249 research outputs found
Apoptotic microparticles generated during acute HIV-1 infection inhibit human dendritic cells via CD44
ISO LWS Spectroscopy of M82: A Unified Evolutionary Model
We present the first complete far-infrared spectrum (43 to 197 um) of M82,
the brightest infrared galaxy in the sky, taken with the Long Wavelength
Spectrometer of the Infrared Space Observatory (ISO). We detected seven fine
structure emission lines, [OI] 63 and 145 um, [OIII] 52 and 88 um, [NII] 122
um, [NIII] 57 um and [CII] 158 um, and fit their ratios to a combination
starburst and photo-dissociation region (PDR) model. The best fit is obtained
with HII regions with n = 250 cm^{-3} and an ionization parameter of 10^{-3.5}
and PDRs with n = 10^{3.3} cm^{-3} and a far-ultraviolet flux of G_o =
10^{2.8}. We applied both continuous and instantaneous starburst models, with
our best fit being a 3-5 Myr old instantaneous burst model with a 100 M_o
cut-off. We also detected the ground state rotational line of OH in absorption
at 119.4 um. No excited level OH transitions are apparent, indicating that the
OH is almost entirely in its ground state with a column density ~ 4x10^{14}
cm^{-2}. The spectral energy distribution over the LWS wavelength range is well
fit with a 48 K dust temperature and an optical depth, tau_{Dust} proportional
to lambda^{-1}.Comment: 23 pages, 4 figures, accepted by ApJ, Feb. 1, 199
Far-IR/Submillimeter Spectroscopic Cosmological Surveys: Predictions of Infrared Line Luminosity Functions for z<4 Galaxies
Star formation and accretion onto supermassive black holes in the nuclei of
galaxies are the two most energetic processes in the Universe, producing the
bulk of the observed emission throughout its history. We simulated the
luminosity functions of star-forming and active galaxies for spectral lines
that are thought to be good spectroscopic tracers of either phenomenon, as a
function of redshift. We focused on the infrared (IR) and sub-millimeter
domains, where the effects of dust obscuration are minimal. Using three
different and independent theoretical models for galaxy formation and
evolution, constrained by multi-wavelength luminosity functions, we computed
the number of star-forming and active galaxies per IR luminosity and redshift
bin. We converted the continuum luminosity counts into spectral line counts
using relationships that we calibrated on mid- and far-IR spectroscopic surveys
of galaxies in the local universe. Our results demonstrate that future
facilities optimized for survey-mode observations, i.e., the Space Infrared
Telescope for Cosmology and Astrophysics (SPICA) and the Cerro Chajnantor
Atacama Telescope (CCAT), will be able to observe thousands of z>1 galaxies in
key fine-structure lines, e.g., [SiII], [OI], [OIII], [CII], in a
half-square-degree survey, with one hour integration time per field of view.
Fainter lines such as [OIV], [NeV] and H_2 (0-0)S1 will be observed in several
tens of bright galaxies at 1<z<2, while diagnostic diagrams of active-nucleus
vs star-formation activity will be feasible even for normal z~1 galaxies. We
discuss the new parameter space that these future telescopes will cover and
that strongly motivate their construction.Comment: Accepted for publication in The Astrophysical Journal on 20/10/2011,
17 pages, 13 figure
Remarkable Disk and Off-nuclear Starburst Activity in the "Tadpole Galaxy" as revealed by the Spitzer Space Telescope
We present ground-based optical and Spitzer infrared imaging observations of
the interacting galaxy UGC 10214, the "Tadpole Galaxy" (z = 0.0310), focusing
on the star formation activity in the nuclear, disk, spiral arms and tidal tail
regions. The major findings of this study are that the Tadpole is actively
forming stars in the main disk outside of the nucleus and in the tidal plume,
with an estimated mean star formation rate of ~2 to 4 M_sun/yr. The most
prominent sites of mid-infrared emission define a "ring" morphology that,
combined with the overall morphology of the system, suggest the interaction may
belong to the rare class of off-center collisional ring systems that form both
shock-induced rings of star formation and tidal plumes. The nuclear emission is
solely powered by older stars, with little evidence for ongoing star formation
at the center of the Tadpole. Extra-nuclear star formation accounts for >50% of
the total star formation in the disk and spiral arms, featuring infrared-bright
'hot spots' that exhibit strong PAH emission, whose band strength is comparable
to that of late-type star-forming disk galaxies. The tidal tail, which extends
2 arcmin (~75 kpc) into the intergalactic medium, is populated by super massive
star clusters likely triggered by the galaxy-galaxy interaction that has
distorted UGC 10214 into its current "tadpole" shape.Comment: to appear in the January 2006 (vol 131) issue of the Astronomical
Journal; high quality graphics are located here:
http://spider.ipac.caltech.edu/staff/jarrett/tadpole.htm
Near-Infrared Molecular Hydrogen Emission from the Central Regions of Galaxies: Regulated Physical Conditions in the Interstellar Medium
The central regions of many interacting and early-type spiral galaxies are
actively forming stars. This process affects the physical and chemical
properties of the local interstellar medium as well as the evolution of the
galaxies. We observed near-infrared H2 emission lines: v=1-0 S(1), 3-2 S(3),
1-0 S(0), and 2-1 S(1) from the central ~1 kpc regions of the archetypical
starburst galaxies, M82 and NGC 253, and the less dramatic but still vigorously
star-forming galaxies, NGC 6946 and IC 342. Like the far-infrared continuum
luminosity, the near-infrared H2 emission luminosity can directly trace the
amount of star formation activity because the H2 emission lines arise from the
interaction between hot and young stars and nearby neutral clouds. The observed
H2 line ratios show that both thermal and non-thermal excitation are
responsible for the emission lines, but that the great majority of the
near-infrared H2 line emission in these galaxies arises from energy states
excited by ultraviolet fluorescence. The derived physical conditions, e.g.,
far-ultraviolet radiation field and gas density, from [C II] and [O I] lines
and far-infrared continuum observations when used as inputs to
photodissociation models, also explain the luminosity of the observed H2 v=1-0
S(1) line. The ratio of the H2 v=1-0 S(1) line to far-IR continuum luminosity
is remarkably constant over a broad range of galaxy luminosities; L_H2/L_FIR =
about 10^{-5}, in normal late-type galaxies (including the Galactic center), in
nearby starburst galaxies, and in luminous IR galaxies (LIRGs: L_FIR > 10^{11}
L_sun). Examining this constant ratio in the context of photodissociation
region models, we conclude that it implies that the strength of the incident UV
field on typical molecular clouds follows the gas density at the cloud surface.Comment: Accepted for ApJ, 24 pages, 17 figures, for complete PDF file, see
http://kao.re.kr/~soojong/mypaper/2004_pak_egh2.pd
Art psychotherapy practice with adults who suffer from depression in the UK: Qualitative findings from a depression-specific questionnaire
Gas cooling within the diffuse ISM of late-type galaxies
We combine observations of spiral galaxies in the [CII] line at 158 micron,
made with the Long Wavelength Spectrometer aboard ISO, with previous data from
the Kuiper Airborne Observatory to study the origin of this line, which is the
main coolant of the interstellar medium at relatively low temperatures. We also
use HI and CO(1-0) observations of these galaxies and estimate the respective
line fluxes in the same beam as the [CII] observations. We confirm the
existence of a linear relation between the [CII] line intensity and the CO(1-0)
line intensity, that we extend to intrinsically fainter galaxies. The
dispersion around this relation is significant and due to variations in the
far-UV flux, thus in the star formation rate. We find that for the least active
galaxies of our sample, in terms of star formation, the rate of [CII] line
emission per interstellar hydrogen atom is similar to that in the Solar
neighbourhood. For those galaxies, most of the [CII] line emission comes
probably from the diffuse cold atomic medium. In more active galaxies,
considered globally, the average [CII] line emission is dominated by dense
photodissociation regions and to some extent by the warm ionized diffuse
medium. This is true in the central region of many spiral galaxies, and
probably even in the interarm regions of the most actively star-forming ones.Comment: 8 pages, 6 Postscript figures, 2 Postscript tables, accepted to A&
Macroevolution of the plant–hummingbird pollination system
ABSTRACTPlant–hummingbird interactions are considered a classic example of coevolution, a process in which mutually dependent species influence each other's evolution. Plants depend on hummingbirds for pollination, whereas hummingbirds rely on nectar for food. As a step towards understanding coevolution, this review focuses on the macroevolutionary consequences of plant–hummingbird interactions, a relatively underexplored area in the current literature. We synthesize prior studies, illustrating the origins and dynamics of hummingbird pollination across different angiosperm clades previously pollinated by insects (mostly bees), bats, and passerine birds. In some cases, the crown age of hummingbirds pre‐dates the plants they pollinate. In other cases, plant groups transitioned to hummingbird pollination early in the establishment of this bird group in the Americas, with the build‐up of both diversities coinciding temporally, and hence suggesting co‐diversification. Determining what triggers shifts to and away from hummingbird pollination remains a major open challenge. The impact of hummingbirds on plant diversification is complex, with many tropical plant lineages experiencing increased diversification after acquiring flowers that attract hummingbirds, and others experiencing no change or even a decrease in diversification rates. This mixed evidence suggests that other extrinsic or intrinsic factors, such as local climate and isolation, are important covariables driving the diversification of plants adapted to hummingbird pollination. To guide future studies, we discuss the mechanisms and contexts under which hummingbirds, as a clade and as individual species (e.g. traits, foraging behaviour, degree of specialization), could influence plant evolution. We conclude by commenting on how macroevolutionary signals of the mutualism could relate to coevolution, highlighting the unbalanced focus on the plant side of the interaction, and advocating for the use of species‐level interaction data in macroevolutionary studies
Beating the blues after Cancer: randomised controlled trial of a tele-based psychological intervention for high distress patients and carers
Background: The diagnosis and treatment of cancer is a major life stress such that approximately 35% of patients experience persistent clinically significant distress and carers often experience even higher distress than patients. This paper presents the design of a two arm randomised controlled trial with patients and carers who have elevated psychological distress comparing minimal contact self management vs. an individualised tele-based cognitive behavioural intervention. Methods/design: 140 patients and 140 carers per condition (560 participants in total) will been recruited after being identified as high distress through caller screening at two community-based cancer helplines and randomised to 1) a single 30-minute telephone support and education session with a nurse counsellor with self management materials 2) a tele-based psychologist delivered five session individualised cognitive behavioural intervention. Session components will include stress reduction, problem-solving, cognitive challenging and enhancing relationship support and will be delivered weekly. Participants will be assessed at baseline and 3, 6 and 12 months after recruitment. Outcome measures include: anxiety and depression, cancer specific distress, unmet psychological supportive care needs, positive adjustment, overall Quality of life. Discussion: The study will provide recommendations about the efficacy and potential economic value of minimal contact self management vs. tele-based psychologist delivered cognitive behavioural intervention to facilitate better psychosocial adjustment and mental health for people with cancer and their carers
A Practical Guide to Rodent Islet Isolation and Assessment
Pancreatic islets of Langerhans secrete hormones that are vital to the regulation of blood glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional islets from the pancreas for study is an intricate process. This review highlights the key elements involved with mouse and rat islet isolation, including choices of collagenase, the collagenase digestion process, purification of islets using a density gradient, and islet culture conditions. In addition, this paper reviews commonly used techniques for assessing islet viability and function, including visual assessment, fluorescent markers of cell death, glucose-stimulated insulin secretion, and intracellular calcium measurements. A detailed protocol is also included that describes a common method for rodent islet isolation that our laboratory uses to obtain viable and functional mouse islets for in vitro study of islet function, beta-cell physiology, and in vivo rodent islet transplantation. The purpose of this review is to serve as a resource and foundation for successfully procuring and purifying high-quality islets for research purposes
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