Assessment of adaptability parameters in hulled oat germplasm accessions in terms of their yield in the environments of Kirov Province

Background. Studying the gene pool of a crop under specific soil and climate conditions makes it possible to predict the breeding value of germplasm, while its subsequent inclusion in the breeding process ensures the development of adaptable cultivars capable of implementing their productive potential in large-scale agriculture.Materials and methods. Stability (Si2) and plasticity (bi; PUSS), Ambient Condition Index (Ij), Homeostatic (Hom), Stress Resistance, and Stability Index (Is) were calculated for 12 hulled oat (Avena sativa L.) accessions at the FARC of North-East.Results. Accessions 2981 IG100720 (USA) and k-15293 BORYNA (Poland) showed the best stress resistance, while the highest genetic flexibility was observed in 2981 IG100720 (USA), 3007 IG100848 (Germany), 5330 СSI  590/05,  and k-15178 ‘Begunok’ (Russia). Sources of intensive-type hulled oats: k-15330 CSI 590/05 (Russia) (bi = 1.36)  and  k-15331 CSI 2167/03 (Russia) (bi = 1.60),  were  identified for their higher yield values: 856 and 889 g/m2 under improved growing conditions in 2017, and 365 and 285 g/m2 under dry conditions in 2016, respectively. Medium-intensive accessions k-15178 ‘Begunok’ (Russia) (bi = 1.07), and ‘Skrokolik’ (k-15321, Russia) (bi = 0.97) were identified for the best plasticity. The reference cv. ‘Krechet’ (Si2 = 0.06) demonstrated high yield stability.Conclusion. Sources were selected for hulled oat breeding: 2981 IG100720 (USA), 3007 IG100848 (Germany), and k-15293 BORYNA (Poland), with high stress resistance and plasticity, and plastic sources k-15178 ‘Begunok’ and k-15321 ‘Skrokolik’ (Russia), with stable high yield under varying environmental conditions

Методы термодеструкции в лечении почечно-клеточного рака

Treatment policy for small renal tumors, up to 4 cm (T1a) varies from a follow-up to organ-removing operations. Renal resection is currently the standard of treatment. The basic principle of organ-preserving treatment is a maximally sparing attitude towards to the renal parenchyma. Mini-invasive treatments for locally advanced renal cancer in small neoplastic sizes have recently found clinical application. These include cryodestruction and radio-frequency ablation. The well-known advantages of mini-invasive treatments are preservation of the renal parenchyma, low traumaticity, and short-term hospitalization, as well as a rapid recovery of the patient’s working capacity after intervention. This paper considers the theoretical and practical aspects of use of current thermodestruction methods in the treatment of renal tumors.

Fashion design in a multicultural space

The collective monograph contains the results of the synthesis of theoretical materials, as well as the authors` applied research developments on the design of the clothes of different assortment and purpose, made from different materials considering the modern scientific methods

ОРТОТОПИЧЕСКАЯ ТРАНСПЛАНТАЦИЯ ПЕЧЕНИ: РОЛЬ ИНТЕРВЕНЦИОННОЙ РАДИОЛОГИИ

To study therapeutic modalities of interventional radiology in patients (pts) before and after orthotopic liver trans- plantation (OLT). OLT was performed in 53 pts between 1998 and 2008. Endovascular treatments were performed in 20 pts. Pre-OLT interventional procedures included transcatheter arterial chemoembolization (5 patients) and TIPS (8 patients). Post-OLT procedures were: dilatation or/and stenting of biliary strictures (4), stenting of IVC (2), balloon dilatation of cava-caval anastomosis (1), partial splenic embolization (PSE) in steel syndrome (1). All IR procedures were technically successful. There was no mortality or serious complication. After chemoemboliza- tion, there was partial tumor response in all 5 patients with HCC; two successfully transplanted are alive without recurrence in 11 and 15 months. After TIPS, 3 pts underwent OLT. Satisfactory biliary passage was achieved in all pts with strictures. Clinical symptoms and liver function improved in three pts with venous strictures. After PSE, steal syndrome regressed rapidly. All pts are asymptomatic and well in 5–24 mo after IR treatment. IR procedures prolong long-term patient survival before OLT and may improve outcomes in pts after OLT. В работе обсуждается эффективность интервенционных радиологических процедур у больных перед и после ортотопической трансплантации печени (ОТП). За период 1998–2008 гг. ОТП выполнена 53 паци- ентам. Лечебные эндоваскулярные вмешательства осуществлены у 20 из этих больных. Предоперацион- ные процедуры выполнены у 13 пациентов: масляная химиоэмболизация печеночной артерии (МХЭПА, n = 5), наложение внутрипеченочного портокавального шунта (TIPS, n = 8). У 7 больных произведены 8 послеоперационных вмешательств: дренирование и/или стентирование желчных протоков (n = 4), ре- канализация и стентирование стеноза/окклюзии нижней полой вены (НПВ, n = 2), баллонная дилатация кава-кавального анастомоза (n = 1), эмболизация селезеночной артерии (n = 1). После МХЭПА отмечено уменьшение злокачественной опухоли или замедление ее роста у всех 5 пациентов, ОТП к настоящему времени осуществлена у 3 из них. В результате TIPS снижение портальной гипертензии произошло у всех больных, ОТП выполнена в 3 наблюдениях. Все послеоперационные процедуры были также технически и клинически успешны. Методы интервенционной радиологии позволяют продлить время ожидания до- норской печени у больных, которым требуется ОТП. Рентгеноэндоваскулярные вмешательства позволяют устранить послеоперационные билиарные и сосудистые стриктуры, а также другие осложнения ОТП.

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk

Hypoxic Pulmonary Vasoconstriction in Humans:Tale or Myth

Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it identifies gaps of knowledge and need for further research in humans to clearly define this phenomenon and the underlying mechanism