The kiloparsec-scale star formation law at redshift 4: wide-spread, highly efficient star formation in the dust-obscured starburst galaxy GN20

We present high-resolution observations of the 880 $\mu$m (rest-frame FIR) continuum emission in the z$=$4.05 submillimeter galaxy GN20 from the IRAM Plateau de Bure Interferometer (PdBI). These data resolve the obscured star formation in this unlensed galaxy on scales of 0.3$^{\prime\prime}$$\times$0.2$^{\prime\prime}$ ($\sim$2.1$\times$1.3 kpc). The observations reveal a bright (16$\pm$1 mJy) dusty starburst centered on the cold molecular gas reservoir and showing a bar-like extension along the major axis. The striking anti-correlation with the HST/WFC3 imaging suggests that the copious dust surrounding the starburst heavily obscures the rest-frame UV/optical emission. A comparison with 1.2 mm PdBI continuum data reveals no evidence for variations in the dust properties across the source within the uncertainties, consistent with extended star formation, and the peak star formation rate surface density (119$\pm$8 M$_{\odot}$ yr$^{-1}$ kpc$^{-2}$) implies that the star formation in GN20 remains sub-Eddington on scales down to 3 kpc$^2$. We find that the star formation efficiency is highest in the central regions of GN20, leading to a resolved star formation law with a power law slope of $\Sigma_{\rm SFR}$ $\sim$ $\Sigma_{\rm H_2}^{\rm 2.1\pm1.0}$, and that GN20 lies above the sequence of normal star-forming disks, implying that the dispersion in the star formation law is not due solely to morphology or choice of conversion factor. These data extend previous evidence for a fixed star formation efficiency per free-fall time to include the star-forming medium on $\sim$kpc-scales in a galaxy 12 Gyr ago.Comment: 6 pages, 5 figures, accepted to ApJ

Genetic Correlates of Brain Aging on MRI and Cognitive Test Measures: A Genome-Wide Association and Linkage Analysis in the Framingham Study

BACKGROUND: Brain magnetic resonance imaging (MRI) and cognitive tests can identify heritable endophenotypes associated with an increased risk of developing stroke, dementia and Alzheimer's disease (AD). We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample. METHODS: A total of 705 stroke- and dementia-free Framingham participants (age 62 +9 yrs, 50% male) who underwent volumetric brain MRI and cognitive testing (1999–2002) were genotyped. We used linear models adjusting for first degree relationships via generalized estimating equations (GEE) and family based association tests (FBAT) in additive models to relate qualifying single nucleotide polymorphisms (SNPs, 70,987 autosomal on Affymetrix 100K Human Gene Chip with minor allele frequency ≥ 0.10, genotypic call rate ≥ 0.80, and Hardy-Weinberg equilibrium p-value ≥ 0.001) to multivariable-adjusted residuals of 9 MRI measures including total cerebral brain (TCBV), lobar, ventricular and white matter hyperintensity (WMH) volumes, and 6 cognitive factors/tests assessing verbal and visuospatial memory, visual scanning and motor speed, reading, abstract reasoning and naming. We determined multipoint identity-by-descent utilizing 10,592 informative SNPs and 613 short tandem repeats and used variance component analyses to compute LOD scores. RESULTS: The strongest gene-phenotype association in FBAT analyses was between SORL1 (rs1131497; p = 3.2 × 10-6) and abstract reasoning, and in GEE analyses between CDH4 (rs1970546; p = 3.7 × 10-8) and TCBV. SORL1 plays a role in amyloid precursor protein processing and has been associated with the risk of AD. Among the 50 strongest associations (25 each by GEE and FBAT) were other biologically interesting genes. Polymorphisms within 28 of 163 candidate genes for stroke, AD and memory impairment were associated with the endophenotypes studied at p < 0.001. We confirmed our previously reported linkage of WMH on chromosome 4 and describe linkage of reading performance to a marker on chromosome 18 (GATA11A06), previously linked to dyslexia (LOD scores = 2.2 and 5.1). CONCLUSION: Our results suggest that genes associated with clinical neurological disease also have detectable effects on subclinical phenotypes. These hypothesis generating data illustrate the use of an unbiased approach to discover novel pathways that may be involved in brain aging, and could be used to replicate observations made in other studies.National Institutes of Health National Center for Research Resources Shared Instrumentation grant (ISI0RR163736-01A1); National Heart, Lung, and Blood Institute's Framingham Heart Study (N01-HC-25195); National Institute of Aging (5R01-AG08122, 5R01-AG16495); National Institute of Neurological Disorders and Stroke (5R01-NS17950

Ionized Nitrogen at High Redshift

We present secure [N II]_(205 μm) detections in two millimeter-bright, strongly lensed objects at high redshift, APM 08279+5255 (z = 3.911) and MM 18423+5938 (z = 3.930), using the IRAM Plateau de Bure Interferometer. Due to its ionization energy [N II]_(205 μm) is a good tracer of the ionized gas phase in the interstellar medium. The measured fluxes are S([N II]_(205 μm)) = (4.8 ± 0.8) Jy km s^(–1) and (7.4 ± 0.5) Jy km s^(–1), respectively, yielding line luminosities of L([N II]_(205 μm)) = (1.8 ± 0.3) × 10^9 μ^(–1) L_⊙ for APM 08279+5255 and L([N II]_(205 μm)) = (2.8 ± 0.2) × 10(^9) μ^(–1) L_⊙ for MM 18423+5938. Our high-resolution map of the [N II]_(205 μm) and 1 mm continuum emission in MM 18423+5938 clearly resolves an Einstein ring in this source and reveals a velocity gradient in the dynamics of the ionized gas. A comparison of these maps with high-resolution EVLA CO observations enables us to perform the first spatially resolved study of the dust continuum-to-molecular gas surface brightness (Σ_(FIR)α Σ^N_CO, which can be interpreted as the star formation law) in a high-redshift object. We find a steep relation (N = 1.4 ± 0.2), consistent with a starbursting environment. We measure a [N II]_(205 μm)/FIR luminosity ratio in APM 08279+5255 and MM 18423+5938 of 9.0 × 10^(–6) and 5.8 × 10^(–6), respectively. This is in agreement with the decrease of the [N II]_(205 μm)/FIR ratio at high FIR luminosities observed in local galaxies

COLDz: Karl G. Jansky Very Large Array discovery of a gas-rich galaxy in COSMOS

The broad spectral bandwidth at mm and cm-wavelengths provided by the recent upgrades to the Karl G. Jansky Very Large Array (VLA) has made it possible to conduct unbiased searches for molecular CO line emission at redshifts, z > 1.31. We present the discovery of a gas-rich, star-forming galaxy at z = 2.48, through the detection of CO(1-0) line emission in the COLDz survey, through a sensitive, Ka-band (31 to 39 GHz) VLA survey of a 6.5 square arcminute region of the COSMOS field. We argue that the broad line (FWHM ~570 +/- 80 km/s) is most likely to be CO(1-0) at z=2.48, as the integrated emission is spatially coincident with an infrared-detected galaxy with a photometric redshift estimate of z = 3.2 +/- 0.4. The CO(1-0) line luminosity is L'_CO = (2.2 +/- 0.3) x 10^{10} K km/s pc^2, suggesting a cold molecular gas mass of M_gas ~ (2 - 8)x10^{10}M_solar depending on the assumed value of the molecular gas mass to CO luminosity ratio alpha_CO. The estimated infrared luminosity from the (rest-frame) far-infrared spectral energy distribution (SED) is L_IR = 2.5x10^{12} L_solar and the star-formation rate is ~250 M_solar/yr, with the SED shape indicating substantial dust obscuration of the stellar light. The infrared to CO line luminosity ratio is ~114+/-19 L_solar/(K km/s pc^2), similar to galaxies with similar SFRs selected at UV/optical to radio wavelengths. This discovery confirms the potential for molecular emission line surveys as a route to study populations of gas-rich galaxies in the future

Quantifying Cognitive Reserve in Older Adults by Decomposing Episodic Memory Variance: Replication and Extension

The theory of cognitive reserve attempts to explain why some individuals are more resilient to age-related brain pathology. Efforts to explore reserve have been hindered by measurement difficulties. Reed et al. (2010) proposed quantifying reserve as residual variance in episodic memory performance that remains after accounting for demographic factors and brain pathology (whole brain, hippocampal, and white matter hyperintensity volumes). This residual variance represents the discrepancy between an individual's predicted and actual memory performance. The goals of the present study were to extend these methods to a larger, community-based sample and to investigate whether the residual reserve variable is explained by age, predicts longitudinal changes in language, and predicts dementia conversion independent of age. Results support this operational measure of reserve. The residual reserve variable was associated with higher reading ability, lower likelihood of meeting criteria for mild cognitive impairment, lower odds of dementia conversion in dependent of age, and less decline in language abilities over 3 years. Finally, the residual reserve variable moderated the negative impact of memory variance explained by brain pathology on language decline. This method has the potential to facilitate research on the mechanisms of cognitive reserve and the efficacy of interventions designed to impart reserve

Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results.

IntroductionWe estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos.MethodsMiddle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50-86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging-Alzheimer's Association diagnostic criteria.ResultsThe overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI.DiscussionMCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos

A molecular line scan in the Hubble Deep Field North

We present a molecular line scan in the Hubble Deep Field North (HDF-N) that covers the entire 3mm window (79-115 GHz) using the IRAM Plateau de Bure Interferometer. Our CO redshift coverage spans z2. We reach a CO detection limit that is deep enough to detect essentially all z>1 CO lines reported in the literature so far. We have developed and applied different line searching algorithms, resulting in the discovery of 17 line candidates. We estimate that the rate of false positive line detections is ~2/17. We identify optical/NIR counterparts from the deep ancillary database of the HDF-N for seven of these candidates and investigate their available SEDs. Two secure CO detections in our scan are identified with star-forming galaxies at z=1.784 and at z=2.047. These galaxies have colors consistent with the `BzK' color selection and they show relatively bright CO emission compared with galaxies of similar dust continuum luminosity. We also detect two spectral lines in the submillimeter galaxy HDF850.1 at z=5.183. We consider an additional 9 line candidates as high quality. Our observations also provide a deep 3mm continuum map (1-sigma noise level = 8.6 μJy/beam). Via a stacking approach, we find that optical/MIR bright galaxies contribute only to <50% of the SFR density at 1<z<3, unless high dust temperatures are invoked. The present study represents a first, fundamental step towards an unbiased census of molecular gas in `normal' galaxies at high-z, a crucial goal of extragalactic astronomy in the ALMA era

Super-critical accretion of supermassive black holes

The observation of extremely massive black holes shining as quasars up to z~7.5 requires either large BH seeds or episodes of supercritical accretion. In the poster are reviewed some of the current constraints on supercritical accretion, on how it can be triggered, and on the possibility of observing supercritically growing MBHs

A panchromatic view of PKS 0558-504: an ideal laboratory to study the disk-jet link

PKS 0558-504 is the brightest radio-loud Narrow-Line Seyfert 1 galaxy at X-ray energies. Here we present results from the radio, optical, UV, and X-ray bands obtained with Swift, XMM, and ATCA during a 10-day monitoring campaign in September 2008. The simultaneous coverage at several wavelengths makes it possible to investigate in detail the broadband spectral energy distribution (SED) and the energetic of this source. The main results can be summarized as follows. The ATCA reveals the presence of an extended radio emission in PKS 0558-504 with two lobe-like structures at ~7" from the bright central source. The extended radio structure and the low value of the radio-loudness similar to radio-quiet Seyfert galaxies coupled with constraints from higher energy bands argue against a jet-dominated emission. The study of the SED, which is dominated by a nearly constant optical-UV emission, supports the conclusion that PKS 0558-504 is accreting at super-Eddington rate. This conclusion was reached assuming M_BH=2.5e8 M_sun, which was obtained with a new scaling method based on X-ray spectral variability results. A comparison between the accretion luminosity and the kinetic power associated with the jet suggests that in this source the accretion power dominates in agreement with the results obtained from Radiation-MHD simulations of Galactic black holes (GBHs) accreting at the Eddington rate. The combined findings from this panchromatic investigation strongly suggest that PKS 0558-504 is a large-scale analog of GBHs in their highly accreting intermediate state. Importantly, PKS 0558-504 may also be the prototype of the parent population of the very radio-loud NLS1s recently detected at gamma-ray energies.Comment: 11 pages, 5 figures, 3 tables, accepted for publication in Ap