Conflictos cognitivos en una muestra comunitaria: un estudio exploratorio

El estudio de los conflictos cognitivos se ha llevado a cabo desde diversas aproximaciones teóricas. En el ámbito de la Psicología de los Constructos Personales, la técnica de la rejilla ha permitido operativizar un tipo de conflicto cognitivo denominado Dilema Implicativo (DI) y estudiar su papel en el campo de la salud. En este trabajo se ha analizado la construcción del sí mismo, la estructura cognitiva y el malestar psicológico en personas con y sin DI pertenecientes a una muestra comunitaria. En la investigación participaron 115 sujetos (56.5% mujeres y 43.5% hombres). Las técnicas de evaluación utilizadas fueron la técnica de la rejilla, y las versiones españolas del Symptom Check List-90-R (SCL-90-R) y el Clinical Outcome in Routine Evaluation (CORE-OM). Los principales resultados revelan correlaciones positivas en las tres medidas del sí mismo, lo que supone una alta autoestima, aunque si se comparan los grupos con/sin DI, se observan correlaciones más bajas en las personas con dilemas. En cuanto a la complejidad cognitiva, las personas con dilemas muestran una estructura cognitiva más diferenciada. Por último, en relación con el malestar psicológico percibido, los dos grupos presentan puntuaciones dentro del rango de la normalidad aunque las personas sin DI se sienten en mayor sintonía consigo mismas/con los demás que las personas con dilemas, presentando estas últimas puntuaciones superiores en escalas de depresión y ansiedad del SCL-90, y en las medidas globales del CORE-O

Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction

The design, synthesis, conformational studies and binding affinity for VEGF receptors of a collection of linear and cyclic peptide analogues of the N-terminal α-helix fragments 13-25 of VEGF and 1-13 of Vammin are described. Linear 13(14)-mer peptides were designed with the help of an AGADIR algorithm and prepared following peptide solid-phase synthetic protocols. Cyclic peptide derivatives were prepared on-resin from linear precursors with conveniently located Glu and Lys residues, by the formation of amide linkages. Conformational analysis, CD and NMR, showed that most synthesized peptides have a clear tendency to be structured as α-helices in solution. Some of the peptides were able to bind a VEGFR-1 receptor with moderate affinity. In addition to the described key residues (Phe17, Tyr21 and Tyr25), Val14 and Val20 seem to be relevant for affinity.Peer Reviewe

Direccionalidad y expresión de la violencia en las relaciones de noviazgo de los jóvenes

Although dating violence frequently begins during adolescence and has been postulated as a risk factor for severe forms of adult partner violence, the body of research on this issue remains limited. In this paper, the directionality and behavioral expression of committed and sustained aggression (psychological and physical) in dating relationships is investigated in a sample (N=69) of students aged 16 to 27 years. The results showed a very frequent pattern of reciprocal psychological aggression. However, as the behavioral expression of violence worsens (e.g., slappings, threats and beatings), reciprocity decreases and directionality increases. Sex did not predict the directionality of violence and did not exert a significant effect on the study variables, committed aggression (perpetration) and assault (victimization).In addition, psychological/verbal violence was the most used by aggressors and the most suffered by victims. The work has practical implications since it can help to make this problematic visible and to raise the awareness of public authorities towards the development of violence prevention measures and intervention with victims.ResumenA pesar de que la violencia en el noviazgo se inicia con frecuencia durante la adolescencia y que se ha postulado como un factor de riesgo para formas graves de violencia en las parejas adultas, el corpus de investigación sobre esta problemática continúa siendo limitado. En este trabajo se investiga la direccionalidad y expresión conductual de las agresiones (psicológicas y físicas) cometidas y sufridas en las relaciones de noviazgo en una muestra (N = 69) de estudiantes con edades comprendidas entre los 16 y los 27 años. Los resultados hallados mostraron un patrón recíproco muy frecuente en la agresión psicológica pero, a medida que se agrava la expresión conductual de la violencia (e.g., golpes, amenazas o palizas), disminuye su carácter recíproco y se incrementa la unidireccionalidad de las agresiones. La variable género no predijo la direccionalidad de la violencia y no ejerció un efecto significativo sobre las variables de estudio, agresión cometida (perpetración) y agresión sufrida (victimización). Además, la violencia psicológica/verbal fue la modalidad agresiva más empleada por los agresores y más sufrida por las víctimas. El trabajo presenta implicaciones prácticas que pueden contribuir a hacer visible esta problemática y a concienciar y sensibilizar a los poderes públicos para el desarrollo de medidas de prevención de la violencia y de intervención con las víctimas.AbstractAlthough dating violence frequently begins during adolescence and has been postulated as a risk factor for severe forms of adult partner violence, the body of research on this issue remains limited. In this paper, the directionality and behavioral expression of committed and sustained aggression (psychological and physical) in dating relationships is investigated in a sample (N=69) of students aged 16 to 27 years. The results showed a very frequent pattern of reciprocal psychological aggression. However, as the behavioral expression of violence worsens (e.g., slappings, threats and beatings), reciprocity decreases and directionality increases. Sex did not predict the directionality of violence and did not exert a significant effect on the study variables, committed aggression (perpetration) and assault (victimization).In addition, psychological/verbal violence was the most used by aggressors and the most suffered by victims. The work has practical implications since it can help to make this problematic visible and to raise the awareness of public authorities towards the development of violence prevention measures and intervention with victims

Conformationally restricted PACAP27 analogues incorporating type II/II′ IBTM β-Turn mimetics. Synthesis, NMR structure determination, and binding affinity

To probe the importance of a proposed β-turn within residues S9-R12 of PACAP for recognition by VIP/PACAP receptors, compounds 1 and 2, two conformationally restricted analogues of PACAP27 incorporating respectively (S)- or (R)-IBTM as type II or II′ β-turn dipeptide mimetic at the Y10-S11 position, were synthesized. According to 1H NMR conformational analyses in aqueous solution and 30% TFE, both PACAP27 and the [S-IBTM10,11]PACAP27 analogue 1 adopt similar ordered structures. PACAP27 shows an N-terminal disordered region (residues H1-F6) and an α-helical conformation within segment T7–L27. For residues S9–R12, our data seem more compatible with a segment of the α-helix than with the β-turn previously proposed for this fragment. In compound 1 the α-helix, also spanning T7–L27 residues, appears slightly distorted at the N-terminus relative to the native peptide. Although this distortion could lead to the marked decrease in binding affinity of this compound at the VIP/PACAP receptors, the lack of the Y10 side chain in analogues 1 and 2 could also significantly affect the binding of these compounds.Work at the Instituto de Quı́mica Médica and Universidad de Navarra was supported by CICYT (SAF 97 0030 and SAF 2000-0147), Fundación La Caixa (97/022) and Comunidad Autónoma de Madrid (08.5/0006/1998). Work at the Instituto de Estructura de la Materia was supported by DGICYT (PB98-0677) and the European Union (CEE B104-97-2086). Work at the Universidad de Barcelona was supported by Generalitat de Catalunya (CERBA). C.M.S. and M.M.-M. are recipients of a pre-doctoral and a post-doctoral fellowship, respectively, from the Comunidad Autónoma de Madrid, Spain. E.de O. is a post-doctoral fellow of Fundació Bosch i Gimpera, Universitat de Barcelona, Spain

Propuesta para la Reestructuración Funcional de la Figura del Coordinador de Virtualización en la UNED

El sistema organizativo académico de la Universidad Nacional de Educación a Distancia (UNED) está integrado por docentes en la Sede Central y profesores tutores en los Centros Asociados repartidos por el territorio español. A partir del nuevo panorama educativo en la enseñanza universitaria europea (Espacio Europeo de Enseñanza Superior, -EEES), la UNED se fue adaptando y situándose en un escenario moderno e innovador, iniciándose la mejora y homogeneización de los servicios que reciben los estudiantes mediante los cursos virtuales. En este contexto, se precisó la formación a profesores tutores y a estudiantes en la utilización de los cursos virtuales de la universidad, surgiendo así el rol del Coordinador de Virtualización (CV). En la actualidad hay 62 coordinadores (uno por cada centro asociado). Tras la implantación de las nuevas titulaciones dentro del marco del EEES y, una vez consolidada esta figura en la institución, se ha hecho necesario ofrecer una nueva organización en las funciones y tareas que los CV han de ejercer. Este trabajo describe la nueva propuesta organizativa diseñada para su aplicación a partir del próximo curso 2014-2015, y para cuya elaboración se han seguido los siguientes pasos: identificación del tipo de tareas a desarrollar (apoyo tecnológico a estudiantes y asesoramiento a profesores tutores), establecimiento de los contextos de trabajo (presencial y virtual), y clasificación por categorías para permitir una asignación de actividades básicas a todos los CV y de actividades más especializadas entre subgrupos de CV. Palabras llave: Aprendizaje semipresencial; Formación de profesorado; Competencias tecnológicas; Habilidades digitales. Virtualization Coordinator: Trainer of Tutor-Professors and Support for Students in the UNED Associate CenterAbstract The academic organizational structure of the Universidad Nacional de Educación a Distancia (UNED) is composed of professors at Central Headquarters and tutor-professors at the Associate Centers spread across the Spanish territory. From the new educational landscape in European university education (European Higher Education Area - EHEA), UNED was adapting and placing itself in a modern and innovative stage, beginning with the improvement and standardization of services provided to students through the online courses. In this context, training for both tutor-professors and students in the use of online courses was required, and that´s how the role of Virtualization Coordinator (VC) emerged. At present time, there are 66 VCs (one for each Associate Center). After implementation of the new qualifications within the framework of the EHEA and once established this role in the institution, it is necessary to provide a new organization in the functions and tasks that have to exercise VC. This paper describes a new organizational proposal designed for use from next year 2014-2015, and to whose development we have followed the following steps: identification of the type of tasks to be performed (technical support to students and advice to tutor-professors), establishment of working contexts (presential and virtual), and categorization to allow distribution of basic activities among all the VC, and more specialized activities among subgroups of VC.Keywords: Blended learning; Teachers training; Technological competences; Digital skills

Recuperación laboral en empleados fuera del trabajo: una revisión paraguas de revisiones sistemáticas y meta-análisis

Work is a fundamental condition of human life, but it can become dysfunctional because in certain situations it may lead to undesirable and harmful consequences. In this con­text, recovery from work (recovery) is conceived as a counterpoint to the straining processes to which the em­ployee is exposed in the workplace. Among the different recovery strategies adopted by workers, those carried out outside working hours are especially relevant. Scientific interest in this filed is evidenced by the publication of nu­merous systematic reviews in recent years. The aim of this study is to shed light and provide evidence on the results of the systematic reviews carried out to date. Thus, it was conducted an umbrella review of systematic reviews and meta-analyses on work recovery outside working hours. To this end, a systematic search of potentially relevant documents was implemented in six databases, both the­matic and multidisciplinary. Eight systematic reviews and meta-analyses that met the established inclusion criteria were retrieved. The content analysis of the selected papers enabled us to identify different approaches to the study of external work recovery: (a) time period; (b) work charac­teristics; (c) recovery experiences; (d) recovery activities; (e) processes that hinder effective recovery; and (f) varia­bles proxy to the recovery process. Likewise, the main considered substantive occupational and psychosocial var­iables were systematized. It is discussed the scarce atten­tion paid in the reviewed studies to possible cultural dif­ferences that could potentially influence the recovery pro­cess.  Furthermore, no research has made special reference to the COVID-19 pandemic in work recovery, nor to the potential influence of new emerging work realities such as teleworking or co-working.El trabajo es una condición fundamental de la vida humana pero puede resultar disfuncional por acarrear consecuencias indeseadas y nefastas en determinadas situaciones. En este contexto se entiende la recuperación del trabajo (recovery) como contrapunto a los procesos de tensión a los que se ve sometida la persona en su puesto de trabajo. Dentro de las diferentes estrategias que los trabajadores ponen en marcha para recuperarse, resultan de especial relevancia las llevadas a cabo fuera de su horario laboral. El interés científico en esta materia queda patente en la publicación de numerosas revisiones sistemáticas en los últimos años. El objetivo de este estudio es clarificar y aportar evidencia sobre los resultados de las revisiones sistemáticas realizadas hasta la fecha. Así, se realizó una revisión paraguas de revisiones sistemáticas y metaanálisis sobre la recuperación laboral fuera del horario de trabajo. Para ello se llevó a cabo una búsqueda sistemática de documentos potencialmente relevantes en seis bases de datos, tanto temáticas como multidisciplinares. Se recuperaron ocho revisiones sistemáticas y metanálisis que cumplieron los criterios de inclusión establecidos. El análisis de contenido de los trabajos seleccionados permitió identificar diversas perspectivas o encuadres en el estudio de la recuperación laboral externa: (a) el período temporal; (b) las características del trabajo; (c) las experiencias de recuperación; (d) las actividades de recuperación; (e) los procesos que impiden que la recuperación sea efectiva; y (f) las variables cercanas al proceso de recuperación. Asimismo, se sistematizaron las principales variables sustantivas de naturaleza laboral y psicosocial consideradas en los diversos trabajos. Se discute la escasa atención prestada en los estudios revisados a las posibles diferencias culturales que podrían afectar al proceso de recuperación. Además, ninguna investigación hace mención especial a la pandemia por la COVID-19 en la recuperación laboral, ni tampoco a la potencial influencia de las nuevas realidades laborales en auge como el teletrabajo o los espacios virtuales compartidos (co-working)

Use of eltrombopag for patients 65 years old or older with immune thrombocytopenia

Background Eltrombopag is useful for immune thrombocytopenia (ITP). However, results of clinical trials may not accurately mirror clinical practice reality. Here we evaluated eltrombopag for primary and secondary ITP in our ≥65‐year‐old population. Methods A total of 106 primary ITP patients (16 with newly diagnosed ITP, 16 with persistent ITP, and 74 with chronic ITP) and 39 secondary ITP patients (20 with ITP secondary to immune disorders, 7 with ITP secondary to infectious diseases, and 12 with ITP secondary to lymphoproliferative disorders [LPD]) were retrospectively evaluated. Results Median age of our cohort was 76 (interquartile range, IQR, 70‐81) years. 75.9% of patients yielded a platelet response including 66.2% complete responders. Median time to platelet response was 14 (IQR, 8‐21) days. Median time on response was 320 (IQR, 147‐526) days. Sixty‐three adverse events (AEs), mainly grade 1‐2, occurred. The most common were hepatobiliary laboratory abnormalities (HBLAs) and headaches. One transient ischemic attack in a newly diagnosed ITP and two self‐limited pulmonary embolisms in secondary ITP were the only thrombotic events observed. Conclusion Eltrombopag showed efficacy and safety in ITP patients aged ≥65 years with primary and secondary ITP. However, efficacy results in LPD‐ITP were poor. A relatively high number of deaths were observed

The O3N2 and N2 abundance indicators revisited: improved calibrations based on CALIFA and T e-based literature data

Astronomy and Astrophysics 559 (2013): A114 reproduced with permission from Astronomy and AstrophysicsThe use of integral field spectroscopy is since recently allowing to measure the emission line fluxes of an increasingly large number of star-forming galaxies, both locally and at high redshift. Many studies have used these fluxes to derive the gas-phase metallicity of the galaxies by applying the so-called strong-line methods. However, the metallicity indicators that these datasets use were empirically calibrated using few direct abundance data points (Te-based measurements). Furthermore, a precise determination of the prediction intervals of these indicators is commonly lacking in these calibrations. Such limitations might lead to systematic errors in determining the gas-phase metallicity, especially at high redshift, which might have a strong impact on our understanding of the chemical evolution of the Universe. The main goal of this study is to review the most widely used empirical oxygen calibrations, O3N2 and N2, by using newdirect abundance measurements. We pay special attention to (1) the expected uncertainty of these calibrations as a function of the index value or abundance derived and (2) the presence of possible systematic offsets. This is possible thanks to the analysis of the most ambitious compilation of Te-based H ii regions to date. This new dataset compiles the Te-based abundances of 603 H ii regions extracted from the literature but also includes new measurements from the CALIFA survey. Besides providing new and improved empirical calibrations for the gas abundance, we also present a comparison between our revisited calibrations with a total of 3423 additional CALIFA H ii complexes with abundances derived using the ONS calibration from the literature. The combined analysis of T e-based and ONS abundances allows us to derive their most accurate calibration to date for both the O3N2 and N2 single-ratio indicators, in terms of all statistical significance, quality, and coverage of the parameters space. In particular, we infer that these indicators show shallower abundance dependencies and statistically significant offsets compared to others'. The O3N2 and N2 indicators can be empirically applied to derive oxygen abundances calibrations from either direct abundance determinations with random errors of 0.18 and 0.16, respectively, or from indirect ones (but based on a large amount of data), reaching an average precision of 0.08 and 0.09 dex (random) and 0.02 and 0.08 dex (systematic; compared to the direct estimations), respectivelyR.A. Marino is funded by the Spanish program of International Campus of Excellence Moncloa (CEI). D. Mast thank the Plan Nacional de Investigación y Desarrollo funding programs, AYA2012-31935 of the Spanish Ministerio de Economía y Competitividad, for the support given to this project. S.F.S thanks the the Ramón y Cajal project RyC-2011-07590 of the spanish Ministerio de Economía y Competitividad, for the support giving to this project. F.F.R.O. acknowledges the Mexican National Council for Science and Technology (CONACYT) for financial support under the program Estancias Postdoctorales y Sabáticas al Extranjero para la Consolidación de Grupos de Investigación, 2010-2012. We acknowledge financial support for the ESTALLIDOS collaboration by the Spanish Ministerio de Ciencia e Innovación under grant AYA2010- 21887-C04-03. BG-L also acknowledges support from the Spanish Ministerio de Economía y Competitividad (MINECO) under grant AYA2012- 39408-C02-02. J.F.-B. acknowledges financial support from the Ramón y Cajal Program and grant AYA2010-21322-C03-02 from the Spanish Ministry of Economy and Competitiveness (MINECO), as well as to the DAGAL network from the People’s Program (Marie Curie Actions) of the European Union’s Seventh Framework Program FP7/2007-2013/ under REA grant agreement number PITN-GA-2011-289313. CK has been funded by project AYA2010-21887 from the Spanish PNAYA. P.P. acknowledges support by the Fundação para a Ciência e a Tecnologia (FCT) under project FCOMP-01-0124-FEDER-029170 (Reference FCT PTDC/FIS-AST/3214/2012), funded by FCT-MEC (PIDDAC) and FEDER (COMPETE). R.M.G.D. and R.G.B. also acknowledge support from the Spanish Ministerio de Economía y Competitividad (MINECO) under grant AyA2010-15081. V.S., L.G., and A.M.M. acknowledge financial support from the Fundação para a Ciência e a Tecnologia (FCT) under program Ciência 2008 and the research grant PTDC/CTE-AST/112582/200

Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF)

Background: Recent lifestyle changes include increased consumption of highly processed foods (HPF), which has been associated with an increased risk of non-communicable diseases (NCDs). However, nutritional information relies on the estimation of HPF consumption from food-frequency questionnaires (FFQ) that are not explicitly developed for this purpose. We aimed to develop a short screening questionnaire of HPF consumption (sQ-HPF) that integrates criteria from the existing food classification systems. Methods: Data from 4400 participants (48.1% female and 51.9% male, 64.9 +/- 4.9 years) of the Spanish PREDIMED-Plus (PREvention with MEDiterranean DIet) trial were used for this analysis. Items from the FFQ were classified according to four main food processing-based classification systems (NOVA, IARC, IFIC and UNC). Participants were classified into tertiles of HPF consumption according to each system. Using binomial logistic regression, food groups associated with agreement in the highest tertile for at least two classification systems were chosen as items for the questionnaire. ROC analysis was used to determine cut-off points for the frequency of consumption of each item, from which a score was calculated. Internal consistency of the questionnaire was assessed through exploratory factor analysis (EFA) and Cronbach's analysis, and agreement with the four classifications was assessed with weighted kappa coefficients. Results: Regression analysis identified 14 food groups (items) associated with high HPF consumption for at least two classification systems. EFA showed that items were representative contributors of a single underlying factor, the HPF dietary pattern (factor loadings around 0.2). We constructed a questionnaire asking about the frequency of consumption of those items. The threshold frequency of consumption was selected using ROC analysis. Comparison of the four classification systems and the sQ-HPF showed a fair to high agreement. Significant changes in lifestyle characteristics were detected across tertiles of the sQ-HPF score. Longitudinal changes in HPF consumption were also detected by the sQ-HPF, concordantly with existing classification systems. Conclusions: We developed a practical tool to measure HPF consumption, the sQ-HPF. This may be a valuable instrument to study its relationship with NCDs

Determination of essential biomarkers in lung cancer: a real-world data study in Spain.

Background: The survival of patients with lung cancer has substantially increased in the last decade by about 15%. This increase is, basically, due to targeted therapies available for advanced stages and the emergence of immunotherapy itself. This work aims to study the situation of biomarker testing in Spain. Patients and Methods: The Thoracic Tumours Registry (TTR) is an observational, prospective, registry-based study that included patients diagnosed with lung cancer and other thoracic tumours, from September 2016 to 2020. This TTR study was sponsored by the Spanish Lung Cancer Group (GECP) Foundation, an independent, scientific, multidisciplinary oncology society that coordinates more than 550 experts and 182 hospitals across the Spanish territory. Results: 9,239 patients diagnosed with stage IV non-small cell lung cancer (NSCLC) between 2106 and 2020 were analysed. 7,467 (80.8%) were non-squamous and 1,772 (19.2%) were squamous. Tumour marker testing was performed in 85.0% of patients with non-squamous tumours vs 56.3% in those with squamous tumours (p-value <0.001). The global testing of EGFR, ALK, and ROS1 was 78.9%, 64.7%, 35.6% respectively, in non-squamous histology. PDL1 was determined globally in the same period (46.9%), although if we focus on the last 3 years it exceeds 85%. There has been a significant increase in the last few years of all determinations and there are even close to 10% of molecular determinations that do not yet have targeted drug approval but will have it in the near future. 4,115 cases had a positive result (44.5%) for either EGFR, ALK, KRAS, BRAF, ROS1, or high PDL1. Conclusions: Despite the lack of a national project and standard protocol in Spain that regulates the determination of biomarkers, the situation is similar to other European countries. Given the growing number of different determinations and their high positivity, national strategies are urgently needed to implement next-generation sequencing (NGS) in an integrated and cost-effective way in lung cancer