Induced pluripotent stem cells as a new approach in therapy for stroke

Stroke is the main cause of disability in Europe and second cause of death. Cell therapy have appeared as new approach in pre-clinical and clinical phases of experimentation. Induced pluripotent stem cells (iPSCs) are stem cells similar to embryonic stem cells but they can be obtained from somatic cells. We administrated iPSCs in an ischemic stroke model by systemic via and in a haemorrhagic stroke model by systemic and intracerebral via. Despite we did not find out any changes in lesion volume, we did observe improvements in functional tests in animals with systemic administration. Also iPSCs-treated animals showed increased neurogenesis in different ways. No tumour formation was detected. Cell tracking study revealed that most of cells travelled to liver and to a lesser extent to spleen and lungs

Diseño de un extensómetro para la medición del esfuerzo en las nanofibras de polímeros para uso biológico

El campo de la medicina se ha vuelto muy complejo ya que cada vez se hacen más necesarias nuevas tecnologías que garanticen la calidad de vida de las personas, el acceso de muchos laboratorios para obtener herramientas óptimas, se hace cada vez más exigente debido a los cambios tecnológicos, esto hace que las prácticas investigativas se desarrollaren eficazmente para bajar los costos de herramientas ya existentes y facilitar el acceso a ellas, de este modo los costos de la medicina bajan y el tratamiento de enfermedades se vuelve más seguro y así los beneficios pueden ser experimentados por muchas personas en el mundo. Teniendo en cuenta lo anterior, se hace referencia a las máquinas para la medición de la elongación de materiales aplicables a tejidos biológicos, ya que se consiguen en el extranjero a un costo elevado. Por esta razón, un desarrollo nacional baja notablemente los costos de adquisición, además de la disminución en los costos de mantenimiento, debido a que el conocimiento es desarrollado por los autores de este trabajo de grado. El desarrollo de este sistema es un valioso aporte al proyecto del instituto de investigación de materiales de la UNAM, sobre el prototipo de la válvula de “trileaflet” Poli (e-caprolactona) (PCL ya que se implementarían técnicas para el mejoramiento de tratamientos médicos

Análisis de valor económico agregado (EVA) Y valor agregado de mercado (MVA) para las empresas del sector petrolero que cotizan en la bolsa de valores de Colombia entre 2008 Y 2011

En este trabajo se realiza un análisis del Valor Económico Agregado EVA y Valor Agregado de Mercado MVA para las empresas del sector petrolero que cotizan en la Bolsa de Valores de Colombia entre los años 2008 y 2011; describiendo los usos y aplicaciones de los indicadores financieros EVA y MVA. Este análisis se realizo a través de la información financiera obtenida del Balance General y Estados de Resultados publicados por las empresas en los periodos de tiempo establecidos para el análisis. El costo de capital se determinó mediante la metodología WACC (Weighted Average Cost of Capital), determinando el costo del patrimonio mediante el método CAPM (Capital Asset Pricing Model), para el cálculo del EVA y la diferencia de la capitalización bursátil y el valor actual en libros para el cálculo del MVA. Estos indicadores fueron empleados y comparados para mostrar la relación y diferencia entre ambos, lo cual permite evaluar el comportamiento del mercado con respecto al de la empresa y de esta forma contribuir en la toma de decisiones de los directivos y/o accionistas.In this work there carries out an analysis of the Economic Value Added EVA and Value Added of Market MVA for the companies of the petroleum sector that quote in the Bolsa de Valores of Colombia between the year 2008 and 2011; describing the uses and applications of the financial indicators EVA and MVA. This analysis I realize across the financial information obtained of the General Balance sheet and States of Results published by the companies in the periods of time established for the analysis. The capital cost decided by means of the methodology WACC (Weighted Average Cost of Capital), determining the cost of the heritage by means of the method CAPM (Capital Asset Pricing Model), for the calculation of EVA and the difference of the stock exchange capitalization and the current value in books for the calculation of the MVA. These indicators were used and compared to show the relation and difference between both, which allows to evaluate the behavior of the market with regard to that of the company and of this form to contribute in the capture of decisions of the executives and / or shareholders

Competencias socioemocionales de los educadores sociales

El contexto educativo y laboral actual ha situado el concepto de competencia como una pieza clave y tema de debate relevante para las distintas profesiones. El objetivo del presente estudio fue describir la valoración que hacen los educadores sociales sobre el grado de dominio de un conjunto de competencias socioemocionales y analizar la relación de esta percepción con otras variables laborales Se analizaron también las diferencias en el dominio de estas competencias en el momento actual con relación a la incorporación al primer trabajo como educador social. La muestra de estudio estuvo formada por 158 profesionales a los que se les aplicó un cuestionario diseñado ad hoc. Se utilizaron técnicas de análisis descriptivo y estadística inferencial no paramétrica. Los resultados mostraron que los profesionales perciben un elevado dominio de las competencias analizadas en su actividad laboral actual. Se encontraron diferencias en las valoraciones de algunas competencias en función de variables como el tipo de recurso o la experiencia laboral. El grado de dominio expresado, en el momento actual, es mayor que el expresado en la incorporación al mercado de trabajo. Se presentan implicaciones de estos resultados para la educación social.El context educatiu i laboral actual ha situat el concepte de competència com una peça clau i tema de debat rellevant per a les diferents professions. L'objectiu del present estudi va ser descriure la valoració que fan els educadors socials sobre el grau de domini d'un conjunt de competències socioemocionals i analitzar la relació d'aquesta percepció amb altres variables laborals. També es van analitzar les diferències en el domini d'aquestes competències en el moment actual amb relació a la incorporació al primer treball com a educador social. La mostra d'estudi va estar formada per 158 professionals als quals es va aplicar un qüestionari dissenyat ad hoc. Es van utilitzar tècniques d'anàlisi descriptiva i estadística inferencial no paramètrica. Els resultats van mostrar que els professionals perceben un domini elevat de les competències analitzades en la seva activitat laboral actual. Es van trobar diferències en les valoracions d'algunes competències en funció de variables com ara el tipus de recurs o l'experiència laboral. El grau de domini expressat, en el moment actual, és més gran que l'expressat en la incorporació al mercat de treball. Es presenten implicacions d‟aquests resultats per al‟educació social.The current educational and work context has placed the concept of competence as a key piece and relevant topic of debate for the different professions. The work performance of social education demands from its professionals an emotional leadership that requires an adequate acquisition and management of the so-called socio-emotional competencies. The objective of this study was to describe the assessment that social educators make of the degree of mastery of a set of socio-emotional competencies and to analyze the relationship of this perception with other labour variables. Differences in the domain of these competencies at the time were also analysed current in relation to the incorporation to the first job as a social educator. The study sample consisted of 158 professionals to whom an ad hoc designed questionnaire was applied. Descriptive analysis techniques and non-parametric inferential statistics were used. The results showed that professionals perceive a high command of the competences analysed in their current work activity. Differences were found in the evaluations of some competences based on variables such as the type of resource or work experience. The degree of mastery expressed, at the present time, is greater than that expressed in joining the labour market. Motivation was the only competence that did not improve this assessment and correlates negatively with the degree of stress. Implications of these results for social education are presented

Generation and characterization of the human iPSC line IDISi001-A isolated from blood cells of a CADASIL patient carrying a NOTCH3 mutation

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary stroke disorder. It is caused by mutations in NOTCH3 that lead to progressive degeneration of the smooth muscle cells in blood vessels. There is currently no treatment for this disorder. We reprogrammed to pluripotency blood mononuclear cells isolated from a patient carrying a NOTCH3 mutation by using a commercially available non-integrating system. The success in the generation of this iPSC line (IDISi001-A) suggests that the NOTCH3 mutation did not limit cell reprogramming and offers an unprecedented opportunity for studying and modeling CADASIL pathology

Re-evaluating the Neolithic: The Impact and the Consolidation of Farming Practices in the Cantabrian Region (Northern Spain)

Abstract:Research projects undertaken in the Cantabrian region since 1980 have produced new, high-quality information about the neolithisation process(es) in this area. It is now necessary to review this archaeological information and test the main hypotheses put forward to explain it. This paper presents an update on the archaeological evidence (sites, chronological dates, archaeozoological, archaeobotanical and technological information) for the early Neolithic in the Cantabrian region. It summarizes recent research on neolithisation in the region, and assesses the impact of this process during the early Neolithic, and its later consolidation. Although the available information is still incomplete, it is now possible to identify the focal point of the introduction of elements characteristic of the Neolithic way of life in the region. Current evidence suggests that it is in the eastern sector, where the earliest arrival of domesticates and new technologies such as pottery has been attested. The existence of continuities?such as sustained reliance on hunting and gathering and the coexistence of old and new funerary rites?suggests the persistence of native populations, which gradually participated in the neolithisation process after an ?availability phase?

Increased Endothelial Progenitor Cell Levels are Associated with Good Outcome in Intracerebral Hemorrhage

Circulating endothelial progenitor cells (EPCs) play a role in the regeneration of damaged brain tissue. However, the relationship between circulating EPC levels and functional recovery in intracerebral hemorrhage (ICH) has not yet been tested. Therefore, our aim was to study the influence of circulating EPCs on the outcome of ICH. Forty-six patients with primary ICH (males, 71.7%; age, 72.7 ± 10.8 years) were prospectively included in the study within 12 hours of symptom onset. The main outcome variable was good functional outcome at 12 months (modified Rankin scale ≤2), considering residual volume at 6 months as a secondary variable. Circulating EPC (CD34+/CD133+/KDR+) levels were measured by flow cytometry from blood samples obtained at admission, 72 hours and day 7. Our results indicate that patients with good outcome show higher EPC numbers at 72 hours and day 7 (all p < 0.001). However, only EPC levels at day 7 were independently associated with good functional outcome at 12 months (OR, 1.15; CI95%, 1.01–1.35) after adjustment by age, baseline stroke severity and ICH volume. Moreover, EPC levels at day 7 were negatively correlated to residual volume (r = −0.525; p = 0.005). In conclusion, these findings suggest that EPCs may play a role in the functional recovery of ICH patients.This study has been partially supported by grants from Instituto de Salud Carlos III (PI14/01879), Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS (RD12/0014), Xunta de Galicia (Consellería Educación GRC2014/027) and the European Union program FEDER. Furthermore, F. Campos (CP14/00154) and T. Sobrino (CP12/03121) are recipients of a research contract from Miguel Servet Program of Instituto de Salud Carlos IIIS

Immune response to SARS-CoV-2 variants after immunization with different vaccines in Mexico

There is limited information on the antibody responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in subjects from developing countries with populations having a high incidence of co-morbidities. Here, we analysed the immunogenicity of homologous schemes using the ChAdOx1-S, Sputnik V, or BNT162b2 vaccines and the effect of a booster dose with ChAdOx1-S in middle-aged adults who were seropositive or seronegative to the SARS-CoV-2 spike protein before vaccination. The study was conducted post-vaccination with a follow-up of 4 months for antibody titre using enzyme-linked immunosorbent assay (ELISA) and pseudovirus (PV) neutralization assays (PNAs). All three vaccines elicited a superior IgG anti-receptor-binding domain (RBD) and neutralization response against the Alpha and Delta variants when administered to individuals with a previous infection by SARS-CoV-2. The booster dose spiked the neutralization activity among individuals with and without a prior SARS-CoV-2 infection. The ChAdOx1-S vaccine induced weaker antibody responses in infection-naive subjects. A follow-up of 4 months post-vaccination showed a drop in antibody titre, with about 20% of the infection-naive and 100% of SARS-CoV-2 pre-exposed participants with detectable neutralization capacity against Alpha pseudovirus (Alpha-PV) and Delta PV (Delta-PV). Our observations support the use of different vaccines in a country with high seroprevalence at the vaccination time

Tendencias en producción científica en el uso del Internet de las Cosas en servicios de restaurantes. Un enfoque bibliométrico

Industry 4.0 and the Internet of Things (IoT) have revolutionized the way processes are managed in organizations, including restaurants. The objective is to identify trends in scientific production in the use of IoT in restaurant services. A literature review was conducted in Scopus (107 records) to build quantity and structure indicators. The results highlight growing research and dissemination, particularly in India, United States, China and Arab Emirates, by different authors and institutions. The research trends are associated with the use, automation and routing of smart mobile devices, IoT-mediated interconnection in smart cities, use of data from the Web, application of neural networks to generate recommendations, waste management and the application of IoT in industrial services. It is concluded that the benefits are reflected in improved decision making and productivity, inventory control, waste reduction, cost savings and improved customer experienceIndustria 4.0 e Internet de las Cosas (IoT) han revolucionado la forma de gestionar procesos en organizaciones, incluidos los restaurantes. El objetivo es identificar tendencias en producción científica en uso del IoT en servicios de restaurantes. Se realiza revisión de literatura en Scopus para construir indicadores de cantidad y estructura. Los resultados resaltan creciente investigación y difusión, particularmente, India, Estados Unidos, China y Emiratos Árabes, por diferentes autores e instituciones. Las tendencias investigativas se asocian con el uso, automatización y enrutamiento de dispositivos móviles inteligentes, interconexión mediada por IoT en ciudades inteligentes, utilización de datos procedentes de la Web, implementación de redes neuronales para generar recomendaciones, gestión de residuos, aprendizaje automático y la aplicación del IoT en servicios industriales. Se concluye que los beneficios se reflejan en mayor toma de decisiones y productividad, control de inventario, reducción de deshechos, ahorro de costos y mejora en experiencia del cliente