4-Bromo­methyl-7-methyl-6,8-dinitro­coumarin

The crystal structure of the title compound, C11H7BrN2O6, establishes the substitution positions of the nitro groups from the nitration reaction of 7-methyl-4-bromo­methyl coumarin. The mean planes of the nitro groups form dihedral angles of 43.9 (8) and 52.7 (10)° with the essentially planar [maximum deviation 0.031 (6) Å] benzopyran ring system

1,3-Bis(hydroxy­meth­yl)benzimidazolin-2-one

The title compound, C9H10N2O3, crystallizes with one and a half mol­ecules in the asymmetric unit, one lying on a general position and the other on a twofold rotation axis. The dihedral angle between the two independent benzimidazole ring systems is 18.96 (5)°. In the crystal, mol­ecules are linked into a three-dimensional network by O—H⋯O hydrogen bonding involving N-hydroxy­methyl and carbonyl groups, and C—H⋯O hydrogen bonds

4-Bromo­methyl-6-meth­oxy-2H-chromen-2-one

The structure of the title coumarin derivative, C11H9BrO3, is stabilized by weak inter­molecular C—H⋯O hydrogen bonds

Synthesis of isomeric naphthofuranyl coumarins as anti-inflammatory and analgesic agents

1007-1013A two-step synthetic scheme has been employed for the synthesis of 4-naphtho [2, 1-b] furan-2-yl-chromen-2-ones/4-(3-alkoxy-naphtho-[2,3-b]furan-2-yl)-chromen-2-ones(angular/linear naphthofuranyl coumarins). The reactions have been monitored by TLC and structures of the intermediates and the target compounds have been ascertained by IR, NMR and mass spectral data. Both the isomeric naphthofuranyl coumarins have been found to exhibit anti-inflammatory activity comparable to asprin but when tested for analgesic activity, angularly fused naphthofuranyl coumarins show better activity comparable to asprin whereas linear naphthofuranyl coumarins are less active

Synthesis of isomeric Naphtho furanyl Coumarins as Anti-inflammatory and Analgesic Agents

A two-step synthetic scheme has been employed for the synthesis of 4-naphtho [2, 1-b] furan-2-yl-chromen-2-ones/4-(3-alkoxy-naphtho-[2,3-b]furan-2-yl)-chromen-2-ones(angular/linear naphthofuranyl coumarins). The reactions have been monitored by TLC and structures of the intermediates and the target compounds have been ascertained by IR, NMR and mass spectral data. Both the isomeric naphthofuranyl coumarins have been found to exhibit anti-inflammatory activity comparable to asprin but when tested for analgesic activity, angularly fused naphthofuranyl coumarins show better activity comparable to asprin whereas linear naphthofuranyl coumarins are less active

4-Bromo­methyl-7,8-dimethyl­coumarin

In the title mol­ecule, C12H11BrO2, all non-H atoms with the exception of the Br atom are essentially coplanar (r.m.s. deviation = 0.018 Å). The C—Br bond is inclined by 80.17 (12)° to this plane. The crystal structure is stabilized by weak C—H⋯O hydrogen bonds

2-Amino-N-(2-methoxy­phen­yl)-4,5-dimethyl­thio­phene-3-carboxamide

In the title compound, C14H16N2O2S, the two aromatic rings make a dihedral angle of 13.9 (1)°. The crystal structure is stabilized by both inter- and intra­molecular N—H⋯O, C—H⋯O and C—H⋯N hydrogen bonds

First Observation of Heavy Baryons \Sigma_b and \Sigma_b^*

We report an observation of new bottom baryons produced in proton-antiproton collisions at the Tevatron. Using 1.1 fb^{-1} of data collected by the CDF II detector, we observe four \Lambda_b^0\pi^{\pm} resonances in the fully reconstructed decay mode \Lambda_b^0 \to \Lambda_c^+ \pi^-, where \Lambda_c^+ \to p K^- \pi^+. We interpret these states as the \Sigma_b^{(*)\pm} baryons and measure the following masses: m_{\Sigma_b^+} = 5807.8^{+2.0}_{-2.2}(stat.) \pm 1.7(syst.) MeV/c^2, m_{\Sigma_b^-} = 5815.2 \pm 1.0(stat.) \pm 1.7(syst.) MeV/c^2, and m(\Sigma_b^*) - m(\Sigma_b) = 21.2^{+2.0}_{-1.9}(stat.) ^{+0.4}_{-0.3}(syst.) MeV/c^2.Comment: 7 Pages, 2 Figures, 2 Tables. Submitted to Phys. Rev. Let

Synthesis and anti-inflammatory activity of 4-(5'-acetyl-6'-hydroxy -3'-methyl-benzofuran-2'-yl) coumarin and 6-acetyl-3, 7-dimethyl-2-(coumarin-4'-yl) furo [3,2-<i style="">g</i>] chromen-5-one

1674-1678Various 4-bromomethylcoumarins 1 have been reacted with diacetyl resorcinol 2 to afford corresponding ethers 3, which undergo intermolecular aldol condensation followed by dehydration to form 4-(5'-acetyl-6'-hydroxy-3'-methylbenzofuran-2'-yl) coumarin 4. Further compound 4 on reaction with sodium acetate and acetic anhydride afford 6-acetyl-3, 7-dimethyl-2-(coumarin 4'-yl) furo [3,2-g] chromen-5-one 5. Their structures have been confirmed by IR, NMR and mass spectral data. Of these compounds, 4e, 4f and 5e show good anti-inflammatory and analgesic activity