66 research outputs found
Kolekcje biblioteczne i muzealne przemieszczone z Niemiec po II wojnie światowej w zbiorach Rosyjskiej Biblioteki Państwowej w świetle publikowanych katalogów Muzeum Książki
In the Book Museum of the State Library of USRR there were found museum and library collections which were taken from Germany after the Second World War in the name of the restitution for destroyed cultural assets. It concerned collections of Museum of Books and Types of Leipzig and the Land Library of Dresden founded by the elector August I in the 16th century. As the war trophies until the period of perestroika they were covered by the greatest secrecy. After the removal of confidentiality, there were started scientific researches in this regard. The publication entitled “Коллекции Российской государственной библиотеки” is the results of those studies. In addition to it, 4 catalogs were elaborated: 1. Каталог художесвеннчх переплетов собрания Карла Бехера; 2. Каталог набивных тканей собрания Роберта Форрерфа; 3. Каталог инкунабулов и палеотипов собрания Генрихха Клемма; 4. Каталог переплетов Якоба Краузе и мастеров его круга (part 1, part 2, and next one in the preparation). Analysing each of these catalogs, the author pays attention to manuscripts, incabulas, paleotypes and old prints. Moreover, he describes the exhibits of textiles imported from Leipzig.W Muzeum Książki Rosyjskiej Biblioteki Państwowej w Moskwie znalazły się kolekcje biblioteczne i muzealne przemieszczone z Niemiec po II wojnie światowej w ramach restytucji za zniszczone dobra kulturalne na okupowanych przez Niemcy terytoriach ZSRR. Obejmują one zbiory Muzeum Książki i Pisma w Lipsku (Deutsches Buch und Schriftmuseum in Leipzig) oraz Biblioteki Krajowej Saksonii w Dreźnie założonej w XVI wieku przez elektora Augusta I. Od czasu zakończenia wojny aż do pierestrojki jako trofea wojenne były one otaczane największą tajemnicą. Po jej uchyleniu rozpoczęto nad nimi badania naukowe. Rezultatem tego jest seria wydawnicza „Коллекции Российской государственной библиотеки”, w ramach której opublikowano dotychczas cztery katalogi: 1. Каталог художесвеннчх переплетов собр ания Карла Бехера; 2. Каталог набивных тканей собрания Роберта Форрерфа; 3. Каталог инкунабулов и палеотипов собрания Генрихха Клемма; 4. Каталог переплетов Якоба Краузе и мастеров его круга (cz. 1, cz. 2, następna jest w opracowaniu). W prowadzonych analizach zawartości każdego z nich badacze poświęcają uwagę manuskryptom, inkunabułom, paleotypom oraz starodrukom. Omawiają też zawartość kolekcji tkanin z Lipska
Activation-induced chromatin reorganization in neurons depends on HDAC1 activity
Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that stimulation of neurons causes condensation of large chromatin domains. This phenomenon can be observed in vitro in cultured rat hippocampal neurons as well as in vivo in the amygdala and hippocampal neurons. Activity-induced chromatin condensation is an active, rapid, energy-dependent, and reversible process. It involves calcium-dependent pathways but is independent of active transcription. It is accompanied by the redistribution of posttranslational histone modifications and rearrangements in the spatial organization of chromosome territories. Moreover, it leads to the reorganization of nuclear speckles and active domains located in their proximity. Finally, we find that the histone deacetylase HDAC1 is the key regulator of this process. Our results suggest that HDAC1-dependent chromatin reorganization constitutes an important level of transcriptional regulation in neurons.publishedVersio
Positronium imaging with the novel multiphoton PET scanner
In vivo assessment of cancer and precise location of altered tissues at
initial stages of molecular disorders are important diagnostic challenges.
Positronium is copiously formed in the free molecular spaces in the patient's
body during positron emission tomography (PET). The positronium properties vary
according to the size of inter- and intramolecular voids and the concentration
of molecules in them such as, e.g., molecular oxygen, O2; therefore,
positronium imaging may provide information about disease progression during
the initial stages of molecular alterations. Current PET systems do not allow
acquisition of positronium images. This study presents a new method that
enables positronium imaging by simultaneous registration of annihilation
photons and deexcitation photons from pharmaceuticals labeled with
radionuclides. The first positronium imaging of a phantom built from cardiac
myxoma and adipose tissue is demonstrated. It is anticipated that positronium
imaging will substantially enhance the specificity of PET diagnostics.Comment: 10 pages, 5 figure
Activation-induced chromatin reorganization in neurons depends on HDAC1 activity
Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that stimulation of neurons causes condensation of large chromatin domains. This phenomenon can be observed in vitro in cultured rat hippocampal neurons as well as in vivo in the amygdala and hippocampal neurons. Activity-induced chromatin condensation is an active, rapid, energy-dependent, and reversible process. It involves calcium-dependent pathways but is independent of active transcription. It is accompanied by the redistribution of posttranslational histone modifications and rearrangements in the spatial organization of chromosome territories. Moreover, it leads to the reorganization of nuclear speckles and active domains located in their proximity. Finally, we find that the histone deacetylase HDAC1 is the key regulator of this process. Our results suggest that HDAC1-dependent chromatin reorganization constitutes an important level of transcriptional regulation in neurons.This work was supported by the National Science Centre grant nos. UMO-2015/18/E/NZ3/00730 (A.M., A.G., H.S.N., E.J. and Y.Y.), 2014/15/N/NZ2/00379 and 2017/24/T/NZ2/00307 (P.T.), 2019/35/O/ST6/02484 (D.P. and G.B.), and 2014/14/M/NZ4/00561 (K.H.O. and R.K.F.). B.W. and B.G. were supported by the Foundation for Polish Science TEAM-TECH Core Facility project “NGS platform for comprehensive diagnostics and personalized therapy in neuro-oncology,” Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund (TEAM to D.P.). A.M.G. was supported by the H2020-MSCA-COFUND-2014 grant Bio4Med (GA no. 665735).Peer reviewe
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
Anna Dymmel: Księgozbiory domowe w Lublinie w pierwszej połowie XIX wieku. Lublin 2013, 533 s., sum.
Anna Dymmel: Księgozbiory domowe w Lublinie w pierwszej połowie XIX wieku. Lublin 2013, 533 s., sum.
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