A review of the methodologies used in compiling owner-occupiers’ housing indices. ESRI Working Paper 651 January 2020

This paper examines the manner in which owner-occupiers housing costs are incorporated in the official inflation index. In particular, the focus is on the net acquisitions and the payments approach, which are currently used by the Central Statistics Office (CSO). The paper provides a detailed overview of the two approaches, along with some suggestion for further refinement

Complex Investigations of Double Layer of Colloid Particles. Electric Conductivity of Suspensions and Anisotropy of Electrophoresis

Conditions for obtaining quantitative .ililformation on the double layer of colloid particles on the basis of electrosurface measurements have been analyzed. A rigorous theory of electric conductivdty of diluted suspensions on the basis of induced dilpole moments of particles has been presented. The .isoconductance point of a suspension has been shown to codncide wd.th the isopolarisation state of a particle. A theory of anisotropy of the electrophoresis of long rod-like particles has been put forward. The identity of the formules of electrophoresis of a sphere and of cylindrical particles oriented pevpendicular towards the field at a small thickness of the double layer has been shown. A good agreement has been found between the values of induced dipole moments and, specific surface conductivity in a wide electrolite concentration range measured by the methods of electric conductivity of suspensions and anisotropy of electrophoresis. The theories of induced dipole moment, electric conductivity of suspension and anisotropy of electrophoresis have been experimentally examined

Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial

Purpose: To improve stratification of risk-adapted treatment for non-metastatic (M0), standard-risk medulloblastoma patients by prospective evaluation of biomarkers of reported biological or prognostic significance, alongside clinico-pathological variables, within the multi-center HIT-SIOP-PNET4 trial. Methods: Formalin-fixed paraffin-embedded tumor tissues were collected from 338 M0 patients (>4.0 years at diagnosis) for pathology review and assessment of the WNT subgroup (MBWNT) and genomic copy-number defects (chromosome 17, MYC/MYCN, 9q22 (PTCH1) and DNA ploidy). Clinical characteristics were reviewed centrally. Results: The favorable prognosis of MBWNT was confirmed, however better outcomes were observed for non-MBWNT tumors in this clinical risk-defined cohort compared to previous disease-wide clinical trials. Chromosome 17p/q defects were heterogeneous when assessed at the cellular copy-number level, and predicted poor prognosis when they occurred against a diploid (ch17(im)/diploid(cen)), but not polyploid, genetic background. These factors, together with post-surgical tumor residuum (R+) and radiotherapy delay, were supported as independent prognostic markers in multivariate testing. Notably, MYC and MYCN amplification were not associated with adverse outcome. In cross-validated survival models derived for the clinical standard-risk (M0/R0) disease group, (ch17(im)/diploid(cen); 14% of patients) predicted high disease-risk, while the outcomes of patients without (ch17(im)/diploid(cen)) did not differ significantly from MBWNT, allowing re-classification of 86% as favorable-risk. Conclusion: Biomarkers, established previously in disease-wide studies, behave differently in clinically-defined standard-risk disease. Distinct biomarkers are required to assess disease-risk in this group, and define improved risk-stratification models. Routine testing for specific patterns of chromosome 17 imbalance at the cellular level, and MBWNT, provides a strong basis for incorporation into future trials

Additional file 4: Figure S2. of Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort

Twins have more similar microbiota to one another than an unrelated infant at 1, 4, 8, and 24 weeks of age. Using t tests with Monte-Carlo permutations, the Spearman distance between twins’ microbiota was determined and compared to unrelated infants’ microbiota (***p < 0.001). (PDF 138 kb