Erfolgsfaktoren in der wissenschaftlichen Weiterbildung. Ergebnisse einer Erhebung an bayerischen Hochschulen

Ziel der in der DGWF Engagierten ist es, hochwertige und dauerhaft erfolgreiche Weiterbildungsangebote zu schaffen. Dieser Beitrag präsentiert die Ergebnisse einer quantitativen Umfrage mit Verantwortlichen für wissenschaftliche Weiterbildung an Hochschulen im Freistaat Bayern zum Thema Erfolgsfaktoren. Darin wird die Facheinschätzung jener 34 Expert*innen zu den wichtigsten Elementen in Konzeption, Organisation und Angebotsausführung wiedergegeben, auf dass eine erfolgreiche Etablierung gelingt. Darüber hinaus liefern die Autorinnen einen Überblick zur aktuellen bayerischen Situation der wissenschaftlichen Weiterbildung mit Verortung auf nationaler Ebene und vergleichen die zentralsten Forschungsergebnisse mit thematisch verwandten Studien. Der Beitrag schließt mit Diskussionsanregungen zu aktuellen Entwicklungsperspektiven. (DIPF/Orig.

Special issue introduction: Approaching spatial uncertainty visualization to support reasoning and decision making

While research on uncertainty and decision-making has a long history across several disciplines, recent technological developments compel researchers to rethink how to best address and advance the understanding of how humans reason and make decisions under spatial uncertainty. This introduction presents a visual summary graphic to provide an overview of each article in this special issue. Upon viewing these visual summaries, the reader will find that each of these articles covers different topics in the uncertainty visualization domain, offering complementary research in this field. Extending this body of research and finding new ways to explore how these visualizations may help or hinder the analytical and reasoning process of humans continues to be a necessary step towards designing more effective uncertainty visualizations to support reasoning and decision-making

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Erfolgsfaktoren in der wissenschaftlichen Weiterbildung: Ergebnisse einer Erhebung an bayerischen Hochschulen

Ziel der in der DGWF Engagierten ist es, hochwertige und dauerhaft erfolgreiche Weiterbildungsangebote zu schaffen. Dieser Beitrag präsentiert die Ergebnisse einer quantitativen Umfrage mit Verantwortlichen für wissenschaftliche Weiterbildung an Hochschulen im Freistaat Bayern zum Thema Erfolgsfaktoren. Darin wird die Facheinschätzung jener 34 Expert*innen zu den wichtigsten Elementen in Konzeption, Organisation und Angebotsausführung wiedergegeben, auf dass eine erfolgreiche Etablierung gelingt. Darüber hinaus liefern die Autorinnen einen Überblick zur aktuellen bayerischen Situation der wissenschaftlichen Weiterbildung mit Verortung auf nationaler Ebene und vergleichen die zentralsten Forschungsergebnisse mit thematisch verwandten Studien. Der Beitrag schließt mit Diskussionsanregungen zu aktuellen Entwicklungsperspektiven

Challenges in supporting extraction of knowledge about environmental objects and events from geosensor data

Technologies for capturing large amounts of real-time and high-detail data about the environment have advanced rapidly; our ability to use this data for understanding the monitored settings for decision-making has not. Visual analytics, creating suitable tools and interfaces that combine computational powers with the human’s capabilities for visual sense making, is a promising approach. Geosensor networks monitor a range of different complex environmental settings, collecting heterogeneous data at different spatial and temporal scales. Similarly domain experts with specific preferences and requirements use the collected data. Additionally, long-term monitoring networks may aim to increase sensor node longevity by minimizing storage and communication load. Based on these aspects, four key challenges for the extraction of knowledge about environmental objects and events from geosensor data are identified: dynamics and uncertainty of the continuous stream of recorded data; different scales in data collection but also data analysis at a range of aggregation levels; decentralized data processing and storage; and evaluation of the effectiveness, efficiency and completeness of implemented decentralized visual analytics approaches

'Bordure Protectrice' ou l'art de dilapider ses atouts

"Bordure protectrice" est l'histoire d'un paradoxe majeur : Benyamin Netanyahou ne voulait pas d'un pareil affrontement, même si dès son élection en 2009 il s'était présenté comme l'homme qui "saura vaincre le Hamas"..

Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial

International audienceBackground and Purpose— Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated inversion recovery relative signal intensity [FLAIR-rSI]) magnetic resonance imaging is associated with time elapsed since stroke onset with higher intensities signifying longer time intervals. In the randomized controlled WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke Trial), intravenous alteplase was effective in patients with unknown onset stroke selected by visual assessment of diffusion weighted imaging fluid-attenuated inversion recovery mismatch, that is, in those with no marked fluid-attenuated inversion recovery hyperintensity in the region of the acute diffusion weighted imaging lesion. In this post hoc analysis, we investigated whether quantitatively measured FLAIR-rSI modifies treatment effect of intravenous alteplase. Methods— FLAIR-rSI of stroke lesions was measured relative to signal intensity in a mirrored region in the contralesional hemisphere. The relationship between FLAIR-rSI and treatment effect on functional outcome assessed by the modified Rankin Scale (mRS) after 90 days was analyzed by binary logistic regression using different end points, that is, favorable outcome defined as mRS score of 0 to 1, independent outcome defined as mRS score of 0 to 2, ordinal analysis of mRS scores (shift analysis). All models were adjusted for National Institutes of Health Stroke Scale at symptom onset and stroke lesion volume. Results— FLAIR-rSI was successfully quantified in stroke lesions in 433 patients (86% of 503 patients included in WAKE-UP). Mean FLAIR-rSI was 1.06 (SD, 0.09). Interaction of FLAIR-rSI and treatment effect was not significant for mRS score of 0 to 1 ( P =0.169) and shift analysis ( P =0.086) but reached significance for mRS score of 0 to 2 ( P =0.004). We observed a smooth continuing trend of decreasing treatment effects in relation to clinical end points with increasing FLAIR-rSI. Conclusions— In patients in whom no marked parenchymal fluid-attenuated inversion recovery hyperintensity was detected by visual judgement in the WAKE-UP trial, higher FLAIR-rSI of diffusion weighted imaging lesions was associated with decreased treatment effects of intravenous thrombolysis. This parallels the known association of treatment effect and elapsing time of stroke onset

Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial

Importance: The rationale for intravenous thrombolysis in patients with lacunar infarcts is debated, since it is hypothesized that the microvascular occlusion underlying lacunar infarcts might not be susceptible to pharmacological reperfusion treatment. Objective: To study the efficacy and safety of intravenous thrombolysis among patients with lacunar infarcts. Design, Setting, and Participants: This exploratory secondary post hoc analysis of the WAKE-UP trial included patients who were screened and enrolled between September 2012 and June 2017 (with final follow-up in September 2017). The WAKE-UP trial was a multicenter, double-blind, placebo-controlled randomized clinical trial to study the efficacy and safety of intravenous thrombolysis with alteplase in patients with an acute stroke of unknown onset time, guided by magnetic resonance imaging. All 503 patients randomized in the WAKE-UP trial were reviewed for lacunar infarcts. Diagnosis of lacunar infarcts was based on magnetic resonance imaging and made by consensus of 2 independent investigators blinded to clinical information. Main Outcomes and Measures: The primary efficacy variable was favorable outcome defined by a score of 0 to 1 on the modified Rankin Scale at 90 days after stroke, adjusted for age and severity of symptoms. Results: Of the 503 patients randomized in the WAKE-UP trial, 108 patients (including 74 men [68.5%]) had imaging-defined lacunar infarcts, whereas 395 patients (including 251 men [63.5%]) had nonlacunar infarcts. Patients with lacunar infarcts were younger than patients with nonlacunar infarcts (mean age [SD], 63 [12] years vs 66 [12] years; P = .003). Of patients with lacunar infarcts, 55 (50.9%) were assigned to treatment with alteplase and 53 (49.1%) to receive placebo. Treatment with alteplase was associated with higher odds of favorable outcome, with no heterogeneity of treatment outcome between lacunar and nonlacunar stroke subtypes. In patients with lacunar strokes, a favorable outcome was observed in 31 of 53 patients (59%) in the alteplase group compared with 24 of 52 patients (46%) in the placebo group (adjusted odds ratio [aOR], 1.67 [95% CI, 0.77-3.64]). There was 1 death and 1 symptomatic intracranial hemorrhage according to Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria in the alteplase group, while no death and no symptomatic intracranial hemorrhage occurred in the placebo group. The distribution of the modified Rankin Scale scores 90 days after stroke also showed a nonsignificant shift toward better outcomes in patients with lacunar infarcts treated with alteplase, with an adjusted common odds ratio of 1.94 (95% CI, 0.95-3.93). Conclusions and Relevance: While the WAKE-UP trial was not powered to demonstrate the efficacy of treatment in subgroups of patients, the results indicate that the association of intravenous alteplase with functional outcome does not differ in patients with imaging-defined lacunar infarcts compared with those experiencing other stroke subtypes.status: publishe