108 research outputs found
The stability of the O(N) invariant fixed point in three dimensions
We study the stability of the O(N) fixed point in three dimensions under
perturbations of the cubic type. We address this problem in the three cases
by using finite size scaling techniques and high precision Monte
Carlo simulations. It is well know that there is a critical value
below which the O(N) fixed point is stable and above which the cubic fixed
point becomes the stable one. While we cannot exclude that , as recently
claimed by Kleinert and collaborators, our analysis strongly suggests that
coincides with 3.Comment: latex file of 18 pages plus three ps figure
A longitudinal study of the faecal microbiome and metabolome of periparturient mares
Periparturient mares are at increased risk of colic including large colon volvulus, which has a high mortality rate. Alterations in colonic microbiota related to either physiological or management changes, or both, that occur at this time have been suggested as potential causes for increased colic risk in this population of horses. Although the effect of management changes on the horse faecal microbiota has been investigated, limited work has been conducted to investigate changes in faecal microbiota structure and function in the periparturient period. The objectives of the current study were to investigate temporal stability of the faecal microbiota and volatile organic compounds (VOCs) of the faecal metabolome in periparturient mares
The stability of a cubic fixed point in three dimensions from the renormalization group
The global structure of the renormalization-group flows of a model with
isotropic and cubic interactions is studied using the massive field theory
directly in three dimensions. The four-loop expansions of the \bt-functions
are calculated for arbitrary . The critical dimensionality and the stability matrix eigenvalues estimates obtained on the basis of
the generalized Pad-Borel-Leroy resummation technique are shown
to be in a good agreement with those found recently by exploiting the five-loop
\ve-expansions.Comment: 18 pages, LaTeX, 5 PostScript figure
Critical thermodynamics of three-dimensional MN-component field model with cubic anisotropy from higher-loop \epsilon expansion
The critical thermodynamics of an -component field model with cubic
anisotropy relevant to the phase transitions in certain crystals with
complicated ordering is studied within the four-loop \ve expansion using the
minimal subtraction scheme. Investigation of the global structure of RG flows
for the physically significant cases M=2, N=2 and M=2, N=3 shows that the model
has an anisotropic stable fixed point with new critical exponents. The critical
dimensionality of the order parameter is proved to be equal to
, that is exactly half its counterpart in the real hypercubic
model.Comment: 9 pages, LaTeX, no figures. Published versio
Stability of a cubic fixed point in three dimensions. Critical exponents for generic N
The detailed analysis of the global structure of the renormalization-group
(RG) flow diagram for a model with isotropic and cubic interactions is carried
out in the framework of the massive field theory directly in three dimensions
(3D) within an assumption of isotropic exchange. Perturbative expansions for RG
functions are calculated for arbitrary up to the four-loop order and
resummed by means of the generalized Pad-Borel-Leroy technique.
Coordinates and stability matrix eigenvalues for the cubic fixed point are
found under the optimal value of the transformation parameter. Critical
dimensionality of the model is proved to be equal to that
agrees well with the estimate obtained on the basis of the five-loop
\ve-expansion [H. Kleinert and V. Schulte-Frohlinde, Phys. Lett. B342, 284
(1995)] resummed by the above method. As a consequence, the cubic fixed point
should be stable in 3D for , and the critical exponents controlling
phase transitions in three-dimensional magnets should belong to the cubic
universality class. The critical behavior of the random Ising model being the
nontrivial particular case of the cubic model when N=0 is also investigated.
For all physical quantities of interest the most accurate numerical estimates
with their error bounds are obtained. The results achieved in the work are
discussed along with the predictions given by other theoretical approaches and
experimental data.Comment: 33 pages, LaTeX, 7 PostScript figures. Final version corrected and
added with an Appendix on the six-loop stud
The N-component Ginzburg-Landau Hamiltonian with cubic anisotropy: a six-loop study
We consider the Ginzburg-Landau Hamiltonian with a cubic-symmetric quartic
interaction and compute the renormalization-group functions to six-loop order
in d=3. We analyze the stability of the fixed points using a Borel
transformation and a conformal mapping that takes into account the
singularities of the Borel transform. We find that the cubic fixed point is
stable for N>N_c, N_c = 2.89(4). Therefore, the critical properties of cubic
ferromagnets are not described by the Heisenberg isotropic Hamiltonian, but
instead by the cubic model at the cubic fixed point. For N=3, the critical
exponents at the cubic and symmetric fixed points differ very little (less than
the precision of our results, which is in the case of
and ). Moreover, the irrelevant interaction bringing from the symmetric to
the cubic fixed point gives rise to slowly-decaying scaling corrections with
exponent . For N=2, the isotropic fixed point is stable and
the cubic interaction induces scaling corrections with exponent . These conclusions are confirmed by a similar analysis of the
five-loop -expansion. A constrained analysis which takes into account
that in two dimensions gives .Comment: 29 pages, RevTex, new refs added, Phys. Rev. B in pres
Critical behavior of weakly-disordered anisotropic systems in two dimensions
The critical behavior of two-dimensional (2D) anisotropic systems with weak
quenched disorder described by the so-called generalized Ashkin-Teller model
(GATM) is studied. In the critical region this model is shown to be described
by a multifermion field theory similar to the Gross-Neveu model with a few
independent quartic coupling constants. Renormalization group calculations are
used to obtain the temperature dependence near the critical point of some
thermodynamic quantities and the large distance behavior of the two-spin
correlation function. The equation of state at criticality is also obtained in
this framework. We find that random models described by the GATM belong to the
same universality class as that of the two-dimensional Ising model. The
critical exponent of the correlation length for the 3- and 4-state
random-bond Potts models is also calculated in a 3-loop approximation. We show
that this exponent is given by an apparently convergent series in
(with the central charge of the Potts model) and
that the numerical values of are very close to that of the 2D Ising
model. This work therefore supports the conjecture (valid only approximately
for the 3- and 4-state Potts models) of a superuniversality for the 2D
disordered models with discrete symmetries.Comment: REVTeX, 24 pages, to appear in Phys.Rev.
The Pathogenic Potential of Campylobacter concisus Strains Associated with Chronic Intestinal Diseases
Campylobacter concisus has garnered increasing attention due to its association with intestinal disease, thus, the pathogenic potential of strains isolated from different intestinal diseases was investigated. A method to isolate C. concisus was developed and the ability of eight strains from chronic and acute intestinal diseases to adhere to and invade intestinal epithelial cells was determined. Features associated with bacterial invasion were investigated using comparative genomic analyses and the effect of C. concisus on host protein expression was examined using proteomics. Our isolation method from intestinal biopsies resulted in the isolation of three C. concisus strains from children with Crohn's disease or chronic gastroenteritis. Four C. concisus strains from patients with chronic intestinal diseases can attach to and invade host cells using mechanisms such as chemoattraction to mucin, aggregation, flagellum-mediated attachment, “membrane ruffling”, cell penetration and damage. C. concisus strains isolated from patients with chronic intestinal diseases have significantly higher invasive potential than those from acute intestinal diseases. Investigation of the cause of this increased pathogenic potential revealed a plasmid to be responsible. 78 and 47 proteins were upregulated and downregulated in cells infected with C. concisus, respectively. Functional analysis of these proteins showed that C. concisus infection regulated processes related to interleukin-12 production, proteasome activation and NF-κB activation. Infection with all eight C. concisus strains resulted in host cells producing high levels of interleukin-12, however, only strains capable of invading host cells resulted in interferon-γ production as confirmed by ELISA. These findings considerably support the emergence of C. concisus as an intestinal pathogen, but more significantly, provide novel insights into the host immune response and an explanation for the heterogeneity observed in the outcome of C. concisus infection. Moreover, response to infection with invasive strains has substantial similarities to that observed in the inflamed mucosa of Crohn's disease patients
Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.
Congenital heart defects (CHDs) have a neonatal incidence of 0.8-1% (refs. 1,2). Despite abundant examples of monogenic CHD in humans and mice, CHD has a low absolute sibling recurrence risk (∼2.7%), suggesting a considerable role for de novo mutations (DNMs) and/or incomplete penetrance. De novo protein-truncating variants (PTVs) have been shown to be enriched among the 10% of 'syndromic' patients with extra-cardiac manifestations. We exome sequenced 1,891 probands, including both syndromic CHD (S-CHD, n = 610) and nonsyndromic CHD (NS-CHD, n = 1,281). In S-CHD, we confirmed a significant enrichment of de novo PTVs but not inherited PTVs in known CHD-associated genes, consistent with recent findings. Conversely, in NS-CHD we observed significant enrichment of PTVs inherited from unaffected parents in CHD-associated genes. We identified three genome-wide significant S-CHD disorders caused by DNMs in CHD4, CDK13 and PRKD1. Our study finds evidence for distinct genetic architectures underlying the low sibling recurrence risk in S-CHD and NS-CHD
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial
Background
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.
Methods
FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762.
Findings
Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839–1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26–6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38–2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months.
Interpretation
Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function.
Funding
UK Stroke Association and NIHR Health Technology Assessment Programme
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