Renal function and peak exercise oxygen consumption in chronic heart failure with reduced left ventricular ejection fraction

Background: Chronic kidney disease is associated with sympathetic activation and muscle abnormalities, which may contribute to decreased exercise capacity. We investigated the correlation of renal function with peak exercise oxygen consumption (V\u2d9O2) in heart failure (HF) patients. Methods and Results: We recruited 2,938 systolic HF patients who underwent clinical, laboratory, echocardiographic and cardiopulmonary exercise testing. The patients were stratified according to estimated glomerular filtration rate (eGFR). Mean follow-up was 3.7 years. The primary outcome was a composite of cardiovascular death and urgent heart transplantation at 3 years. On multivariable regression, eGFR was predictor of peakV\u2d9O2 (P<0.0001). Other predictors were age, sex, body mass index, HF etiology, NYHA class, atrial fibrillation, resting heart rate, Btype natriuretic peptide, hemoglobin, and treatment. After adjusting for significant covariates, the hazard ratio for primary outcome associated with peakVO2 <12 ml \u30fb kg 121 \u30fb min 121 was 1.75 (95% confidence interval (CI): 1.06\u20132.91; P=0.0292) in patients with eGFR 6560, 1.77 (0.87\u20133.61; P=0.1141) in those with eGFR of 45\u201359, and 2.72 (1.01\u2013 7.37; P=0.0489) in those with eGFR <45 ml \u30fb min 121 \u30fb 1.73 m 122. The area under the receiver-operating characteristic curve for peakV\u2d9O2 <12 ml \u30fb kg 121 \u30fb min 121 was 0.63 (95% CI: 0.54\u20130.71), 0.67 (0.56\u20130.78), and 0.57 (0.47\u20130.69), respectively. Testing for interaction was not significant. Conclusions: Renal dysfunction is correlated with peakV O2. A peakV O2 cutoff of 12 ml \u30fb kg\u20131 \u30fb min\u20131 offers limited prognostic information in HF patients with more severely impaired renal function

Experimental study of hard photon radiation processes at HERA

We present an experimental study of the ep→eγ+p and ep→eγ+X processes using data recorded by the H1 detector in 1993 at the electron-proton collider HERA. These processes are employed to measure the luminosity with an accuracy of 4.5 %. A subsample of the ep→eγ+X events in which the hard photon is detected at angles θγ′ ≤ 0.45 mrad with respect to the incident electron direction is used to verify experimentally the size of radiative corrections to the ep→eX inclusive cross section and to investigate the structure of the proton in the Q2 domain down to 2 GeV2, lower than previously attained at HERA. © 1995 Springer-Verlag.0400 auteursSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Amplitude analysis of the decay D0→K-K+π0

Using 385 fb(-1) of e(+)e(-) collisions, we study the amplitudes of the singly Cabibbo-suppressed decay D-0 -> K-K+pi(0). We measure the strong phase difference between the (D) over bar (0) and D-0 decays to K-*(892)K-+(-) to be -35.5 degrees +/- 1.9 degrees(stat)+/- 2.2 degrees(syst), and their amplitude ratio to be 0.599 +/- 0.013(stat)+/- 0.011(syst). We observe contributions from the K pi and K-K+ scalar and vector amplitudes, and analyze their angular moments. We find no evidence for charged kappa, nor for higher spin states. We also perform a partial-wave analysis of the K-K+ system in a limited mass range

Observation of Decays B0→Ds(∗)+π−B^0 \to D^{(*)}_s + \pi^- and B0→Ds(∗)−K+B^0\to D^{(*)}_s - K^+

7 pages, 2 postscript figues, submitted to Physical Review Letters - P. Grenier aussi au LPCWe report the observation of decays B0->D_s(*)+pi- and B0->D_s(*)-K+ in a sample of 230*10^6 Upsilon(4S)->BBbar events recorded with the BaBar detector at the PEP-II asymmetric-energy e+e- storage ring. We measure the branching fractions B(B0->D_s+pi-)=(1.3 +/- 0.3 (stat.) +/- 0.2 (syst.))*10^{-5}, B(B0->D_s-K+)=(2.5 +/- 0.4 (stat.) +/- 0.4 (syst.))*10^{-5}, B(B0->D_s*+pi-)=(2.8 +/- 0.6 (stat.) +/- 0.5 (syst.))*10^{-5}, and B(B0->D_s*-K+)=(2.0 +/- 0.5 (stat.) +/- 0.4 (syst.))*10^{-5}. The significance of the measurements to differ from zero are 5, 9, 6, and 5 standard deviations, respectively

Measurements of CP-Violating Asymmetries in the Decay B^{0}→K^{+}K^{-}K^{0}

We analyze the decay B0→K+K-K0 using 383×106 BB̅ events collected by the BABAR detector at SLAC to extract CP violation parameter values over the Dalitz plot. Combining all K+K-K0 events, we find ACP=-0.015±0.077±0.053 and βeff=0.352±0.076±0.026  rad, corresponding to a CP violation significance of 4.8σ. A second solution near π/2-βeff is disfavored with a significance of 4.5σ. We also report ACP and βeff separately for decays to ϕ(1020)K0, f0(980)K0, and K+K-K0 with mK+K->1.1  GeV/c2

Measurement of the time-dependent CP asymmetry in B0→DCP(*)h0 decays

We report a measurement of the time-dependent CP-asymmetry parameters S and C in color-suppressed B-0 -> D((*)0)h(0) decays, where h(0) is a pi(0), eta, or omega meson, and the decays to one of the CP eigenstates K+K-, K-S(0)pi(0), or K-S(0)omega. The data sample consists of 383x10(6) Upsilon(4S)-> B (B) over bar decays collected with the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC. The results are S=-0.56 +/- 0.23 +/- 0.05 and C=-0.23 +/- 0.16 +/- 0.04, where the first error is statistical and the second is systematic

Branching fraction measurements of B+→ρ+γ, B0→ρ0γ, and B0→ωγ

We present a study of the decays B+->rho(+)gamma, B-0 ->rho(0)gamma, and B-0 ->omega gamma. The analysis is based on data containing 347x10(6) B (B) over bar events recorded with the BABAR detector at the PEP-II asymmetric B factory. We measure the branching fractions B(B+->rho(+)gamma)=(1.10(-0.33)(+0.37)+/- 0.09)x10(-6) and B(B-0 ->rho(0)gamma)=(0.79(-0.20)(+0.22)+/- 0.06)x10(-6), and set a 90% C.L. upper limit B(B-0 ->omega gamma)(rho/omega)gamma)=(1.25(-0.24)(+0.25)+/- 0.09)x10(-6), from which we determine vertical bar V-td/V-ts vertical bar=0.200(-0.020)(+0.021)+/- 0.015, where the first uncertainty is experimental and the second is theoretical

Measurement of cos2β in B0→D(*)h0 decays with a time-dependent Dalitz plot analysis of D→Ks0π+π-

We study the time-dependent Dalitz plot of D -> K-S(0)pi(+) pi(-) in B-0 -> D((*))h(0) decays, where h(0) is a pi(0), eta, eta', or omega meson and D-* -> D pi(0), using a data sample of 383 x 10(6) Upsilon(4S) -> B (B) over bar decays collected with the BABAR detector. We determine cos2 beta = 0.42 +/- 0.49 +/- 0.09 +/- 0.13, sin2 beta = 0.29 +/- 0.34 +/- 0.03 +/- 0.05, and |lambda| = 1.01 +/- 0.08 +/- 0.02, where the first error is statistical, the second is the experimental systematic uncertainty, and the third, where given, is the Dalitz model uncertainty. Assuming the world average value for sin2 beta and |lambda| = 1, cos2 beta > 0 is preferred over cos2 beta < 0 at 86% confidence level