Geotechnical characterization and stability analysis of subaqueous slopes in Lake Lucerne (Switzerland).

Tsunamis occur not only in marine settings but also in lacustrine environments. Most of the lacustrine tsunamis are caused by seismically- or aseismically-triggered mass movements. Therefore, an assessment of the stability of subaqueous slopes is crucial for tsunami hazard assessment in a lake. We selected Lake Lucerne (Switzerland) as a natural laboratory to perform an in-depth geotechnical characterization of its subaqueous slopes. This lake experienced documented tsunamis in 1601 and 1687. Some of its slopes still bear sediment volumes with a potential for tsunamigenic failure. To identify such slopes, we interpreted available reflection seismic data and analyzed the bathymetric map. Then, we performed 152 dynamic Cone Penetration Tests with pore pressure measurement (CPTu) and retrieved 49 sediment cores at different locations in the lake. These data were used to characterize the failure-prone sediments and to evaluate the present-day static stability of subaqueous slopes. Obtained results allowed the definition of three classes of slopes in terms of static stability: unstable slopes, stable slopes close to the unstable state, and stable areas. Non-deltaic slopes with thicker unconsolidated fine-grained sediment drape and moderate-to-high slope gradients (> 5-10°) have the lowest Factor of Safety. In agreement with previous studies, the failure plane for the non-deltaic slopes is embedded within the fine-grained glaciolacustrine sediments. Deltaic slopes with prevailing coarse-grained sediments mostly appear statically stable. Finally, we generalized the measured undrained shear strength profiles into the depth-dependent power-law models. These models define the of Lake Lucerne's sediments and can be applied to other lakes with similar sedimentation history. Supplementary Information The online version contains supplementary material available at 10.1007/s11069-022-05310-1

In-situ and laboratory geotechnical investigations (CPTu, sediment coring) performed in Lake Lucerne (Switzerland) in 2018–2020

In the framework of an SNSF-funded SINERGIA project “Lake Tsunamis: Causes, Controls and Hazard” we performed dense geotechnical investigations along the slope-perpendicular profiles at 11 sites in Lake Lucerne, central Switzerland, where the slopes have failed in the past or might be susceptible to future failures. In total, 152 in-situ free-fall cone penetration tests with pore pressure measurement (CPTu) and laboratory analysis of 49 sediment cores were performed. In this report, we present all conducted field investigations, data processing steps, laboratory experiments and results obtained. Based on the acquired data and results of data processing, we produced a comprehensive dataset with geotechnical (e.g. undrained shear strength) and sediment-physical information (e.g. density, compression wave velocity) regarding the different types of sediments and lithologies found on the failure-prone slopes of Lake Lucerne. The derived parameters are important inputs for the analysis of the stability of sublacustrine slopes and the tsunami hazard assessment for Lake Lucerne

Stability assessment of submerged lateral and deltaic slopes in Lake Lucerne

Numerous studies indicate that tsunamis do not only occur in oceans but also in lakes. Lake Tsunamis are mainly caused by sublacustrine and subaerial mass movements that can be triggered by seismic or aseismic processes (Schnellmann et al. 2002, Strasser et al. 2007, Kremer at al. 2012, Hilbe and Anselmetti 2015). Such tsunamis can have devastating effects on the surrounding population and infrastructure. To assess the tsunami hazard triggered by sublacustrine mass movements, the stability of the lake slopes needs to be examined. As a part of the SNSF funded SINERGIA project “Lake Tsunamis: Causes, Controls and Hazard”, we perform the slope stability analysis based on the comprehensive geotechnical in situ and laboratory dataset for the selected sites of Lake Lucerne, Central Switzerland. During 2018-2019 dense geotechnical investigations were carried out along slope-perpendicular profiles at 10 sites where the slopes have failed in the past or are susceptible to failure and included more than 130 in-situ free-fall cone penetration tests with pore pressure measurement (CPTu) and laboratory analysis of 30 short sediment cores. Already existing reflection seismic dataset complements these data and provides the thickness of different sediment layers. 1D undrained, infinite slope stability analysis following Morgenstern and Price (1965) is used to define the Factor of Safety and critical conditions for deltaic and lateral slopes, where different triggers can be responsible for the failure. Based on the conducted analysis, static and dynamic stability together with critical failure conditions for different slopes in Lake Lucerne can be compared

De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder.

Next-generation sequencing is a powerful tool for the discovery of genes related to neurodevelopmental disorders (NDDs). Here, we report the identification of a distinct syndrome due to de novo or inherited heterozygous mutations in Tousled-like kinase 2 (TLK2) in 38 unrelated individuals and two affected mothers, using whole-exome and whole-genome sequencing technologies, matchmaker databases, and international collaborations. Affected individuals had a consistent phenotype, characterized by mild-borderline neurodevelopmental delay (86%), behavioral disorders (68%), severe gastro-intestinal problems (63%), and facial dysmorphism including blepharophimosis (82%), telecanthus (74%), prominent nasal bridge (68%), broad nasal tip (66%), thin vermilion of the upper lip (62%), and upslanting palpebral fissures (55%). Analysis of cell lines from three affected individuals showed that mutations act through a loss-of-function mechanism in at least two case subjects. Genotype-phenotype analysis and comparison of computationally modeled faces showed that phenotypes of these and other individuals with loss-of-function variants significantly overlapped with phenotypes of individuals with other variant types (missense and C-terminal truncating). This suggests that haploinsufficiency of TLK2 is the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype. This work illustrates the power of international data sharing, by the identification of 40 individuals from 26 different centers in 7 different countries, allowing the identification, clinical delineation, and genotype-phenotype evaluation of a distinct NDD caused by mutations in TLK2

The elite athlete´s mental recovery

Att vila fysiskt är för många en självklarhet, däremot pratas det sällan om den mentala återhämtningen. Båda är viktiga och har stor påverkan på prestation och hälsa. I den här studien är syftet att undersöka elitidrottares upplevelser och erfarenheter av mental återhämtning. För att ta reda på detta har vi genomfört kvalitativa intervjuer. På vilket sätt respondenterna får återhämtning, hur de påverkas av frånvaro av mental återhämtning och om dessa idrottare upplever ett samband mellan frånvaron av mental återhämtning och psykisk ohälsa presenteras i resultatet. När vi analyserade resultaten av intervjuerna gjorde vi innehållsanalyser. Vi kom fram till att samtliga får återhämtning genom att tänka på annat än idrotten och genom att utöva aktiviteter som är roliga. Vid frånvaro av mental återhämtning upplevde majoriteten en försämrad prestation och att hälsan påverkades negativt. Respondenterna beskrev ett samband mellan psykisk ohälsa och frånvaro av mental återhämtning. Det finns relativt lite forskning inom detta område, däremot stämde resultaten med tidigare forskning som idag finns tillgänglig.To many people, resting physically is a matter of course, however, mental recovery is rarely talked about. Both are important and have major impact on performance and health. In this study, the aim is to investigate athletes experiences of mental recovery. In order to find out, we have conducted qualitative interviews. In what way the respondents receive recovery, how they are affected by the absence of mental recovery and if these athletes experience a connection between the absence of mental recovery and mental illness is presented in the results. When we analyzed the results of the interviews, we used content analyses. We concluded that all respondents receive recovery by thinking about other things than sport and by doing activities that are fun. In the absence of mental recovery, the majority experienced a deterioration in performance and a negative impact on health. The respondents described a link between mental illness and the absence of mental recovery. There is limited research in this area, but the results were consistent with previous research available today