A Low Noise and High Dynamic Charge Sensitive Amplifier-Shaper associated with Silicon Strip Detector for Compton Camera in hadrontherapy

submitted to conference record of IEEE NSS-MIC, Anaheim USA, 29 october-3 november 2012International audienceA 8 channel Front End Electronics (FEE) circuit has been designed and fabricated in 0.35 μm CMOS process from Austria Micro System to be coupled with the Silicon Strip Detector (SSD) of the Compton Camera for quality control of hadrontherapy. Each channel includes a Charge Sensitive Amplifier (CSA) followed by two parallel CR-RC shapers. Slow and fast shapers, with 1 μs and 15 ns shaping time, are used to measure the energy and to time stamp all events respectively. The two sides of the SSD are read thanks to a configurable system for holes and electrons. The CSA presents an open loop gain of 67 dB and 90 degrees phase margin assuring a high stability. The circuit has been successfully tested. The test results are in good agreement with analytic and simulation calculations. Here, we describe the principles and present measured performances of the prototype. A high linearity over the range of 3E3 to 3E6 electrons is reached with a conversion gain of 3.6 mV/fC. The circuit achieves an ENC (Equivalent Noise Charge) of 412 electrons rms. 75% of the total noise is generated by the small value of the feedback resistor chosen to avoid pile up phenomenon due to the 1E5 hits/s occupancy rate. A cross-talk of 2 % was measured, 99% of which is due to the power supply disturbances. The power supply dissipation is 21 mW/channel for 3.3 V supply voltage. The area of this design is 2871×1881 μm2 including pads

Double di ffential fragmentation cross sections measurements of 95 MeV/u 12C on thin targets for hadrontherapy

During therapeutic treatment with heavy ions like carbon, the beam undergoes nuclear fragmentation and secondary light charged particles, in particular protons and alpha particles, are produced. To estimate the dose deposited into the tumors and the surrounding healthy tissues, an accurate prediction on the fluences of these secondary fragments is necessary. Nowadays, a very limited set of double di ffential carbon fragmentation cross sections are being measured in the energy range used in hadrontherapy (40 to 400 MeV/u). Therefore, new measurements are performed to determine the double di ffential cross section of carbon on di erent thin targets. This work describes the experimental results of an experiment performed on May 2011 at GANIL. The double di ffential cross sections and the angular distributions of secondary fragments produced in the 12C fragmentation at 95 MeV/u on thin targets (C, CH2, Al, Al2O3, Ti and PMMA) have been measured. The experimental setup will be precisely described, the systematic error study will be explained and all the experimental data will be presented.Comment: Submitted to PR

Interaction vertex imaging (IVI) for carbon ion therapy monitoring: a feasibility study

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Proton Interaction Vertex Imaging With Silicon-Pixel CMOS Telescope For Carbon Therapy Quality control

International audienceMonitoring of the dose deposition during carbon ion therapy is a crucial issue for the quality control of such treatments. Recent studies have demonstrated that an ion-range control with millimeter resolution is feasible on a pencil-beam basis in homogeneous targets with prompt gamma detection for proton beams [1] and with Proton Interaction Vertex Imaging (PIVI) for carbon beams [2]. The present communication aims at describing our experimental and Monte Carlo simulation results. [1] J. Smeets et al., Phys. Med. Biol. 57 (2012) 3371-3405 [2] P. Henriquet et al., Phys. Med. Biol. 57 (2012) 4655-466

Synthesis and Properties of 1,3,5,7-Tetra-tert-butyl-s-indacene

To check the influence of substituents on the bonding of the 12π-perimeter of s-indacene, a tetraalkyl derivative, the title compound 1, was synthesized. 1, red needles, is weakly paratropic. Crystal structure analysis and NMR investigations indicate a delocalized or a localized π-electron system with only a small energy barrier between the π-bond isomers

Synthese und Eigenschaften von 1,3,5,7-Tetra-tert-butyl-s-indacen

Um den Substituenteneinfluß auf den Bindungszustand des 12π-Perimeters von s-Indacen zu prüfen, wurde ein Tetraalkylderivat, die Titelverbindung 1, synthetisiert. 1, rote Nadeln, ist schwach paratrop. Kristallstrukturanalyse und NMR-Untersuchungen weisen auf ein delokalisiertes oder ein lokalisiertes π-Elektronensystem mit nur kleiner Energiebarriere zwischen den π-Bindungsisomeren hin

Comparison of two analysis methods for nuclear reaction measurements of 12C +12C interactions at 95 MeV/u for hadrontherapy

During therapeutic treatment with heavier ions like carbon, the beam undergoes nuclear fragmentation and secondary light charged particles, in particular protons and alpha particles, are produced. To estimate the dose deposited into the tumors and the surrounding healthy tissues, the accuracy must be higher than ($\pm$3% and$\pm$1 mm). Therefore, measurements are performed to determine the double differential cross section for different reactions. In this paper, the analysis of data from 12C +12C reactions at 95 MeV/u are presented. The emitted particles are detected with \DeltaEthin-\DeltaEthick-E telescopes made of a stack of two silicon detectors and a CsI crystal. Two different methods are used to identify the particles. One is based on graphical cuts onto the \DeltaE-E maps, the second is based on the so-called KaliVeda method using a functional description of \DeltaE versus E. The results of the two methods will be presented in this paper as well as the comparison between both

Instrumentation pour le suivi en ligne des traitements par hadronthérapie

National audienceInstrumentation for on-line monitoring of hadrontherapy treatments Localization of the dose deposited in the patient is a key point for the hadrontherapy cancer treatment. Different modalities of on-line control are explored, motivating acquisition systems and detectors developments, such as a Compton gamma camera, a proton trajectometer and a beam hodoscope

Development of a Compton camera for medical applications based on silicon strip and scintillation detectors

International audienceA Compton camera is being developed for the purpose of ion-range monitoring during hadrontherapy via the detection of prompt-gamma rays. The system consists of a scintillating fiber beam tagging hodoscope, a stack of double sided silicon strip detectors (90 Â 90 Â 2 mm 3 , 2 Â 64 strips) as scatter detectors, as well as bismuth germanate (BGO) scintillation detectors (38 Â 35 Â 30 mm 3 , 100 blocks) as absorbers. The individual components will be described, together with the status of their characterization