Synthesis and anti-inflammatory activity of 4-(5'-acetyl-6'-hydroxy -3'-methyl-benzofuran-2'-yl) coumarin and 6-acetyl-3, 7-dimethyl-2-(coumarin-4'-yl) furo [3,2-<i style="">g</i>] chromen-5-one

Abstract

1674-1678Various 4-bromomethylcoumarins 1 have been reacted with diacetyl resorcinol 2 to afford corresponding ethers 3, which undergo intermolecular aldol condensation followed by dehydration to form 4-(5'-acetyl-6'-hydroxy-3'-methylbenzofuran-2'-yl) coumarin 4. Further compound 4 on reaction with sodium acetate and acetic anhydride afford 6-acetyl-3, 7-dimethyl-2-(coumarin 4'-yl) furo [3,2-g] chromen-5-one 5. Their structures have been confirmed by IR, NMR and mass spectral data. Of these compounds, 4e, 4f and 5e show good anti-inflammatory and analgesic activity