58 research outputs found
Legal by Design: A New Paradigm for Handling Complexity in Banking Regulation and Elsewhere in Law
20 pagesIn this Article, we will describe the information-mapping aspects of the resolution planning challenge as an exemplary Manhattan Project5 of law: a critical enterprise that will require and trigger the development of new tools and methods for lawyers to apply when handling complex problems without unsustainably swelling the workforce and wasting resources. Consistent with Dodd-Frank’s focus on reorganizing and simplifying banks, we will focus here on the information architecture issues which underlie much of what is changing about how law and legal work product is delivered, not just for resolution planning, but more broadly
Fragment-based version management for repositories of business process models
As organizations reach higher levels of Business Process Management maturity, they tend to accumulate large collections of process models. These repositories may contain thousands of activities and be managed by different stakeholders with varying skills and responsibilities. However, while being of great value, these repositories induce high management costs. Thus, it becomes essential to keep track of the various model versions as they may mutually overlap, supersede one another and evolve over time. We propose an innovative versioning model and associated storage structure, specifically designed to maximize sharing across process model versions, and to automatically handle change propagation. The focal point of this technique is to version single process model fragments, rather than entire process models. Indeed empirical evidence shows that real-life process model repositories have numerous duplicate fragments. Experiments on two industrial datasets confirm the usefulness of our technique
Facilitating efferent inhibition of inner hair cells in the cochlea of the neonatal rat
Cholinergic brainstem neurones make inhibitory synapses on outer hair cells (OHCs) in the mature mammalian cochlea and on inner hair cells (IHCs) prior to the onset of hearing. We used electrical stimulation in an excised organ of Corti preparation to examine evoked release of acetylcholine (ACh) onto neonatal IHCs from these efferent fibres. Whole-cell voltage-clamp recording revealed that low frequency (0.25–1 Hz) electrical stimulation produced evoked inhibitory postsynaptic currents (IPSCs) at a relatively high fraction of failures (65%) and with mean amplitudes of about −20 pA at −90 mV, corresponding to a quantum content of ∼1. Evoked IPSCs had biphasic waveforms at −60 mV, were blocked reversibly by α-bungarotoxin and strychnine and are most likely mediated by the α9/α10 acetylcholine receptor, with subsequent activation of calcium-dependent potassium (SK2) channels. Paired pulse stimulation with intervals of 10–100 ms caused facilitation of 200–300% in the mean IPSC amplitude. A train of 10 pulses with an interpulse interval of 25 ms produced increasingly larger IPSCs with maximum amplitudes greater than −100 pA due to facilitation and summation throughout the train. Repetitive efferent stimulation at 5 Hz or higher hyperpolarized IHCs by 5–10 mV and could completely prevent the generation of calcium action potentials normally evoked by depolarizing current injection
Interweaving the public and the private: Women's responses to population policy shifts in Singapore
10.1002/(SICI)1099-1220(199903/04)5:23.0.CO;2-1International Journal of Population Geography5279-9
- …