Free Form Deformation Techniques Applied to 3D Shape Optimization Problems

The purpose of this work is to analyse and study an efficient parametrization technique for a 3D shape optimization problem. After a brief review of the techniques and approaches already available in literature, we recall the Free Form Deformation parametrization, a technique which proved to be efficient and at the same time versatile, allowing to manage complex shapes even with few parameters. We tested and studied the FFD technique by establishing a path, from the geometry definition, to the method implementation, and finally to the simulation and to the optimization of the shape. In particular, we have studied a bulb and a rudder of a race sailing boat as model applications, where we have tested a complete procedure from Computer-Aided-Design to build the geometrical model to discretization and mesh generation

Free Form Deformation Techniques for 3D Shape Optimization Problems

The purpose of this work is to analyse and study an efficient parametrization technique for a 3D shape optimization problem. After a brief review of the techniques and approaches already available in literature, we choose to use the Free Form Deformation parametrization, a recent technique which proved to be efficient and at the same time versatile, allowing to manage complex shapes even with few parameters. We tested and studied the technique by developing a link among different specialized softwares, in order to establish a path, from the geometry definition, to the method implementation, and finally to the simulation and to the optimization of the problem. In particular, we have studied a bulb and a rudder of a race sailing boat as model problems

Free form deformation techniques applied to 3D shape optimization problems

The purpose of this work is to analyse and study an efficient parametrization technique for a 3D shape optimization problem. After a brief review of the techniques and approaches already available in literature, we recall the Free Form Deformation parametrization, a technique which proved to be efficient and at the same time versatile, allowing to manage complex shapes even with few parameters. We tested and studied the FFD technique by establishing a path, from the geometry definition, to the method implementation, and finally to the simulation and to the optimization of the shape. In particular, we have studied a bulb and a rudder of a race sailing boat as model applications, where we have tested a complete procedure from Computer-Aided-Design to build the geometrical model to discretization and mesh generation

Free-form deformation, mesh morphing and reduced-order methods: enablers for efficient aerodynamic shape optimisation

The work provides an integrated pipeline for the model order reduction of turbulent flows around parametrised geometries in aerodynamics. In particular, Free-Form Deformation is applied for geometry parametrisation, whereas two different reduced-order models based on Proper Orthogonal Decomposition (POD) are employed in order to speed-up the full-order simulations: the first method exploits POD with interpolation, while the second one is based on domain decomposition. For the sampling of the parameter space, we adopt a Greedy strategy coupled with Constrained Centroidal Voronoi Tessellations, in order to guarantee a good compromise between space exploration and exploitation. The proposed framework is tested on an industrially relevant application, i.e. the front-bumper morphing of the DrivAer car model, using the finite-volume method for the full-order resolution of the Reynolds-Averaged Navier-Stokes equations

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 20, Revision 3 (FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30

<p>The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate five flavouring substances in the Flavouring Group Evaluation 304, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the substances were considered to have genotoxic potential. The substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that the three substances [FL-no: 16.117, 16.123 and 16.125] do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. For the remaining two candidate substances [FL-no: 16.118 and 16.124], no appropriate NOAEL was available and additional data are required. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered. Specifications including complete purity criteria and identity for the materials of commerce have been provided for all five candidate substances.</p&gt

Enprostil, in contrast to cimetidine, does not inhibit propranolol metabolism

Enprostil, an orally active prostaglandin E2 analog, is undergoing clinical trials in the treatment of peptic ulcer disease. Because results of animal studies suggested that prostaglandins might affect both hepatic drug metabolizing ability and hepatic blood flow, the effects of enprostil on drug elimination were studied and compared with those of the standard antiulcer drug cimetidine in a double-blind, randomized, crossover study of nine normal subjects. Cimetidine reduced the oral clearance of propranolol by 50%, consistent with the inhibition of drug metabolism reported in previous studies. On the other hand, enprostil had no effect on propranolol elimination. Neither drug altered liver blood flow as assessed either by the clearance of indocyanine green or by the technique of dual route of administration of propranolol. Thus in contrast to cimetidine, enprostil had no effect on hepatic drug metabolism

Influence of debrisoquin phenotype on the inducibility of propranolol metabolism.

The effects of rifampin (600 mg) once daily for 22 days on the total and fractional metabolic clearances of propranolol were determined in a group of six genetically extensive (EM) and six poor metabolizers (PM) of debrisoquin. The impaired ability of PMs to metabolize propranolol to the ring-oxidized metabolite 4-hydroxypropranolol was confirmed. The total oral clearance of propranolol increased about fourfold in both phenotypes from 219.2 +/- 52.8 to 976.7 L/hr in the EMs and from 75.0 +/- 12.6 to 289.8 +/- 78.2 L/hr in the PMs. The extent of induction of glucuronidation was similar in the two groups. 4-Hydroxylation was induced in both phenotypes but the increase was fifteenfold greater in EMs than in PMs. This would imply that the cytochrome P-450 determined by the debrisoquin allele or some coinherited 4-hydroxylase(s) was induced to a greater extent in EMs than PMs