8 research outputs found
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Adams Mark
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z
- Alptekin Köksal
- Als Thomas D
- Amin Farooq
- Andreassen Ole A
- Arango Celso
- Arolt Volker
- Arrojo Manuel
- Atbaşoğlu Eşref Cem
- Athanasiu Lavinia
- Atkinson Elizabeth G
- Awasthi Swapnil
- Ayub Muhammad
- Azevedo Maria Helena
- Bacanu Silviu A
- Bass Nicholas J
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia Iole
- Belliveau Richard A
- Bene Judit
- Benner Christian
- Benyamin Beben
- Bergen Sarah E
- Bertolino Alessandro
- Bigdeli Tim B
- Black Donald W
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Braff David
- Bramon Elvira
- Braun Alice
- Bray Nicholas J
- Breen Gerome
- Bressan Rodrigo Affonseca
- Bromet Evelyn J
- Bruggeman Richard
- Bryois Julien
- Buccola Nancy G
- Buckley Peter F
- Buckner Randy L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William F
- Børglum Anders D
- Cahn Wiepke
- Cairns Murray J
- Calkins Monica E
- Campion Dominique
- Carr Vaughan J
- Castle David
- Catts Stanley V
- Cervilla Jorge A
- Chambert Kimberley D
- Chan Raymond CK
- Chaumette Boris
- Chen Chia-Yen
- Chen Wei J
- Cheng Wei
- Cheung Eric FC
- Chong Siow Ann
- Cichon Sven
- Cloninger C Robert
- Cohen David
- Collier David A
- Consoli Angèle
- Cordeiro Quirino
- Corvin Aiden
- Costas Javier
- Crespo-Facorro Benedicto
- Curtis Charles
- Curtis David
- Daly Mark J
- Davidson Michael
- Davis Kenneth L
- de Haan Lieuwe
- Degenhardt Franziska
- DeLisi Lynn E
- Demontis Ditte
- Dennison Charlotte A
- Dickerson Faith
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Duan Jubao
- Ducci Giuseppe
- Dudbridge Frank
- Ehrenreich Hannelore
- Eriksson Johan G
- Escott-Price Valentina
- Esko Tõnu
- Fanous Ayman H
- Faraone Stephen V
- Fañanás Lourdes
- Fiorentino Alessia
- Forstner Andreas
- Forti Marta Di
- Frank Josef
- Freedman Robert
- Frei Oleksandr
- Freimer Nelson B
- Fromer Menachem
- Frustaci Alessandra
- Gadelha Ary
- Galletly Cherrie
- Gandal Michael J
- Gareeva Anna
- Gawlik Micha
- Ge Tian
- Gejman Pablo V
- Gennarelli Massimo
- Genovese Giulio
- Gershon Elliot S
- Giannitelli Marianna
- Giegling Ina
- Gill Michael
- Giusti-Rodríguez Paola
- Glatt Stephen J
- Godard Stephanie
- Goldstein Jacqueline I
- Golimbet Vera
- González Peñas Javier
- González-Pinto Ana
- Gopal Srihari
- Gratten Jacob
- Green Michael F
- Greenwood Tiffany A
- Grove Jakob
- Guillin Olivier
- Gur Raquel E
- Gur Ruben C
- Gutiérrez Blanca
- Gülöksüz Sinan
- Hahn Eric
- Hakonarson Hakon
- Hall Lynsey S
- Haroutunian Vahram
- Hartmann Annette M
- Harvey Carol
- Harwood Janet C
- Hayward Caroline
- Henskens Frans A
- Herms Stefan
- Hoffmann Per
- Holmans Peter A
- Hong Kyung Sue
- Hougaard David M
- Howrigan Daniel P
- Huang Hailiang
- Hultman Christina M
- Hwu Hai-Gwo
- Hyman Steven E
- Ikeda Masashi
- Indonesia Schizophrenia Consortium
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen V
- Joa Inge
- Julià Antonio
- Jönsson Erik G
- Kahn René S
- Kam-Thong Tony
- Kamatani Yoichiro
- Karachanak-Yankova Sena
- Kebir Oussama
- Keller Matthew C
- Kelly Brian J
- Kendler Kenneth S
- Kennedy James L
- Khrunin Andrey
- Khusnutdinova Elza
- Kim Minsoo
- Kim Sung-Wan
- Kirov George
- Klovins Janis
- Knowles James A
- Kondratiev Nikolay
- Konte Bettina
- Koopmans Frank
- Kraft Julia
- Krebs Marie-Odile
- Kubo Michiaki
- Kusumawardhani Agung
- Kuzelova-Ptackova Hana
- Kučinskas Vaidutis
- Kučinskiene Zita Ausrele
- Kähler Anna K
- Lam Max
- Landi Stefano
- Laurent-Levinson Claudine
- Lazzeroni Laura C
- Lee Jimmy
- Lee Phil H
- Legge Sophie E
- Lehrer Douglas S
- Lencer Rebecca
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F
- Li Miaoxin
- Li Qingqin S
- Li Zhiqiang
- Lieberman Jeffrey
- Light Gregory A
- Limborska Svetlana
- Liu Chih-Min
- Liu Jianjun
- Loughland Carmel M
- Lubinski Jan
- Luykx Jurjen J
- Lynham Amy
- Lönnqvist Jouko
- Macek Milan
- Mackinnon Andrew
- Magnusson Patrik KE
- Magnusson Sigurdur
- Maher Brion S
- Maier Wolfgang
- Malaspina Dolores
- Malhotra Anil K
- Malhotra Dheeraj
- Mallet Jacques
- Marder Stephen R
- Marsal Sara
- Martin Alicia R
- Martorell Lourdes
- Mattheisen Manuel
- McCarley Robert W
- McCarroll Steven A
- McDonald Colm
- McGrath John J
- McIntosh Andrew
- McQuillin Andrew
- Medeiros Helena
- Meier Sandra
- Melegh Bela
- Melle Ingrid
- Menezes Paulo R
- Mesholam-Gately Raquelle I
- Metspalu Andres
- Michie Patricia T
- Milani Lili
- Milanova Vihra
- Mitjans Marina
- Molden Espen
- Molina Esther
- Molto María Dolores
- Mondelli Valeria
- Moran Jennifer L
- Moreno Carmen
- Morgan Vera A
- Morley Christopher P
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mowry Bryan J
- Muntané Gerard
- Murphy Kieran C
- Murray Robin M
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Neale Benjamin M
- Neil Amanda L
- Nenadić Igor
- Nestadt Gerald
- Nikitina-Zake Liene
- Nimgaonkar Vishwajit
- Nordentoft Merete
- Noto Cristiano
- Nuechterlein Keith H
- Nöthen Markus M
- O'Brien Niamh Louise
- O'Donovan Michael C
- O'Neill F Anthony
- Oh Sang-Yun
- Olincy Ann
- Ophoff Roel A
- Ota Vanessa Kiyomi
- Owen Michael J
- Paciga Sara A
- Palotie Aarno
- Panagiotaropoulou Georgia
- Pantelis Christos
- Papadimitriou George N
- Pardiñas Antonio F
- Parellada Mara
- Pato Carlos N
- Pato Michele T
- Paunio Tiina
- Pellegrino Renata
- Periyasamy Sathish
- Perkins Diana O
- Petryshen Tracey L
- Pfuhlmann Bruno
- Pietiläinen Olli
- Pimm Jonathan
- Pirinen Matti
- Pocklington Andrew J
- Porteous David
- Posthuma Danielle
- Powell John
- PsychENCODE
- Psychosis Endophenotypes International Consortium
- Pulver Ann E
- Qi Ting
- Qin Shengying
- Quattrone Diego
- Quested Digby
- Radant Allen D
- Rampino Antonio
- Rapaport Mark H
- Rautanen Anna
- Reichenberg Abraham
- Richards Alexander L
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Rivera Margarita
- Roe Cheryl
- Roffman Joshua L
- Roth Julian
- Rothermundt Matthias
- Roussos Panos
- Rujescu Dan
- Rutten Bart PF
- Saka Meram C
- Saker-Delye Safaa
- Salomaa Veikko
- Sanders Alan R
- Sanjuan Julio
- Santoro Marcos Leite
- Savitz Adam
- Schall Ulrich
- Schizophrenia Working Group of the Psychiatric Genomics Consorti
- Schulze Thomas G
- Schwab Sibylle G
- Scott Rodney J
- Seidman Larry J
- Serretti Alessandro
- Sham Pak C
- Sharp Sally Isabel
- Shi Jianxin
- Shi Yongyong
- Sidorenko Julia
- Siever Larry J
- Sigurdsson Engilbert
- Silverman Jeremy M
- Sim Kang
- Skarabis Nora
- Slominsky Petr
- Smoller Jordan W
- So Hon-Cheong
- Sobell Janet L
- St Clair David
- Stahl Eli A
- Stain Helen J
- Steen Nils Eiel
- Stefansson Kari
- Stefánsson Hreinn
- Steixner-Kumar Agnes A
- Stone William S
- Straub Richard E
- Streit Fabian
- Strengman Eric
- Stroup T Scott
- Stögmann Elisabeth
- Subramaniam Mythily
- Sugar Catherine A
- Sullivan Patrick F
- Suvisaari Jaana
- Svrakic Dragan M
- Swerdlow Neal R
- SynGO Consortium
- Szatkiewicz Jin P
- Söderman Erik
- Ta Thi Minh Tam
- Takahashi Atsushi
- Terao Chikashi
- Thibaut Florence
- Toncheva Draga
- Tooney Paul A
- Torretta Silvia
- Tosato Sarah
- Trubetskoy Vassily
- Tsuang Debby W
- Tsuang Ming T
- Tura Gian Battista
- Turetsky Bruce I
- Vaaler Arne
- van Amelsvoort Therese
- van Os Jim
- van Winkel Ruud
- Vassos Evangelos
- Vawter Marquis P
- Veijola Juha
- Verhage Matthijs
- Vilella Elisabet
- Visscher Peter M
- Voloudakis Georgios
- Waddington John
- Walter Henrik
- Walters James TR
- Wang Shi-Heng
- Watanabe Kyoko
- Waterreus Anna
- Webb Bradley T
- Weinberger Daniel R
- Weiser Mark
- Werge Thomas
- Wildenauer Dieter B
- Williams Nigel M
- Witt Stephanie H
- Wormley Brandon K
- Wray Naomi R
- Wu Jing Qin
- Wu Yang
- Xu Shuhua
- Xu Zhida
- Yang Jian
- Yolken Robert
- Yu Xin
- Yue Weihua
- Zai Clement C
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
- Üçok Alp
- Publication venue
- NATURE PORTFOLIO
- Publication date
- 21/04/2022
- Field of study
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies
Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
- Author
- Adams Mark
- Affonseca Bressan Rodrigo
- Agartz Ingrid
- Agerbo Esben
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z.
- Alptekin Köksal
- Als Thomas D.
- Amin Farooq
- Arolt Volker
- Arrojo Manuel
- Athanasiu Lavinia
- Atkinson Elizabeth G.
- Ausrele Kučinskiene Zita
- Awasthi Swapnil
- Azevedo Maria Helena
- Bacanu Silviu A.
- Bass Nicholas J.
- Begemann Martin
- Belliveau Richard A.
- Bene Judit
- Benyamin Beben
- Bergen Sarah E.
- Bigdeli Tim B.
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Braun Alice
- Bromet Evelyn J.
- Bruggeman Richard
- Bryois Julien
- Buckley Peter F.
- Buckner Randy L.
- Bybjerg-Grauholm Jonas
- Cahn Wiepke
- Cairns Murray J.
- Calkins Monica E.
- Carr Vaughan J.
- Castle David
- Catts Stanley V.
- Chambert Kimberley D.
- Chan Raymond C. K.
- Chaumette Boris
- Chen Chia-Yen
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Cohen David
- Consoli Angele
- Cordeiro Quirino
- Costas Javier
- Curtis Charles
- Davidson Michael
- Davis Kenneth L.
- De Haan Lieuwe
- Degenhardt Franziska
- DeLisi Lynn E.
- Demontis Ditte
- Dennison Charlotte A.
- Dickerson Faith
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Duan Jubao
- Ducci Giuseppe
- Dudbridge Frank
- Eriksson Johan G.
- Fananas Lourdes
- Faraone Stephen V.
- Fiorentino Alessia
- Forstner Andreas
- Frank Josef
- Frei Oleksandr
- Freimer Nelson B.
- Fromer Menachem
- Frustaci Alessandra
- Gadelha Ary
- Ge Tian
- Genovese Giulio
- Gershon Elliot S.
- Giannitelli Marianna
- Giegling Ina
- Giusti-Rodríguez Paola
- Godard Stephanie
- Goldstein Jacqueline I.
- González Peñas Javier
- González-Pinto Ana
- Gopa Srihari
- Gratten Jacob
- Green Michael F.
- Greenwood Tiffany A.
- Grove Jakob
- Guillin Olivier
- Gur Raquel E.
- Gur Ruben C.
- Gutiérrez Blanca
- Gülöksüz Sinan
- Hahn Eric
- Hakonarson Hakon
- Hall Lynsey
- Haroutunian Vahram
- Hartmann Annette M.
- Harvey Carol
- Harwood Janet C.
- Hayward Caroline
- Henskens Frans A.
- Herms Stefan
- Hoffmann Per
- Howrigan Daniel P.
- Ikeda Masashi
- Iyegbe Conrad
- Joa Inge
- Julià Antonio
- Kam-Thong Tony
- Kamatani Yoichiro
- Karachanak-Yankova Sena
- Kebir Oussama
- Keller Matthew C.
- Kelly Brian J.
- Khrunin Andrey
- Kim Minsoo
- Kim Sung-Wan
- Klovins Janis
- Kondratiev Nikolay
- Konte Bettina
- Koopmans Frank
- Kraft Julia
- Kubo Michiaki
- Kusumawardhani Agung
- Kuzelov a-Ptackova Hana
- Kučinskas Vaidutis
- Kähler Anna K.
- Lam Max
- Land Stefano
- Lazzeroni Laura C.
- Lee Phil H.
- Legge Sophie E.
- Lehrer Douglas S.
- Lencer Rebecca
- Lerer Bernard
- Li Miaoxin
- Li Zhiqiang
- Lieberman Jeffrey
- Light Gregory A.
- Limborska Svetlana
- Liu Chih-Min
- Loughland Carmel M.
- Lubiski Jan
- Luykx Jurjen J.
- Lynham Amy
- Lönnqvist Jouko
- Macel Jr. Milan
- Mackinnon Andrew
- Magnusson Patrik K. E.
- Magnusson Sigurdur
- Maher Brion S.
- Maier Wolfgang
- Malaspina Dolores
- Mallet Jacques
- Marder Stephen R.
- Marsal Sara
- Martin Alicia R.
- Martorell Lourdes
- Mattheisen Manuel
- McCarley Robert W.
- McDonald Colm
- McGrath John J.
- Medeiros Helena
- Meier Sandra
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihara
- Mitjans Marina
- Molden Espen
- Molina Esther
- Molto María Dolores
- Mondelli Valeria
- Moreno Carmen
- Morley Christopher P.
- Muntané Gerard
- Murphy Kieran C.
- Myin-Germeys Inez
- Nenadić Igor
- Nestadt Gerald
- Neuchterlein Keith H.
- Nikitina-Zake Liene
- Noto Cristiano
- O'Brien Niamh Louise
- O'Neill F. Anthony.
- Oh Sang-Yun
- Olincy Ann
- Ota Vanessa Kiyomi
- Panagiotaropoulou Georgia
- Pantelis Christos
- Papadimitrou George N.
- Pardinas Antonio
- Paredella Mara
- Paurio Tiina
- Pellegrino Renata
- Periyasamy Sathish
- Perkins Diana O.
- Pfuhlmann Bruno
- Pietilainen Olli
- Pimm Jonathan
- Porteous David
- Powell John
- Qi Ting
- Quattrone Diego
- Quested Digby
- Radant Allen D.
- Rampino Antonio
- Rapaport Mark H.
- Rautanen Anna
- Reichenberg Abraham
- Richards Alexander L.
- Roe Cheryl
- Roffman Joshua L.
- Roth Julian
- Rothermundt Matthias
- Rutten Bart P. F.
- Saker-Delye Safaa
- Salomaa Veiko
- Sanjuan Julio
- Santoro Marcos Leite
- Savitz Adam
- Schall Ulrich
- Scott Rodney J.
- Seidman Larry J.
- Sharp Sally Isabel
- Shi Jianxin
- Sidorenko Julia
- Sigurdsson Engilbert
- Sim Kang
- Skarabis Nora
- Slominsky Petr
- So Hon-Cheong
- Sobell Janet L.
- Soderman Erik
- Stain Helen J.
- Steen Nils Eiel
- Steixner-Kumar Agnes
- Stogmann Elisabeth
- Stone William S.
- Straub Richard E.
- Stregman Eric
- Streit Fabian
- Stroup T. Scott
- Subramaniam Mythily
- Sugar Catherine A.
- Suvisaari Jaana
- Svrakic Dragan M.
- Swerdlow Neal R.
- Szatkiewicz Jin P.
- Ta Thi Minh Tam
- Takahashi Atsushi
- Terao Chikashi
- Thibaut Florence
- Toncheva Draga
- Tooney Paul A.
- Torretta Silvia
- Tosato Sarah
- Trubetskoy Vassily
- Tura Gian Battista
- Turetsky Bruce I.
- Ucock Alp
- Vaaler Arne
- Van Amelsvoort Therese
- Van Winkel Ruud
- Veijola Juha
- Voloudakis Georgios
- Waddington John
- Walter Henrik
- Watanabe Kyoto
- Waterreus Anna
- Webb Bradley T.
- Weiser Mark
- Williams Nigel M.
- Witt Stephanie H.
- Wormley Brandon K.
- Wu Jing Qin
- Wu Yang
- Xu Zhida
- Yolken Robert
- Zai Clement C.
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 21/04/2022
- Field of study
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Adams Mark
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z
- Alptekin Köksal
- Als Thomas D
- Amin Farooq
- Andreassen Ole A
- Arango Celso
- Arolt Volker
- Arrojo Manuel
- Atbaşoğlu Eşref Cem
- Athanasiu Lavinia
- Atkinson Elizabeth G
- Awasthi Swapnil
- Ayub Muhammad
- Azevedo Maria Helena
- Bacanu Silviu A
- Bass Nicholas J
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia Iole
- Belliveau Richard A
- Bene Judit
- Benner Christian
- Benyamin Beben
- Bergen Sarah E
- Bertolino Alessandro
- Bigdeli Tim B
- Black Donald W
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Braff David
- Bramon Elvira
- Braun Alice
- Bray Nicholas J
- Breen Gerome
- Bressan Rodrigo Affonseca
- Bromet Evelyn J
- Bruggeman Richard
- Bryois Julien
- Buccola Nancy G
- Buckley Peter F
- Buckner Randy L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William F
- Børglum Anders D
- Cahn Wiepke
- Cairns Murray J
- Calkins Monica E
- Campion Dominique
- Carr Vaughan J
- Castle David
- Catts Stanley V
- Cervilla Jorge A
- Chambert Kimberley D
- Chan Raymond CK
- Chaumette Boris
- Chen Chia-Yen
- Chen Wei J
- Cheng Wei
- Cheung Eric FC
- Chong Siow Ann
- Cichon Sven
- Cloninger C Robert
- Cohen David
- Collier David A
- Consoli Angèle
- Cordeiro Quirino
- Corvin Aiden
- Costas Javier
- Crespo-Facorro Benedicto
- Curtis Charles
- Curtis David
- Daly Mark J
- Davidson Michael
- Davis Kenneth L
- de Haan Lieuwe
- Degenhardt Franziska
- DeLisi Lynn E
- Demontis Ditte
- Dennison Charlotte A
- Dickerson Faith
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Duan Jubao
- Ducci Giuseppe
- Dudbridge Frank
- Ehrenreich Hannelore
- Eriksson Johan G
- Escott-Price Valentina
- Esko Tõnu
- Fanous Ayman H
- Faraone Stephen V
- Fañanás Lourdes
- Fiorentino Alessia
- Forstner Andreas
- Forti Marta Di
- Frank Josef
- Freedman Robert
- Frei Oleksandr
- Freimer Nelson B
- Fromer Menachem
- Frustaci Alessandra
- Gadelha Ary
- Galletly Cherrie
- Gandal Michael J
- Gareeva Anna
- Gawlik Micha
- Ge Tian
- Gejman Pablo V
- Gennarelli Massimo
- Genovese Giulio
- Gershon Elliot S
- Giannitelli Marianna
- Giegling Ina
- Gill Michael
- Giusti-Rodríguez Paola
- Glatt Stephen J
- Godard Stephanie
- Goldstein Jacqueline I
- Golimbet Vera
- González Peñas Javier
- González-Pinto Ana
- Gopal Srihari
- Gratten Jacob
- Green Michael F
- Greenwood Tiffany A
- Grove Jakob
- Guillin Olivier
- Gur Raquel E
- Gur Ruben C
- Gutiérrez Blanca
- Gülöksüz Sinan
- Hahn Eric
- Hakonarson Hakon
- Hall Lynsey S
- Haroutunian Vahram
- Hartmann Annette M
- Harvey Carol
- Harwood Janet C
- Hayward Caroline
- Henskens Frans A
- Herms Stefan
- Hoffmann Per
- Holmans Peter A
- Hong Kyung Sue
- Hougaard David M
- Howrigan Daniel P
- Huang Hailiang
- Hultman Christina M
- Hwu Hai-Gwo
- Hyman Steven E
- Ikeda Masashi
- Indonesia Schizophrenia Consortium
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen V
- Joa Inge
- Julià Antonio
- Jönsson Erik G
- Kahn René S
- Kam-Thong Tony
- Kamatani Yoichiro
- Karachanak-Yankova Sena
- Kebir Oussama
- Keller Matthew C
- Kelly Brian J
- Kendler Kenneth S
- Kennedy James L
- Khrunin Andrey
- Khusnutdinova Elza
- Kim Minsoo
- Kim Sung-Wan
- Kirov George
- Klovins Janis
- Knowles James A
- Kondratiev Nikolay
- Konte Bettina
- Koopmans Frank
- Kraft Julia
- Krebs Marie-Odile
- Kubo Michiaki
- Kusumawardhani Agung
- Kuzelova-Ptackova Hana
- Kučinskas Vaidutis
- Kučinskiene Zita Ausrele
- Kähler Anna K
- Lam Max
- Landi Stefano
- Laurent-Levinson Claudine
- Lazzeroni Laura C
- Lee Jimmy
- Lee Phil H
- Legge Sophie E
- Lehrer Douglas S
- Lencer Rebecca
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F
- Li Miaoxin
- Li Qingqin S
- Li Zhiqiang
- Lieberman Jeffrey
- Light Gregory A
- Limborska Svetlana
- Liu Chih-Min
- Liu Jianjun
- Loughland Carmel M
- Lubinski Jan
- Luykx Jurjen J
- Lynham Amy
- Lönnqvist Jouko
- Macek Milan
- Mackinnon Andrew
- Magnusson Patrik KE
- Magnusson Sigurdur
- Maher Brion S
- Maier Wolfgang
- Malaspina Dolores
- Malhotra Anil K
- Malhotra Dheeraj
- Mallet Jacques
- Marder Stephen R
- Marsal Sara
- Martin Alicia R
- Martorell Lourdes
- Mattheisen Manuel
- McCarley Robert W
- McCarroll Steven A
- McDonald Colm
- McGrath John J
- McIntosh Andrew
- McQuillin Andrew
- Medeiros Helena
- Meier Sandra
- Melegh Bela
- Melle Ingrid
- Menezes Paulo R
- Mesholam-Gately Raquelle I
- Metspalu Andres
- Michie Patricia T
- Milani Lili
- Milanova Vihra
- Mitjans Marina
- Molden Espen
- Molina Esther
- Molto María Dolores
- Mondelli Valeria
- Moran Jennifer L
- Moreno Carmen
- Morgan Vera A
- Morley Christopher P
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mowry Bryan J
- Muntané Gerard
- Murphy Kieran C
- Murray Robin M
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Neale Benjamin M
- Neil Amanda L
- Nenadić Igor
- Nestadt Gerald
- Nikitina-Zake Liene
- Nimgaonkar Vishwajit
- Nordentoft Merete
- Noto Cristiano
- Nuechterlein Keith H
- Nöthen Markus M
- O'Brien Niamh Louise
- O'Donovan Michael C
- O'Neill F Anthony
- Oh Sang-Yun
- Olincy Ann
- Ophoff Roel A
- Ota Vanessa Kiyomi
- Owen Michael J
- Paciga Sara A
- Palotie Aarno
- Panagiotaropoulou Georgia
- Pantelis Christos
- Papadimitriou George N
- Pardiñas Antonio F
- Parellada Mara
- Pato Carlos N
- Pato Michele T
- Paunio Tiina
- Pellegrino Renata
- Periyasamy Sathish
- Perkins Diana O
- Petryshen Tracey L
- Pfuhlmann Bruno
- Pietiläinen Olli
- Pimm Jonathan
- Pirinen Matti
- Pocklington Andrew J
- Porteous David
- Posthuma Danielle
- Powell John
- PsychENCODE
- Psychosis Endophenotypes International Consortium
- Pulver Ann E
- Qi Ting
- Qin Shengying
- Quattrone Diego
- Quested Digby
- Radant Allen D
- Rampino Antonio
- Rapaport Mark H
- Rautanen Anna
- Reichenberg Abraham
- Richards Alexander L
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Rivera Margarita
- Roe Cheryl
- Roffman Joshua L
- Roth Julian
- Rothermundt Matthias
- Roussos Panos
- Rujescu Dan
- Rutten Bart PF
- Saka Meram C
- Saker-Delye Safaa
- Salomaa Veikko
- Sanders Alan R
- Sanjuan Julio
- Santoro Marcos Leite
- Savitz Adam
- Schall Ulrich
- Schizophrenia Working Group of the Psychiatric Genomics Consorti
- Schulze Thomas G
- Schwab Sibylle G
- Scott Rodney J
- Seidman Larry J
- Serretti Alessandro
- Sham Pak C
- Sharp Sally Isabel
- Shi Jianxin
- Shi Yongyong
- Sidorenko Julia
- Siever Larry J
- Sigurdsson Engilbert
- Silverman Jeremy M
- Sim Kang
- Skarabis Nora
- Slominsky Petr
- Smoller Jordan W
- So Hon-Cheong
- Sobell Janet L
- St Clair David
- Stahl Eli A
- Stain Helen J
- Steen Nils Eiel
- Stefansson Kari
- Stefánsson Hreinn
- Steixner-Kumar Agnes A
- Stone William S
- Straub Richard E
- Streit Fabian
- Strengman Eric
- Stroup T Scott
- Stögmann Elisabeth
- Subramaniam Mythily
- Sugar Catherine A
- Sullivan Patrick F
- Suvisaari Jaana
- Svrakic Dragan M
- Swerdlow Neal R
- SynGO Consortium
- Szatkiewicz Jin P
- Söderman Erik
- Ta Thi Minh Tam
- Takahashi Atsushi
- Terao Chikashi
- Thibaut Florence
- Toncheva Draga
- Tooney Paul A
- Torretta Silvia
- Tosato Sarah
- Trubetskoy Vassily
- Tsuang Debby W
- Tsuang Ming T
- Tura Gian Battista
- Turetsky Bruce I
- Vaaler Arne
- van Amelsvoort Therese
- van Os Jim
- van Winkel Ruud
- Vassos Evangelos
- Vawter Marquis P
- Veijola Juha
- Verhage Matthijs
- Vilella Elisabet
- Visscher Peter M
- Voloudakis Georgios
- Waddington John
- Walter Henrik
- Walters James TR
- Wang Shi-Heng
- Watanabe Kyoko
- Waterreus Anna
- Webb Bradley T
- Weinberger Daniel R
- Weiser Mark
- Werge Thomas
- Wildenauer Dieter B
- Williams Nigel M
- Witt Stephanie H
- Wormley Brandon K
- Wray Naomi R
- Wu Jing Qin
- Wu Yang
- Xu Shuhua
- Xu Zhida
- Yang Jian
- Yolken Robert
- Yu Xin
- Yue Weihua
- Zai Clement C
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
- Üçok Alp
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Schizophrenia has a heritability of 60-80%(1), much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factorSP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Abyzov Alexej
- Achsel Tilmann
- Adams Mark
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agiananda Feranindhya
- Akbarian Schahram
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z.
- Alptekin Köksal
- Als Thomas D.
- Amin Farooq
- Amir Nurmiati
- Andreassen Ole A.
- Andres-Alonso Maria
- Antoni Ronald
- Arango Celso
- Arolt Volker
- Arranz Maria J.
- Arrojo Manuel
- Arsianti Tiana
- Ashley-Koch Allison
- Asmarahadi Asmarahadi
- Atbaşoğlu Eşref Cem
- Athanasiu Lavinia
- Atkinson Elizabeth G.
- Awasthi Swapnil
- Ayub Muhammad
- Azevedo Maria Helena
- Bacanu Silviu A.
- Bagni Claudia
- Bakker Steven
- Bass Nicholas J.
- Baune Bernhard T.
- Bayés Àlex
- Begemann Martin
- Belangero Sintia Iole
- Belliveau Richard A.
- Bender Stephan
- Bene Judit
- Benner Christian
- Benyamin Beben
- Bergen Sarah E.
- Bertolino Alessandro
- Biederer Thomas
- Bigdeli Tim B.
- Black Donald W.
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Braff David
- Bramon Elvira
- Bramon Elvira
- Braun Alice
- Bray Nicholas J.
- Breen Gerome
- Breen Michael
- Bressan Rodrigo Affonseca
- Bromet Evelyn J.
- Brose Nils
- Brown Miguel
- Brown Tyler C.
- Bruggeman Richard
- Bryois Julien
- Bryois Julien
- Buccola Nancy G.
- Buckley Peter F.
- Buckner Randy L.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byerley William F.
- Børglum Anders D.
- Cahn Wiepke
- Cairns Murray J.
- Calkins Monica E.
- Campion Dominique
- Carlyle Becky
- Carr Vaughan J.
- Castle David
- Catts Stanley V.
- Cervilla Jorge A.
- Chambert Kimberley D.
- Chan Raymond C. K.
- Charney Alex
- Chaumette Boris
- Chen Chia-Yen
- Chen Wei J.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Chua John Jia En
- Cichon Sven
- Cloninger C. Robert
- Coba Marcelo P.
- Coetzee Gerard
- Cohen David
- Collier David A.
- Collier David A.
- Consoli Angèle
- Cordeiro Quirino
- Cornelisse L. Niels
- Corvin Aiden
- Costas Javier
- Crawford Gregory
- Crepo-Facorro Benedicto
- Crespo-Facorro Benedicto
- Curtis Charles
- Curtis David
- Dai Nan
- Daly Mark J.
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- de Haan Lieuwe
- de Jong Arthur P. H.
- de Juan-Sanz Jaime
- Degenhardt Franziska
- DeLisi Lynn E.
- Demontis Ditte
- Dennison Charlotte A.
- Diatri H.
- Dickerson Faith
- Dieterich Daniela C.
- Dikeos Dimitris
- Dinan Timothy
- Djatmiko Prianto
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Dracheva Stella
- Duan Jubao
- Ducci Giuseppe
- Dudbridge Frank
- Ehrenreich Hannelore
- Emani Prashant
- Eriksson Johan G.
- Escott-Price Valentina
- Esko Tõnu
- Eunjoon Kim
- Evalina None
- Fanous Ayman H.
- Faraone Stephen V.
- Farnham Peggy
- Fañanás Lourdes
- Feng Guoping
- Fiorentino Alessia
- Forstner Andreas
- Forti Marta Di
- Frank Josef
- Freedman Robert
- Frei Oleksandr
- Freimer Nelson B.
- Fromer Menachem
- Fromer Menachem
- Frustaci Alessandra
- Gadelha Ary
- Galeev Timur
- Galletly Cherrie
- Gandal Michael J.
- Gandal Mike
- Gareeva Anna
- Gareeva Anna
- Gawlik Micha
- Ge Tian
- Gejman Pablo V.
- Gennarelli Massimo
- Genovese Giulio
- Gershon Elliot S.
- Gerstein Mark
- Giannitelli Marianna
- Giase Gina
- Giegling Ina
- Gill Michael
- Girdhar Kiran
- Giusti-Rodríguez Paola
- Glatt Stephen J.
- Godard Stephanie
- Goes Fernando
- Goldschmidt Hana L.
- Goldstein Jacqueline I.
- Golimbet Vera
- González Peñas Javier
- González-Pinto Ana
- Gopal Srihari
- Gratten Jacob
- Green Michael F.
- Greenwood Tiffany A.
- Grennan Kay
- Grove Jakob
- Gu Mengting
- Guerra Brittney
- Guillin Olivier
- Gundelfinger Eckart D.
- Gur Raquel E.
- Gur Ruben C.
- Gursoy Gamze
- Gutiérrez Blanca
- Gülöksüz Sinan
- Hahn Eric
- Hakonarson Hakon
- Hall Jeremy
- Hall Lynsey S.
- Hananto A. J.
- Haroutunian Vahram
- Hartmann Annette M.
- Harvey Carol
- Harwood Janet C.
- Hayward Caroline
- Henskens Frans A.
- Henuhili Supiyani
- Herms Stefan
- Hoffman Gabriel
- Hoffmann Per
- Holmans Peter A.
- Hong Kyung Sue
- Hoogenraad Casper
- Hougaard David M.
- Howrigan Daniel P.
- Huang Hailiang
- Huganir Richard L.
- Hultman Christina M.
- Hwa Jin Jung
- Hwu Hai-Gwo
- Hyde Thomas
- Hyman Steven E.
- Hyman Steven E.
- Ikeda Masashi
- Imig Cordelia
- Irmansyah Irmansyah
- Ismoyo Joni H.
- Iwata Nakao
- Iyegbe Conrad
- Iyegbe Conrad
- Jablensky Assen V.
- Jaffe Andrew
- Jahn Reinhard
- Jiang Shan
- Jiang Yan
- Joa Inge
- Julià Antonio
- Jönsson Erik G.
- Kaeser Pascal S.
- Kahn René
- Kahn René S.
- Kam-Thong Tony
- Kamatani Yoichiro
- Karachanak-Yankova Sena
- Kebir Oussama
- Kefi Amira
- Keller Matthew C.
- Kelly Brian J.
- Kendler Kenneth S.
- Kennedy James L.
- Khalimah Siti
- Khrunin Andrey
- Khusnutdinova Elza
- Kim Minsoo
- Kim Sung-Wan
- Kim Yunjung
- Kirov George
- Kitchen Robert
- Klovins Janis
- Knowles James A.
- Knowles James A.
- Kondratiev Nikolay
- Konte Bettina
- Koopmans Frank
- Koopmans Frank
- Kraft Julia
- Krebs Marie-Odile
- Kreutz Michael R.
- Kubo Michiaki
- Kusumadewi Irmia
- Kusumaningrum Profitasari
- Kusumawardhani Agung
- Kuzelova-Ptackova Hana
- Kučinskas Vaidutis
- Kučinskiene Zita Ausrele
- Kähler Anna K.
- Lam Max
- Landi Stefano
- Laurent-Levinson Claudine
- Lawrie Stephen
- Lay Fides
- Lazzeroni Laura C.
- Lee Donghoon
- Lee Jimmy
- Lee Phil H.
- Legge Sophie E.
- Lehrer Douglas S.
- Lencer Rebecca
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Lewis Cathryn
- Li Miaoxin
- Li Mingfeng
- Li Qingqin S.
- Li Zhiqiang
- Lieberman Jeffrey
- Light Gregory A.
- Limborska Svetlana
- Lin Kuang
- Linszen Don H.
- Lipstein Noa
- Liu Chih-Min
- Liu Chunyu
- Liu Jianjun
- Liu Shuang
- Loughland Carmel M.
- Lubinski Jan
- Lukman Petrin R.
- Luykx Jurjen J.
- Lynham Amy
- Lönnqvist Jouko
- Macek Milan
- MacGillavry Harold D.
- Mackinnon Andrew
- Magnusson Patrik K. E.
- Magnusson Sigurdur
- Maher Brion S.
- Maier Wolfgang
- Malaspina Dolores
- Malenka Robert
- Malhotra Anil K.
- Malhotra Dheeraj
- Mallet Jacques
- Marder Stephen R.
- Marini T. M.
- Marsal Sara
- Martin Alicia R.
- Martorell Lourdes
- Mata Ignacio
- Mattei Eugenio
- Mattheisen Manuel
- McCarley Robert W.
- McCarroll Steven A.
- McDonald Colm
- McGrath John J.
- McIntosh Andrew
- McIntosh Andrew
- McPherson Peter S.
- McQuillin Andrew
- Medeiros Helena
- Meier Sandra
- Melegh Bela
- Melle Ingrid
- Menezes Paulo R.
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mitjans Marina
- Molden Espen
- Molina Esther
- Molto María Dolores
- Mondelli Valeria
- Moran Jennifer L.
- Moreno Carmen
- Morgan Vera A.
- Morley Christopher P.
- Morris Derek W.
- Mors Ole
- Mortensen Preben B.
- Mowry Bryan J.
- Muntané Gerard
- Murphy Kieran C.
- Murray Robin M.
- Murray Robin M.
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Nasrun Martina W.
- Navarro Fabio
- Neale Benjamin M.
- Neil Amanda L.
- Nenadić Igor
- Nestadt Gerald
- Nikitina-Zake Liene
- Nimgaonkar Vishwajit
- Nordentoft Merete
- Noto Cristiano
- Nuechterlein Keith H.
- Nöthen Markus M.
- Oh Sang-Yun
- Olincy Ann
- Ophoff Roel A.
- Ophoff Roel A.
- Ota Vanessa Kiyomi
- Owen Michael J.
- O’Brien Niamh Louise
- O’Connor Vincent
- O’Donovan Michael C.
- O’Neill F. Anthony
- Paciga Sara A.
- Palotie Aarno
- Pan Xinghua
- Panagiotaropoulou Georgia
- Pantelis Christos
- Papadimitriou George N.
- Pardiñas Antonio F.
- Parellada Mara
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pellegrino Renata
- Periyasamy Sathish
- Perkins Diana O.
- Peters Mette A.
- Petryshen Tracey L.
- Pfuhlmann Bruno
- Pielot Rainer
- Pietiläinen Olli
- Pimm Jonathan
- Pinto Dalila
- Pirinen Matti
- Pochareddy Sirisha
- Pocklington Andrew J.
- Polioudakis Damon
- Porteous David
- Posthuma Danielle
- Powell John
- Powell John
- Prasetyawan Prasetyawan
- Pratt Henry
- Pulver Ann E.
- Purcaro Michael
- Purcell Shaun
- Qi Ting
- Qin Shengying
- Quattrone Diego
- Quested Digby
- Radant Allen D.
- Rampino Antonio
- Rapaport Mark H.
- Rautanen Anna
- Reddy Tim
- Reichenberg Abraham
- Reza Muhammad
- Rhie Suhn
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Rivera Margarita
- Roe Cheryl
- Roffman Joshua L.
- Roth Julian
- Rothermundt Matthias
- Roussos Panagiotis
- Roussos Panos
- Rozowsky Joel
- Rujescu Dan
- Rujescu Dan
- Rutten Bart P. F.
- Ryan Timothy A.
- Safyuni N. S.
- Sahasrabudhe Dnyanada
- Saka Meram C.
- Saker-Delye Safaa
- Sala Carlo
- Salomaa Veikko
- Sanders Alan R.
- Sanders Stephan
- Sanjuan Julio
- Santoro Marcos Leite
- Savitz Adam
- Schall Ulrich
- Schulze Thomas G.
- Schwab Sibylle G.
- Scott Rodney J.
- Seidman Larry J.
- Semen G.
- Serretti Alessandro
- Sestan Nenad
- Sethi Anurag
- Sham Pak C.
- Sham Pak C.
- Sharp Sally Isabel
- Sheng Morgan
- Shi Jianxin
- Shi Xu
- Shi Yongyong
- Shi Yongyong
- Shieh Annie
- Sidorenko Julia
- Siever Larry J.
- Sigurdsson Engilbert
- Silverman Jeremy M.
- Sim Kang
- Siste Kristiana
- Skarabis Nora
- Slominsky Petr
- Smalla Karl-Heinz
- Smit August B.
- Smoller Jordan W.
- So Hon-Cheong
- Sobell Janet L.
- St Clair David
- St Clair David
- Stahl Eli A.
- Stain Helen J.
- Steen Nils Eiel
- Stefansson Kari
- Stefánsson Hreinn
- Steixner-Kumar Agnes A.
- Stone William S.
- Straub Richard E.
- Streit Fabian
- Strengman Eric
- Stroup T. Scott
- Stögmann Elisabeth
- Subramaniam Mythily
- Sugar Catherine A.
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Swarup Vivek
- Swerdlow Neal R.
- Szatkiewicz Jin P.
- Szekely Anna
- Söderman Erik
- Südhof Thomas C.
- Ta Thi Minh Tam
- Takahashi Atsushi
- Terao Chikashi
- Thibaut Florence
- Thomas Paul D.
- Tobing Heriani
- Toncheva Draga
- Toonen Ruud F.
- Tooney Paul A.
- Torretta Silvia
- Tosato Sarah
- Trubetskoy Vassily
- Tsuang Debby W.
- Tsuang Ming T.
- Tura Gian Battista
- Turetsky Bruce I.
- Vaaler Arne
- van Amelsvoort Therese
- van Amelsvoort Therese
- van Bakel Harm
- van Os Jim
- van Os Jim
- van Os Jim
- van Weering Jan R. T.
- van Winkel Ruud
- van Winkel Ruud
- Vassos Evangelos
- Vawter Marquis P.
- Veijola Juha
- Verhage Matthijs
- Verhage Matthijs
- Verpelli Chiara
- Vilella Elisabet
- Visscher Peter M.
- Voloudakis Georgios
- Waddington John
- Walshe Muriel
- Walter Henrik
- Walters James T. R.
- Wang Daifeng
- Wang Shi-Heng
- Warrell Jonathan
- Watanabe Kyoko
- Waterreus Anna
- Webb Bradley T.
- Weinberger Daniel R.
- Weisbrod Matthias
- Weiser Mark
- Weissman Sherman
- Weng Zhiping
- Wenwen Qin
- Werge Thomas
- White Kevin
- Widiasih Natalia
- Wiguna Tjhin
- Wildenauer D. B.
- Wildenauer Dieter B.
- Williams Nigel M.
- Wiseman Jennifer
- Witt Heather
- Witt Stephanie H.
- Won Hyejung
- Wood Shannon
- Wormley Brandon K.
- Wray Naomi R.
- Wu Feinan
- Wu Jing Qin
- Wu Yang
- Wulandari D.
- Xu Shuhua
- Xu Xuming
- Xu Zhida
- Yang Jian
- Yao Lijing
- Yolken Robert
- Yu Xin
- Yue Weihua
- Yusnadewi Suzy
- Zai Clement C.
- Zandi Peter
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
- Üçok Alp
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.11Nsciescopu
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Abyzov Alexej
- Achsel Tilmann
- Adams Mark
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agiananda Feranindhya
- Akbarian Schahram
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z.
- Alptekin Köksal
- Als Thomas D.
- Amin Farooq
- Amir Nurmiati
- Andreassen Ole A.
- Andres-Alonso Maria
- Antoni Ronald
- Arango Celso
- Arolt Volker
- Arranz Maria J.
- Arrojo Manuel
- Arsianti Tiana
- Ashley-Koch Allison
- Asmarahadi Asmarahadi
- Atbaşoğlu Eşref Cem
- Athanasiu Lavinia
- Atkinson Elizabeth G.
- Awasthi Swapnil
- Ayub Muhammad
- Azevedo Maria Helena
- Bacanu Silviu A.
- Bagni Claudia
- Bakker Steven
- Bass Nicholas J.
- Baune Bernhard T.
- Bayés Àlex
- Begemann Martin
- Belangero Sintia Iole
- Belliveau Richard A.
- Bender Stephan
- Bene Judit
- Benner Christian
- Benyamin Beben
- Bergen Sarah E.
- Bertolino Alessandro
- Biederer Thomas
- Bigdeli Tim B.
- Black Donald W.
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Braff David
- Bramon Elvira
- Bramon Elvira
- Braun Alice
- Bray Nicholas J.
- Breen Gerome
- Breen Michael
- Bressan Rodrigo Affonseca
- Bromet Evelyn J.
- Brose Nils
- Brown Miguel
- Brown Tyler C.
- Bruggeman Richard
- Bryois Julien
- Bryois Julien
- Buccola Nancy G.
- Buckley Peter F.
- Buckner Randy L.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byerley William F.
- Børglum Anders D.
- Cahn Wiepke
- Cairns Murray J.
- Calkins Monica E.
- Campion Dominique
- Carlyle Becky
- Carr Vaughan J.
- Castle David
- Catts Stanley V.
- Cervilla Jorge A.
- Chambert Kimberley D.
- Chan Raymond C. K.
- Charney Alex
- Chaumette Boris
- Chen Chia-Yen
- Chen Wei J.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Chua John Jia En
- Cichon Sven
- Cloninger C. Robert
- Coba Marcelo P.
- Coetzee Gerard
- Cohen David
- Collier David A.
- Collier David A.
- Consoli Angèle
- Cordeiro Quirino
- Cornelisse L. Niels
- Corvin Aiden
- Costas Javier
- Crawford Gregory
- Crepo-Facorro Benedicto
- Crespo-Facorro Benedicto
- Curtis Charles
- Curtis David
- Dai Nan
- Daly Mark J.
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- de Haan Lieuwe
- de Jong Arthur P. H.
- de Juan-Sanz Jaime
- Degenhardt Franziska
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- Kusumadewi Irmia
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- Vaaler Arne
- van Amelsvoort Therese
- van Amelsvoort Therese
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- van Weering Jan R. T.
- van Winkel Ruud
- van Winkel Ruud
- Vassos Evangelos
- Vawter Marquis P.
- Veijola Juha
- Verhage Matthijs
- Verhage Matthijs
- Verpelli Chiara
- Vilella Elisabet
- Visscher Peter M.
- Voloudakis Georgios
- Waddington John
- Walshe Muriel
- Walter Henrik
- Walters James T. R.
- Wang Daifeng
- Wang Shi-Heng
- Warrell Jonathan
- Watanabe Kyoko
- Waterreus Anna
- Webb Bradley T.
- Weinberger Daniel R.
- Weisbrod Matthias
- Weiser Mark
- Weissman Sherman
- Weng Zhiping
- Wenwen Qin
- Werge Thomas
- White Kevin
- Widiasih Natalia
- Wiguna Tjhin
- Wildenauer D. B.
- Wildenauer Dieter B.
- Williams Nigel M.
- Wiseman Jennifer
- Witt Heather
- Witt Stephanie H.
- Won Hyejung
- Wood Shannon
- Wormley Brandon K.
- Wray Naomi R.
- Wu Feinan
- Wu Jing Qin
- Wu Yang
- Wulandari D.
- Xu Shuhua
- Xu Xuming
- Xu Zhida
- Yang Jian
- Yao Lijing
- Yolken Robert
- Yu Xin
- Yue Weihua
- Yusnadewi Suzy
- Zai Clement C.
- Zandi Peter
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
- Üçok Alp
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Aarno Palotie (41342)
- Abraham Reichenberg (111006)
- Adam Savitz (2816050)
- Agnes A Steixner-Kumar (12556900)
- Agung Kusumawardhani (12556765)
- Aiden Corvin (221286)
- Alan R Sanders (12557083)
- Alessandra Frustaci (627712)
- Alessandro Bertolino (252850)
- Alessandro Serretti (127197)
- Alessia Fiorentino (337442)
- Alexander L Richards (12556639)
- Alice Braun (12464946)
- Alicia R Martin (12556807)
- Allen D Radant (12556855)
- Alp Ucok (12556933)
- Amanda L Neil (11362707)
- Amy Lynham (12556798)
- Ana Gonzalez-Pinto (3555599)
- Anders D Borglum (12557008)
- Andreas Forstner (8440308)
- Andres Metspalu (61760)
- Andrew J Pocklington (12557104)
- Andrew Mackinnon (194271)
- Andrew McIntosh (83234)
- Andrew McQuillin (82209)
- Andrey Khrunin (264236)
- Angele Consoli (12556699)
- Anil K Malhotra (8536308)
- Ann E Pulver (12556987)
- Ann Olincy (521692)
- Anna Gareeva (12557023)
- Anna K Kahler (12556750)
- Anna Rautanen (246408)
- Anna Waterreus (499361)
- Annette M Hartmann (12556741)
- Antonio F Pardinas (12556618)
- Antonio Julia (7437728)
- Antonio Rampino (562822)
- Arne Vaaler (525065)
- Ary Gadelha (291025)
- Assen Jablensky (176467)
- Atsushi Takahashi (128295)
- Ayman H Fanous (12557020)
- Bart PF Rutten (10260760)
- Beben Benyamin (75571)
- Behrooz Z Alizadeh (12556651)
- Bela Melegh (3999857)
- Benedicto Crespo-Facorro (757227)
- Benjamin M Neale (3809995)
- Bernard Lerer (188298)
- Bernhard T Baune (6568502)
- Bertram Muller-Myhsok (12556978)
- Bettina Konte (511722)
- Blanca Gutierrez (560875)
- Boris Chaumette (3924791)
- Bradley T Webb (12556936)
- Brandon K Wormley (12556945)
- Brian J Kelly (12556756)
- Brien P Riley (12557074)
- Brion S Maher (12556801)
- Bruce Turetsky (521701)
- Bruno Pfuhlmann (12556852)
- Bryan J Mowry (12557062)
- C Robert Cloninger (12556963)
- Carlos N Pato (12557071)
- Carmel M Loughland (12556795)
- Carmen Moreno (76007)
- Carol Harvey (9410305)
- Caroline Hayward (149856)
- Catherine A Sugar (12556912)
- Celso Arango (2937681)
- Charles Curtis (4634179)
- Charlotte A Dennison (12556627)
- Cherrie Galletly (4444402)
- Cheryl Roe (12556861)
- Chia-Yen Chen (489003)
- Chih-Min Liu (173117)
- Chikashi Terao (137128)
- Christian Benner (775884)
- Christina M Hultman (12557032)
- Christopher P Morley (12556822)
- Christos Pantelis (272264)
- Claudine Laurent-Levinson (12557047)
- Clement C Zai (3351386)
- Colm McDonald (12556813)
- Conrad Iyegbe (3129249)
- Cristiano Noto (519130)
- Dan Rujescu (109427)
- Daniel P Howrigan (12556747)
- Daniel R Weinberger (12557095)
- Danielle Posthuma (237783)
- David A Collier (12557017)
- David Braff (521682)
- David Castle (796181)
- David Cohen (133780)
- David Curtis (82224)
- David M Hougaard (12556969)
- David Porteous (150029)
- David St Clair (77620)
- Debby W Tsuang (12557002)
- Derek W Morris (12557059)
- Dheeraj Malhotra (246403)
- Diana O Perkins (12556849)
- Diego Quattrone (9960317)
- Dieter B Wildenauer (12557098)
- Digby Quested (82223)
- Dimitris Dikeos (665137)
- Ditte Demontis (469970)
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- Erik Soderman (12556894)
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- Espen Molden (3902095)
- Esther Molina (12556816)
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- F Anthony O'Neill (12556837)
- Fabian Streit (3720028)
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- Farooq Amin (12556660)
- Feng Zhu (685)
- Florence Thibaut (6174902)
- Frank Dudbridge (102283)
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- Franziska Degenhardt (429524)
- Fritz Zimprich (12362)
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- Gregory A Light (12556789)
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- Helen J Stain (12556897)
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- Javier Costas (232327)
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- Jeffrey Lieberman (12556786)
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- Jeremy M Silverman (12556993)
- Jian Yang (12136)
- Jian Zeng (182624)
- Jianjun Liu (28194)
- Jianxin Shi (90453)
- Jim van Os (114336)
- Jimmy Lee (446122)
- Jin P Szatkiewicz (12556921)
- Jing Qin Wu (7874423)
- Johan G Eriksson (4683706)
- John J McGrath (8674098)
- John Powell (237327)
- John Waddington (2903360)
- Jonas Bybjerg-Grauholm (2614411)
- Jonathan Pimm (82214)
- Jordan W Smoller (12556996)
- Jorge A Cervilla (12557014)
- Josef Frank (378047)
- Joseph D Buxbaum (12557011)
- Joshua L Roffman (12556864)
- Jouko Lonnqvist (12556792)
- Jubao Duan (802555)
- Judit Bene (725901)
- Juha Veijola (150307)
- Julia Kraft (12464949)
- Julia Sidorenko (3694489)
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- Julio Bobes (4247548)
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- Jurjen J Luykx (8536323)
- Kang Sim (335914)
- Kari Stefansson (26484)
- Keith H Nuechterlein (12556831)
- Kenneth L Davis (12556702)
- Kenneth S Kendler (12557110)
- Kieran C Murphy (12556828)
- Kimberley D Chambert (12556690)
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- Ole A Andreassen (5243117)
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- Publication venue
- Publication date
- 08/04/2022
- Field of study
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies
1997 Amerasia Journal
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- Abueg Francis R
- Adachi Nobuhiro
- Alba Richard D
- Alexander
- Alexander Meena
- Ali Mehmed
- Aliani Ayesha
- Allen James P
- Allen James P
- Allibhai Gulshan
- Almeida Rhea
- Almendraia Laarni C
- Amerman Stephen Kent
- Ang Len
- Aquilar D.
- Archibold Randal C
- Archibold Randal C
- Asian Pacific American
- Astin Helen S
- Ayuyang Rachelle Q
- Babich Phillip
- Bacho Peter
- Bacon Jean Leslie
- Bahri
- Bahri Deepika
- Baird V.
- Bankston
- Bankston C. L.
- Bankston Carl L
- Bankston Carl L
- Bannerji Himanji
- Baron G. Deborah G.
- Barrett Giles A
- Barrett James R
- Batayola Maria
- Bates Timothy
- Beem K. J.
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- Bemak Fred
- Bemak Fred
- Bermejo
- Berson Misha
- Berthelsen Christian
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- Bizzini Silva Caporale
- Bjorck J. P.
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- Bonzon Teodulo Cruz
- Booth Alan
- Bracero William
- Brah A.
- Braun K. L.
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- Braun Kathryn
- Brock R. N.
- Brown K.
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- Buchholdt Thelma
- Buriel Raymond
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- Cabrera Yvette
- Cage Mary Crystal
- Cahill Peter
- Cameron M.
- Carbo Nick
- Carolyn
- Castro Rafaela Castro
- Catolico Olivia
- Cha Dia
- Chai Arlene J
- Chan Connie
- Chan Sharon
- Chan Sucheng
- Chang Hsiao-Hung
- Chang Juliana
- Chang Juliana
- Chang Leonard
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- Chao Patricia
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- Chemerinsky Erwin
- Chen Chiung Hwang
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- Wong Nellie
- Wong Steve
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- Woodland Hills California
- Woods L. Shelton.
- Woods Ruth Dial
- Wright Richard A
- Wrobleski David Eugene
- Wrynn Alison M
- Wu
- Wu Cheryl
- Xiaojing Zhou
- Xin K. R.
- Xinyang Wang
- Xu G.
- Xu Wu
- Yamamoto Eric K
- Yang Belle
- Yang Haiou
- Yang Hyunah
- Yang Jeff
- Yatabe Suzie
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- Yeh C. J.
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- Yew Chay
- Ying Yu-Wen
- Yip Alethea
- Yip Alethea
- Yip Alethea
- Yogi Stan
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- Yoo David
- Yoo David
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- Publication venue
- 'UCLA American Indian Studies Center'
- Publication date
- Field of study
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- A-Ptackova Hana Kuzelov
- Adams Mark
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z.
- Alptekin Koksal
- Als Thomas D.
- Amin Farooq
- Andreassen Ole A.
- Arango Celso
- Arolt Volker
- Arrojo Manuel
- Athanasiu Lavinia
- Atkinson Elizabeth G.
- Awasthi Swapnil
- Ayub Muhammad
- Azevedo Maria Helena
- Bacanu Silviu A.
- Bass Nicholas J.
- Baune Bernhard T.
- Begemann Martin
- Belangero Sintia Iole
- Belliveau Richard A.
- Bene Judit
- Benner Christian
- Benyamin Beben
- Bergen Sarah E.
- Bertolino Alessandro
- Bigdeli Tim B.
- Black Donald W.
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Borglum Anders D.
- Braff David
- Bramon Elvira
- Braun Alice
- Bray Nicholas J.
- Breen Gerome
- Bressan Rodrigo Affonseca
- Bromet Evelyn J.
- Bruggeman Richard
- Bryois Julien
- Buccola Nancy G.
- Buckley Peter F.
- Buckner Randy L.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byerley William F.
- Cahn Wiepke
- Cairns Murray J.
- Calkins Monica E.
- Campion Dominique
- Carr Vaughan J.
- Castle David
- Catts Stanley, V
- Cervilla Jorge A.
- Chambert Kimberley D.
- Chan Raymond C. K.
- Chaumette Boris
- Chen Chia-Yen
- Chen Wei J.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Cichon Sven
- Cloninger C. Robert
- Cohen David
- Collier David A.
- Consoli Angele
- Cordeiro Quirino
- Corvin Aiden
- Costas Javier
- Crespo-Facorro Benedicto
- Curtis Charles
- Curtis David
- Daly Mark J.
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- Degenhardt Franziska
- DeLisi Lynn E.
- Demontis Ditte
- Dennison Charlotte A.
- Di Forti Marta
- Dickerson Faith
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Duan Jubao
- Ducci Giuseppe
- Dudbridge Frank
- Ehrenreich Hannelore
- Eriksson Johan G.
- Escott-Price Valentina
- Esko Tonu
- Fananas Lourdes
- Fanous Ayman H.
- Faraone Stephen, V
- Fiorentino Alessia
- Forstner Andreas
- Frank Josef
- Freedman Robert
- Frei Oleksandr
- Freimer Nelson B.
- Fromer Menachem
- Frustaci Alessandra
- Gadelha Ary
- Galletly Cherrie
- Gandal Michael J.
- Gareeva Anna
- Gawlik Micha
- Ge Tian
- Gejman Pablo, V
- Gennarelli Massimo
- Genovese Giulio
- Gershon Elliot S.
- Giannitelli Marianna
- Giegling Ina
- Gill Michael
- Giusti-Rodriguez Paola
- Glatt Stephen J.
- Godard Stephanie
- Goldstein Jacqueline, I
- Golimbet Vera
- Gonzalez-Pinto Ana
- Gopal Srihari
- Gratten Jacob
- Green Michael F.
- Greenwood Tiffany A.
- Grove Jakob
- Guillin Olivier
- Guloksuz Sinan
- Gur Raquel E.
- Gur Ruben C.
- Gutierrez Blanca
- Hahn Eric
- Hakonarson Hakon
- Hall Lynsey S.
- Haroutunian Vahram
- Hartmann Annette M.
- Harvey Carol
- Harwood Janet C.
- Hayward Caroline
- Henskens Frans A.
- Herms Stefan
- Hoffmann Per
- Holmans Peter A.
- Hong Kyung Sue
- Hougaard David M.
- Howrigan Daniel P.
- Huang Hailiang
- Hultman Christina M.
- Hwu Hai-Gwo
- Hyman Steven E.
- Ikeda Masashi
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen, V
- Joa Inge
- Jonsson Erik G.
- Julia Antonio
- Kahler Anna K.
- Kahn Rene S.
- Kam-Thong Tony
- Kamatani Yoichiro
- Karachanak-Yankova Sena
- Kebir Oussama
- Keller Matthew C.
- Kelly Brian J.
- Kendler Kenneth S.
- Kennedy James L.
- Khrunin Andrey
- Khusnutdinova Elza
- Kim Minsoo
- Kim Sung-Wan
- Kirov George
- Klovins Janis
- Knowles James A.
- Kondratiev Nikolay
- Konte Bettina
- Koopmans Frank
- Kraft Julia
- Krebs Marie-Odile
- Kubo Michiaki
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kusumawardhani Agung
- Lam Max
- Landi Stefano
- Laurent-Levinson Claudine
- Lazzeroni Laura C.
- Lee Jimmy
- Lee Phil H.
- Legge Sophie E.
- Lehrer Douglas S.
- Lencer Rebecca
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Li Miaoxin
- Li Qingqin S.
- Li Zhiqiang
- Lieberman Jeffrey
- Light Gregory A.
- Limborska Svetlana
- Liu Chih-Min
- Liu Jianjun
- Lonnqvist Jouko
- Loughland Carmel M.
- Lubinski Jan
- Luykx Jurjen J.
- Lynham Amy
- Macek Milan, Jr.
- Mackinnon Andrew
- Magnusson Patrik K. E.
- Magnusson Sigurdur
- Maher Brion S.
- Maier Wolfgang
- Malaspina Dolores
- Malhotra Anil K.
- Malhotra Dheeraj
- Mallet Jacques
- Marder Stephen R.
- Marsal Sara
- Martin Alicia R.
- Martorell Lourdes
- Mattheisen Manuel
- McCarley Robert W.
- McCarroll Steven A.
- McDonald Colm
- McGrath John J.
- McIntosh Andrew
- McQuillin Andrew
- Medeiros Helena
- Meier Sandra
- Melegh Bela
- Melle Ingrid
- Menezes Paulo R.
- Mesholam-Gately Raquelle, I
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mitjans Marina
- Molden Espen
- Molina Esther
- Molto Maria Dolores
- Mondelli Valeria
- Moran Jennifer L.
- Moreno Carmen
- Morgan Vera A.
- Morley Christopher P.
- Morris Derek W.
- Mors Ole
- Mortensen Preben B.
- Mowry Bryan J.
- Muller-Myhsok Bertram
- Muntane Gerard
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Neale Benjamin M.
- Neil Amanda L.
- Nenadic Igor
- Nestadt Gerald
- Nikitina-Zake Liene
- Nimgaonkar Vishwajit
- Nordentoft Merete
- Nothen Markus M.
- Noto Cristiano
- Nuechterlein Keith H.
- O'Brien Niamh Louise
- O'Donovan Michael C.
- O'Neill F. Anthony
- Oh Sang-Yun
- Olincy Ann
- Ophoff Roel A.
- Ota Vanessa Kiyomi
- Owen Michael J.
- Paciga Sara A.
- Palotie Aarno
- Panagiotaropoulou Georgia
- Pantelis Christos
- Papadimitriou George N.
- Pardinas Antonio F.
- Parellada Mara
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pellegrino Renata
- Penas Javier Gonzalez
- Periyasamy Sathish
- Perkins Diana O.
- Petryshen Tracey L.
- Pfuhlmann Bruno
- Pietilainen Olli
- Pimm Jonathan
- Pirinen Matti
- Pocklington Andrew J.
- Porteous David
- Posthuma Danielle
- Powell John
- Pulver Ann E.
- Qi Ting
- Qin Shengying
- Quattrone Diego
- Quested Digby
- Radant Allen D.
- Rampino Antonio
- Rapaport Mark H.
- Rautanen Anna
- Reichenberg Abraham
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Rivera Margarita
- Roe Cheryl
- Roffman Joshua L.
- Roth Julian
- Rothermundt Matthias
- Roussos Panos
- Rujescu Dan
- Rutten Bart P. F.
- Saka Meram C.
- Saker-Delye Safaa
- Salomaa Veikko
- Sanders Alan R.
- Sanjuan Julio
- Santoro Marcos Leite
- Savitz Adam
- Schall Ulrich
- Schulze Thomas G.
- Schwab Sibylle G.
- Scott Rodney J.
- Seidman Larry J.
- Serretti Alessandro
- Sham Pak C.
- Sharp Sally Isabel
- Shi Jianxin
- Shi Yongyong
- Sidorenko Julia
- Siever Larry J.
- Sigurdsson Engilbert
- Silverman Jeremy M.
- Sim Kang
- Skarabis Nora
- Slominsky Petr
- Smoller Jordan W.
- So Hon-Cheong
- Sobell Janet L.
- Soderman Erik
- St Clair David
- Stahl Eli A.
- Stain Helen J.
- Steen Nils Eiel
- Stefansson Hreinn
- Stefansson Kari
- Steixner-Kumar Agnes A.
- Stogmann Elisabeth
- Stone William S.
- Straub Richard E.
- Streit Fabian
- Strengman Eric
- Stroup T. Scott
- Subramaniam Mythily
- Sugar Catherine A.
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Swerdlow Neal R.
- Szatkiewicz Jin P.
- Takahashi Atsushi
- Terao Chikashi
- Thi Minh Tam Ta
- Thibaut Florence
- Toncheva Draga
- Tooney Paul A.
- Torretta Silvia
- Tosato Sarah
- Trubetskoy Vassily
- Tsuang Debby W.
- Tsuang Ming T.
- Tura Gian Battista
- Turetsky Bruce, I
- Ucok Alp
- Vaaler Arne
- van Amelsvoort Therese
- van Os Jim
- van Winkel Ruud
- Vassos Evangelos
- Vawter Marquis P.
- Veijola Juha
- Verhage Matthijs
- Vilella Elisabet
- Visscher Peter M.
- Voloudakis Georgios
- Waddington John
- Walter Henrik
- Walters James T. R.
- Wang Shi-Heng
- Watanabe Kyoko
- Waterreus Anna
- Webb Bradley T.
- Weinberger Daniel R.
- Weiser Mark
- Werge Thomas
- Wildenauer Dieter B.
- Williams Nigel M.
- Witt Stephanie H.
- Wormley Brandon K.
- Wray Naomi R.
- Wu Jing Qin
- Wu Yang
- Xu Shuhua
- Xu Zhida
- Yang Jian
- Yolken Robert
- Yu Xin
- Yue Weihua
- Zai Clement C.
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
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- 'Springer Science and Business Media LLC'
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