157 research outputs found
Infrastructure for the Circular Economy: The Role of Policy in System Change
The concept of a Circular Economy has gained policy traction as a mainstream solution for preserving and
renewing. This work sought to understand which policy instruments have been successful, might still be
necessary, and are most likely in the future to deliver a high penetration Circular Economy for materials, wastes
and associated energy. Waste related policy decisions in England over the past 20 years were reviewed,
exploring the regulatory means that had achieved the current 44% diversion of municipal wastes from landfill.
The hypothesis is that to achieve a far-reaching Circular Economy, at a greater scale, across different sectors
and for a wider product range, suitable physical infrastructure (waste treatment assets) must be available to
circulate those materials in the economy. Furthermore, the study set out to value financially and in terms of
social and economic benefits that could be derived from a circular approach across the whole economy. We
found the financial value to be significant at circa 1.5% of English GDP or â32bn and 72,000-175,000 jobs. It
was demonstrated by calculation that DEFRA analysis (for England) underestimated the capacity gap for
infrastructure by 11.3 million tonnes per annum in 2014.
The policy findings were that the early implementation of blunt instruments such as a landfill tax and separate
collection of recyclables did allow for diversion performance of approximately 45-50% recycling and
composting, the remaining 50% of which was progressively treated by energy from waste rather than landfill.
It is apparent that policies that drive system changes are effective in bringing about ecological transformations
of how societies, economies, and governments operate at all levels. This ecological transformation is
undoubtedly difficult to achieve since it will require consumers, manufacturers, regulators, policymakers,
media, and business all to move differently and together, but nevertheless it is critical at a global scale.Open Acces
The Jacobian algebras
A new class of algebras (the Jacobian algebras) is introduced and studied in detail. The Jacobian algebras are obtained from the Weyl algebras by inverting (not in the sense of Ore) certain elements. Surprisingly, the Jacobian algebras and the Weyl algebras have little in common. Moreover, they have almost opposite properties
Preferences for the selection of unique tRNA primers revealed from analysis of HIV-1 replication in peripheral blood mononuclear cells
BACKGROUND: All human immunodeficiency virus (HIV-1) uses a host tRNA(Lys,3 )as the primer for reverse transcription. The tRNA(Lys,3 )is bound to a region on the HIV-1 genome, the primer-binding site (PBS), that is complementary to the 18 terminal nucleotides of tRNA(Lys,3). How HIV-1 selects the tRNA from the intracellular milieu is unresolved. RESULTS: HIV-1 tRNA primer selection has been investigated using viruses in which the primer-binding site (PBS) and a sequence within U5 were altered so as to be complementary to tRNA(Met), tRNA(Pro )or tRNA(Ile). Analysis of the replication of these viruses in human peripheral blood mononuclear cells (PBMC) revealed preferences for the selection of certain tRNAs. HIV-1 with the PBS altered to be complementary to tRNA(Met), with and without the additional mutation in U5 to be complementary to the anticodon of tRNA(Met), stably maintains the PBS complementary to tRNA(Met )following extended in vitro culture in PBMC. In contrast, viruses with either the PBS or PBS and U5 mutated to be complementary to tRNA(Ile )were unstable during in vitro replication in PBMC and reverted to utilize tRNA(Lys,3). Viruses with the PBS altered to be complementary to tRNA(Pro )replicated in PBMC but reverted to use tRNA(Lys,3); viruses with mutations in both the U5 and PBS complementary to tRNA(Pro )maintained this PBS, yet replicated poorly in PBMC. CONCLUSION: The results of these studies demonstrate that HIV-1 has preferences for selection of certain tRNAs for high-level replication in PBMC
Greater Omentectomy Improves Insulin Sensitivity in Nonobese Dogs
Visceral adiposity is strongly associated with insulin resistance; however, little evidence directly demonstrates that visceral fat per se impairs insulin action. Here, we examine the effects of the surgical removal of the greater omentum and its occupying visceral fat, an omentectomy (OM), on insulin sensitivity (SI) and ÎČ-cell function in nonobese dogs. Thirteen male mongrel dogs were used in this research study; animals were randomly assigned to surgical treatment with either OM (n = 7), or sham-surgery (SHAM) (n = 6). OM failed to generate measurable changes in body weight (+2%; P = 0.1), or subcutaneous adiposity (+3%; P = 0.83) as assessed by magnetic resonance imaging (MRI). The removal of the greater omentum did not significantly reduce total visceral adipose volume (â7.3 ± 6.4%; P = 0.29); although primary analysis showed a trend for OM to increase SI when compared to sham operated animals (P = 0.078), further statistical analysis revealed that this minor reduction in visceral fat alleviated insulin resistance by augmenting SI of the periphery (+67.7 ± 35.2%; P = 0.03), as determined by the euglycemic-hyperinsulinemic clamp. Insulin secretory response during the hyperglycemic step clamp was not directly influenced by omental fat removal (presurgery 6.82 ± 1.4 vs. postsurgery: 6.7 ± 1.2 pmol/l/mg/dl, P = 0.9). These findings provide new evidence for the deleterious role of visceral fat in insulin resistance, and suggest that a greater OM procedure may effectively improve insulin sensitivity
Measurements of the UV background at 4.6 < z < 6.4 using the quasar proximity effect
We present measurements of the ionising ultraviolet background (UVB) at z ~
5-6 using the quasar proximity effect. The fifteen quasars in our sample cover
the range 4.6 < z_q < 6.4, enabling the first proximity effect measurements of
the UVB at z > 5. The metagalactic hydrogen ionisation rate, Gamma_bkg, was
determined by modelling the combined ionisation field from the quasar and the
UVB in the proximity zone on a pixel-by-pixel basis. The optical depths in the
spectra were corrected for the expected effect of the quasar until the mean
flux in the proximity region equalled that in the average Ly-alpha forest, and
from this we make a measurement of Gamma_bkg. A number of systematic effects
were tested using synthetic spectra. Noise in the flux was found to be the
largest source of bias at z ~ 5, while uncertainties in the mean transmitted
Ly-alpha flux are responsible for the largest bias at z ~ 6. The impacts of
large-scale overdensities and Lyman limit systems on Gamma_bkg were also
investigated, but found to be small at z > 5. We find a decline in Gamma_bkg
with redshift, from log(Gamma_bkg) = -12.15 0.16 at z ~ 5 to
log(Gamma_bkg) = -12.84 0.18 at z ~ 6 (1 sigma errors). Compared to UVB
measurements at lower redshifts, our measurements suggest a drop of a factor of
five in the HI photoionisation rate between z ~ 4 and z ~ 6. The decline of
Gamma_bkg appears to be gradual, and we find no evidence for a sudden change in
the UVB at any redshift that would indicate a rapid change in the attenuation
length of ionising photons. Combined with recent measurements of the evolution
of the mean free path of ionising photons, our results imply decline in the
emissivity of ionising photons by roughly a factor of two from z ~ 5 to 6,
albeit with significant uncertainty due to the measurement errors in both
Gamma_bkg and the mean free path.Comment: 22 pages, 19 figures, 5 tables; accepted for publication in MNRA
The Lithium Content of the Galactic Halo Stars
Thanks to the accurate determination of the baryon density of the universe by
the recent cosmic microwave background experiments, updated predictions of the
standard model of Big Bang nucleosynthesis now yield the initial abundance of
the primordial light elements with an unprecedented precision. In the case of
Li, the CMB+SBBN value is significantly higher than the generally reported
abundances for Pop II stars along the so-called Spite plateau. In view of the
crucial importance of this disagreement which has cosmological, galactic and
stellar implications, we decided to tackle the most critical issues of the
problem by revisiting a large sample of literature Li data in halo stars that
we assembled following some strict selection criteria on the quality of the
original analyses. [Abridged]Comment: 34 pages. Accepted for publication in A&A. Includes additional
references and minor correction
Precision Primordial He Measurement with CMB Experiments
Big bang nucleosynthesis (BBN) and the cosmic microwave background (CMB) are
two major pillars of cosmology. Standard BBN accurately predicts the primordial
light element abundances (He, D, He and Li), depending on one
parameter, the baryon density. Light element observations are used as a
baryometers. The CMB anisotropies also contain information about the content of
the universe which allows an important consistency check on the Big Bang model.
In addition CMB observations now have sufficient accuracy to not only determine
the total baryon density, but also resolve its principal constituents, H and
He. We present a global analysis of all recent CMB data, with special
emphasis on the concordance with BBN theory and light element observations. We
find and
(fraction of baryon mass as He) using CMB data alone, in agreement with
He abundance observations. With this concordance established we show that
the inclusion of BBN theory priors significantly reduces the volume of
parameter space. In this case, we find
and . We also find that the inclusion of deuterium
abundance observations reduces the and ranges by a factor
of 2. Further light element observations and CMB anisotropy experiments
will refine this concordance and sharpen BBN and the CMB as tools for precision
cosmology.Comment: 7 pages, 3 color figures made minor changes to bring inline with
journal versio
Nucleosynthesis Constraints on a Massive Gravitino in Neutralino Dark Matter Scenarios
The decays of massive gravitinos into neutralino dark matter particles and
Standard Model secondaries during or after Big-Bang nucleosynthesis (BBN) may
alter the primordial light-element abundances. We present here details of a new
suite of codes for evaluating such effects, including a new treatment based on
PYTHIA of the evolution of showers induced by hadronic decays of massive,
unstable particles such as a gravitino. We also develop an analytical treatment
of non-thermal hadron propagation in the early universe, and use this to derive
analytical estimates for light-element production and in turn on decaying
particle lifetimes and abundances. We then consider specifically the case of an
unstable massive gravitino within the constrained minimal supersymmetric
extension of the Standard Model (CMSSM). We present upper limits on its
possible primordial abundance before decay for different possible gravitino
masses, with CMSSM parameters along strips where the lightest neutralino
provides all the astrophysical cold dark matter density. We do not find any
CMSSM solution to the cosmological Li7 problem for small m_{3/2}. Discounting
this, for m_{1/2} ~ 500 GeV and tan beta = 10 the other light-element
abundances impose an upper limit m_{3/2} n_{3/2}/n_\gamma < 3 \times 10^{-12}
GeV to < 2 \times 10^{-13} GeV for m_{3/2} = 250 GeV to 1 TeV, which is similar
in both the coannihilation and focus-point strips and somewhat weaker for tan
beta = 50, particularly for larger m_{1/2}. The constraints also weaken in
general for larger m_{3/2}, and for m_{3/2} > 3 TeV we find a narrow range of
m_{3/2} n_{3/2}/n_\gamma, at values which increase with m_{3/2}, where the Li7
abundance is marginally compatible with the other light-element abundances.Comment: 74 pages, 40 Figure
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney
L-2-hydroxyglutarate (L-2HG) is an oncometabolite found elevated in renal tumors. However, this molecule might have physiological roles that extend beyond its association with cancer, as L-2HG levels are elevated in response to hypoxia and during Drosophila larval development. L-2HG is known to be metabolized by L-2HG dehydrogenase (L2HGDH), and loss of L2HGDH leads to elevated L-2HG levels. Despite L2HGDH being highly expressed in the kidney, its role in renal metabolism has not been explored. Here, we report our findings utilizing a novel CRISPR/Cas9 murine knockout model, with a specific focus on the role of L2HGDH in the kidney. Histologically, L2hgdh knockout kidneys have no demonstrable histologic abnormalities. However, GC-MS metabolomics demonstrates significantly reduced levels of the TCA cycle intermediate succinate in multiple tissues. Isotope labeling studies with [U-13C] glucose demonstrate that restoration of L2HGDH in renal cancer cells (which lowers L-2HG) leads to enhanced incorporation of label into TCA cycle intermediates. Subsequent biochemical studies demonstrate that L-2HG can inhibit the TCA cycle enzyme α-ketoglutarate dehydrogenase. Bioinformatic analysis of mRNA expression data from renal tumors demonstrates that L2HGDH is co-expressed with genes encoding TCA cycle enzymes as well as the gene encoding the transcription factor PGC-1α, which is known to regulate mitochondrial metabolism. Restoration of PGC-1α in renal tumor cells results in increased L2HGDH expression with a concomitant reduction in L-2HG levels. Collectively, our analyses provide new insight into the physiological role of L2HGDH as well as mechanisms that promote L-2HG accumulation in disease states
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