Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

SummaryAgouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA agonist results in the marked escalation of food consumption with temporal variance. Given the orexigenic capability of all three of these neuroactive substances in conjunction with their coexpression in AgRP neurons, we looked to unravel their relative temporal role in driving food intake. After the acute stimulation of AgRP neurons with DREADD technology, we found that either GABA or NPY is required for the rapid stimulation of feeding, and the neuropeptide AgRP, through action on MC4 receptors, is sufficient to induce feeding over a delayed yet prolonged period. These studies help to elucidate the neurochemical mechanisms of AgRP neurons in controlling temporally distinct phases of eating

On the origin of the Tully-Fisher relation

We discuss the origin of the Tully-Fisher (TF) relation using the $N$-body/SPH method, which includes cooling, star formation and stellar feedback of energy, mass and metals. We consider initially rotating overdense spheres, and trace formation processes of disk galaxies from $z=25$ to $z=0$ in the Cold Dark Matter (CDM) cosmology. To clarify the origin of the TF relation, we simulate formation of 14 galaxies with different masses and spin parameters, and compute observable values, such as the total magnitude and the line-width. We find that the simulated galaxies reproduce the slope and scatter of the TF relation: the slope is originated in the difference of total galactic masses, and the scatter is produced by the difference of initial spin parameters. As well as the TF relation, observed features of spiral galaxies, such as the exponential light-profile and the flat rotation curve, are reproduced in our simulations, which were assumed {\it a priori} in past semi-analytical approaches.Comment: 11 pages, including 6 figures, submitted to Ap

The properties of the Malin 1 galaxy giant disk: A panchromatic view from the NGVS and GUViCS surveys

Low surface brightness galaxies (LSBGs) represent a significant percentage of local galaxies but their formation and evolution remain elusive. They may hold crucial information for our understanding of many key issues (i.e., census of baryonic and dark matter, star formation in the low density regime, mass function). The most massive examples - the so called giant LSBGs - can be as massive as the Milky Way, but with this mass being distributed in a much larger disk. Malin 1 is an iconic giant LSBG, perhaps the largest disk galaxy known. We attempt to bring new insights on its structure and evolution on the basis of new images covering a wide range in wavelength. We have computed surface brightness profiles (and average surface brightnesses in 16 regions of interest), in six photometric bands (FUV, NUV, u, g, i, z). We compared these data to various models, testing a variety of assumptions concerning the formation and evolution of Malin 1. We find that the surface brightness and color profiles can be reproduced by a long and quiet star-formation history due to the low surface density; no significant event, such as a collision, is necessary. Such quiet star formation across the giant disk is obtained in a disk model calibrated for the Milky Way, but with an angular momentum approximately 20 times larger. Signs of small variations of the star-formation history are indicated by the diversity of ages found when different regions within the galaxy are intercompared.For the first time, panchromatic images of Malin 1 are used to constrain the stellar populations and the history of this iconic example among giant LSBGs. Based on our model, the extreme disk of Malin 1 is found to have a long history of relatively low star formation (about 2 Msun/yr). Our model allows us to make predictions on its stellar mass and metallicity.Comment: Accepted in Astronomy and Astrophysic

The HST Cosmos Project: Contribution from the Subaru Telescope

The Cosmic Evolution Survey (COSMOS) is a Hubble Space Telescope (HST) treasury project.The COSMOS aims to perform a 2 square degree imaging survey of an equatorial field in $I$(F814W) band, using the Advanced Camera for Surveys (ACS). Such a wide field survey, combined with ground-based photometric and spectroscopic data, is essential to understand the interplay between large scale structure, evolution and formation of galaxies and dark matter. In 2004, we have obtained high-quality, broad band images of the COSMOS field ($B, V, r^\prime, i^\prime,$ and $z^\prime$) using Suprime-Cam on the Subaru Telescope, and we have started our new optical multi-band program, COSMOS-21 in 2005. Here, we present a brief summary of the current status of the COSMOS project together with contributions from the Subaru Telescope. Our future Subaru program, COSMOS-21, is also discussed briefly.Comment: 4 pages, 3 figures, to appear in the Proceedings of the 6th East Asian Meeting on Astronomy, JKAS, 39, in pres

Enhanced stability of layered phases in parallel hard-spherocylinders due to the addition of hard spheres

There is increasing evidence that entropy can induce microphase separation in binary fluid mixtures interacting through hard particle potentials. One such phase consists of alternating two dimensional liquid-like layers of rods and spheres. We study the transition from a uniform miscible state to this ordered state using computer simulations and compare results to experiments and theory. We conclude that (1) there is stable entropy driven microphase separation in mixtures of parallel rods and spheres, (2) adding spheres smaller then the rod length decreases the total volume fraction needed for the formation of a layered phase, therefore small spheres effectively stabilize the layered phase; the opposite is true for large spheres and (3) the degree of this stabilization increases with increasing rod length.Comment: 11 pages, 9 figures. Submitted to Phys. Rev. E. See related website http://www.elsie.brandeis.ed

A Unified Scaling Law in Spiral Galaxies

We investigate the origin of a unified scaling relation in spiral galaxies. Observed spiral galaxies are spread on a plane in the three-dimensionallogarithmic space of luminosity L, radius R and rotation velocity V. The plane is expressed as $L \propto (V R)^{\alpha}$ in I-passband, where $\alpha$ is a constant. On the plane, observed galaxies are distributed in an elongated region which looks like the shape of a surfboard. The well-known scaling relations, L-V (Tully-Fisher relation), V-R (also the Tully-Fisher relation) and R-L (Freeman's law), can be understood as oblique projections of the surfboard-like plane into 2-D spaces. This unified interpretation of the known scaling relations should be a clue to understand the physical origin of all the relations consistently. Furthermore, this interpretation can also explain why previous studies could not find any correlation between TF residuals and radius. In order to clarify the origin of this plane, we simulate formation and evolution of spiral galaxies with the N-body/SPH method, including cooling, star formation and stellar feedback. Initial conditions are set to isolated 14 spheres with two free parameters, such as mass and angular momentum. The CDM (h=0.5, $\Omega_0=1$) cosmology is considered as a test case. The simulations provide the following two conclusions: (a) The slope of the plane is well reproduced but the zero-point is not. This zero-point discrepancy could be solved in a low density ($\Omega_00.5) cosmology. (b) The surfboard-shaped plane can be explained by the control of galactic mass and angular momentum.Comment: Accepted for publication in ApJ Letters. 6 pages including 2 figure

The Large-Scale Atomic and Molecular Gas in the Circinus Galaxy

We have used the ATCA and the SEST to map the large-scale atomic and molecular gas in the nearby Circinus galaxy. The HI mosaic of Circinus exhibits the warps in position angle and inclination revealed in the single-pointing image, both of which appear to settle beyond the inner 30 kpc which was previously imaged. The molecular gas has been mapped in both the CO transitions, where we derive a total molecular gas mass of ~2e9 Mo. Within a radius of 3 kpc, i.e. where CO was clearly detected, the molecular fraction climbs steeply from ~0.7 to unity with proximity to the nucleus. Our HI mosaic gives an atomic gas mass of ~6e9 Mo which is 70% of the fully mapped single dish value. The total neutral gas mass to dynamical mass ratio is therefore 3%, consistent with the SAS3 classification of Circinus. The high (molecular) gas mass fraction found previously, only occurs close to the central ~0.5 kpc and falls to < 10% within and outwith this region, allaying previous concerns regarding the validity of applying the Galactic conversion ratio to Circinus. The rotation curve, as traced by both the HI and CO, exhibits a steep dip at ~1 kpc, the edge of the atomic/molecular ring, within which the star-burst is occurring. We find the atomic and molecular gases to trace different kinematical features and believe that the fastest part of the sub-kpc ring consists overwhelmingly of molecular gas. Beyond the inner kpc, the velocity climbs to settle into a solid body rotation at >10 kpc. Most of the starlight emanates from within this radius and so much of the dynamical mass, which remains climbing to the limit of our data (>50 kpc), must be due to the dark matter halo.Comment: 13 pages, MNRAS in pres

A Resolved Ring of Debris Dust around the Solar Analog HD 107146

We present resolved images of the dust continuum emission from the debris disk around the young (80-200 Myr) solar-type star HD 107146 with CARMA at λ = 1.3 mm and the CSO at λ = 350 μ. Both images show that the dust emission extends over an approximately 10" diameter region. The high-resolution (3") CARMA image further reveals that the dust is distributed in a partial ring with significant decrease in a flux inward of 97 AU. Two prominent emission peaks appear within the ring separated by ~140° in the position angle. The morphology of the dust emission is suggestive of dust captured into a mean motion resonance, which would imply the presence of a planet at an orbital radius of ~45-75 AU

Dynamically Driven Evolution of the Interstellar Medium in M51

We report the highest-fidelity observations of the spiral galaxy M51 in CO emission, revealing the evolution of giant molecular clouds (GMCs) vis-a-vis the large-scale galactic structure and dynamics. The most massive GMCs (so-called GMAs) are first assembled and then broken up as the gas flow through the spiral arms. The GMAs and their H2 molecules are not fully dissociated into atomic gas as predicted in stellar feedback scenarios, but are fragmented into smaller GMCs upon leaving the spiral arms. The remnants of GMAs are detected as the chains of GMCs that emerge from the spiral arms into interarm regions. The kinematic shear within the spiral arms is sufficient to unbind the GMAs against self-gravity. We conclude that the evolution of GMCs is driven by large-scale galactic dynamics --their coagulation into GMAs is due to spiral arm streaming motions upon entering the arms, followed by fragmentation due to shear as they leave the arms on the downstream side. In M51, the majority of the gas remains molecular from arm entry through the inter-arm region and into the next spiral arm passage.Comment: 6 pages, including 3 figures. Accepted, ApJ

Are peculiar velocity surveys competitive as a cosmological probe?

Peculiar velocity surveys, which measure galaxy velocities directly from standard candles in addition to redshifts, can provide strong constraints on the growth rate of structure at low redshift. The improvement originates from the physical relationship between galaxy density and peculiar velocity, which substantially reduces cosmic variance. We use Fisher matrix forecasts to show that peculiar velocity data can improve the growth rate constraints by about a factor of 2 compared to density alone for surveys with galaxy number density of 10(-2) (h(-1) Mpc)(-3), if we can use all the information for wavenumber