PENGARUH LOCUS OF CONTROL DAN ENVIRONMENTAL RISK FACTORS TERHADAP KINERJA AUDITOR PEMERINTAH DALAM MELAKSANAKAN AUDIT PEMERINTAHAN (STUDI KASUS PADA BPKP PROPINSI LAMPUNG)

This study purposed to understand the effect of locus of control and environmental risk factors to financial and development monitoring board (Badan Pengawasan Keuangan dan Pembangunan/BPKP) Lampung province. Sampling method used in this study is purposive judgment sampling method. Data collected by interviewing method and sending guestionnaire directly to respondent. From 100 guestionnaires, 62 guestionnaires returned egual to 62% return rate. Analysis method used in this study is double linear regression by SPSS (Statistical Package for The Social Science). The result shows that Jocus of control an environmental risk factors partially have positive and significant effect to the performance of governmen internal auditor. Partial testing used t-count at 95% of certainty rate and at 5%. Result of hypothesis testing simultaneously shows that locus of control and environmental risk factors variable positively and significantly influence the performance of government internal auditor. Hypothesis testing towards regression coefficient simultaneously used by F-test at 0,228 means that 22,8% of government internal auditor performance can be explained by second variation of independent variable in this study

Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity

A delicate interneuronal communication between pre- and postsynaptic membranes is critical for synaptic plasticity and the formation of memory. Evidence shows that membrane/lipid rafts (MLRs), plasma membrane microdomains enriched in cholesterol and sphingolipids, organize presynaptic proteins and postsynaptic receptors necessary for synaptic formation and signaling. MLRs establish a cell polarity that facilitates transduction of extracellular cues to the intracellular environment. Here we show that neuron-targeted overexpression of an MLR protein, caveolin-1 (SynCav1), in the adult mouse hippocampus increased the number of presynaptic vesicles per bouton, total excitatory type I glutamatergic synapses, number of same-dendrite multiple-synapse boutons, increased myelination, increased long-term potentiation, and increased MLR-localized N-methyl-d-aspartate receptor subunits (GluN1, GluN2A, and GluN2B). Immunogold electron microscopy revealed that Cav-1 localizes to both the pre- and postsynaptic membrane regions as well as in the synaptic cleft. These findings, which are consistent with a significant increase in ultrastructural and functional synaptic plasticity, provide a fundamental framework that underlies previously demonstrated improvements in learning and memory in adult and aged mice by SynCav1. Such observations suggest that Cav-1 and MLRs alter basic aspects of synapse biology that could serve as potential therapeutic targets to promote neuroplasticity and combat neurodegeneration in a number of neurological disorders