Identification of common genetic risk variants for autism spectrum disorder

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.Peer reviewe

As lógicas territoriais do desenvolvimento: diversidades e regulação

La présentation des logiques territoriales du développement, objet du présent article, résulte de la compilation de lectures systématisées, dont l'objectif est présenter les principales associations entre des théories, concepts et typologies. La relation exprimée, hypothétiquement, la possibilité d'une action collective intentionnelle des agents et les institutions pour le développement.A apresentação das lógicas territoriais do desenvolvimento, objeto do presente artigo, resulta da compilação de leituras sistematizadas, cujo objetivo é apresentar as principais associações entre teorias, conceitos e tipologias. A questão central é a relação entre o território e o desenvolvimento, entendido como um processo de mudança social dinamizado por expectativas territorialmente localizadas e geradoras de cidadania. A relação expressa, hipoteticamente, a possibilidade de uma ação coletiva intencional dos agentes e instituições para o desenvolvimento.La presentación de las lógicas territoriales del desarrollo, objeto del presente artículo, resulta de la compilación de lecturas sistematizadas, cuyo objetivo es presentar las principales asociaciones entre teorías, conceptos y tipologías. La relación expresada, hipotéticamente, la posibilidad de una acción colectiva intencional de los agentes y las instituciones para el desarrollo.The presentation of the territorial logics of the development, object of the present article, results of the compilation of systemize readings, whose objective is to present the main associations between theories, concepts and typologies. The central question is the relation between the territory and the development, understood as one process of social change dynamic by expectations territorially located and generating of citizenship. The express relation, hypothetically, the possibility of an intentional collective action of the agents and institutions for the development

Improving the ozone gas-sensing properties of CuWO4 nanoparticles

This paper consists of an experimental investigation on the effects of annealing temperature on the structural, surface and ozone gas-sensing properties of CuWO4 nanoparticles prepared via a sonochemical route. X-ray diffraction patterns and X-ray absorption near-edge structure spectroscopy revealed that both long- and short-order structures increase with the annealing temperature. Electrical resistance measurements indicated that CuWO4 samples were sensitive in the range of 15–1400 ppb, exhibiting a good reversibility and repeatability. The enhancement of the ozone gas-sensing properties was attributed to the reduction of hydroxyl species and the improvement of the crystallization degree. This study provides a versatile strategy for obtaining CuWO4 nanoparticles for practical applications as an ozone gas sensor