23 research outputs found

    Pathways to a healthy net-zero future:report of the Lancet Pathfinder Commission

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    Deep, rapid cuts in greenhouse gas emissions are needed to limit future global temperature increases to 1·5°C above pre-industrial levels, but current progress is inadequate to achieve the goals of the Paris Climate Agreement and to reduce future risks from climate change. Many actions to mitigate greenhouse gas emissions can also deliver near-term health co-benefits, for example from reduced air pollution, consumption of healthy diets, and increased physical activity. High-quality evidence on the type and magnitude of co-benefits that can be realised and improved knowledge of how to promote the implementation of such actions can support progress towards net-zero greenhouse gas emissions by 2050. The Lancet Pathfinder Commission was established to collate and assess the evidence on the near-term health effects of greenhouse gas mitigation, including both modelling studies and evaluated implemented actions. The Commission's aim is to assess the potential and achieved magnitude of the benefits for health and climate of different mitigation actions and, where possible, the factors facilitating or impeding implementation

    Pathways to a healthy net-zero future:report of the Lancet Pathfinder Commission

    Get PDF
    Deep, rapid cuts in greenhouse gas emissions are needed to limit future global temperature increases to 1·5°C above pre-industrial levels, but current progress is inadequate to achieve the goals of the Paris Climate Agreement and to reduce future risks from climate change. Many actions to mitigate greenhouse gas emissions can also deliver near-term health co-benefits, for example from reduced air pollution, consumption of healthy diets, and increased physical activity. High-quality evidence on the type and magnitude of co-benefits that can be realised and improved knowledge of how to promote the implementation of such actions can support progress towards net-zero greenhouse gas emissions by 2050. The Lancet Pathfinder Commission was established to collate and assess the evidence on the near-term health effects of greenhouse gas mitigation, including both modelling studies and evaluated implemented actions. The Commission's aim is to assess the potential and achieved magnitude of the benefits for health and climate of different mitigation actions and, where possible, the factors facilitating or impeding implementation

    Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403)

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    The purpose of this study was to evaluate the efficacy of gefitinib and the feasibility of screening for epidermal growth factor receptor (EGFR) mutations among select patients with advanced non-small cell lung cancer (NSCLC). Stage IIIB/IV NSCLC, chemotherapy-naive patients or patients with recurrences after up to two prior chemotherapy regimens were eligible. Direct sequencing using DNA from tumour specimens was performed by a central laboratory to detect EGFR mutations. Patients harbouring EGFR mutations received gefitinib. The primary study objective was response; the secondary objectives were toxicity, overall survival (OS), progression-free survival (PFS), 1-year survival (1Y-S) and the disease control rate (DCR). Between March 2005 and January 2006, 118 patients were recruited from 15 institutions and were screened for EGFR mutations, which were detected in 32 patients – 28 of whom were enrolled in the present study. The overall response rate was 75%, the DCR was 96% and the median PFS was 11.5 months. The median OS has not yet been reached, and the 1Y-S was 79%. Thus, gefitinib chemotherapy in patients with advanced NSCLC harbouring EGFR mutations was highly effective. This trial documents the feasibility of performing a multicentre phase II study using a central typing laboratory, demonstrating the benefit to patients of selecting gefitinib treatment based on their EGFR mutation status

    The 2020 report of The Lancet Countdown on health and climate change: responding to converging crises

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    The Lancet Countdown is an international collaboration, established to provide an independent, global monitoring system dedicated to tracking the emerging health profile of the changing climate. The 2020 report presents 43 indicators across five sections: climate change impacts, exposures, and vulnerability; adaptation, planning, and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement. This report represents the findings and consensus of the 35 leading academic institutions and UN agencies that make up the Lancet Countdown, and draws on the expertise of climate scientists, geographers, and engineers; of energy, food, and transport experts; and of economists, social and political scientists, data scientists, public health professionals, and doctors

    Dengue fever in Saudi Arabia : A review of environmental and population factors impacting emergence and spread

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    Dengue fever (DF) is the most important mosquito-transmitted viral disease causing a large economic and dis- ease burden in many parts of the world. Most DF research focuses on Latin America and Asia, where burdens are highest. There is a critical need for studies in other regions where DF is an important public health problem but less well-characterized and can differ, such as the Middle East. The first documented case of DF in Saudi Arabia occurred in 1993. After a decade of sporadic outbreaks, the disease was declared endemic in 2004 and this designation persists. Climate, sociodemographic factors, and increasing urbanization impact the spread of DF in Saudi Arabia, as in other areas. However, DF transmission in Saudi Arabia is also affected by several unique factors, including large numbers of migrant workers and religious pilgrims from other dengue endemic areas across the Middle East, North Africa, and Asia. Important knowledge gaps relate to the role of climatic factors as drivers of DF in Saudi Arabia and the role of foreign workers and pilgrims in the original and continuous importation of dengue virus. Filling these gaps would improve health system preparedness

    Correction to: Addressing vulnerability, building resilience: community-based adaptation to vector-borne diseases in the context of global change

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    Correction After publication of this article [1] it came to our attention that the name of the author Sadie Ryan was incorrectly shown. Her correct name is Sadie J. Ryan
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