Review of From Classroom to Battlefield: Victoria High School and the First World War by Barry Gough

Review of From Classroom to Battlefield: Victoria High School and the First World War by Barry Gough

Songs of War: Anglo-Canadian Popular Songs on the Home Front, 1914-1918

This article explores the production, content, and reception of Anglo-Canadian popular songs composed during the First World War. It argues that popular songs reflected the changing attitudes of Anglo-Canadians, as composers and publishers created music to fulfill different purposes for those on the home front at various stages of the war. In the beginning, the majority of songs were patriotic marches composed to gather support for Britain and the Empire. As the war continued, there was an increase in the number of patriotic songs that expressed a growing sense of wartime Canadian nationalism to enlist recruits. Throughout the war, music was significant to the First World War experience on Canada’s home front

Review of From Classroom to Battlefield: Victoria High School and the First World War by Barry Gough

Review of From Classroom to Battlefield: Victoria High School and the First World War by Barry Gough

Historical Empathy: A Cognitive-Affective Theory for History Education in Canada

Historical empathy involves a process of attempting to understand the thoughts, feelings, experiences, decisions, and actions of people from the past within specific historical contexts. Although historical empathy has been a rich area of study in history education for several decades, this research has largely taken place outside of Canada. In this article, I argue that greater attention should be paid to historical empathy in Canadian history education research and curriculum because it can support learning outcomes related to historical thinking and historical consciousness, citizenship, and decolonizing and anti-racist approaches to history education. Drawing from and commenting on other scholarship, I present a cognitive-affective theory of historical empathy which includes five elements: (1) evidence and contextualization, (2) informed historical imagination, (3) historical perspectives, (4) ethical judgements, and (5) caring. Through exploring each element and some pedagogical considerations for educators, I emphasize the affective dimensions of history to centre their importance for history education in Canada.L’empathie historique est un processus qui cherche à comprendre les pensées, les sentiments, les expériences, les décisions et les actions des personnes du passé dans des contextes historiques précis. L’empathie historique est un champ d’études riche dans le domaine de l’enseignement de l’histoire depuis plusieurs décennies, mais ces recherches ont surtout eu lieu à l’extérieur du contexte canadien. Dans cet article, je soutiens qu’une plus grande attention devrait être accordée à l’empathie historique dans la recherche et dans les programmes d’enseignement de l’histoire au Canada, car elle peut soutenir les résultats d’apprentissages liés à la réflexion historique, à la conscience historique, à la citoyenneté et aux approches décolonisatrices et antiracistes de l’enseignement de l’histoire. En m’inspirant et en commentant d’autres études, je présente une théorie cognitive affective de l’empathie historique qui comprend cinq éléments : (1) la preuve et la contextualisation ; (2) l’imagination historique informée ; (3) les perspectives historiques ; (4) les jugements éthiques ; et (5) la sollicitude. En explorant chacun de ces éléments et certaines considérations pédagogiques pour les éducateurs, cet article met l’accent sur les dimensions affectives de l’histoire afin de centrer leur importance pour l’enseignement de l’histoire au Canada

History Education in the Anthropocene

As much as history education is supposed to be about the past, it is oriented towards the future. History teachers are guided by a variety of purposes, such as cultural inheritance, critical and disciplinary thinking, identity formation and personal development, or activism and social change. Each of these purposes is imbued with particular notions of memory, citizenship and other values relevant to preparing young people for the future. While it may not always be explicit, a prevailing assumption in history education, as with Canadian curriculum, generally speaking, is that the future is a place and time to which we should look forward, as it will improve upon the past. But as we are coming to know, that may not be a responsible or accurate frame to pass on to the next generation. What theoretical and practical supports can help history educators renew their teaching in light of the Anthropocene, and particularly the climate crisis? In seeking to attune history education to a relational, ecological and ethical future orientation, we turned to the fields of Indigenous studies, environmental history and climate change education. We suggest some new, and even radical, directions we might look as a community of history educators. In doing so, we hope to nurture solidarity in navigating uncertainty together. With a set of common questions, assumptions and goals to guide us, we may find ways of teaching and learning that respond more meaningfully to the precarity of our times

Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021

Background: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050. Methods: Using forecasts of major drivers of health such as the Socio-demographic Index (SDI; a composite measure of lag-distributed income per capita, mean years of education, and total fertility under 25 years of age) and the full set of risk factor exposures captured by GBD, we provide cause-specific forecasts of mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) by age and sex from 2022 to 2050 for 204 countries and territories, 21 GBD regions, seven super-regions, and the world. All analyses were done at the cause-specific level so that only risk factors deemed causal by the GBD comparative risk assessment influenced future trajectories of mortality for each disease. Cause-specific mortality was modelled using mixed-effects models with SDI and time as the main covariates, and the combined impact of causal risk factors as an offset in the model. At the all-cause mortality level, we captured unexplained variation by modelling residuals with an autoregressive integrated moving average model with drift attenuation. These all-cause forecasts constrained the cause-specific forecasts at successively deeper levels of the GBD cause hierarchy using cascading mortality models, thus ensuring a robust estimate of cause-specific mortality. For non-fatal measures (eg, low back pain), incidence and prevalence were forecasted from mixed-effects models with SDI as the main covariate, and YLDs were computed from the resulting prevalence forecasts and average disability weights from GBD. Alternative future scenarios were constructed by replacing appropriate reference trajectories for risk factors with hypothetical trajectories of gradual elimination of risk factor exposure from current levels to 2050. The scenarios were constructed from various sets of risk factors: environmental risks (Safer Environment scenario), risks associated with communicable, maternal, neonatal, and nutritional diseases (CMNNs; Improved Childhood Nutrition and Vaccination scenario), risks associated with major non-communicable diseases (NCDs; Improved Behavioural and Metabolic Risks scenario), and the combined effects of these three scenarios. Using the Shared Socioeconomic Pathways climate scenarios SSP2-4.5 as reference and SSP1-1.9 as an optimistic alternative in the Safer Environment scenario, we accounted for climate change impact on health by using the most recent Intergovernmental Panel on Climate Change temperature forecasts and published trajectories of ambient air pollution for the same two scenarios. Life expectancy and healthy life expectancy were computed using standard methods. The forecasting framework includes computing the age-sex-specific future population for each location and separately for each scenario. 95% uncertainty intervals (UIs) for each individual future estimate were derived from the 2·5th and 97·5th percentiles of distributions generated from propagating 500 draws through the multistage computational pipeline. Findings: In the reference scenario forecast, global and super-regional life expectancy increased from 2022 to 2050, but improvement was at a slower pace than in the three decades preceding the COVID-19 pandemic (beginning in 2020). Gains in future life expectancy were forecasted to be greatest in super-regions with comparatively low life expectancies (such as sub-Saharan Africa) compared with super-regions with higher life expectancies (such as the high-income super-region), leading to a trend towards convergence in life expectancy across locations between now and 2050. At the super-region level, forecasted healthy life expectancy patterns were similar to those of life expectancies. Forecasts for the reference scenario found that health will improve in the coming decades, with all-cause age-standardised DALY rates decreasing in every GBD super-region. The total DALY burden measured in counts, however, will increase in every super-region, largely a function of population ageing and growth. We also forecasted that both DALY counts and age-standardised DALY rates will continue to shift from CMNNs to NCDs, with the most pronounced shifts occurring in sub-Saharan Africa (60·1% [95% UI 56·8–63·1] of DALYs were from CMNNs in 2022 compared with 35·8% [31·0–45·0] in 2050) and south Asia (31·7% [29·2–34·1] to 15·5% [13·7–17·5]). This shift is reflected in the leading global causes of DALYs, with the top four causes in 2050 being ischaemic heart disease, stroke, diabetes, and chronic obstructive pulmonary disease, compared with 2022, with ischaemic heart disease, neonatal disorders, stroke, and lower respiratory infections at the top. The global proportion of DALYs due to YLDs likewise increased from 33·8% (27·4–40·3) to 41·1% (33·9–48·1) from 2022 to 2050, demonstrating an important shift in overall disease burden towards morbidity and away from premature death. The largest shift of this kind was forecasted for sub-Saharan Africa, from 20·1% (15·6–25·3) of DALYs due to YLDs in 2022 to 35·6% (26·5–43·0) in 2050. In the assessment of alternative future scenarios, the combined effects of the scenarios (Safer Environment, Improved Childhood Nutrition and Vaccination, and Improved Behavioural and Metabolic Risks scenarios) demonstrated an important decrease in the global burden of DALYs in 2050 of 15·4% (13·5–17·5) compared with the reference scenario, with decreases across super-regions ranging from 10·4% (9·7–11·3) in the high-income super-region to 23·9% (20·7–27·3) in north Africa and the Middle East. The Safer Environment scenario had its largest decrease in sub-Saharan Africa (5·2% [3·5–6·8]), the Improved Behavioural and Metabolic Risks scenario in north Africa and the Middle East (23·2% [20·2–26·5]), and the Improved Nutrition and Vaccination scenario in sub-Saharan Africa (2·0% [–0·6 to 3·6]). Interpretation: Globally, life expectancy and age-standardised disease burden were forecasted to improve between 2022 and 2050, with the majority of the burden continuing to shift from CMNNs to NCDs. That said, continued progress on reducing the CMNN disease burden will be dependent on maintaining investment in and policy emphasis on CMNN disease prevention and treatment. Mostly due to growth and ageing of populations, the number of deaths and DALYs due to all causes combined will generally increase. By constructing alternative future scenarios wherein certain risk exposures are eliminated by 2050, we have shown that opportunities exist to substantially improve health outcomes in the future through concerted efforts to prevent exposure to well established risk factors and to expand access to key health interventions

VOICES of YOUTH in WARTIME : Students at Kitchener-Waterloo Collegiate and Vocational School during the Second World War

This article examines the experiences of adolescents in Canada during the Second World War through a case study of Kitchener-Waterloo Collegiate and Vocational School (K.C.I.) in Kitchener, Ontario. Although many prewar school activities remained a significant part of the student experience at K.C.I., the war impacted the students’ daily lives in ways specific to adolescents who attended school during this time period. Through their participation in various initiatives for the war effort, largely divided along gendered lines, students at K.C.I. contributed towards “school spirit” and developed a sense of responsibility as a future generation of Canadian citizens. This in-depth study of one Ontario high school in wartime demonstrates that age must be emphasized as a prominent factor in shaping experiences on the home front.Dans cet article, nous allons examiner les expériences d’adolescents au Canada durant la Seconde Guerre Mondiale grâce à une étude de cas du Kitchener-Waterloo Collegiate and Vocational School (K.C.I), un établissement d’études secondaires situé à Kitchener, en Ontario. Bien que beaucoup d’activités scolaires d’avant-guerre restaient intégrales à l’expérience estudiantine de KCI, la guerre impacta la vie quotidienne des écoliers d’une façon spécifique aux adolescents de cette période. À travers leur participation à diverses initiatives pour soutenir l’effort de guerre, d’habitude divisées selon les rôles traditionnels, les étudiants de KCI contribuèrent à « l’esprit d’école » et développèrent un sentiment de responsabilité en tant que future génération de Canadiens. Cette étude approfondie d’une école secondaire de l’Ontario en temps de guerre démontre que l’âge doit être souligné comme un facteur important dans la formation des expériences sur le front intérieur

Sex Differences in Human Immunodeficiency Virus Persistence and Reservoir Size During Aging.

BackgroundSex differences in human immunodeficiency virus (HIV) reservoir dynamics remain underexplored.MethodsLongitudinal samples from virally suppressed midlife women (n = 59, median age 45 years) and age-matched men (n = 31) were analyzed retrospectively. At each time point, we measured sex hormones (by means of enzyme-linked immunosorbent assay) and cellular HIV DNA and RNA (by means of digital droplet polymerase chain reaction). Number of inducible HIV RNA+ cells, which provides an upper estimate of the replication-competent reservoir, was quantified longitudinally in a different subset of 14 women, across well-defined reproductive stages. Mixed-effects models included normalized reservoir outcomes and sex, time since antiretroviral therapy (ART) initiation, and the sex-by-time interaction as predictors.ResultsAt ART initiation, women and men had median (interquartile range [IQR]) CD4+ T-cell counts of 204/μL (83-306/μL) versus 238/μL (120-284/μL), respectively; median ages of 45 (42-48) versus 47 (43-51) years; and median follow-up times of 79.2/μL (60.5-121.1/μL) versus 66.2/μL (43.2-80.6/μL) months. We observed a significant decline of total HIV DNA over time in both men and women (P < .01). However, the rates of change differed significantly between the sexes (P < .01), with women having a significantly slower rate of decline than men, more pronounced with age. By contrast, the levels of inducible HIV RNA increased incrementally over time in women during reproductive aging (P < .01).ConclusionsIn contrast to men, in whom the HIV reservoir steadily declines with aging, the HIV reservoir in women is more dynamic. Total HIV DNA (including intact and defective genomes) declines more slowly in women than in men, while the inducible HIV RNA+ reservoir, which is highly enriched in replication-competent virus, increases in women after menopause

β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

International audienceNuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show that oncogenic β-catenin signaling negatively regulates the expression of NHERF1 (Na+/H+ exchanger 3 regulating factor 1), a PDZ-adaptor protein that is usually lost or downregulated in early dysplastic adenomas to exacerbate nuclear β-catenin activity. Chromatin immunoprecipitation (ChIP) assays demonstrated that β-catenin represses NHERF1 via TCF4 directly, while the association between TCF1 and the Nherf1 promoter increased upon β-catenin knockdown. To note, the occurrence of a cytostatic survival response in settings of single β-catenin-depleted CRC cells was abrogated by combining NHERF1 inhibition via small hairpin RNA (shRNA) or RS5517, a novel PDZ1-domain ligand of NHERF1 that prevented its ectopic nuclear entry. Mechanistically, dual NHERF1/β-catenin targeting promoted an autophagy-to-apoptosis switch consistent with the activation of Caspase-3, the cleavage of PARP and reduced levels of phospho-ERK1/2, Beclin-1, and Rab7 autophagic proteins compared with β-catenin knockdown alone. Collectively, our data unveil novel β-catenin/TCF-dependent mechanisms of CRC carcinogenesis, also offering preclinical proof of concept for combining β-catenin and NHERF1 pharmacological inhibitors as a mechanism-based strategy to augment apoptotic death of CRC cells refractory to current Wnt/β-catenin-targeted therapeutics