199 research outputs found

    The ecology of immune state in a wild mammal, Mus musculus domesticus

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    The immune state of wild animals is largely unknown. Knowing this and what affects it is important in understanding how infection and disease affects wild animals. The immune state of wild animals is also important in understanding the biology of their pathogens, which is directly relevant to explaining pathogen spillover among species, including to humans. The paucity of knowledge about wild animals' immune state is in stark contrast to our exquisitely detailed understanding of the immunobiology of laboratory animals. Making an immune response is costly, and many factors (such as age, sex, infection status, and body condition) have individually been shown to constrain or promote immune responses. But, whether or not these factors affect immune responses and immune state in wild animals, their relative importance, and how they interact (or do not) are unknown. Here, we have investigated the immune ecology of wild house mice—the same species as the laboratory mouse—as an example of a wild mammal, characterising their adaptive humoral, adaptive cellular, and innate immune state. Firstly, we show how immune variation is structured among mouse populations, finding that there can be extensive immune discordance among neighbouring populations. Secondly, we identify the principal factors that underlie the immunological differences among mice, showing that body condition promotes and age constrains individuals’ immune state, while factors such as microparasite infection and season are comparatively unimportant. By applying a multifactorial analysis to an immune system-wide analysis, our results bring a new and unified understanding of the immunobiology of a wild mammal

    Particle physics models of inflation

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    Inflation models are compared with observation on the assumption that the curvature perturbation is generated from the vacuum fluctuation of the inflaton field. The focus is on single-field models with canonical kinetic terms, classified as small- medium- and large-field according to the variation of the inflaton field while cosmological scales leave the horizon. Small-field models are constructed according to the usual paradigm for beyond Standard Model physicsComment: Based on a talk given at the 22nd IAP Colloquium, ``Inflation +25'', Paris, June 2006 Curve omitted from final Figur

    Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation

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    The current status of electric dipole moments of diamagnetic atoms which involves the synergy between atomic experiments and three different theoretical areas -- particle, nuclear and atomic is reviewed. Various models of particle physics that predict CP violation, which is necessary for the existence of such electric dipole moments, are presented. These include the standard model of particle physics and various extensions of it. Effective hadron level combined charge conjugation (C) and parity (P) symmetry violating interactions are derived taking into consideration different ways in which a nucleon interacts with other nucleons as well as with electrons. Nuclear structure calculations of the CP-odd nuclear Schiff moment are discussed using the shell model and other theoretical approaches. Results of the calculations of atomic electric dipole moments due to the interaction of the nuclear Schiff moment with the electrons and the P and time-reversal (T) symmetry violating tensor-pseudotensor electron-nucleus are elucidated using different relativistic many-body theories. The principles of the measurement of the electric dipole moments of diamagnetic atoms are outlined. Upper limits for the nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained combining the results of atomic experiments and relativistic many-body theories. The coefficients for the different sources of CP violation have been estimated at the elementary particle level for all the diamagnetic atoms of current experimental interest and their implications for physics beyond the standard model is discussed. Possible improvements of the current results of the measurements as well as quantum chromodynamics, nuclear and atomic calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for EPJ

    Multiwavelength studies of MHD waves in the solar chromosphere: An overview of recent results

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    The chromosphere is a thin layer of the solar atmosphere that bridges the relatively cool photosphere and the intensely heated transition region and corona. Compressible and incompressible waves propagating through the chromosphere can supply significant amounts of energy to the interface region and corona. In recent years an abundance of high-resolution observations from state-of-the-art facilities have provided new and exciting ways of disentangling the characteristics of oscillatory phenomena propagating through the dynamic chromosphere. Coupled with rapid advancements in magnetohydrodynamic wave theory, we are now in an ideal position to thoroughly investigate the role waves play in supplying energy to sustain chromospheric and coronal heating. Here, we review the recent progress made in characterising, categorising and interpreting oscillations manifesting in the solar chromosphere, with an impetus placed on their intrinsic energetics.Comment: 48 pages, 25 figures, accepted into Space Science Review

    Anomalous accelerations in spacecraft flybys of the Earth

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    [EN] The flyby anomaly is a persistent riddle in astrodynamics. Orbital analysis in several flybys of the Earth since the Galileo spacecraft flyby of the Earth in 1990 have shown that the asymptotic post-encounter velocity exhibits a difference with the initial velocity that cannot be attributed to conventional effects. To elucidate its origin, we have developed an orbital program for analyzing the trajectory of the spacecraft in the vicinity of the perigee, including both the Sun and the Moon¿s tidal perturbations and the geopotential zonal, tesseral and sectorial harmonics provided by the EGM96 model. The magnitude and direction of the anomalous acceleration acting upon the spacecraft can be estimated from the orbital determination program by comparing with the trajectories fitted to telemetry data as provided by the mission teams. This acceleration amounts to a fraction of a mm/s2 and decays very fast with altitude. The possibility of some new physics of gravity in the altitude range for spacecraft flybys is discussed.Acedo Rodríguez, L. (2017). Anomalous accelerations in spacecraft flybys of the Earth. Astrophysics and Space Science. 362(12):1-15. doi:10.1007/s10509-017-3205-xS11536212Acedo, L.: Galaxies 3, 113 (2015)Acedo, L.: Mon. Not. R. Astron. Soc. 463(2), 2119 (2016)Acedo, L.: Adv. Space Res. 59(7), 1715 (2017). 1701.06939Acedo, L., Bel, L.: Astron. Nachr. 338(1), 117 (2017). 1602.03669Adler, S.L.: Int. J. Mod. Phys. A 25, 4577 (2010). 0908.2414 . doi: 10.1142/S0217751X10050706Adler, S.L.: In: Proceedings of the Conference in Honour of Murray Gellimann’s 80th Birthday, p. 352 (2011). doi: 10.1142/9789814335614_0032Anderson, J.D., Nieto, M.M.: In: Klioner, S.A., Seidelmann, P.K., Soffel, M.H. (eds.) Relativity in Fundamental Astronomy: Dynamics, Reference Frames, and Data Analysis. IAU Symposium, vol. 261, p. 189 (2010). doi: 10.1017/S1743921309990378Anderson, J.D., Laing, P.A., Lau, E.L., Liu, A.S., Nieto, M.M., Turyshev, S.G.: Phys. Rev. Lett. 81(14), 2858 (1998). gr-qc/0104064 . doi: 10.1103/PhysRevLett.81.2858Anderson, J.D., Laing, P.A., Lau, E.L., Liu, A.S., Nieto, M.M., Turyshev, S.G.: Phys. Rev. D 65(8), 082004 (2002). gr-qc/0104064 . doi: 10.1103/PhysRevD.65.082004Anderson, J.D., Campbell, J.K., Ekelund, J.E., Ellis, J., Jordan, J.F.: Phys. Rev. Lett. 100(9), 091102 (2008). doi: 10.1103/PhysRevLett.100.091102Atchison, J.A., Peck, M.A.: J. Guid. Control Dyn. 33, 1115 (2010). doi: 10.2514/1.47413Bertolami, O., Francisco, F., Gil, P.J.S.: Class. Quantum Gravity 33(12), 125021 (2016). 1507.08457 . doi: 10.1088/0264-9381/33/12/125021Bolton, S.J., Adriani, A., Adumitroaie, V., Allison, M., Anderson, J., Atreya, S., Bloxham, J., Brown, S., Connerney, J.E.P., DeJong, E., Folkner, W., Gautier, D., Grassi, D., Gulkis, S., Guillot, T., Hansen, C., Hubbard, W.B., Iess, L., Ingersoll, A., Janssen, M., Jorgensen, J., Kaspi, Y., Levin, S.M., Li, C., Lunine, J., Miguel, Y., Mura, A., Orton, G., Owen, T., Ravine, M., Smith, E., Steffes, P., Stone, E., Stevenson, D., Thorne, R., Waite, J., Durante, D., Ebert, R.W., Greathouse, T.K., Hue, V., Parisi, M., Szalay, J.R., Wilson, R.: Science 356, 821 (2017). doi: 10.1126/science.aal2108Cahill, R.T.: ArXiv e-prints (2008). 0804.0039Chamberlin, A., Yeomans, D., Giorgini, J., Chodas, P.: Horizons Ephemeris System (2016). http://ssd.jpl.nasa.gov/horizons.cgi . Accessed: 2016-10-27Chao, B.F.: C. R. Géosci. 338, 1123 (2006). doi: 10.1016/j.crte.2006.09.014Coddington, E., Levinson, N.: McGraw-Hill, New York (1955)Debono, I., Smoot, G.F.: Universe 2(4), 23 (2016). doi: 10.3390/universe2040023Desai, S.D.: J. Geophys. Res., Oceans 107(C11), 7 (2002). 3186. doi: 10.1029/2001JC001224Dickey, J.O., Bender, P.L., Faller, J.E., Newhall, X.X., Ricklefs, R.L., Ries, J.G., Shelus, P.J., Veillet, C., Whipple, A.L., Wiant, J.R., Williams, J.G., Yoder, C.F.: Science 265, 482 (1994). doi: 10.1126/science.265.5171.482Dyson, F.W., Eddington, A.S., Davidson, C.: Philos. Trans. R. Soc. Lond., Ser. A 220, 291 (1920). doi: 10.1098/rsta.1920.0009Everitt, C.W.F., et al.: Phys. Rev. Lett. 221101(106) (2011)Feng, J.L., Fornal, B., Galon, I., Gardner, S., Smolinsky, J., Tait, T.M.P., Tanedo, P.: Phys. Rev. Lett. 117, 071803 (2016). 1604.07411 . doi: 10.1103/PhysRevLett.117.071803Folkner, W.M., Williams, J.G., Boggs, D.H., Park, R.S., Kuchynka, P.: IPN Prog. Rep. 42(196) (2014)Fornberg, B.: Math. Comput. 51(184), 699 (1988). doi: 10.1090/S0025-5718-1988-0935077-0Franklin, A., Fischback, E.: The Rise and Fall of the Fifth Force. Discovery, Pursuit, and Justification in Modern Physics, second edition. Springer, New York (2016)Giorgini, J.D.: Personal communication (2015)Hackmann, E., Laemmerzahl, C.: In: 38th COSPAR Scientific Assembly. COSPAR Meeting, vol. 38, p. 3 (2010)Hafele, J.C.: ArXiv e-prints (2009). 0904.0383ICGEM: International Center for Global Gravity Field Models. http://icgem.gfz-potsdam.de/tom_longtimeIERS: In: Petit, G., Luzum, B. (eds.) IERS Conventions (2010), p. 1. Verlag des Bundesamts für Kartographie und Geodäsie, Frankfurt am Main (2010)Iess, L., Asmar, S.: Int. J. Mod. Phys. D 16, 2117 (2007). doi: 10.1142/S0218271807011449Iess, L., Asmar, S., Tortora, P.: Acta Astronaut. 65, 666 (2009). doi: 10.1016/j.actaastro.2009.01.049Iess, L., Di Benedetto, M., James, M., Mercolino, M., Simone, L., Tortora, P.: Acta Astronaut. 94, 699 (2014). doi: 10.1016/j.actaastro.2013.06.011Iorio, L.: Sch. Res. Exch. (2009). 0811.3924 . doi: 10.3814/2009/807695Iorio, L.: Astron. J. 142, 68 (2011a). 1102.4572 . doi: 10.1088/0004-6256/142/3/68Iorio, L.: Mon. Not. R. Astron. Soc. 415, 1266 (2011b). 1102.0212Iorio, L.: Europhys. Lett. (2011c). 1105.4145 . doi: 10.1209/0295-5075/96/30001Iorio, L.: Adv. Space Res. 54(11), 2441 (2014a). 1311.4218 . doi: 10.1016/j.asr.2014.06.035Iorio, L.: Galaxies 2, 259 (2014b). 1404.6537 . doi: 10.3390/galaxies2020259Iorio, L.: Universe 1(1), 38 (2015a). doi: 10.3390/universe1010038Iorio, L.: Int. J. Mod. Phys. D 24, 1530015 (2015b). 1412.7673Iorio, L., Giudice, G.: New Astron. 11, 600 (2006). gr-qc/0601055Iorio, L., Lichtenegger, H.I.M., Ruggiero, M.L., Corda, C.: Astrophys. Space Sci. 331, 351 (2011). 1009.3225 . doi: 10.1007/s10509-010-0489-5Jouannic, B., Noomen, R., van den IJSel, J.A.A.: In: Proceedings of the 25th International Symposium on Space Flight Dynamics ISSFD, Munich, Germany (2015)Kennefick, D.: Phys. Today 62, 37 (2009). doi: 10.1063/1.3099578King-Hele, D.: Satellite Orbits in an Atmosphere. Theory and Applications. Blackie and Son Ltd., Glasgow (1987)Lämmerzahl, C., Preuss, O., Dittus, H.: In: Dittus, H., Lammerzahl, C., Turyshev, S.G. (eds.) Lasers, Clocks and Drag-Free Control: Exploration of Relativistic Gravity in Space. Astrophysics and Space Science Library, vol. 349, p. 75 (2008). doi: 10.1007/978-3-540-34377-6_3Le Verrier, U.: C. R. Hebd. Acad. Sci. 49, 379 (1859)Lemoine, F.G.E.A.: NASA/TP-1998-206861 (1998)Lewis, R.A.: In: Robertson, G.A. (ed.) American Institute of Physics Conference Series. American Institute of Physics Conference Series, vol. 1103, p. 226 (2009). doi: 10.1063/1.3115499Longair, M.: Philos. Trans. R. Soc., Math. Phys. Eng. Sci. (2015). doi: 10.1098/rsta.2014.0287McCulloch, M.E.: Mon. Not. R. Astron. Soc. 389, 57 (2008). 0806.4159 . doi: 10.1111/j.1745-3933.2008.00523.xMoe, M.M., Wallace, S.D., Moe, K.: In: Washington DC American Geophysical Union Geophysical Monograph Series, vol. 87, p. 349 (1995). doi: 10.1029/GM087p0349Murphy, E.M.: Phys. Rev. Lett. 83, 1890 (1998). doi: 10.1103/PhysRevLett.83.1890Naval Observatory: Dept. of the Navy, USA (2009)Newcomb, S.: Tables of the Four Inner Planets. Government Printing Office, Washington (1895)Nyambuya, G.G.: ArXiv e-prints (2008). 0803.1370Nyambuya, G.G.: New Astron. 57, 22 (2017). doi: 10.1016/j.newast.2017.06.001Páramos, J., Hechenblaikner, G.: Adv. Space Res. 79–80(7), 76 (2013). 1210.7333v1Peskin, M.E., Schroeder, D.V.: An Introduction to Quantum Field Theory. Westview Press, Perseus Books Group, London (1995)Pinheiro, M.J.: Phys. Lett. A 378, 3007 (2014). 1404.1101Pinheiro, M.J.: Mon. Not. R. Astron. Soc. 461(4), 3948 (2016)Renzetti, G.: Cent. Eur. J. Phys. 11, 531 (2013). doi: 10.2478/s11534-013-0189-1Rievers, B., Lämmerzahl, C.: Ann. Phys. 523, 439 (2011). 1104.3985 . doi: 10.1002/andp.201100081Roseveare, N.T.: Mercury’s Perihelion, from Le Verrier to Einstein. Clarendon Press, Wotton-under-Edge (1982)Rubincam, D.P.: Icarus 148, 2 (2000). doi: 10.1006/icar.2000.6485Standish, E.M.: In: Macias, A., Lämmerzahl, C., Camacho, A. (eds.) Recent Developments in Gravitation and Cosmology. American Institute of Physics Conference Series, vol. 977, p. 254 (2008). doi: 10.1063/1.2902789Standish, E.M.: In: Klioner, S.A., Seidelmann, P.K., Soffel, M.H. (eds.) Relativity in Fundamental Astronomy: Dynamics, Reference Frames, and Data Analysis. IAU Symposium, vol. 261, p. 179 (2010). doi: 10.1017/S1743921309990354Thompson, P.F., Abrahamson, M., Ardalan, S., Bordi, J.: In: 24th AAS/AIAA Space Flight Mechanics Meeting, Santa Fe, New Mexico, January 26–30, 2014 (2014). http://hdl.handle.net/2014/45519Turyshev, S.G., Toth, V.T.: Living Rev. Relativ. (2010). 1001.3686 . doi: 10.12942/lrr-2010-4Turyshev, S.G., Toth, V.T., Kinsella, G., Lee, S.-C., Lok, S.M., Ellis, J.: Phys. Rev. Lett. 108(24), 241101 (2012). 1204.2507 . doi: 10.1103/PhysRevLett.108.241101Varieschi, G.U.: Gen. Relativ. Gravit. 46, 1741 (2014). 1401.6503 . doi: 10.1007/s10714-014-1741-zWilhelm, K., Dwivedi, B.N.: Astrophys. Space Sci. 358, 18 (2015). doi: 10.1007/s10509-015-2413-5Will, C.M.: Living Rev. Relativ. 3(9) (2006)Will, C.M.: Class. Quantum Gravity (2015). doi: 10.1098/rsta.2014.0287Will, C.M.: In: Peron, R., Colpi, M., Gorini, V., Moschella, U. (eds.) Gravity: Where Do We Stand? Astrophysics and Space Science Library, vol. 349, p. 9 (2016). doi: 10.1007/978-3-319-20224-2_2Williams, J.G., Boggs, D.H.: Celest. Mech. Dyn. Astron. 126, 89 (2016). doi: 10.1007/s10569-016-9702-3Williams, J.G., Dickey, J.O.: In: Noomen, R., Klosko, S., Noll, C., Pearlman, M. (eds.) Proceedings of 13th International Workshop on Laser Ranging, p. 75 (2003). http://cddisa.gsfc.nasa.gov/lw13/lw_proceedings.htmlWilliams, J.G., Newhall, X.X., Dickey, J.O.: Phys. Rev. D 53, 6730 (1996). doi: 10.1103/PhysRevD.53.6730Williams, J.G., Turyshev, S.G., Boggs, D.H.: Phys. Rev. Lett. 93(26), 261101 (2004). gr-qc/0411113 . doi: 10.1103/PhysRevLett.93.261101Williams, J.G., Turyshev, S.G., Boggs, D.H.: Planet. Sci. 3, 2 (2014). doi: 10.1186/s13535-014-0002-5Williams, J.G., Boggs, D.H., Yoder, C.F., Ratcliff, J.T., Dickey, J.O.: J. Geophys. Res. 106, 27933 (2001). doi: 10.1029/2000JE001396Wolfram, S.: The Mathematica Book, fifth edition. Wolfram Media, Champaign (2003

    Differences in microbial metabolites in urine headspace of subjects with Immune Thrombocytopenia (ITP) detected by volatile organic compound (VOC) analysis and metabolomics

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    ITP is an organ-specific autoimmune disorder characterised by a low platelet count whose cause is uncertain. A possible factor is food intolerance, although much of the information linking this with ITP is anecdotal. The role of food intolerance in ITP was studied by replacing a normal diet with an elemental diet (E028), but this did not increase platelet counts. Clear differences, however, were apparent between the volatile organic compounds (VOCs) in the urine headspace of patients with ITP and those present in healthy volunteers, which leads to speculation that abnormal metabolic activity of the intestinal microbiome may be a factor causing ITP. However, further work is needed to confirm this. There were also differences between the VOCs of patients on a normal diet and those on the elemental diet, and in this case, the VOCs involved are very likely to be of bacterial origin, as their production is affected by dietary manipulation. Many of these VOCs are known to be toxic

    The sensorium at work: the sensory phenomenology of the working body

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    The sociology of the body and the sociology of work and occupations have both neglected to some extent the study of the ‘working body’ in paid employment, particularly with regard to empirical research into the sensory aspects of working practices. This gap is perhaps surprising given how strongly the sensory dimension features in much of working life. This article is very much a first step in calling for a more phenomenological, embodied and ‘fleshy’ perspective on the body in employment, and examines some of the theoretical and conceptual resources available to researchers wishing to focus on the lived working-body experiences of the sensorium. We also consider some possible representational forms for a more evocative, phenomenologically-inspired portrayal of sensory, lived-working-body experiences, and offer suggestions for future avenues of research
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