ
- Bis J
- Bis JC
- Bis JC
- Bis Joshua C
- Blankenberg S
- Blankenberg S
- Blankenberg S
- Blettner M
- Boban M
- Boban Mladen
- Bochud M
- Bochud Murielle
- Boehnke Michael
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle Eric
- Boomsma Dorret I.
- Borecki I
- Bragg-Gresham Jennifer L.
- Brandstätter A
- Braund P
- Braund PS
- Breteler Monique
- Brown MJ
- Bruse P
- Buckley Brendan
- Burke Gregory L
- Burnett MS
- Burtt N
- Böger CA
- Böhm BO
- Cambien F
- Cambien F
- Campbell H
- Campbell S
- Campbell Harry
- Caulfield MJ
- Caulfield Mark J.
- Cavalieri M
- Chakravarti Aravinda
- Chambers JC
- Chambers John C.
- Chang PP
- Chasman DI
- Chasman Daniel I.
- Chen IY
- Chen L
- Chen L
- Chen Yii-Der Ida
- Clarke Robert
- Cockcroft JR
- Collins Francis S.
- Connell JM
- Cook HT
- Cooper J
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- Cornelia M. McEniery CM
- Cornelis MC
- Corre Tanguy
- Corsi Anna Maria
- Cotlarciuc I
- Couper D
- Crisp-Hihn A
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- D'Adamo Adamo Pio
- Dandona S
- Davey Smith G
- Davies Gail
- de Andrade M
- De Backer GG
- De Bacquer D
- de Boer IH
- De Buyzere ML
- De Geus Eco J. C.
- de Jong PE
- De Meyer T
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- Deckers JW
- Dehghan A
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- Deloukas P
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- Deng G
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- Dörr M
- Dörr Marcus
- Eardman J
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- Hepkema BG
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- Herrington DM
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- Hoffmann MM
- Hofman A
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- Lawlor DA
- Leak TS
- Lehtimäki Terho
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- van Duijn C
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- Waeber Gérard
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- Wang TJ
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- Wang Thomas J.
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- Publication venue
- Nat Genet
- Publication date
- 01/01/2011
- Field of study
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP
Accuracy versus precision in boosted top tagging with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abdelhameed S
- Abeling K
- Abicht NJ
- Abidi SH
- Aboelela M
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Ackermann A
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Agullo PM
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Aitbenchikh B
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Aktas S
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Alegria ZL
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
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- Alimonti G
- Alkakhi W
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- Allen JF
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- Alsolami ZMK
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- Alviggi MG
- Aly M
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- Amini B
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- Anastopoulos C
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- Anders JK
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- Angelidakis S
- Angerami A
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- Kostyukhin VV
- Kotsokechagia A
- Kotwal A
- Koulouris A
- Kourkoumeli-Charalampidi A
- Kourkoumelis C
- Kourlitis E
- Kovanda O
- Kowalewski R
- Kozanecki W
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- Kramarenko VA
- Kramberger G
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- Kurdysh O
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- Kyriacou NG
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- Lari T
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- Latonova V
- Latour BMD
- Laurier A
- Lawlor SD
- Lawrence Z
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- Le Pottier LT
- Le B
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- Lebedev A
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- Li Z
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- Liberti B
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- Loiacono E
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- Longarini I
- Longo R
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- Losada M
- Loseva O
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- Lou X
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- Luci C
- Luehring F
- Luengo SIF
- Luise I
- Lukianchuk O
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- Lutz MS
- Lux AB
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- Lyubushkin V
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- Lyukova MM
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- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- IOP Publishing
- Publication date
- 01/08/2024
- Field of study
Abstract
The identification of top quark decays where the top quark has a large momentum transverse to the beam axis, known as top tagging, is a crucial component in many measurements of Standard Model processes and searches for beyond the Standard Model physics at the Large Hadron Collider.
Machine learning techniques have improved the performance of top tagging algorithms, but the size of the systematic uncertainties for all proposed algorithms has not been systematically studied.
This paper presents the performance of several machine learning based top tagging algorithms on a dataset constructed from simulated proton-proton collision events measured with the ATLAS detector at √
s
= 13 TeV.
The systematic uncertainties associated with these algorithms are estimated through an approximate procedure that is not meant to be used in a physics analysis, but is appropriate for the level of precision required for this study.
The most performant algorithms are found to have the largest uncertainties, motivating the development of methods to reduce these uncertainties without compromising performance.
To enable such efforts in the wider scientific community, the datasets used in this paper are made publicly available.</jats:p
Association between hyperglycemia and retinopathy of prematurity: a systemic review and meta-analysis
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The First Row Transition Metal Intercalation Complexes of Some Metallic Group VA Transition Metal Dichalcogenides
- Author
- A Blanc-Soreau Le
- A Meerschaut
- A Meerschaut
- A Royer
- AH Thompson
- AM Clogston
- AR Beal
- AR Beal
- B Laar van
- B Laar van
- DA Whitney
- DE Nixon
- DJ Bradley
- F Hulliger
- F Kadijk
- FJ Salvo di
- FR Gamble
- FR Gamble
- FR Gamble
- G Lucovsky
- G Wexler
- G. R. Henning
- GV Subba Rao
- HE Barz
- HNS Lee
- J Rouxel
- J. A. Benda
- JA Benda
- JA Wilson
- JJ Hauser
- JJ Murray
- JM Berg van den
- JM Voorhoeve
- JM Voorhoeve
- JV Acrivos
- K Anzenhofer
- K Selte
- L Corliss
- L. F
- LCF Blackman
- LJ Pau van der
- M Eibschiitz
- MG Bell
- MH Maaren van
- NB Hannay
- NV Volkenstein
- PM Williams
- R. V. Kasowski
- RB Somoano
- RB Somoano
- RB Somoano
- RC Morris
- RE Grim
- RF Frindt
- RM White
- TH Geballe
- VL Ginzburg
- W. P. F. A. M. Omloo and F
- WB Clark
- WB Clark
- WY Liang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1979
- Field of study
Amyopathic Dermatomyositis: A Concise Review of Clinical Manifestations and Associated Malignancies
- Author
- A Bohan
- A Bohan
- A Bohan
- A Cosnes
- A Mebazaa
- A Nofal
- A Uchida
- A Villers
- AA Amato
- AF Adili
- AJ Kooi van der
- AM Molina-Ruiz
- AM Seidler
- AN Femia
- B Sigurgeirsson
- BW Russ
- C Requena
- CL Dunn
- CL Hill
- CM Orme
- DR Finger
- DZ Eichenfield
- E Ghazi
- EE Bailey
- ES Smith
- F Galimberti
- GR Connors
- H Cao
- H Chinoy
- HL Ee
- I Pau-Charles
- IE Lundberg
- IH Olhoffer
- IM Bronner
- Jeremy Udkoff
- JP Callen
- JP Callen
- JWK Fung
- K Azuma
- K Fujii
- K Kikuchi
- LA Drake
- LC Pérez-Pérez
- LCM Ortigosa
- LJ Ledwich
- M Blanes
- M Fathi
- M Labrador-Horrillo
- M Labrador-Horrillo
- M Ogawa
- MA Dawkins
- MC Dalakas
- MFG Meulen van der
- MJ Reeder
- MR Stonecipher
- N Ikeda
- N Kubo
- NR Rockerbie
- P Ang
- P Gerami
- P Gerami
- P Ungprasert
- Philip R. Cohen
- R Apaydin
- RA El-Azhary
- RL Euwer
- RQ Klein
- S Aslanidis
- S Celebi
- S Goyal
- S Ikeda
- S Nogi
- S Norrenberg
- S Sato
- S Tansley
- S Yasar
- SA Ritchie
- SE Whitmore
- SH Park
- SM Langan
- V Pusceddu
- WWM Lam
- Y Hamaguchi
- Y Kita
- Y Muro
- Y Osman
- Y Takahashi
- Y Yamasaki
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
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- A'Court J
- Aawsaj Y
- Abbadessa F
- Abbas A
- Abbott S
- Abdalaziz H
- Abdalla M
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- Abdelsaid K
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- Abood A
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- Abrate A
- Abu-Nayla I
- Abual-Rub Z
- Abuown A
- Adamec A
- Adegbola S
- Ademuyiwa AO
- Advani R
- Aftab R
- Agarwal A
- Agarwal K
- Aggarwal A
- Aghababyan K
- Agilinko J
- Agrawal S
- Ahad S
- Ahmad Y
- Ahmed Elamin H
- Ahmed I
- Ahmeidat A
- Akhtar MA
- Al Ameer E
- Al-mukhtar A
- Al-omishy H
- Al-Samaraee A
- Al-Sukaini A
- Al-Yaseen M
- Aladeojebi A
- Alanbuki A
- Alderson D
- Aldridge K
- Alexander ME
- Alga A
- Ali M
- Ali Mahmoud F
- Ali S
- Allana A
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- Almeida AC
- Almond M
- Alotaibi M
- Alqallaf A
- Alsakkaf M
- Alser O
- Alser O
- Altomare DF
- Alves R
- Alwadiya A
- Alzetani A
- Amaral MJ
- Ambler GK
- Ameerally P
- Anania G
- Anazor F
- Anderson C
- Andrade R
- Andreani SM
- Andronic A
- Aneke IA
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- Antar M
- Anthoney J
- Anton-Eguia BT
- Antunes J
- Apampa AA
- Aragon Achig EJ
- Archer JE
- Arigoni M
- Arkani S
- Armao T
- Arminio A
- Arnaud AP
- Arrieta M
- Asaad P
- Ascensao J
- Ashcroft J
- Asher S
- Askari A
- Athayde Nemesio R
- Augestad KM
- Aujayeb A
- Aujayeb A
- Awadallah M
- Ayeni F
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- Azevedo P
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- Babawale O
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- Bacarese-Hamilton J
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- Badran A
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- Balakrishnan A
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- Balasubramanian SP
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- Bankhad-Kendall B
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- Baquedano M
- Barbe Y
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- de Lacy FB
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- Publication venue
- 'BMJ'
- Publication date
- 01/01/2021
- Field of study
Objectives Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis. Setting Prospective, international, multicentre, observational cohort study. Participants Patients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative). Primary outcome 30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality. Results This study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787). Conclusions Patients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups. Trial registration number NCT0432364
Search for the Zγ decay mode of new high-mass resonances in pp collisions at s = 13 TeV with the ATLAS detector
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- Abbott B
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- Abicht NJ
- Abidi SH
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- Acharya BS
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/12/2023
- Field of study
This letter presents a search for narrow, high-mass resonances in the Zγ final state with the Z boson decaying into a pair of electrons or muons. The
TeV pp collision data were recorded by the ATLAS detector at the CERN Large Hadron Collider and have an integrated luminosity of 140 fb−1. The data are found to be in agreement with the Standard Model background expectation. Upper limits are set on the resonance production cross section times the decay branching ratio into Zγ. For spin-0 resonances produced via gluon–gluon fusion, the observed limits at 95% confidence level vary between 65.5 fb and 0.6 fb, while for spin-2 resonances produced via gluon–gluon fusion (or quark–antiquark initial states) limits vary between 77.4 (76.1) fb and 0.6 (0.5) fb, for the mass range from 220 GeV to 3400 GeV
Pursuit of paired dijet resonances in the Run 2 dataset with ATLAS
- Author
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- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
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- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
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- Zhou Y
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- American Physical Society (APS)
- Publication date
- 01/01/2023
- Field of study
New particles with large masses that decay into hadronically interacting particles are predicted by many models of physics beyond the Standard Model. A search for a massive resonance that decays into pairs of dijet resonances is performed using..
Measurement of the t t ¯ cross section and its ratio to the Z production cross section using pp collisions at s = 13.6 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
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- Affolder AA
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- Agheorghiesei C
- Agullo PM
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- Ahmed WS
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- Akbiyik M
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- Akiyama D
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- Albouy GL
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- Aleksandrov IN
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- Andana RYG
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- Atmasiddha PA
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- Boeriu OEV
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- Bogdanchikov AG
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- Boonekamp M
- Booth CD
- Borbély AG
- Bordulev IS
- Borecka-Bielska HM
- Borissov G
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- Boscherini D
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- Carlson EM
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- Caspar M
- Castillo FL
- Castillo LRF
- Castro NF
- Catinaccio A
- Catmore JR
- Cavaliere V
- Cavalli N
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- Cheremushkina E
- Cherepanova E
- Cheu E
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- Chizhov MV
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- Ciesla KM
- Cindro V
- Ciocio A
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- Conventi F
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- Cornell SD
- Corpe LD
- Corradi M
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- Costa MJ
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- da Costa JBG
- Da Fonseca Pinto JV
- Da Silva GG
- Da Via C
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- Dal Santo D
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- Dam M
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- Dawson I
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- De Acedo LFS
- de Andrade Filho LM
- De Araujo MV
- De Asmundis R
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- De Carvalho ALM
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- De la Torre H
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- De Moura NMJN
- de Renstrom PAB
- De Sa RCL
- De Salvo A
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- Della Pietra M
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- Di Donato C
- Di Girolamo A
- Di Gregorio G
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- Di Micco B
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- Filmer EK
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- Fleck I
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- Gingrich DM
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- Yue L
- Zaazoua M
- Zabinski B
- Zagazeta LFG
- Zaid E
- Zak ZK
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zang J
- Zanzi D
- Zaplatilek O
- Zeitnitz C
- Zeng H
- Zeng JC
- Zenger DT
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zhai M
- Zhang B
- Zhang DF
- Zhang J
- Zhang J
- Zhang K
- Zhang L
- Zhang P
- Zhang R
- Zhang S
- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/12/2023
- Field of study