Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock

Whole-genome sequencing has provided fundamental insights into infectious disease epidemiology, but has rarely been used for examining transmission dynamics of a bacterial pathogen in wildlife. In the Greater Yellowstone Ecosystem (GYE), outbreaks of brucellosis have increased in cattle along with rising seroprevalence in elk. Here we use a genomic approach to examine Brucella abortus evolution, cross-species transmission and spatial spread in the GYE. We find that brucellosis was introduced into wildlife in this region at least five times. The diffusion rate varies among Brucella lineages (∼3 to 8 km per year) and over time. We also estimate 12 host transitions from bison to elk, and 5 from elk to bison. Our results support the notion that free-ranging elk are currently a self-sustaining brucellosis reservoir and the source of livestock infections, and that control measures in bison are unlikely to affect the dynamics of unrelated strains circulating in nearby elk populations

"Outside, it is snowing": Experience and finitude in the nonrepresentational landscapes of Alain Robbe-Grillet

Copyright © 2008 PionRomanillos J L, 2008. The definitive, peer-reviewed and edited version of this article is published in Environment and Planning D: Society and Space 26(5) 795 – 822 DOI: 10.1068/d6207This paper presents and explicates the anonymous and impersonal spatialities tentatively mapped in the novels of Alain Robbe-Grillet. Emerging from the kinds of landscapes and visualities articulated, these spatialities are at odds with the kind of anthropocentrism characteristic of phenomenological narratives of spatial experience that would start from an apparently stable human-subject position. It is argued that his body of literature dismantles the anthropocentric narratives and biographies that would produce in both the space of the world and the ‘phenomenological subject’ an unwarranted depth and naturalism. Importantly, and reflecting the theoretical turn towards the being of language, Robbe-Grillet questions the legitimacy of linguistic subjects to capture the spaces of the visible. As such, it is argued that his literature reflects an experience of the critiques of phenomenology. Importantly, this ‘critique’ goes hand in hand with the kinds of spatialities and landscapes that are rendered in the novels—the indefinite perspectives they open up, the paradoxical visualities they sustain or deny, and the disorientation they inject into the heart of spatial experience. These literary effects produce a nonanthropocentric and nonpersonal spatiality which, although contributing to an erasure of the ‘subject’, at the same time expose and open up a sociospatiality based on singularities, intensities, and finitude

First results from VLTI near-infrared interferometry on high-mass young stellar objects

This is the author accepted manuscript. The final version is available from SPIE via the DOI in this record.Due to the recent dramatic technological advances, infrared interferometry can now be applied to new classes of objects, resulting in exciting new science prospects, for instance, in the area of high-mass star formation. Although extensively studied at various wavelengths, the process through which massive stars form is still only poorly understood. For instance, it has been proposed that massive stars might form like low-mass stars by mass accretion through a circumstellar disk/envelope, or otherwise by coalescence in a dense stellar cluster. Therefore, clear observational evidence, such as the detection of disks around high-mass young stellar objects (YSOs), is urgently needed in order to unambiguously identify the formation mode of the most massive stars. After discussing the technological challenges which result from the special properties of these objects, we present first near-infrared interferometric observations, which we obtained on the massive YSO IRAS 13481-6124 using VLTI/AMBER infrared long-baseline interferometry and NTT speckle interferometry. From our extensive data set, we reconstruct a model-independent aperture synthesis image which shows an elongated structure with a size of ~ 13 x 19 AU, consistent with a disk seen under an inclination of - 45°. The measured wavelengthdependent visibilities and closure phases allow us to derive the radial disk temperature gradient and to detect a dust-free region inside of 9.5 AU from the star, revealing qualitative and quantitative similarities with the disks observed in low-mass star formation. In complementary mid-infrared Spitzer and sub-millimeter APEX imaging observations we detect two bow shocks and a molecular outflow, which are oriented perpendicular to the disk plane and indicate the presence of a bipolar outflow emanating from the inner regions of the system.This work was performed in part under contract with the California Institute of Technology (Caltech) funded by NASA through the Sagan Fellowship Program

A hot compact dust disk around a massive young stellar object

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Circumstellar disks are an essential ingredient of the formation of low-mass stars. It is unclear, however, whether the accretion-disk paradigm can also account for the formation of stars more massive than about 10 solar masses, in which strong radiation pressure might halt mass infall. Massive stars may form by stellar merging, although more recent theoretical investigations suggest that the radiative-pressure limit may be overcome by considering more complex, non-spherical infall geometries. Clear observational evidence, such as the detection of compact dusty disks around massive young stellar objects, is needed to identify unambiguously the formation mode of the most massive stars. Here we report near-infrared interferometric observations that spatially resolve the astronomical-unit-scale distribution of hot material around a high-mass ( approximately 20 solar masses) young stellar object. The image shows an elongated structure with a size of approximately 13 x 19 astronomical units, consistent with a disk seen at an inclination angle of approximately 45 degrees . Using geometric and detailed physical models, we found a radial temperature gradient in the disk, with a dust-free region less than 9.5 astronomical units from the star, qualitatively and quantitatively similar to the disks observed in low-mass star formation. Perpendicular to the disk plane we observed a molecular outflow and two bow shocks, indicating that a bipolar outflow emanates from the inner regions of the system.This work was done in part under contract with the California Institute of Technology (Caltech), funded by NASA through the Sagan Fellowship Program (S.K. is a Sagan Fellow). We thank the ESO Paranal staff for support and their efforts in improving the VLTI. This paper is based on observations made with ESO telescopes at the La Silla Paranal Observatory and archival data obtained with the Spitzer Space Telescope, operated by the Jet Propulsion Laboratory, Caltech, under a contract with NASA. We also used data acquired with APEX, a collaboration between the Max-Planck-Institut für Radioastronomie, ESO, and the Onsala Space Observatory

Strong near-infrared emission in the sub-AU disk of the Herbig Ae star HD 163296: evidence of refractory dust?

This is the author accepted manuscript. The final version is available from EDP Sciences via the DOI in this record.We present new long-baseline spectro-interferometric observations of the Herbig Ae star HD 163296 (MWC 275) obtained in the H and K bands with the AMBER instrument at the VLTI. The observations cover a range of spatial resolutions between ∼3 and ∼12 milliarcseconds, with a spectral resolution of ∼30. With a total of 1481 visibilities and 432 closure phases, they represent the most comprehensive (u, v) coverage achieved so far for a young star. The circumstellar material is resolved at the sub-AU spatial scale and closure phase measurements indicate a small but significant deviation from point-symmetry. We discuss the results assuming that the near-infrared excess in HD 163296 is dominated by the emission of a circumstellar disk. A successful fit to the spectral energy distribution, near-infrared visibilities and closure phases is found with a model in which a dominant contribution to the H and K band emission originates in an optically thin, smooth and point-symmetric region extending from about 0.1 to 0.45 AU. At a distance of 0.45 AU from the star, silicates condense, the disk becomes optically thick and develops a puffed-up rim, whose skewed emission can account for the non-zero closure phases. We discuss the source of the inner disk emission and tentatively exclude dense molecular gas as well as optically thin atomic or ionized gas as its possible origin. We propose instead that the smooth inner emission is produced by very refractory grains in a partially cleared region, extending to at least ∼0.5 AU. If so, we may be observing the disk of HD 163296 just before it reaches the transition disk phase. However, we note that the nature of the refractory grains or, in fact, even the possibility of any grain surviving at the very high temperatures we require (∼2100−2300 K at 0.1 AU from the star) is unclear and should be investigated further.We acknowledge fundings from CNRS and INAF (grant ASI-INAF I/016/07/0). This work was in part performed under contract with the Jet Propulsion Laboratory (JPL) funded by NASA through the Michelson Fellowship Progra

Near-infrared interferometric observation of the Herbig Ae star HD144432 with VLTI/AMBER

We study the sub-AU-scale circumstellar environment of the Herbig Ae star HD144432 with near-infrared (NIR) VLTI/AMBER observations to investigate the structure of its inner dust disk. The interferometric observations were carried out with the AMBER instrument in the H and K band. We interpret the measured H- and K-band visibilities, the near- and mid-infrared visibilities from the literature, and the SED of HD144432 by using geometric ring models and ring-shaped temperature-gradient disk models with power-law temperature distributions. We derived a K-band ring-fit radius of 0.17 \pm 0.01 AU and an H-band radius of 0.18 \pm 0.01 AU (for a distance of 145 pc). This measured K-band radius of \sim0.17 AU lies in the range between the dust sublimation radius of \sim0.13 AU (predicted for a dust sublimation temperature of 1500 K and gray dust) and the prediction of models including backwarming (\sim0.27 AU). We found that an additional extended halo component is required in both the geometric and temperature-gradient modeling. In the best temperature- gradient model, the disk consists of two components. The inner part of the disk is a thin ring with an inner radius of \sim0.21 AU, a temperature of \sim1600 K, and a ring thickness \sim0.02 AU. The outer part extends from \sim1 AU to \sim10 AU with an inner temperature of \sim400 K. We find that the disk is nearly face-on with an inclination angle of < 28 degree. Our temperature-gradient modeling suggests that the NIR excess is dominated by emission from a narrow, bright rim located at the dust sublimation radius, while an extended halo component contributes \sim6% to the total flux at 2 {\mu}m. The MIR model emission has a two-component structure with \sim20% flux from the inner ring and the rest from the outer part. This two-component structure suggests a disk gap, which is possibly caused by the shadow of a puffed-up inner rim.Comment: 7 pages, 5 figures, accepted by A&

Heavy-flavour and quarkonium production in the LHC era: from proton-proton to heavy-ion collisions

This report reviews the study of open heavy-flavour and quarkonium production in high-energy hadronic collisions, as tools to investigate fundamental aspects of Quantum Chromodynamics, from the proton and nucleus structure at high energy to deconfinement and the properties of the Quark-Gluon Plasma. Emphasis is given to the lessons learnt from LHC Run 1 results, which are reviewed in a global picture with the results from SPS and RHIC at lower energies, as well as to the questions to be addressed in the future. The report covers heavy flavour and quarkonium production in proton-proton, proton-nucleus and nucleus-nucleus collisions. This includes discussion of the effects of hot and cold strongly interacting matter, quarkonium photo-production in nucleus-nucleus collisions and perspectives on the study of heavy flavour and quarkonium with upgrades of existing experiments and new experiments. The report results from the activity of the SaporeGravis network of the I3 Hadron Physics programme of the European Union 7th Framework Programme

An overview of the mid-infrared spectro-interferometer MATISSE: science, concept, and current status

MATISSE is the second-generation mid-infrared spectrograph and imager for the Very Large Telescope Interferometer (VLTI) at Paranal. This new interferometric instrument will allow significant advances by opening new avenues in various fundamental research fields: studying the planet-forming region of disks around young stellar objects, understanding the surface structures and mass loss phenomena affecting evolved stars, and probing the environments of black holes in active galactic nuclei. As a first breakthrough, MATISSE will enlarge the spectral domain of current optical interferometers by offering the L and M bands in addition to the N band. This will open a wide wavelength domain, ranging from 2.8 to 13 um, exploring angular scales as small as 3 mas (L band) / 10 mas (N band). As a second breakthrough, MATISSE will allow mid-infrared imaging - closure-phase aperture-synthesis imaging - with up to four Unit Telescopes (UT) or Auxiliary Telescopes (AT) of the VLTI. Moreover, MATISSE will offer a spectral resolution range from R ~ 30 to R ~ 5000. Here, we present one of the main science objectives, the study of protoplanetary disks, that has driven the instrument design and motivated several VLTI upgrades (GRA4MAT and NAOMI). We introduce the physical concept of MATISSE including a description of the signal on the detectors and an evaluation of the expected performances. We also discuss the current status of the MATISSE instrument, which is entering its testing phase, and the foreseen schedule for the next two years that will lead to the first light at Paranal.Comment: SPIE Astronomical Telescopes and Instrumentation conference, June 2016, 11 pages, 6 Figure