Large NN Universality of 4d N=1\mathcal{N}=1 Superconformal Index and AdS Black Holes

We study the large $N$ limit of the matrix models associated with the superconformal indices of four-dimensional $\mathcal{N}=1$ superconformal field theories. We find that for a large class of $\mathcal{N}=1$ superconformal gauge theories, the superconformal indices in the large $N$ limit of such theories are dominated by the 'parallelogram' saddle, providing $O(N^2)$ free energy for the generic value of chemical potentials. This saddle corresponds to BPS black holes in AdS$_5$ whenever a holographic dual description is available. Our saddle applies to a large class of gauge theories, including ADE quiver gauge theories, and the theories with rank-2 tensor matters. Our analysis works for most $\mathcal{N}=1$ superconformal gauge theories that admit a suitable large $N$ limit while keeping the flavor symmetry fixed. We also find 'multi-cut' saddle points, which correspond to the orbifolded Euclidean black holes in AdS$_5$.Comment: 34 pages, 2 figure

Structural Damping by the Use of Fibrous Materials

Because of the increasing concern with vehicle weight, there is an interest in lightweight materials that can serve several functions at once. Here we consider the vibration damping performance provided by an “acoustical” material (i.e., a fibrous layer that would normally be used for airborne noise control). It has been previously established that the vibration of panel structures creates a non-propagating nearfield in the region close to the panel. In that region, there is an oscillatory, incompressible fluid flow parallel to the panel whose strength decays exponentially with distance from the panel. When a fibrous medium is placed close to the panel in the region where the oscillatory nearfield is significant, energy is dissipated by the viscous interaction of the flow and the fibers, and hence the panel vibration is damped. The degree of panel damping is then proportional to the energy removed from the nearfield by the viscous interaction with the fibrous medium. In his paper, experiments are described that demonstrate this effect. Fibrous layers were placed next to a lightly damped panel driven by a shaker, and the vibration of the panel was quantified by using a scanning laser vibrometer. These experiments showed that it is possible to achieve a strong damping effect by using fibrous layers. In addition a new theory that can be used to predict the depth of treatment needed to achieve a damping effect is presented. The theory is based on analyzing the wave number transforms of the panel motion in terms of radiating and non-radiating components, and by using that approach to identify the spatial extent of the oscillatory nearfield, and hence the depth of the fibrous layer required to provide effective structural damping

Defending Against Flush+Reload Attack With DRAM Cache by Bypassing Shared SRAM Cache

Cache side-channel attack is one of the critical security threats to modern computing systems. As a representative cache side-channel attack, Flush+Reload attack allows an attacker to steal confidential information (e.g., private encryption key) by monitoring a victim's cache access patterns while generating the confidential values. Meanwhile, for providing high performance with memory-intensive applications that do not fit in the on-chip SRAM-based last-level cache (e.g., L3 cache), modern computing systems start to deploy DRAM cache between the SRAM-based last-level cache and the main memory DRAM, which can provide low latency and/or high bandwidth. However, in this work, we propose an approach that exploits the DRAM cache for security rather than performance, called ByCA. ByCA bypasses the L3 shared cache when accessing cache blocks suspected as target blocks of an attacker. Consequently, ByCA eliminates the timing difference when the attacker accesses the target cache blocks, nullifying the Flush+Reload attacks. To this end, ByCA keeps cache blocks suspected as target blocks of the attacker and stores their states (i.e., flushed by clflush or not) in the L4 DRAM cache even with clflush instruction; ByCA re-defines and re-implements clflush instruction not to flush cache blocks from the L4 DRAM cache while flushing the blocks from other level caches (i.e., L1, L2, and L3 caches). In addition, ByCA bypasses L3 cache when the attacker or the victim accesses the target blocks flushed by clflush, making the attacker always obtain the blocks from L4 DRAM cache regardless of the victim's access patterns. Consequently, ByCA eliminates the timing difference, thus the attacker cannot monitor the victim's cache access patterns. For L4 DRAM cache, we implement Alloy Cache design and use an unused bit in a tag entry for each block to store its state. ByCA only requires a single bit extension to cache blocks in L1 and L2 private caches, and a tag entry for each block in the L4 DRAM cache. Our experimental results show that ByCA completely eliminates the timing differences when the attacker reloads the target blocks. Furthermore, ByCA does not show the performance degradation for the victim while co-running with the attacker that flushes and reloads target blocks temporally and repetitively.1

A Case of Ciliary Body Melanocytoma Presenting as a Painful Iris Mass

We report a case of ciliary body melanocytoma in a Korean patient, which presented as an intermittently painful pigmented iris mass and was successfully managed by iridocyclectomy. A 52-year-old healthy man presented with an irregularly-shaped and heavily-pigmented mass at the iris root of his right eye. Visual acuity of the right eye was 20/20 with normal intraocular pressure. Ultrasound biomicroscopy showed a 1.5x1.3-mm ciliary-body mass with extension into the iris root. Iridocyclectomy with scleral resection under a lamellar scleral flap was performed, and the histopathologic features of the resected tissue were consistent with melanocytoma of the ciliary body. The patient's visual acuity remained 20/20 with good postoperative cosmesis. During one year of follow-up, no signs of tumor recurrence were seen, and the patient reported resolution of the intermittent ocular pain in the involved eye

Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels

<p>Abstract</p> <p>Background</p> <p>N-type Ca²⁺channels (Ca_v2.2) play an important role in the transmission of pain signals to the central nervous system. ω-Conotoxin (CTx)-MVIIA, also called ziconotide (Prialt^®), effectively alleviates pain, without causing addiction, by blocking the pores of these channels. Unfortunately, CTx-MVIIA has a narrow therapeutic window and produces serious side effects due to the poor reversibility of its binding to the channel. It would thus be desirable to identify new analgesic blockers with binding characteristics that lead to fewer adverse side effects.</p> <p>Results</p> <p>Here we identify a new CTx, FVIA, from the Korean <it>Conus Fulmen </it>and describe its effects on pain responses and blood pressure. The inhibitory effect of CTx-FVIA on N-type Ca²⁺channel currents was dose-dependent and similar to that of CTx-MVIIA. However, the two conopeptides exhibited markedly different degrees of reversibility after block. CTx-FVIA effectively and dose-dependently reduced nociceptive behavior in the formalin test and in neuropathic pain models, and reduced mechanical and thermal allodynia in the tail nerve injury rat model. CTx-FVIA (10 ng) also showed significant analgesic effects on writhing in mouse neurotransmitter- and cytokine-induced pain models, though it had no effect on acute thermal pain and interferon-γ induced pain. Interestingly, although both CTx-FVIA and CTx-MVIIA depressed arterial blood pressure immediately after administration, pressure recovered faster and to a greater degree after CTx-FVIA administration.</p> <p>Conclusions</p> <p>The analgesic potency of CTx-FVIA and its greater reversibility could represent advantages over CTx-MVIIA for the treatment of refractory pain and contribute to the design of an analgesic with high potency and low side effects.</p

A Novel BEST1 Mutation in Autosomal Recessive Bestrophinopathy

Citation: Lee CS, Jun I, Choi S, et al. A novel BEST1 mutation in autosomal recessive bestrophinopathy. Invest Ophthalmol Vis Sci. 2015;56:8141-8150. DOI:10.1167/iovs.15-18168 PURPOSE. To describe the clinical characteristics associated with a newly identified mutant of autosomal recessive bestrophinopathy (ARB) and confirm the associated physiological functional defects. METHODS. Two patients with ARB from one family underwent a full ophthalmic examination, including dilated fundus examination, fundus photography, fluorescein angiography, fundus autofluorescence imaging, spectral-domain optical coherence tomography (OCT), electroretinography (ERG), and electrooculography (EOG). Subsequently, genetic analysis for bestrophin-1 (BEST1) mutations was conducted through direct Sanger sequencing. The effect of ARB-associated mutations of BEST1 on the cellular localization was determined by in vitro experiments. Whole-cell patch clamping was conducted to measure the chloride conductance of wild-type BEST1 and the identified BEST1 mutants in transfected HEK293T cells. RESULTS. Two related patients (66-year-old brother and 52-year-old sister) presented with reduced visual acuity and bilateral symmetrical subretinal deposits of hyperautofluorescent materials in the posterior pole. Spectral-domain OCT showed macular thinning with submacular fluid. The female patient had a concomitant macular edema associated with branched retinal vein occlusion in the left eye, which responded well to intravitreal bevacizumab injections. Genetic analysis demonstrated that both patients were compound heterozygous for one novel (Leu40Pro) and one previously identified (Ala195Val) BEST1 variant. HEK293T cells transfected with the identified BEST1 mutant showed significantly small currents compared to those transfected with the wild-type gene, whereas cells cotransfected with mutant and wild-type BEST1 showed good chloride conductance. Cellular localization of BEST1 was well conserved to the plasma membrane in the mutants. CONCLUSIONS. We have identified and described the phenotype and in vitro functional aspects of a new BEST1 mutation causing ARB. Clinically suspected ARB cases warrant genetic confirmation to confirm the diagnosis

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe