The choice of the medium sanation in the treatment of acute widespread purulent peritonitis by the method of laparostomy in combination with programmed of the abdominal cavity sanitation

The accumulated clinical experience and analysis of our own results of treatment of patients with severe forms of acute widespread purulent peritonitis, speaks about the growing urgency of this problem. The aim of this study was determination of the most optimal medium sanation during execution programs of the abdominal cavity sanitation in acute diffuse purulent peritonitis.Was studied the treatment results of 79 patients with severe forms of acute widespread purulent peritonitis. After laparotomy and performing a biopsy was conducted qualitative and quantitative morphological study of the inflammatory process in the peritoneum on the background of the landmark of the abdominal cavity sanitation of  two groups of patients with acute widespread purulent peritonitis before and after carrying out the programmatic sanitation of the abdominal cavity, using a solution of octenidine dihydrochloride and saline solution.In the result of study, authors came to the conclusion, that the application, as it seemed different sanation mediums do not affect on the basic morphometric parameters of the studied biopsies of the peritoneum after sanitation of abdominal cavity.This confirms the theory of "mechanical purification" of the abdominal cavity, and sanitation of the abdominal cavity does not depend on the qualitative composition of the sanation medium

Rationale for extent of operation choice in rectal cancer

Colorectal cancer (CRC) remains relevant occupying one of the leading places in morbidity and mortality among oncological diseases. It reaches 13.5% in the structure of tumor diseases tending to increase. The aim of the work to improve the choice of surgical treatment management and reduce the number of intraoperative and postoperative complications in rectal cancer patients

Micelle formation, gelation and phase separation of amphiphilic multiblock copolymers

The phase behaviour of amphiphilic multiblock copolymers with a large number of blocks in semidilute solutions is studied by lattice Monte Carlo simulations. The influence on the resulting structures of the concentration, the solvent quality and the ratio of hydrophobic to hydrophilic monomers in the chains has been assessed explicitely. Several distinct regimes are put in evidence. For poorly substituted (mainly hydrophilic) copolymers formation of micelles is observed, either isolated or connected by the hydrophilic moieties, depending on concentration and chain length. For more highly substituted chains larger tubular hydrophobic structures appear which, at higher concentration, join to form extended hydrophobic cores. For both substitution ratios gelation is observed, but with a very different gel network structure. For the poorly substituted chains the gel consists of micelles cross-linked by hydrophilic blocks whereas for the highly substituted copolymers the extended hydrophobic cores form the gelling network. The interplay between gelation and phase separation clearly appears in the phase diagram. In particular, for poorly substituted copolymers and in a narrow concentration range, we observe a sol-gel transition followed by an inverse gel-sol transition when increasing the interaction energy. The simulation results are discussed in the context of the experimentally observed phase properties of methylcellulose, a hydrophobically substituted polysaccharide.Comment: 14 pages, 14 figures; Soft Matter (2011

Blogging the Virtual: New Geographies of Domination and Resistance In and Beyond Russia

Russia’s accelerating authoritarian turn has not ignored the internet, and in recent years, the Russian state has clamped down on internet activities that diverge from the statist line, employing a variety of strategies to dominate online spaces. Nevertheless, oppositional voices flourish on the Russian internet, taking shape in independent blogs and videos. This paper explores three political bloggers through surveillant and resistance assemblages, making sense of this contestation through an interpretation of the Deleuzian virtual that underscores the emancipatory potential of online activities for producing more egalitarian configurations, but also taking stock of the ways that these technologies have increased domination. Encompassing the blurriness between digital and corporeal spaces, the paper contributes by revealing new geographies of contestation against state strategies to dominate the Russian internet. Overlapping with but not corresponding to Russian territorial boundaries, these dynamics highlight shifting spaces of power and resistance in the increasingly illiberal world

Molecular dynamics simulations reveal that AEDANS is an inert fluorescent probe for the study of membrane proteins

Computer simulations were carried out of a number of AEDANS-labeled single cysteine mutants of a small reference membrane protein, M13 major coat protein, covering 60% of its primary sequence. M13 major coat protein is a single membrane-spanning, α-helical membrane protein with a relatively large water-exposed region in the N-terminus. In 10-ns molecular dynamics simulations, we analyze the behavior of the AEDANS label and the native tryptophan, which were used as acceptor and donor in previous FRET experiments. The results indicate that AEDANS is a relatively inert environmental probe that can move unhindered through the lipid membrane when attached to a membrane protein

The choice of the medium sanation in the treatment of acute widespread purulent peritonitis by the method of laparostomy in combination with programmed of the abdominal cavity sanitation

Накопленный клинический опыт и анализ собственных результатов лечения пациентов с тяжелыми формами острого распространенного гнойного перитонита, говорит о нарастающей актуальности данной проблемы. Целью данного исследования явилось определение наиболее оптимальной санационной среды при выполнении программных санаций брюшной полости при остром разлитом гнойном перитоните. Исследованы результаты лечения 79 пациентов с тяжелыми формами острого распространенного гнойного перитонита. После лапаротомии и выполнения биопсии проведено квалитативное и квантитативное морфологическое исследование воспалительного процесса в брюшине на фоне этапных санаций брюшной полости двух групп пациентов с острым распространенным гнойным перитонитом до и после проведения программных санаций брюшной полости с применением р-ра октенидина дигидрохлорида и физиологического раствора. В результате исследования авторы пришли к выводу, что применение, как бы казалось разных санирующих сред не повлияло на основные морфометрические показатели исследуемых биоптатов брюшины после санации брюшной полости. Это подтверждает теорию «механического очищения» брюшной полости, а санация брюшной полости не зависит от качественного состава санирующей среды.Накопичений клінічний досвід і аналіз власних результатів лікування пацієнтів з важкими формами гострого розповсюдженого гнійного перитоніту, говорить про збушуюся актуальність даної проблеми. Метою даного дослідження було визначення найбільш оптимального санаційного середовища при виконанні програмних санацій черевної порожнини при гострому розлитому гнійному перитоніті. Досліджено результати лікування 79 пацієнтів з важкими формами гострого поширеного гнійного перитоніту. Після лапаротомії та виконання біопсії проведено квалітативну і квантитативне морфологічне дослідження запального процесу в очеревині на тлі етапних санацій черевної порожнини двох груп пацієнтів з гострим розповсюдженим гнійним перитонітом до і після проведення програмних санацій черевної порожнини із застосуванням розчину октенідіна дигідрохлориду і фізіологічного розчину. В результаті дослідження ми прийшли до висновку, що застосування, як би здавалося різних санаційних середовищ не вплинуло на основні морфометричні показники досліджуваних біоптатів очеревини після санації черевної порожнини. Це підтверджує теорію «механічного очищення» черевної порожнини, а санація черевної порожнини не залежить від якісного складу сануючого середовища.The accumulated clinical experience and analysis of our own results of treatment of patients with severe forms of acute widespread purulent peritonitis, speaks about the growing urgency of this problem. The aim of this study was determination of the most optimal medium sanation during execution programs of the abdominal cavity sanitation in acute diffuse purulent peritonitis. Was studied the treatment results of 79 patients with severe forms of acute widespread purulent peritonitis. After laparotomy and performing a biopsy was conducted qualitative and quantitative morphological study of the inflammatory process in the peritoneum on the background of the landmark of the abdominal cavity sanitation of two groups of patients with acute widespread purulent peritonitis before and after carrying out the programmatic sanitation of the abdominal cavity, using a solution of octenidine dihydrochloride and saline solution. In the result of study, authors came to the conclusion, that the application, as it seemed different sanation mediums do not affect on the basic morphometric parameters of the studied biopsies of the peritoneum after sanitation of abdominal cavity. This confirms the theory of "mechanical purification" of the abdominal cavity, and sanitation of the abdominal cavity does not depend on the qualitative composition of the sanation medium

«NOW I HAVE NO CHOICE, BUT TO GO TO BERLIN» [13, P. 35]: UKRAINIAN EMIGRATION TO GERMANY IN THE 1920-1980S.

В статье рассматриваются две волны эмиграции украинцев в Германию в ХХ в. Автор анализирует сущность и цели международного сотрудничества, общественно-политической деятельности и культурной работы украинской диаспоры в Германии в 1920–1980-е гг.The article devoted to two wave of the Ukrainian emigration to Germany and genesis of the Ukrainian diaspora in this country in the XX-th century. The author analyzes its features as well as aims of the international cooperation, both political and cultural activity of the Ukrainian dispora in Germany in 1920-1980s

Electrostatically Cross-Linked Reversible Gels - Effects of pH and Ionic Strength

Mixing of oppositely charged macromolecules can, under certain conditions, lead to the formation of electrostatically cross-linked coacervate gels. In this simulation study, we determine the conditions under which equimolar mixtures of oppositely charged monodisperse four-armed star copolymers with charged end-blocks are able to form such coacervate gels. The cationic charged blocks consist of quenched charges, whereas the anionic blocks contain pH-responsive weak acid groups. We used the Grand-reaction method to determine the phase stability, equilibrium composition, and structural properties of these systems in equilibrium with a supernatant solution at various pH levels and salt concentrations. Depending on the pH and hence on the charge state of the polyanion blocks, we observed the emergence of three regimes: a solution, a sol of isolated star clusters, and a gel-percolating network of stars. Moreover, we demonstrate that the charge state of the stars in the gel phase can be well described by the ideal Henderson-Hasselbalch (HH) equation, despite the presence of strong interactions violating ideality. We can backtrace this surprising result to two deviations from the ideal titration behavior that almost quantitatively cancel each other. This observation explains why various experiments on coacervate gels can be well described by the HH equation, even though the basic assumptions of ideality are clearly violated