Alta disponibilidad 24/7 : el reto

En la actualidad, las actividades diarias para los ne- gocios, instituciones, instituciones educativas o nivel de usuario común están directamente vinculadas a la red de redes, la Internet. Su desarrollo ha permitido a la mayoría de los servicios y aplicaciones, que hace años eran sólo para el modo cliente-servidor, ahora acceder desde cualquier lugar en cualquier dispositi- vo con conexión a Internet. Por lo tanto, ofrecer un ambiente que da conexiones y transacciones 7/24 es necesario para cada empresa e institución con servicios en línea. Sin embargo, es una premisa difícil de cumplir

Tiempo de fotogrametría. Una propuesta de clasificación para el levantamiento fotogramétrico

The graphic survey of the built heritage allows and makes possible a graphic territory of learning, analysis, experimentation, communication and deposit for architecture. It supposes, in addition to the connection between the theory and the practice of our discipline, an excellent framework for teaching. In this context, photogrammetry is evidenced as a rigorous and efficient technique that, at the service of relevant hypotheses, is capable of producing results that are as valuable as they are contemporary. This research paper, created after the tutelage of more than forty final degree projects that use the photogrammetric technique, develops a classification proposal for qualified point clouds (as part of the technique workflow) based on the temporal nature of the drawings. In this way we will argue the three possible positions (previous or tool, intermediate or process and later or result) to conclude by claiming the relevance and importance of their consideration during the value of the drawings of the built architecture.El levantamiento del patrimonio construido permite y hace posible un territorio gráfico de aprendizaje, análisis, experimentación, comunicación y depósito para la arquitectura. Supone, además de la conexión entre la teoría y la práctica de nuestra disciplina, un marco inmejorable para la enseñanza. En este contexto la fotogrametría se evidencia como una técnica rigurosa y eficaz que, al servicio de unas hipótesis pertinentes, es capaz de producir resultados tan valiosos como contemporáneos. El presente artículo de investigación, producido tras la tutela de más de cuarenta trabajos finales de grado que emplean la técnica fotogramétrica, desarrolla una propuesta de clasificación para las nubes de puntos cualificados (parte del flujo de trabajo de la técnica) atendiendo al carácter temporal de la grafía. De esta forma argumentaremos las tres posibles posiciones (anterior o herramienta, intermedia o proceso y posterior o resultado) para concluir reivindicando la pertinencia e importancia de su consideración durante la puesta en valor de los dibujos de la arquitectura construida.This work is developed as part of an R+D+I project entitled “The representation of time in graphic expression”, with reference project-emergent-GRE18-10 and funded, in public concurrence, by the Vice-Rector’s Office for Research and Transfer of Knowledge of the University of Alicante

Nursing Motives for Helping Scale (N-MHS): Reliability and Validity

This paper presents the Nursing Motives for Helping Scale (N-MHS), an instrument designed for the evaluation of three of the four motives for helping derived from Batson’s helping pathway theory. Dimensionality was analyzed by means of principal component analysis (n = 113), followed by confirmatory factor analysis. A 3-factor structure (corresponding to Batson’s differentiation among altruistic motivation, reward-seeking motivation, and punishment-avoidance motivation, respectively), with 9 items distributed in three latent variables, revealed an acceptable fit to the data. Alpha values (.60 - .74) showed that internal consistency was acceptable for a newly developed subscale with a small number of items. Convergence validity was evaluated with correlations between N-MHS subscales scores and scores on the Professional Expectations Scale (Garrosa, Moreno-Jiménez, Rodríguez-Carvajal, & Morante, 2005). The three resulting subscales are a promising instrument for the evaluation of three nursing motives for helping that can contribute to reduce the potential risks and to improve the potential benefits both for the nurse and the patient.En este articulo se presenta la Escala de Motivaciones de Ayuda en Enfermería [The Nursing Motives for Helping Scale (N MHS)], un instrumento elaborado para evaluar tres de las cuatro motivaciones de ayuda derivadas del modelo de motivación prosocial de Batson. Se analizó la dimensionalidad mediante análisis de componentes principales (n = 113), seguido de análisis factorial confirmatorio. La estructura de 3 factores (correspondiendo a la diferenciación de Batson entre las motivaciones altruista, la de búsqueda de recompensa y la de evitación del castigo, respectivamente), con 9 ítems distribuidos en 3 variables latentes, mostró un ajuste aceptable a los datos. Los valores de alfa (.60 - .74) indicaron que la consistencia interna era aceptable para una subescala nueva con un número pequeño de ítems. La validez convergente se evaluó mediante las correlaciones entre las puntuaciones de las subescalas de la N-MHS y las puntuaciones en la Escala de Expectativas Profesionales (Garrosa, Moreno-Jiménez, Rodríguez-Carvajal y Morante, 2005). Las tres subescalas resultantes constituyen un instrumento prometedor para la evaluación de tres motivaciones de ayuda de enfermería que pueden contribuir a reducir los riesgos y a incrementar los beneficios potenciales tanto de los profesionales de enfermería como de los pacientes

Factors that influence French consumer satisfaction in the preference for Chilean avocados (Persea americana Mill.)

Most avocados consumed in France come from Peru or Chile. French suppliers vary based on the season; however, Chile is the main supplier of avocados during the winter season. The aim of this study is to analyze the key variables that influence French consumer satisfaction in the preference for Chilean avocados.This is substantiated using an exploratory multivariate analysis, which was performed on a causal model comprised of endogenous constructs: perceived extrinsic and intrinsic quality, perceived risk and perceived value. The sample consists of 346 French consumers of Chilean avocados in supermarkets of the Auvergne-Rhône-Alpes region. The main results show that the risk perceived by French consumers can only be related to the perceived extrinsic quality of the product. On the other hand, both perceived intrinsic and extrinsic quality are directly related to perceived value. Finally, it is concluded that French consumer satisfaction in the preference for Chilean avocados can be explained by the variables perceived intrinsic quality, perceived extrinsic quality and perceived value

On the track of the missing tRNA genes: a source of non-canonical functions?

Cellular tRNAs appear today as a diverse population of informative macromolecules with conserved general elements ensuring essential common functions and different and distinctive features securing specific interactions and activities. Their differential expression and the variety of post-transcriptional modifications they are subject to, lead to the existence of complex repertoires of tRNA populations adjusted to defined cellular states. Despite the tRNA-coding genes redundancy in prokaryote and eukaryote genomes, it is surprising to note the absence of genes coding specific translational-active isoacceptors throughout the phylogeny. Through the analysis of different releases of tRNA databases, this review aims to provide a general summary about those “missing tRNA genes.” This absence refers to both tRNAs that are not encoded in the genome, as well as others that show critical sequence variations that would prevent their activity as canonical translation adaptor molecules. Notably, while a group of genes are universally missing, others are absent in particular kingdoms. Functional information available allows to hypothesize that the exclusion of isodecoding molecules would be linked to: 1) reduce ambiguities of signals that define the specificity of the interactions in which the tRNAs are involved; 2) ensure the adaptation of the translational apparatus to the cellular state; 3) divert particular tRNA variants from ribosomal protein synthesis to other cellular functions. This leads to consider the “missing tRNA genes” as a source of putative non-canonical tRNA functions and to broaden the concept of adapter molecules in ribosomal-dependent protein synthesis

Competencia táctica y técnica de alumnos de segundo curso de Educación Primaria. Preparados para aprender deporte

The purpose of the study was threefold: (a) to implement a game context approach to assess the game performance components and, in doing so, (b) to know if second graders have the appropriate development to learn games, and (c) to design a suitable learning progressions within tactical teaching approaches. Game performance was assessed in second graders (n=16; age 7-8 years) with special attention to decision making component. Participants achieved a high level of tactical awareness in attacking the goal contexts and low performance in response execution. Findings suggested that second grade students are ready to learn games as long as a tactical approach as Teaching Games for Understanding was used.El objetivo de nuestro estudio fue triple: (a) analizar los conocimientos previos de alumnos de segundo de Educación Primaria sobre deportes de invasión, y a partir de esto, (b) deducir si los alumnos de estas edades están preparados para aprender deportes de invasión y, en caso positivo, (c) desarrollar una propuesta de progresión adecuada a su nivel de desarrollo. Para ello se evaluó y analizó el rendimiento de juego de alumnos de segundo de Educación Primaria (n=16; edad: 7-8 años), prestando especial atención al componente de toma de decisión. Destacó el alto nivel de conciencia táctica en contextos de logro del objetivo y el bajo rendimiento en el componente de ejecución motriz. Los datos apoyan la hipótesis de la posibilidad de una iniciación deportiva a partir de los 7 años con el enfoque adecuado, tal y como es la Enseñanza Comprensiva del Deporte

Antecedentes del uso de los medios sociales por el turista: motivación, oportunidad y capacidad

This work uses the MOA model to explain to what level motivation, opportunity and ability of users are factors determining the intentions to use social media when organizing and taking vacation trips. The conclusions of the study reveal that the intentions to use social media are directly influenced by the motivation and ability of users; however, the opportunity does not significantly affect the predisposition to use such technologies. In turn, functional and hedonic benefits have an influence on motivations, while social benefits do not.El presente trabajo utiliza el modelo MOA para analizar en qué medida la motivación, la oportunidad y la capacidad de los usuarios son factores determinantes de las intenciones de uso de medios sociales en la organización y desarrollo de viajes turísticos. Las conclusiones del estudio revelan que las intenciones de uso de los medios sociales se ven afectadas por la motivación y las capacidades de los usuarios y, sin embargo, no se ven influenciadas por la oportunidad. A su vez, en las motivaciones influyen los beneficios funcionales y hedónicos, pero no los sociales

A repairability index for reinforced concrete members based on fracture mechanics

This paper proposes a repairability index for damage assessment in reinforced concrete structural members. The procedure discussed in this paper differs from the standard methods in two aspects: the structural and damage analyses are coupled and it is based on the concepts of fracture and continuum damage mechanics. The relationship between the repairability index and the well-known Park and Ang index is shown in some particular cases

In silico whole-genome screening for cancer-related single-nucleotide polymorphisms located in human mRNA untranslated regions

BACKGROUND: A promising application of the huge amounts of genetic data currently available lies in developing a better understanding of complex diseases, such as cancer. Analysis of publicly available databases can help identify potential candidates for genes or mutations specifically related to the cancer phenotype. In spite of their huge potential to affect gene function, no systematic attention has been paid so far to the changes that occur in untranslated regions of mRNA. RESULTS: In this study, we used Expressed Sequence Tag (EST) databases as a source for cancer-related sequence polymorphism discovery at the whole-genome level. Using a novel computational procedure, we focused on the identification of untranslated region (UTR)-localized non-coding Single Nucleotide Polymorphisms (UTR-SNPs) significantly associated with the tumoral state. To explore possible relationships between genetic mutation and phenotypic variation, bioinformatic tools were used to predict the potential impact of cancer-associated UTR-SNPs on mRNA secondary structure and UTR regulatory elements. We provide a comprehensive and unbiased description of cancer-associated UTR-SNPs that may be useful to define genotypic markers or to propose polymorphisms that can act to alter gene expression levels. Our results suggest that a fraction of cancer-associated UTR-SNPs may have functional consequences on mRNA stability and/or expression. CONCLUSION: We have undertaken a comprehensive effort to identify cancer-associated polymorphisms in untranslated regions of mRNA and to characterize putative functional UTR-SNPs. Alteration of translational control can change the expression of genes in tumor cells, causing an increase or decrease in the concentration of specific proteins. Through the description of testable candidates and the experimental validation of a number of UTR-SNPs discovered on the secreted protein acidic and rich in cysteine (SPARC) gene, this report illustrates the utility of a cross-talk between in silico transcriptomics and cancer genetics