Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones

The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.publishedVersio

Sexual Relationships in Hispanic Countries: a Literature Review

This is a pre-print of an article published in Current Sexual Health Reports. The final authenticated version is available online at: https://doi.org/10.1007/s11930-020-00272-6Purpose of Review: Sexuality is a complex dimension for which culture seems to play an important role, particularly in countries that are more traditional. This review summarizes the knowledge about sexual relationships in Hispanic countries, considering sexual debut, attitudes, behaviors, and satisfaction. Recent Findings: In line with the literature reviewed, the sexual double standard seems to be continuing to influence sexual relationships. Some countries show more open expressions of sexuality based on the level of gender inequality or sexualized context, and within countries, variables such as religious commitment, family characteristics, and access to resources may play important roles in sexuality. Summary: Future research, policies, and interventions should consider these specific characteristics, including these forms of expression of sexuality, in the adjustment of cross-cultural and cross-national strategies

The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors

In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved in thyroid cell differentiation and proliferation, and in genes found to be differentially expressed in thyroid carcinoma. A total of 768 SNPs in 97 genes were genotyped in a Spanish series of 615 cases and 525 controls, the former comprising the largest collection of patients with this pathology from a single population studied to date. SNPs in an LD block spanning the entire FOXE1 gene showed the strongest evidence of association with papillary thyroid carcinoma susceptibility. This association was validated in a second stage of the study that included an independent Italian series of 482 patients and 532 controls. The strongest association results were observed for rs1867277 (OR[per-allele] = 1.49; 95%CI = 1.30–1.70; P = 5.9×10−9). Functional assays of rs1867277 (NM_004473.3:c.−283G>A) within the FOXE1 5′ UTR suggested that this variant affects FOXE1 transcription. DNA-binding assays demonstrated that, exclusively, the sequence containing the A allele recruited the USF1/USF2 transcription factors, while both alleles formed a complex in which DREAM/CREB/αCREM participated. Transfection studies showed an allele-dependent transcriptional regulation of FOXE1. We propose a FOXE1 regulation model dependent on the rs1867277 genotype, indicating that this SNP is a causal variant in thyroid cancer susceptibility. Our results constitute the first functional explanation for an association identified by a GWAS and thereby elucidate a mechanism of thyroid cancer susceptibility. They also attest to the efficacy of candidate gene approaches in the GWAS era

The CALIFA survey across the Hubble sequence Spatially resolved stellar population properties in galaxies

Various different physical processes contribute to the star formation and stellar mass assembly histories of galaxies. One important approach to understanding the significance of these different processes on galaxy evolution is the study of the stellar population content of today’s galaxies in a spatially resolved manner. The aim of this paper is to characterize in detail the radial structure of stellar population properties of galaxies in the nearby universe, based on a uniquely large galaxy sample, considering the quality and coverage of the data. The sample under study was drawn from the CALIFA survey and contains 300 galaxies observed with integral field spectroscopy. These cover a wide range of Hubble types, from spheroids to spiral galaxies, while stellar masses range from M? ∼ 109 to 7 × 1011 M . We apply the fossil record method based on spectral synthesis techniques to recover the following physical properties for each spatial resolution element in our target galaxies: the stellar mass surface density (µ?), stellar extinction (AV ), light-weighted and mass-weighted ages (hlog ageiL, hlog ageiM), and mass-weighted metallicity (hlog Z?iM). To study mean trends with overall galaxy properties, the individual radial profiles are stacked in seven bins of galaxy morphology (E, S0, Sa, Sb, Sbc, Sc, and Sd). We confirm that more massive galaxies are more compact, older, more metal rich, and less reddened by dust. Additionally, we find that these trends are preserved spatially with the radial distance to the nucleus. Deviations from these relations appear correlated with Hubble type: earlier types are more compact, older, and more metal rich for a given M?, which is evidence that quenching is related to morphology, but not driven by mass. Negative gradients of hlog ageiL are consistent with an inside-out growth of galaxies, with the largest hlog ageiL gradients in Sb–Sbc galaxies. Further, the mean stellar ages of disks and bulges are correlated and with disks covering a wider range of ages, and late-type spirals hosting younger disks. However, age gradients are only mildly negative or flat beyond R ∼ 2 HLR (half light radius), indicating that star formation is more uniformly distributed or that stellar migration is important at these distances. The gradients in stellar mass surface density depend mostly on stellar mass, in the sense that more massive galaxies are more centrally concentrated. Whatever sets the concentration indices of galaxies obviously depends less on quenching/morphology than on the depth of the potential well. There is a secondary correlation in the sense that at the same M? early-type galaxies have steeper gradients. The µ? gradients outside 1 HLR show no dependence on Hubble type. We find mildly negative hlog Z?iM gradients, which are shallower than predicted from models of galaxy evolution in isolation. In general, metallicity gradients depend on stellar mass, and less on morphology, hinting that metallicity is affected by both – the depth of the potential well and morphology/quenching. Thus, the largest hlog Z?iM gradients occur in Milky Way-like Sb–Sbc galaxies, and are similar to those measured above the Galactic disk. Sc spirals show flatter hlog Z?iM gradients, possibly indicating a larger contribution from secular evolution in disks. The galaxies from the sample have decreasing-outward stellar extinction; all spirals show similar radial profiles, independent from the stellar mass, but redder than E and S0. Overall, we conclude that quenching processes act in manners that are independent of mass, while metallicity and galaxy structure are influenced by mass-dependent processes.CALIFA is the first legacy survey carried out at Calar Alto. The CALIFA collaboration would like to thank the IAA-CSIC and MPIA-MPG as major partners of the observatory, and CAHA itself, for the unique access to telescope time and support in manpower and infrastructures. We also thank the CAHA staff for the dedication to this project. Support from the Spanish Ministerio de Economía y Competitividad, through projects AYA2010-15081 (PI R.G.D.), and Junta de Andalucía FQ1580 (PI R.G.D.), AYA2010-22111-C03-03, and AYA2010-10904E (S.F.S.). We also thank the Viabilidad, Diseño, Acceso y Mejora funding program, ICTS-2009-10, for funding the data acquisition of this project. R.C.F. thanks the hospitality of the IAA and the support of CAPES and CNPq. R.G.D. acknowledges the support of CNPq (Brazil) through Programa Ciencia sem Fronteiras (401452/2012-3). A.G. acknowledges support from EU FP7/2007-2013 under grant agreement n.267251 (AstroFIt) and from the EU Marie Curie Integration Grant “SteMaGE” Nr. PCIG12-GA-2012-326466. C.J.W. acknowledges support through the Marie Curie Career Integration Grant 303912. E.P. acknowledges support from the Guillermo Haro program at INAOE. Support for L.G. is provided by the Ministry of Economy, Development, and Tourism’s Millennium Science Initiative through grant IC120009, awarded to The Millennium Institute of Astrophysics, MAS. L.G. acknowledges support by CONICYT through FONDECYT grant 3140566. J.I.P. acknowledges financial support from the Spanish MINECO under grant AYA2010-21887- C04-01 and from Junta de Andalucía Excellence Project PEX2011-FQM7058. I.M., J.M. and A.d.O. acknowledge support from the project AYA2013-42227-P. RAM is funded by the Spanish program of International Campus of Excellence Moncloa (CEI). J.M.A. acknowledges support from the European Research Council Starting Grant (SEDmorph; P.I. V. Wild

EUSO-SPB1 mission and science

The Extreme Universe Space Observatory on a Super Pressure Balloon 1 (EUSO-SPB1) was launched in 2017 April from Wanaka, New Zealand. The plan of this mission of opportunity on a NASA super pressure balloon test flight was to circle the southern hemisphere. The primary scientific goal was to make the first observations of ultra-high-energy cosmic-ray extensive air showers (EASs) by looking down on the atmosphere with an ultraviolet (UV) fluorescence telescope from suborbital altitude (33 km). After 12 days and 4 h aloft, the flight was terminated prematurely in the Pacific Ocean. Before the flight, the instrument was tested extensively in the West Desert of Utah, USA, with UV point sources and lasers. The test results indicated that the instrument had sensitivity to EASs of ⪆ 3 EeV. Simulations of the telescope system, telescope on time, and realized flight trajectory predicted an observation of about 1 event assuming clear sky conditions. The effects of high clouds were estimated to reduce this value by approximately a factor of 2. A manual search and a machine-learning-based search did not find any EAS signals in these data. Here we review the EUSO-SPB1 instrument and flight and the EAS search

Neutrino Target-of-Opportunity Observations with Space-based and Suborbital Optical Cherenkov Detectors

Cosmic-ray accelerators capable of reaching ultra-high energies are expected to also produce very-high energy neutrinos via hadronic interactions within the source or its surrounding environment. Many of the candidate astrophysical source classes are either transient in nature or exhibit flaring activity. Using the Earth as a neutrino converter, suborbital and space-based optical Cherenkov detectors, such as EUSO-SPB2 and POEMMA, will be able to detect upward-moving extensive air showers induced by decay tau-leptons generated from cosmic tau neutrinos with energies ∼10 PeV and above. Both EUSO-SPB2 and POEMMA will be able to quickly repoint, enabling rapid response to astrophysical transient events. we calculate the transient sensitivity and sky coverage for both EUSO-SPB2 and POEMMA, accounting for constraints imposed by the Sun and the Moon on the observation time. We also calculate both detectors\u27 neutrino horizons for a variety of modeled astrophysical neutrino fluences. We find that both EUSO-SPB2 and POEMMA will achieve transient sensitivities at the level of modeled neutrino fluences for nearby sources. We conclude with a discussion of the prospects of each mission detecting at least one transient event for various modeled astrophysical neutrino sources

Neutrino Target-of-Opportunity Observations with Space-based and Suborbital Optical Cherenkov Detectors

Cosmic-ray accelerators capable of reaching ultra-high energies are expected to also produce very-high energy neutrinos via hadronic interactions within the source or its surrounding environment. Many of the candidate astrophysical source classes are either transient in nature or exhibit flaring activity. Using the Earth as a neutrino converter, suborbital and space-based optical Cherenkov detectors, such as POEMMA and EUSO-SPB2, will be able to detect upward-moving extensive air showers induced by decaying tau-leptons generated from cosmic tau neutrinos with energies ∼10 PeV and above. Both EUSO-SPB2 and POEMMA will be able to quickly repoint, enabling rapid response to astrophysical transient events. We calculate the transient sensitivity and sky coverage for both EUSO-SPB2 and POEMMA, accounting for constraints imposed by the Sun and the Moon on the observation time. We also calculate both detectors\u27 neutrino horizons for a variety of modeled astrophysical neutrino fluences. We find that both EUSO-SPB2 and POEMMA will achieve transient sensitivities at the level of modeled neutrino fluences for nearby sources. We conclude with a discussion of the prospects of each mission detecting at least one transient event for various modeled astrophysical neutrino sources

Simulation studies for the Mini-EUSO detector

Mini-EUSO is a mission of the JEM-EUSO program flying onboard the International Space Station since August 2019. Since the first data acquisition in October 2019, more than 35 sessions have been performed for a total of 52 hours of observations. The detector has been observing Earth at night-time in the UV range and detected a wide variety of transient sources all of which have been modeled through Monte Carlo simulations. Mini-EUSO is also capable of detecting meteors and potentially space debris and we performed simulations for such events to estimate their impact on future missions for cosmic ray science from space. We show here examples of the simulation work done in this framework to analyze the Mini-EUSO data. The expected response of Mini-EUSO with respect to ultra high energy cosmic ray showers has been studied. The efficiency curve of Mini-EUSO as a function of primary energy has been estimated and the energy threshold for Cosmic Rays has been placed to be above 10$^{21}$ eV. We compared the morphology of several transient events detected during the mission with cosmic ray simulations and excluded that they can be due to cosmic ray showers. To validate the energy threshold of the detector, a system of ground based flashers is being used for end-to-end calibration purposes. We therefore implemented a parameterization of such flashers into the JEM-EUSO simulation framework and studied the response of the detector with respect to such sources