Faculty Formation in the Jesuit and Mercy Traditions

Mentorship plays a major role in engaging faculty and supporting their development and growth within an academic institution. In order to support new faculty members’ success and belonging, the host institution piloted the Faculty Formation Program during the 2022-2023 academic year. The foundation of this mentorship program is based on Jesuit and Mercy values that align with the mission of the university. The program has engaged new and seasoned faculty in shared conversations about their roles as faculty members and their place in Jesuit and Mercy higher education. This paper articulates the foundation and characteristics of high-impact mentorship and describes how a mission-centered mentoring program was implemented at the host institution, along with lessons learned and future program enhancements. The paper also offers faculty members’ reflections on their relationship to Catholic higher education and how working in a Jesuit and Mercy institution informs their roles as faculty. The Faculty Formation Program can be adapted by other mission-focused institutions as a tool for faculty development and retention

Xenoestrogen-Induced ERK-1 and ERK-2 Activation via Multiple Membrane-Initiated Signaling Pathways

Xenoestrogens can mimic or antagonize the activity of physiological estrogens, and the suggested mechanism of xenoestrogen action involves binding to estrogen receptors (ERs). However, the failure of various in vitro or in vivo assays to show strong genomic activity of xenoestrogens compared with estradiol (E(2)) makes it difficult to explain their ability to cause abnormalities in animal (and perhaps human) reproductive functions via this pathway of steroid action. E(2) has also been shown to initiate rapid intracellular signaling, such as changes in levels of intracellular calcium, cAMP, and nitric oxide, and activations of a variety of kinases, via action at the membrane. In this study, we demonstrate that several xenoestrogens can rapidly activate extracellular-regulated kinases (ERKs) in the pituitary tumor cell line GH(3)/B6/F10, which expresses high levels of the membrane receptor for ER-α(mER). We tested a phytoestrogen (coumestrol), organochlorine pesticides or their metabolites (endosulfan, dieldrin, and DDE), and detergent by-products of plastics manufacturing (p-nonylphenol and bisphenol A). These xenoestrogens (except bisphenol A) produced rapid (3–30 min after application), concentration (10(−14)–10(−8) M)-dependent ERK-1/2 phosphorylation but with distinctly different activation patterns. To identify signaling pathways involved in ERK activation, we used specific inhibitors of ERs, epidermal growth factor receptors, Ca(2+) signaling, Src and phosphoinositide-3 kinases, and a membrane structure disruption agent. Multiple inhibitors blocked ERK activation, suggesting simultaneous use of multiple pathways and complex signaling web interactions. However, inhibitors differentially affected each xenoestrogen response examined. These actions may help to explain the distinct abilities of xenoestrogens to disrupt reproductive functions at low concentrations

X-ray Reflection By Photoionized Accretion Discs

We present the results of reflection calculations that treat the relevant physics with a minimum of assumptions. The temperature and ionization structure of the top five Thomson depths of an illuminated disc are calculated while also demanding that the atmosphere is in hydrostatic equilibrium. In agreement with Nayakshin, Kazanas & Kallman, we find that there is a rapid transition from hot to cold material in the illuminated layer. However, the transition is usually not sharp so that often we find a small but finite region in Thomson depth where there is a stable temperature zone at T \sim 2 x 10^{6} K due to photoelectric heating from recombining ions. As a result, the reflection spectra often exhibit strong features from partially-ionized material, including helium-like Fe K lines and edges. We find that due to the highly ionized features in the spectra these models have difficulty correctly parameterizing the new reflection spectra. There is evidence for a spurious $R-\Gamma$ correlation in the ASCA energy range, where $R$ is the reflection fraction for a power-law continuum of index $\Gamma$, confirming the suggestion of Done & Nayakshin that at least part of the R-Gamma correlation reported by Zdziarski, Lubinski & Smith for Seyfert galaxies and X-ray binaries might be due to ionization effects. Although many of the reflection spectra show strong ionized features, these are not typically observed in most Seyfert and quasar X-ray spectra.Comment: 16 pages, accepted by MNRAS, Fig. 8 is in colour Figures and tables changed by a code update. Conclusions unchange

Information Processing Versus Social Cognitive Mediators of Weight Loss in a Podcast-Delivered Health Intervention

Podcasting is an emerging technology, and previous interventions have shown promising results using theory-based podcast for weight loss among overweight and obese individuals. This study investigated whether constructs of social cognitive theory and information processing theories (IPTs) mediate the effect of a podcast intervention on weight loss among overweight individuals. Data are from Pounds off Digitally, a study testing the efficacy of two weight loss podcast interventions (control podcast and theory-based podcast). Path models were constructed (n = 66). The IPTs—elaboration likelihood model, information control theory, and cognitive load theory—mediated the effect of a theory-based podcast on weight loss. The intervention was significantly associated with all IPTs. Information control theory and cognitive load theory were related to elaboration, and elaboration was associated with weight loss. Social cognitive theory constructs did not mediate weight loss. Future podcast interventions grounded in theory may be effective in promoting weight loss

Evolution of the X-ray spectrum in the flare model of Active Galactic Nuclei

Nayakshin & Kazanas (2002) have considered the time-dependent illumination of an accretion disc in Active Galactic Nuclei, in the lamppost model. We extend their study to the flare model, which postulates the release of a large X-ray flux above a small region of the accretion disc. A fundamental difference with the lamppost model is that the region of the disc below the flare is not illuminated before the onset of the flare. A few test models show that the spectrum which follows immediately the increase in continuum flux should display the characteristics of a highly illuminated but dense gas, i.e. very intense X-ray emission lines and ionization edges in the soft X-ray range. The behaviour of the iron line is different in the case of a "moderate" and a ``strong'' flare: for a moderate flare, the spectrum displays a neutral component of the Fe K$\alpha$ line at 6.4 keV, gradually leading to more highly ionized lines. For a strong flare, the lines are already emitted by FeXXV (around 6.7 keV) after the onset, and have an equivalent width of several hundreds of eV. We find that the observed correlations between $R$, $\Gamma$, and the X-ray flux, are well accounted by a combination of flares having not achieved pressure equilibrium, strongly suggesting that the observed spectrum is dominated by regions in non-pressure equilibrium, typical of the onset of the flares. Finally a flare being confined to a small region of the disc, the spectral lines should be narrow (except for a weak Compton broadening), Doppler shifted, and moving.Comment: 14 pages, 13 figures, accepted in A & A, english corrected versio

Evidence for Soft Selective Sweeps in the Evolution of Pneumococcal Multidrug Resistance and Vaccine Escape

The multidrug-resistant Streptococcus pneumoniae Taiwan19F-14, or PMEN14, clone was first observed with a 19F serotype, which is targeted by the heptavalent polysaccharide conjugate vaccine (PCV7). However, “vaccine escape” PMEN14 isolates with a 19A serotype became an increasingly important cause of disease post-PCV7. Whole genome sequencing was used to characterize the recent evolution of 173 pneumococci of, or related to, PMEN14. This suggested that PMEN14 is a single lineage that originated in the late 1980s in parallel with the acquisition of multiple resistances by close relatives. One of the four detected serotype switches to 19A generated representatives of the sequence type (ST) 320 isolates that have been highly successful post-PCV7. A second produced an ST236 19A genotype with reduced resistance to β-lactams owing to alteration of pbp1a and pbp2x sequences through the same recombination that caused the change in serotype. A third, which generated a mosaic capsule biosynthesis locus, resulted in serotype 19A ST271 isolates. The rapid diversification through homologous recombination seen in the global collection was similarly observed in the absence of vaccination in a set of isolates from the Maela refugee camp in Thailand, a collection that also allowed variation to be observed within carriage through longitudinal sampling. This suggests that some pneumococcal genotypes generate a pool of standing variation that is sufficiently extensive to result in “soft” selective sweeps: The emergence of multiple mutants in parallel upon a change in selection pressure, such as vaccine introduction. The subsequent competition between these mutants makes this phenomenon difficult to detect without deep sampling of individual lineages

Social disorganization and history of child sexual abuse against girls in sub-Saharan Africa : a multilevel analysis

Background: Child sexual abuse (CSA) is a considerable public health problem. Less focus has been paid to the role of community level factors associated with CSA. The aim of this study was to examine the association between neighbourhood-level measures of social disorganization and CSA. Methods: We applied multiple multilevel logistic regression analysis on Demographic and Health Survey data for 6,351 adolescents from six countries in sub-Saharan Africa between 2006 and 2008. Results: The percentage of adolescents that had experienced CSA ranged from 1.04% to 5.84%. There was a significant variation in the odds of reporting CSA across the communities, suggesting 18% of the variation in CSA could be attributed to community level factors. Respondents currently employed were more likely to have reported CSA than those who were unemployed (odds ratio [OR] = 2.05, 95% confidence interval [CI] 1.48 to 2.83). Respondents from communities with a high family disruption rate were 57% more likely to have reported CSA (OR=1.57, 95% CI 1.14 to 2.16). Conclusion: We found that exposure to CSA was associated with high community level of family disruption, thus suggesting that neighbourhoods may indeed have significant important effects on exposure to CSA. Further studies are needed to explore pathways that connect the individual and neighbourhood levels, that is, means through which deleterious neighbourhood effects are transmitted to individuals

Modeling of non-stationary accretion disks in X-ray novae A 0620-00 and GRS 1124-68 during outburst

We address the task of modeling soft X-ray and optical light curves of X-ray novae in the high/soft state. The analytic model of viscous evolution of an externally truncated accretion \alpha-disk is used. Relativistic effects near a Kerr black hole and self-irradiation of an accretion disk are taken into account. The model is applied to the outbursts of X-ray nova Monocerotis 1975 (A 0620-00) and X-ray nova Muscae 1991 (GRS 1124-68). Comparison of observational data with the model yields constraints on the angular momentum (the Kerr parameter) of the black holes in A 0620-00 and GRS 1124-68: 0.3-0.6 and \leq 0.4, and on the viscosity parameter \alpha of the disks: 0.7-0.95 and 0.55-0.75. We also conclude that the accretion disks should have an effective geometrical thickness 1.5-2 times greater than the theoretical value of the distance between the photometric layers.Comment: 12 pages, 11 figures, 1 table, accepted for publication in A&A (minor changens following the referee's comments, five references added

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels can be modulated by receptor-driven alterations of cyclic AMP-dependent protein kinase (PKA) activity. Here, we demonstrate that Kv channel activity is maintained by tonic activity of PKA. Whole-cell recording was used to assess the effect of manipulating PKA signalling on Kv and ATP-dependent K+ channels of rat mesenteric artery smooth muscle cells. Application of PKA inhibitors, KT5720 or H89, caused a significant inhibition of Kv currents. Tonic PKA-mediated activation of Kv appears maximal as application of isoprenaline (a β-adrenoceptor agonist) or dibutyryl-cAMP failed to enhance Kv currents. We also show that this modulation of Kv by PKA can be reversed by protein phosphatase 2B/calcineurin (PP2B). PKA-dependent inhibition of Kv by KT5720 can be abrogated by pre-treatment with the PP2B inhibitor cyclosporin A, or inclusion of a PP2B auto-inhibitory peptide in the pipette solution. Finally, we demonstrate that tonic PKA-mediated modulation of Kv requires intact caveolae. Pre-treatment of the cells with methyl-β-cyclodextrin to deplete cellular cholesterol, or adding caveolin-scaffolding domain peptide to the pipette solution to disrupt caveolae-dependent signalling each attenuated PKA-mediated modulation of the Kv current. These findings highlight a novel, caveolae-dependent, tonic modulatory role of PKA on Kv channels providing new insight into mechanisms and the potential for pharmacological manipulation of vascular tone

Systematic review of safety checklists for use by medical care teams in acute hospital settings - limited evidence of effectiveness

<p>Abstract</p> <p>Background</p> <p>Patient safety is a fundamental component of good quality health care. Checklists have been proposed as a method of improving patient safety. This systematic review, asked "In acute hospital settings, would the use of safety checklists applied by medical care teams, compared to not using checklists, improve patient safety?"</p> <p>Methods</p> <p>We searched the Cochrane Library, MEDLINE, CINAHL, and EMBASE for randomised controlled trials published in English before September 2009. Studies were selected and appraised by two reviewers independently in consultation with colleagues, using inclusion, exclusion and appraisal criteria established a priori.</p> <p>Results</p> <p>Nine cohort studies with historical controls studies from four hospital care settings were included-intensive care unit, emergency department, surgery, and acute care. The studies used a variety of designs of safety checklists, and implemented them in different ways, however most incorporated an educational component to teach the staff how to use the checklist. The studies assessed outcomes occurring a few weeks to a maximum of 12 months post-implementation, and these outcomes were diverse.</p> <p>The studies were generally of low to moderate quality and of low levels of evidence, with all but one of the studies containing a high risk of bias.</p> <p>The results of these studies suggest some improvements in patient safety arising from use of safety checklists, but these were not consistent across all studies or for all outcomes. Some studies showed no difference in outcomes between checklist use and standard care without a checklist. Due to the variations in setting, checklist design, educational training given, and outcomes measured, it was unfeasible to accurately summarise any trends across all studies.</p> <p>Conclusions</p> <p>The included studies suggest some benefits of using safety checklists to improve protocol adherence and patient safety, but due to the risk of bias in these studies, their results should be interpreted with caution. More high quality and studies, are needed to enable confident conclusions about the effectiveness of safety checklists in acute hospital settings.</p