331 research outputs found
Comparative study of CH+ and SH+ absorption lines observed towards distant star-forming regions
Aims. The HIFI instrument onboard Herschel has allowed high spectral
resolution and sensitive observations of ground-state transi- tions of three
molecular ions: the methylidyne cation CH+, its isotopologue 13CH+, and
sulfanylium SH+. Because of their unique chemical properties, a comparative
analysis of these cations provides essential clues to the link between the
chemistry and dynamics of the diffuse interstellar medium. Methods. The CH+,
13CH+, and SH+ lines are observed in absorption towards the distant high-mass
star-forming regions (SFRs) DR21(OH), G34.3+0.1, W31C, W33A, W49N, and W51, and
towards two sources close to the Galactic centre, SgrB2(N) and SgrA*+50. All
sight lines sample the diffuse interstellar matter along pathlengths of several
kiloparsecs across the Galactic Plane. In order to compare the velocity
structure of each species, the observed line profiles were deconvolved from the
hyperfine structure of the SH+ transition and the CH+, 13CH+, and SH+ spectra
were independently decomposed into Gaussian velocity components. To analyse the
chemical composition of the foreground gas, all spectra were divided, in a
second step, into velocity intervals over which the CH+, 13CH+, and SH+ column
densities and abundances were derived. Results. SH+ is detected along all
observed lines of sight, with a velocity structure close to that of CH+ and
13CH+. The linewidth distributions of the CH+, SH+, and 13CH+ Gaussian
components are found to be similar. These distributions have the same mean
( ~ 4.2 km s-1) and standard deviation
(\sigma(\delta\u{psion}) ~ 1.5 km s-1). This mean value is also close to that
of the linewidth distribution of the CH+ visible transitions detected in the
solar neighbourhood. We show that the lack of absorption components narrower
than 2 km s-1 is not an artefact caused by noise: the CH+, 13CH+, and SH+ line
profiles are therefore statistically broader than those of most species
detected in absorption in diffuse interstellar gas (e. g. HCO+, CH, or CN). The
SH+/CH+ column density ratio observed in the components located away from the
Galactic centre spans two orders of magnitude and correlates with the CH+
abundance. Conversely, the ratio observed in the components close to the
Galactic centre varies over less than one order of magnitude with no apparent
correlation with the CH+ abundance. The observed dynamical and chemical
properties of SH+ and CH+ are proposed to trace the ubiquitous process of
turbulent dissipation, in shocks or shears, in the diffuse ISM and the specific
environment of the Galactic centre regions
The UKIRT Hemisphere Survey: Definition and Full J-band Data Release
This paper defines the UK Infra-red Telescope (UKIRT) Hemisphere Survey (UHS) and release of the complete J-band dataset. The UHS provides continuous coverage in the northern hemisphere from a declination of 0 deg to 60 deg by combining the existing Large Area Survey, Galactic Plane Survey and Galactic Clusters Survey conducted under the UKIRT Infra-red Deep Sky Survey (UKIDSS) programme with a new additional ~12,700 sq.deg area not covered by UKIDSS. This data release includes J-band imaging and source catalogues over the new area, which, together with UKIDSS, completes the J-band UHS coverage over the full ~17,900 sq.deg area. 98 per cent of the data in this release have passed quality control criteria, the remaining 2 per cent being scheduled for re-observation. The median 5-sigma point source sensitivity of the released data is 19.6 mag (Vega). The median full width at half-maximum of the point spread function across the dataset is 0.75 arcsec. In this paper, we outline the survey management, data acquisition, processing and calibration, quality control and archiving as well as summarising the characteristics of the released data products. The data are initially available to a limited consortium with a world-wide release scheduled for August 2018
A population of gamma-ray emitting globular clusters seen with the Fermi Large Area Telescope
Globular clusters with their large populations of millisecond pulsars (MSPs)
are believed to be potential emitters of high-energy gamma-ray emission. Our
goal is to constrain the millisecond pulsar populations in globular clusters
from analysis of gamma-ray observations. We use 546 days of continuous
sky-survey observations obtained with the Large Area Telescope aboard the Fermi
Gamma-ray Space Telescope to study the gamma-ray emission towards 13 globular
clusters. Steady point-like high-energy gamma-ray emission has been
significantly detected towards 8 globular clusters. Five of them (47 Tucanae,
Omega Cen, NGC 6388, Terzan 5, and M 28) show hard spectral power indices and clear evidence for an exponential cut-off in the range
1.0-2.6 GeV, which is the characteristic signature of magnetospheric emission
from MSPs. Three of them (M 62, NGC 6440 and NGC 6652) also show hard spectral
indices , however the presence of an exponential cut-off
can not be unambiguously established. Three of them (Omega Cen, NGC 6388, NGC
6652) have no known radio or X-ray MSPs yet still exhibit MSP spectral
properties. From the observed gamma-ray luminosities, we estimate the total
number of MSPs that is expected to be present in these globular clusters. We
show that our estimates of the MSP population correlate with the stellar
encounter rate and we estimate 2600-4700 MSPs in Galactic globular clusters,
commensurate with previous estimates. The observation of high-energy gamma-ray
emission from a globular cluster thus provides a reliable independent method to
assess their millisecond pulsar populations that can be used to make
constraints on the original neutron star X-ray binary population, essential for
understanding the importance of binary systems in slowing the inevitable core
collapse of globular clusters.Comment: Accepted for publication in A&A. Corresponding authors: J.
Kn\"odlseder, N. Webb, B. Pancraz
Framing the concept of satellite remote sensing essential biodiversity variables: challenges and future directions
Although satellite-based variables have for long been expected to be key components to a unified and global biodiversity monitoring strategy, a definitive and agreed list of these variables still remains elusive. The growth of interest in biodiversity variables observable from space has been partly underpinned by the development of the essential biodiversity variable (EBV) framework by the Group on Earth Observations – Biodiversity Observation Network, which itself was guided by the process of identifying essential climate variables. This contribution aims to advance the development of a global biodiversity monitoring strategy by updating the previously published definition of EBV, providing a definition of satellite remote sensing (SRS) EBVs and introducing a set of principles that are believed to be necessary if ecologists and space agencies are to agree on a list of EBVs that can be routinely monitored from space. Progress toward the identification of SRS-EBVs will require a clear understanding of what makes a biodiversity variable essential, as well as agreement on who the users of the SRS-EBVs are. Technological and algorithmic developments are rapidly expanding the set of opportunities for SRS in monitoring biodiversity, and so the list of SRS-EBVs is likely to evolve over time. This means that a clear and common platform for data providers, ecologists, environmental managers, policy makers and remote sensing experts to interact and share ideas needs to be identified to support long-term coordinated actions
Drug use patterns associated with risk of non-adherence to antiretroviral therapy among HIV-positive illicit drug users in a Canadian setting: a longitudinal analysis
New Petro‐aggression in the Middle East: Saudi Arabia in the Spotlight
That hydrocarbon abundance may lead to more violence is an established truism in the literature on the resource curse. Looking at the Middle East, however, the literature relates bellicose state behaviour entirely to oil-producing revolutionary republics. Instead, dynastic monarchies are claimed to be the more peacefully behaving actors. Current developments turn this conclusion upside down, however. Since 2015 at the latest, the foreign policy of Saudi Arabia, the leading monarchy in the Middle East, has transformed from multi-dependence to petro-aggression. By discussing this striking transformation, the paper puts forward a framework looking at the interaction of three crucial dimensions: first, the decreasing power projection towards the Middle East by the United States, the decade-long hegemon, due to gradual changes in world energy markets and war fatigue at home; second, the lasting fiscal potency of the Saudi regime; and, third, the personalization of the Saudi monarchy under King Salman as a historically contingent result of transferring power to the generation of Ibn Saud's grandsons
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
MicroRNA expression as risk biomarker of breast cancer metastasis : a pilot retrospective case-cohort study
Background: MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in post-transcriptional gene regulation and have recently been shown to play a role in cancer metastasis. In solid tumors, especially breast cancer, alterations in miRNA expression contribute to cancer pathogenesis, including metastasis. Considering the emerging role of miRNAs in metastasis, the identification of predictive markers is necessary to further the understanding of stage-specific breast cancer development. This is a retrospective analysis that aimed to identify molecular biomarkers related to distant breast cancer metastasis development.
Methods: A retrospective case cohort study was performed in 64 breast cancer patients treated during the period from 1998-2001. The case group (n = 29) consisted of patients with a poor prognosis who presented with breast cancer recurrence or metastasis during follow up. The control group (n = 35) consisted of patients with a good prognosis who did not develop breast cancer recurrence or metastasis. These patient groups were stratified according to TNM clinical stage (CS) I, II and III, and the main clinical features of the patients were homogeneous. MicroRNA profiling was performed and biomarkers related to metastatic were identified independent of clinical stage. Finally, a hazard risk analysis of these biomarkers was performed to evaluate their relation to metastatic potential.
Results: MiRNA expression profiling identified several miRNAs that were both specific and shared across all clinical stages (p <= 0.05). Among these, we identified miRNAs previously associated with cell motility (let-7 family) and distant metastasis (hsa-miR-21). In addition, hsa-miR-494 and hsa-miR-21 were deregulated in metastatic cases of CSI and CSII. Furthermore, metastatic miRNAs shared across all clinical stages did not present high sensitivity and specificity when compared to specific-CS miRNAs. Between them, hsa-miR-183 was the most significative of CSII, which miRNAs combination for CSII (hsa-miR-494, hsa-miR-183 and hsa-miR-21) was significant and were a more effective risk marker compared to the single miRNAs.
Conclusions: Women with metastatic breast cancer, especially CSII, presented up-regulated levels of miR-183, miR-494 and miR-21, which were associated with a poor prognosis. These miRNAs therefore represent new risk biomarkers of breast cancer metastasis and may be useful for future targeted therapies.We thank the Researcher Support Center of Barretos Cancer Hospital, especially the statistician Zanardo C. for assisting in the statistical analysis.This study received financial support from Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Fapesp, Proc: 10/ 16796-0, Sao Paulo, Brazil)
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