91 research outputs found
Using Basic Science to Design a Clinical Trial: Baseline Characteristics of Women Enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)
- Author
- A Steiner
- AL Eilertsen
- AR Folsom
- AR Folsom
- B Ettinger
- B Ettinger
- BE Henderson
- C Schairer
- C Spencer
- CC Slater
- CJ Crandall
- CR White
- D Grady
- D. M. Black
- DH Blankenhorn
- DM Herrington
- DM Herrington
- E Farish
- E. A. Brinton
- F Grodstein
- F Grodstein
- F Grodstein
- F Grodstein
- F. Naftolin
- G. R. Merriam
- GA Colditz
- GM Darling
- H. N. Hodis
- H. S. Taylor
- HN Hodis
- HN Hodis
- HN Hodis
- HN Hodis
- HN Hodis
- IS Ockene
- J Hsia
- J Manson
- J. E. Manson
- JA Cauley
- JA Rumberger
- JC Lo
- JD Wagner
- JE Manson
- JE Rossouw
- JE Rossouw
- K Sudhir
- K Sudhir
- K Sudhir
- K Sutton-Tyrrell
- KM Randell
- KM Rexrode
- L Bergkvist
- LE Spieker
- LG Futterman
- M Jayachandran
- M Jayachandran
- M. I. Cedars
- M. J. Budoff
- MA Allison
- ME Mendelsohn
- MJ Budoff
- MJ Stampfer
- MMH Cho
- MR Adams
- MR Adams
- MR Sowers
- MR Sowers
- MR Sowers
- MR Sowers
- MY Desai
- N. Santoro
- NF Col
- NL Benowitz
- P Greenland
- P Raggi
- PB Hoyer
- PH Wolf
- PW Wilson
- PY Scarabin
- PY Scarabin
- R Detrano
- R Karim
- R. A. Lobo
- RH Karas
- RL Levine
- RP Byington
- S Hulley
- S Kalantaridou
- S. M. Harman
- SE Appt
- SG Lakoski
- SL Murphy
- SM Harman
- TB Clarkson
- TB Clarkson
- The Women’s Health Initiative Study Group
- The Writing Group for the PEPI Trial
- TK Waddell
- TL Bush
- TL Bush
- V. M. Miller
- VL Jacoby
- VM Miller
- W Rocca
- WA Rocca
- WA Rocca
- WA Rocca
- WJ Mack
- WS Weintraub
- Y Zhu
- Publication venue
- Springer US
- Publication date
- 01/01/2009
- Field of study
Observational and epidemiological studies suggest that menopausal hormone therapy (MHT) reduces cardiovascular disease (CVD) risk. However, results from prospective trials showed neutral or adverse effects most likely due to differences in participant demographics, such as age, timing of initiation of treatment, and preexisting cardiovascular disease, which reflected in part the lack of basic science information on mechanisms of action of hormones on the vasculature at the time clinical trials were designed. The Kronos Early Estrogen Replacement Study (KEEPS) is a prospective, randomized, controlled trial designed, using findings from basic science studies, to test the hypothesis that MHT when initiated early in menopause reduces progression of atherosclerosis. KEEPS participants are younger, healthier, and within 3 years of menopause thus matching more closely demographics of women in prior observational and epidemiological studies than women in the Women’s Health Initiative hormone trials. KEEPS will provide information relevant to the critical timing hypothesis for MHT use in reducing risk for CVD
Phosphoproteomics Identifies Oncogenic Ras Signaling Targets and Their Involvement in Lung Adenocarcinomas
- Author
- A Persidis
- AE Karnoub
- CC Tsou
- CF Tsai
- Chia-Lang Hsu
- D Schwartz
- D Van Hoof
- E Castro-Rivera
- E Lee
- GJ Riely
- H Kosako
- H Wu
- J Downward
- Jeou-Yuan Chen
- JK Voice
- JL Lee
- K Lawlor
- KM Haigis
- L Ding
- M Malumbres
- M Mann
- M Popescu
- M Sato
- Mei-Jung Wang
- ML Miller
- PR Cutillas
- Putty-Reddy Sudhir
- R Linding
- RA Zubarev
- RD Ramirez
- RH Palmer
- S Yoon
- T Obata
- TB Schreiber
- Ting-Yi Sung
- U Guha
- Ueng-Cheng Yang
- Venugopalan Cheriyath
- Wen-Lian Hsu
- WJ Wilbur
- WM Old
- X Lu
- Yi-Ting Wang
- Yu-Ju Chen
- Publication venue
- Public Library of Science
- Publication date
- 26/05/2011
- Field of study
Ras is frequently mutated in a variety of human cancers, including lung cancer, leading to constitutive activation of MAPK signaling. Despite decades of research focused on the Ras oncogene, Ras-targeted phosphorylation events and signaling pathways have not been described on a proteome-wide scale.By functional phosphoproteomics, we studied the molecular mechanics of oncogenic Ras signaling using a pathway-based approach. We identified Ras-regulated phosphorylation events (n = 77) using label-free comparative proteomics analysis of immortalized human bronchial epithelial cells with and without the expression of oncogenic Ras. Many were newly identified as potential targets of the Ras signaling pathway. A majority (∼60%) of the Ras-targeted events consisted of a [pSer/Thr]-Pro motif, indicating the involvement of proline-directed kinases. By integrating the phosphorylated signatures into the Pathway Interaction Database, we further inferred Ras-regulated pathways, including MAPK signaling and other novel cascades, in governing diverse functions such as gene expression, apoptosis, cell growth, and RNA processing. Comparisons of Ras-regulated phosphorylation events, pathways, and related kinases in lung cancer-derived cells supported a role of oncogenic Ras signaling in lung adenocarcinoma A549 and H322 cells, but not in large cell carcinoma H1299 cells.This study reveals phosphorylation events, signaling networks, and molecular functions that are regulated by oncogenic Ras. The results observed in this study may aid to extend our knowledge on Ras signaling in lung cancer
Transcriptional Downregulation of Rice rpL32 Gene under Abiotic Stress Is Associated with Removal of Transcription Factors within the Promoter Region
- Author
- A Barakat
- A Kanazawa
- A Lambertsson
- A Lauchli
- A Ludwig
- A Ueda
- D Giannino
- D Trémousaygue
- DJ Klein
- E Beltrán-Peña
- F Turck
- J Bailey-Serres
- J Gao
- J Saez-Vasquez
- J Sambrook
- J Wang
- J Wu
- JC Larkin
- K Tatematsu
- K-Y Kim
- KM Folta
- L Xiong
- L Xiong
- L Xiong
- LA Wanner
- M Brosché
- M Rogalski
- M Tester
- Malireddy K. Reddy
- ME Williams
- MM Mahfouz
- MS Singer
- N Hirose
- PK Busk
- Pradipto Mukhopadhyay
- R Kawaguchi
- RA Richards
- RJ Planta
- S Kosugi
- S Kosugi
- S Kosugi
- S Ma
- S Wullschleger
- S Yoshida
- Sneh Lata Singla-Pareek
- Steven R. Ellis
- Sudhir K. Sopory
- X He
- X Liu
- X Yu
- YY Yamamoto
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Background: The regulation of ribosomal proteins in plants under stress conditions has not been well studied. Although a few reports have shown stress-specific post-transcriptional and translational mechanisms involved in downregulation of ribosomal proteins yet stress-responsive transcriptional regulation of ribosomal proteins is largely unknown in plants. Methodology/Principal Findings: In the present work, transcriptional regulation of genes encoding rice 60S ribosomal protein L32 (rpL32) in response to salt stress has been studied. Northern and RT-PCR analyses showed a significant downregulation of rpL32 transcripts under abiotic stress conditions in rice. Of the four rpL32 genes in rice genome, the gene on chromosome 8 (rpL32_8.1) showed a higher degree of stress-responsive downregulation in salt sensitive rice variety than in tolerant one and its expression reverted to its original level upon withdrawal of stress. The nuclear run-on and promoter:reporter assays revealed that the downregulation of this gene is transcriptional and originates within the promoter region. Using in vivo footprinting and electrophoretic mobility shift assay (EMSA), cis-elements in the promoter of rpL32_8.1 showing reduced binding to proteins in shoots of salt stressed rice seedlings were identified. Conclusions: The present work is one of the few reports on study of stress downregulated genes. The data revealed that rpL32 gene is transcriptionally downregulated under abiotic stress in rice and that this transcriptional downregulation i
Role of non-nitric oxide non-prostaglandin endothelium-derived relaxing factor(s) in bradykinin vasodilation
- Author
- A.C. Resende
- Altura BM
- Antonio A
- Bauersachs J
- Baydoun AR
- Bennet BM
- Berguer R
- Bjfrnstad-Østensen A
- Chataigneau T
- Cherry PD
- Cohen RA
- Corriu C
- Cowan CL
- Cowan CL
- D'Orléans-Juste P
- Dienemann H
- Erikson U
- Fiksen-Olsen MJ
- Fukao M
- Fulton D
- Fulton K
- Furchgott RF
- Furchgott RF
- G. Ballejo
- Gardiner SM
- Garland CJ
- Garland CJ
- Haddy FJ
- Hecker M
- Kemp BK
- Lippton HL
- M.C.O. Salgado
- Messina EJ
- Mombouli JV
- Mombuli JV
- Myers PR
- Nakashima M
- Needleman P
- O'Shaughnessy KM
- Ohlmann P
- Pacicca C
- Palmer RMJ
- Palmer RMJ
- Quilley J
- Randall MD
- Rapacon M
- Regoli D
- Resende AC
- Rinaldi-Carmona M
- Rocha e Silva M
- Salgado MCO
- Sudhir K
- Tare M
- Tschudi M
- Urakami-Harasawa L
- Vanheel B
- Vials A
- Wang Y-X
- Whittle BR
- Zygmunt PM
- Zygmunt PM
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Sequence variation, evolutionary constraint, and selection at the CD163 gene in pigs
- Author
- A McKenna
- A Wilm
- AB Gussow
- BL Aken
- BO Fabriek
- D Bates
- D Smedley
- DJ Holtkamp
- E Eisenberg
- Gregor Gorjanc
- H Yang
- I Bartha
- J Hermisson
- JG Calvert
- JM Hickey
- JM Rodriguez
- JM Smith
- John M. Hickey
- Jonathan Lightner
- KD Wells
- KE Eilertson
- Kimberly Kelly
- KM Whitworth
- KM Whitworth
- LC Bover
- M Kristiansen
- M Nei
- MAM Groenen
- Martin Johnsson
- Matt A. Campbell
- MM Heuvel Van den
- NR Garud
- P Cingolani
- P Danecek
- P Philippidis
- R Ros-Freixedes
- R Ros-Freixedes
- RD Finn
- Roger Ros-Freixedes
- S Gonen
- S Petrovski
- Steve Rounsley
- Sudhir Naswa
- W McLaren
- WJ Kent
- Y Caì
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Abstract Background In this work, we investigated sequence variation, evolutionary constraint, and selection at the CD163 gene in pigs. A functional CD163 protein is required for infection by porcine reproductive and respiratory syndrome virus, which is a serious pathogen with major impacts on pig production. Results We used targeted pooled sequencing of the exons of CD163 to detect sequence variants in 35,000 pigs of diverse genetic backgrounds and to search for potential stop-gain and frameshift indel variants. Then, we used whole-genome sequence data from three pig lines to calculate: a variant intolerance score that measures the tolerance of genes to protein coding variation; an estimate of selection on protein-coding variation over evolutionary time; and haplotype diversity statistics to detect recent selective sweeps during breeding. Conclusions Using a deep survey of sequence variation in the CD163 gene in domestic pigs, we found no potential knockout variants. The CD163 gene was moderately intolerant to variation and showed evidence of positive selection in the pig lineage, but no evidence of recent selective sweeps during breeding
Bioprospecting of strains of Streptococcus thermophilus from Indian fermented milk products for folate production
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: A systematic analysis from the Global Burden of Disease Study 2016
- Author
- Abay Solomon M
- Abbafati Cristiana
- Abd-Allah Foad
- Abdela Jemal
- Abdelalim Ahmed
- Abebe Zegeye
- Abebo Teshome Abuka
- Aboyans Victor
- Abraha Haftom Niguse
- Abreu Daisy M X
- Abu-Raddad Laith J
- Adane Akilew Awoke
- Adedoyin Rufus Adesoji
- Adetokunboh Olatunji
- Adhikari Tara Ballav
- Afarideh Mohsen
- Afshin Ashkan
- Agarwal Gina
- Agius Dominic
- Agrawal Anurag
- Agrawal Sutapa
- Ahmad Kiadaliri Aliasghar
- Aichour Miloud Taki Eddine
- Akibu Mohammed
- Akinyemi Rufus Olusola
- Akinyemiju Tomi F
- Akseer Nadia
- Al Lami Faris Hasan
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Tahiya
- Alasfoor Deena
- Albittar Mohammed I
- Alene Kefyalew Addis
- Ali Syed Danish
- Alijanzadeh Mehran
- Aljunid Syed M
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Allen Christine
- Alomari Mahmoud A
- Alsharif Ubai
- Altirkawi Khalid A
- Alvis-Guzman Nelson
- Amare Azmeraw T
- Amenu Kebede
- Ammar Walid
- Amoako Yaw Ampem
- Anber Nahla
- Andrei Catalina Liliana
- Androudi Sofia
- Antonio Carl Abelardo T
- Araújo Valdelaine E M
- Aremu Olatunde
- Artaman Al
- Aryal Krishna Kumar
- Asayesh Hamid
- Asfaw Ephrem Tsegay
- Asgedom Solomon Weldegebreal
- Asghar Rana Jawad
- Ashebir Mengistu Mitiku
- Asseffa Netsanet Abera
- Atey Tesfay Mehari
- Atre Sachin R
- Atteraya Madhu S
- Avila-Burgos Leticia
- Avokpaho Euripide Frinel G Arthur
- Awasthi Ashish
- Ayala Quintanilla Beatriz Paulina
- Ayalew Animut Alebel
- Ayele Henok Tadesse
- Ayer Rakesh
- Ayuk Tambe Betrand
- Azzopardi Peter
- Azzopardi-Muscat Natasha
- Babalola Tesleem Kayode
- Badali Hamid
- Badawi Alaa
- Banach Maciej
- Banerjee Amitava
- Banstola Amrit
- Barber Ryan M
- Barboza Miguel A
- Barker-Collo Suzanne L
- Barquera Simon
- Barrero Lope H
- Bassat Quique
- Basu Sanjay
- Baune Bernhard T
- Bazargan-Hejazi Shahrzad
- Bedi Neeraj
- Beghi Ettore
- Behzadifar Masoud
- Behzadifar Meysam
- Bekele Bayu Begashaw
- Belachew Abate Bekele
- Belay Saba Abraham
- Belay Yihalem Abebe
- Bell Michelle L
- Bello Aminu K
- Bennett Derrick A
- Bennett James R
- Bensenor Isabela M
- Berhe Derbew Fikadu
- Bernabé Eduardo
- Bernstein Robert Steven
- Beuran Mircea
- Bhalla Ashish
- Bhatt Paurvi
- Bhaumik Soumyadeep
- Bhutta Zulfiqar A
- Biadgo Belete
- Bijani Ali
- Bikbov Boris
- Birungi Charles
- Biryukov Stan
- Bizuneh Hailemichael
- Bolliger Ian W
- Bolt Kaylin
- Bou-Orm Ibrahim R
- Bozorgmehr Kayvan
- Brady Oliver Jerome
- Brazinova Alexandra
- Breitborde Nicholas J K
- Brenner Hermann
- Britton Gabrielle
- Brugha Traolach S
- Butt Zahid A
- Bärnighausen Till
- Cahuana-Hurtado Lucero
- Campos-Nonato Ismael Ricardo
- Campuzano Julio Cesar
- Car Josip
- Car Mate
- Carrero Juan Jesus
- Carvalho Felix
- Castañeda-Orjuela Carlos A
- Castillo Rivas Jacqueline
- Catalá-López Ferrán
- Cercy Kelly
- Chalek Julian
- Chang Hsing-Yi
- Chang Jung-Chen
- Chattopadhyay Aparajita
- Chaturvedi Pankaj
- Chiang Peggy Pei-Chia
- Chisumpa Vesper Hichilombwe
- Choi Jee-Young J
- Christensen Hanne
- Christopher Devasahayam Jesudas
- Chung Sheng-Chia
- Ciobanu Liliana G
- Cirillo Massimo
- Colombara Danny
- Conti Sara
- Cooper Cyrus
- Cornaby Leslie
- Cortesi Paolo Angelo
- Cortinovis Monica
- Costa Pereira Alexandre
- Cousin Ewerton
- Criqui Michael H
- Cromwell Elizabeth A
- Crowe Christopher Stephen
- Crump John A
- Cárdenas Rosario
- Daba Alemneh Kabeta
- Dachew Berihun Assefa
- Dadi Abel Fekadu
- Dandona Lalit
- Dandona Rakhi
- Dargan Paul I
- Daryani Ahmad
- Daryani Maryam
- das Neves José
- Das Jai
- Das Siddharth Kumar
- Davis Weaver Nicole
- Davletov Kairat
- de Courten Barbora
- De Leo Diego
- De Neve Jan-Walter
- Dellavalle Robert P
- Demoz Gebre
- Deribe Kebede
- Des Jarlais Don C
- Dey Subhojit
- Dharmaratne Samath D
- Dhimal Meghnath
- Djalalinia Shirin
- Doku David Teye
- Dolan Kate
- Dorsey E Ray
- dos Santos Kadine Priscila Bender
- Doyle Kerrie E
- Driscoll Tim R
- Dubey Manisha
- Dubljanin Eleonora
- Duncan Bruce Bartholow
- Echko Michelle
- Edessa Dumessa
- Edvardsson David
- Ehrlich Joshua R
- El-Khatib Ziad Ziad
- Eldrenkamp Erika
- Endres Matthias
- Endries Aman Yesuf
- Eshrati Babak
- Eskandarieh Sharareh
- Esteghamati Alireza
- Fakhar Mahdi
- Farag Tamer
- Faramarzi Mahbobeh
- Faraon Emerito Jose Aquino
- Faro André
- Farzadfar Farshad
- Fatusi Adesegun
- Fazeli Mir Sohail
- Feigin Valery L
- Feigl Andrea B
- Fentahun Netsanet
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Fernandes João C
- Fijabi Daniel Obadare
- Filip Irina
- Fischer Florian
- Fitzmaurice Christina
- Flaxman Abraham D
- Flor Luisa Sorio
- Foigt Nataliya
- Foreman Kyle J
- Frostad Joseph J
- Fullman Nancy
- Futran Neal D
- Fürst Thomas
- Gakidou Emmanuela
- Gallus Silvano
- Gambashidze Ketevan
- Gamkrelidze Amiran
- Ganji Morsaleh
- Gebre Abadi Kahsu
- Gebrehiwot Tsegaye Tewelde
- Gebremedhin Amanuel Tesfay
- Gelaw Yalemzewod Assefa
- Geleijnse Johanna M
- Geremew Demeke
- Gething Peter W
- Ghadimi Reza
- Ghasemi Falavarjani Khalil
- Ghasemi-Kasman Maryam
- Gill Paramjit Singh
- Giref Ababi Zergaw
- Giroud Maurice
- Gishu Melkamu Dedefo
- Giussani Giorgia
- Godwin William W
- Goli Srinivas
- Gomez-Dantes Hector
- Gona Philimon N
- Goodridge Amador
- Gopalani Sameer Vali
- Goryakin Yevgeniy
- Goulart Alessandra Carvalho
- Grada Ayman
- Griswold Max
- Grosso Giuseppe
- Gugnani Harish Chander
- Guo Yuming
- Gupta Rahul
- Gupta Rajeev
- Gupta Tanush
- Gupta Tarun
- Gupta Vipin
- Haagsma Juanita A
- Hachinski Vladimir
- Hafezi-Nejad Nima
- Hailu Gessessew Bugssa
- Hamadeh Randah Ribhi
- Hamidi Samer
- Hankey Graeme J
- Harb Hilda L
- Harewood Heather C
- Harikrishnan Sivadasanpillai
- Haro Josep Maria
- Hassen Hamid Yimam
- Havmoeller Rasmus
- Hawley Caitlin
- Hay Simon I
- He Jiawei
- Hearps Stephen J C
- Hegazy Mohamed I
- Heibati Behzad
- Heidari Mohsen
- Hendrie Delia
- Henry Nathaniel J
- Herrera Ballesteros Victor Hugo
- Herteliu Claudiu
- Hibstu Desalegn Tsegaw
- Hiluf Molla Kahssay
- Hoek Hans W
- Homaie Rad Enayatollah
- Horita Nobuyuki
- Hosgood H Dean
- Hosseini Mostafa
- Hosseini Seyed Reza
- Hostiuc Mihaela
- Hostiuc Sorin
- Hoy Damian G
- Hsairi Mohamed
- Htet Aung Soe
- Hu Guoqing
- Huang John J
- Iburg Kim Moesgaard
- Idris Fachmi
- Igumbor Ehimario Uche
- Ikeda Chad
- Ileanu Bogdan Vasile
- Ilesanmi Olayinka S
- Innos Kaire
- Irvani Seyed Sina Naghibi
- Irvine Caleb M S
- Islami Farhad
- Jacobs Troy A
- Jacobsen Kathryn H
- Jahanmehr Nader
- Jain Rajesh
- Jain Sudhir Kumar
- Jakovljevic Mihajlo B
- Jalu Moti Tolera
- Jamal Amr A
- Javanbakht Mehdi
- Jayatilleke Achala Upendra
- Jeemon Panniyammakal
- Jha Ravi Prakash
- Jha Vivekanand
- John Oommen
- Johnson Sarah Charlotte
- Jonas Jost B
- Joshua Vasna
- Jóúwiak Jacek
- Jürisson Mikk
- Kabir Zubair
- Kadel Rajendra
- Kahsay Amaha
- Kalani Rizwan
- Kar Chittaranjan
- Karanikolos Marina
- Karch André
- Karema Corine Kakizi
- Karimi Seyed M
- Kasaeian Amir
- Kassa Dessalegn Haile
- Kassa Getachew Mullu
- Kassa Tesfaye Dessale
- Kassebaum Nicholas J
- Katikireddi Srinivasa Vittal
- Kaul Anil
- Kawakami Norito
- Kazanjan Konstantin
- Kebede Seifu
- Keiyoro Peter Njenga
- Kemp Grant Rodgers
- Kengne Andre Pascal
- Kereselidze Maia
- Ketema Ezra Belay
- Khader Yousef Saleh
- Khafaie Morteza Abdullatif
- Khajavi Alireza
- Khalil Ibrahim A
- Khan Ejaz Ahmad
- Khan Gulfaraz
- Khan Md Nuruzzaman
- Khan Muhammad Ali
- Khanal Mukti Nath
- Khang Young-Ho
- Khater Mona M
- Khoja Abdullah Tawfih Abdullah
- Khosravi Ardeshir
- Khubchandani Jagdish
- Kibret Getiye Dejenu
- Kiirithio Daniel Ngari
- Kim Daniel
- Kim Yun Jin
- Kimokoti Ruth W
- Kinfu Yohannes
- Kinra Sanjay
- Kisa Adnan
- Kissoon Niranjan
- Kochhar Sonali
- Kokubo Yoshihiro
- Kopec Jacek A
- Kosen Soewarta
- Koul Parvaiz A
- Koyanagi Ai
- Kravchenko Michael
- Krishan Kewal
- Krohn Kristopher J
- Kuate Defo Barthelemy
- Kumar G Anil
- Kumar Pushpendra
- Kutz Michael
- Kuzin Igor
- Kyu Hmwe H
- Lad Deepesh Pravinkumar
- Lafranconi Alessandra
- Lal Dharmesh Kumar
- Lalloo Ratilal
- Lam Hilton
- Lan Qing
- Lang Justin J
- Lansingh Van C
- Lansky Sonia
- Larsson Anders
- Latifi Arman
- Lazarus Jeffrey Victor
- Leasher Janet L
- Lee Paul H
- Legesse Yirga
- Leigh James
- Leshargie Cheru Tesema
- Leta Samson
- Leung Janni
- Leung Ricky
- Levi Miriam
- Li Yongmei
- Liang Juan
- Liben Misgan Legesse
- Lim Lee-Ling
- Lim Stephen S
- Lind Margaret
- Linn Shai
- Listl Stefan
- Liu Patrick
- Liu Shiwei
- Lodha Rakesh
- Lopez Alan D
- Lorch Scott A
- Lorkowski Stefan
- Lotufo Paulo A
- Lozano Rafael
- Lucas Timothy C D
- Lunevicius Raimundas
- Lurton Grégoire
- Lyons Ronan A
- Maalouf Fadi
- Macarayan Erlyn Rachelle King
- Mackay Mark T
- Maddison Emilie R
- Madotto Fabiana
- Magdy Abd El Razek Hassan
- Magdy Abd El Razek Mohammed
- Majdan Marek
- Majdzadeh Reza
- Majeed Azeem
- Malekzadeh Reza
- Malhotra Rajesh
- Malta Deborah Carvalho
- Mamun Abdullah A
- Manguerra Helena
- Manhertz Trey
- Mansournia Mohammad Ali
- Mantovani Lorenzo G
- Manyazewal Tsegahun
- Mapoma Chabila C
- Margono Christopher
- Martinez-Raga Jose
- Martins Sheila Cristina Ouriques
- Martins-Melo Francisco Rogerlândio
- Martopullo Ira
- Massenburg Benjamin Ballard
- Mathur Manu Raj
- Maulik Pallab K
- Mazidi Mohsen
- McAlinden Colm
- McGrath John J
- McKee Martin
- Mehata Suresh
- Mehrotra Ravi
- Mehta Kala M
- Mehta Varshil
- Meier Toni
- Mejia-Rodriguez Fabiola
- Meles Kidanu Gebremariam
- Melku Mulugeta
- Memiah Peter
- Memish Ziad A
- Mendoza Walter
- Mengiste Degu Abate
- Mengistu Desalegn Tadese
- Menota Bereket Gebremichael
- Mensah George A
- Meretoja Atte
- Meretoja Tuomo J
- Mezgebe Haftay Berhane
- Miazgowski Tomasz
- Micha Renata
- Milam Robert
- Millear Anoushka
- Miller Ted R
- Mini GK
- Minnig Shawn
- Mirica Andreea
- Mirrakhimov Erkin M
- Misganaw Awoke
- Mitchell Philip B
- Mlashu Fitsum Weldegebreal
- Moazen Babak
- Mohammad Karzan Abdulmuhsin
- Mohammadibakhsh Roghayeh
- Mohammed Ebrahim
- Mohammed Mohammed A
- Mohammed Shafiu
- Mokdad Ali H
- Mola Glen Liddell
- Molokhia Mariam
- Momeniha Fatemeh
- Monasta Lorenzo
- Montañez Hernandez Julio Cesar
- Moosazadeh Mahmood
- Moradi-Lakeh Maziar
- Moraga Paula
- Morawska Lidia
- Moreno Velasquez Ilais
- Mori Rintaro
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- Winkler Andrea Sylvia
- Wiysonge Charles Shey
- Wolfe Charles DA
- Wondimkun Yohanes Ayele
- Workicho Abdulhalik
- Wyper Grant M A
- Xavier Denis
- Xu Gelin
- Yan Lijing L
- Yano Yuichiro
- Yaseri Mehdi
- Yearwood Jamal
- Yimer Nigus Bililign
- Yin Peng
- Yip Paul
- Yirsaw Biruck Desalegn
- Yonemoto Naohiro
- Yonga Gerald
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z
- Yu Chuanhua
- Zadnik Vesna
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zaman Sojib Bin
- Zamani Mohammad
- Zenebe Zerihun Menlkalew
- Zhou Maigeng
- Zhu Jun
- Zimsen Stephanie R M
- Zipkin Ben
- Zodpey Sanjay
- Zuhlke Liesl Joanna
- Ärnlöv Johan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Copyright © 2018 The Author(s). Published by Elsevier Ltd. Background A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) to assess personal health-care access and quality with the Healthcare Access and Quality (HAQ) Index for 195 countries and territories, as well as subnational locations in seven countries, from 1990 to 2016. Methods Drawing from established methods and updated estimates from GBD 2016, we used 32 causes from which death should not occur in the presence of effective care to approximate personal health-care access and quality by location and over time. To better isolate potential effects of personal health-care access and quality from underlying risk factor patterns, we risk-standardised cause-specific deaths due to non-cancers by location-year, replacing the local joint exposure of environmental and behavioural risks with the global level of exposure. Supported by the expansion of cancer registry data in GBD 2016, we used mortality-to-incidence ratios for cancers instead of risk-standardised death rates to provide a stronger signal of the effects of personal health care and access on cancer survival. We transformed each cause to a scale of 0-100, with 0 as the first percentile (worst) observed between 1990 and 2016, and 100 as the 99th percentile (best); we set these thresholds at the country level, and then applied them to subnational locations. We applied a principal components analysis to construct the HAQ Index using all scaled cause values, providing an overall score of 0-100 of personal health-care access and quality by location over time. We then compared HAQ Index levels and trends by quintiles on the Socio-demographic Index (SDI), a summary measure of overall development. As derived from the broader GBD study and other data sources, we examined relationships between national HAQ Index scores and potential correlates of performance, such as total health spending per capita. Findings In 2016, HAQ Index performance spanned from a high of 97·1 (95% UI 95·8-98·1) in Iceland, followed by 96·6 (94·9-97·9) in Norway and 96·1 (94·5-97·3) in the Netherlands, to values as low as 18·6 (13·1-24·4) in the Central African Republic, 19·0 (14·3-23·7) in Somalia, and 23·4 (20·2-26·8) in Guinea-Bissau. The pace of progress achieved between 1990 and 2016 varied, with markedly faster improvements occurring between 2000 and 2016 for many countries in sub-Saharan Africa and southeast Asia, whereas several countries in Latin America and elsewhere saw progress stagnate after experiencing considerable advances in the HAQ Index between 1990 and 2000. Striking subnational disparities emerged in personal health-care access and quality, with China and India having particularly large gaps between locations with the highest and lowest scores in 2016. In China, performance ranged from 91·5 (89·1-93·6) in Beijing to 48·0 (43·4-53·2) in Tibet (a 43·5-point difference), while India saw a 30·8-point disparity, from 64·8 (59·6-68·8) in Goa to 34·0 (30·3-38·1) in Assam. Japan recorded the smallest range in subnational HAQ performance in 2016 (a 4·8-point difference), whereas differences between subnational locations with the highest and lowest HAQ Index values were more than two times as high for the USA and three times as high for England. State-level gaps in the HAQ Index in Mexico somewhat narrowed from 1990 to 2016 (from a 20·9-point to 17·0-point difference), whereas in Brazil, disparities slightly increased across states during this time (a 17·2-point to 20·4-point difference). Performance on the HAQ Index showed strong linkages to overall development, with high and high-middle SDI countries generally having higher scores and faster gains for non-communicable diseases. Nonetheless, countries across the development spectrum saw substantial gains in some key health service areas from 2000 to 2016, most notably vaccine-preventable diseases. Overall, national performance on the HAQ Index was positively associated with higher levels of total health spending per capita, as well as health systems inputs, but these relationships were quite heterogeneous, particularly among low-to-middle SDI countries. Interpretation GBD 2016 provides a more detailed understanding of past success and current challenges in improving personal health-care access and quality worldwide. Despite substantial gains since 2000, many low-SDI and middle- SDI countries face considerable challenges unless heightened policy action and investments focus on advancing access to and quality of health care across key health services, especially non-communicable diseases. Stagnating or minimal improvements experienced by several low-middle to high-middle SDI countries could reflect the complexities of re-orienting both primary and secondary health-care services beyond the more limited foci of the Millennium Development Goals. Alongside initiatives to strengthen public health programmes, the pursuit of universal health coverage hinges upon improving both access and quality worldwide, and thus requires adopting a more comprehensive view - and subsequent provision - of quality health care for all populations
Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abercrombie Daniel
- Abreu A.
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamidis K.
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Aime` Chiara
- Aime‘ C.
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albergo Sebastiano
- Albert Andreas
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Almond John
- Alpana Km
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
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- Amin Nick
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreassi Guido
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano J.
- Antchev Georgy
- Anthony David
- Antunovic Zeljko
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
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- Arenton Michael Wayne
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- De Moraes Gregores Eduardo
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- de Trocóniz Jorge F
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- Hatakeyama Kenichi
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- Hoorani Hafeez R
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- Wang Bingran
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- Wang Quan
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- Wang Zhixing
- Waqas Muhammad
- Wardle Nicholas
- Warner Z.
- Wassmer Michael
- Watson I. J.
- Wayne Mitchell
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- Weber Marc
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- Wezenbeek Liam
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- Wickramage Nadeesha
- Wiedenbeck Sebastian
- Wieland Sebastian
- Wiens Lucas
- Wightman Andrew
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- Williams Justin
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- Wissing Christoph
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- Wong Wing Yan
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- Wu Hsin-yeh
- Wu Zhenbin
- Wuchterl Sebastian
- Wulz Claudia-Elisabeth
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- Würthwein Frank
- Xiang Yifan
- Xiao Jie
- Xiao Meng
- Xiao Rui
- Xie Si
- Xie Wei
- Yagil Avraham
- Yalvac Metin
- Yan Furong
- Yan Xuli
- Yang S.
- Yang Shuai
- Yang Unki
- Yang Yu Chul
- Yao Yao
- Yarar Hevjin
- Yates Brent
- Yazgan Efe
- Ye Zhenyu
- Yetkin Elif Asli
- Yi Kai
- Yigitbasi Efe
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Geum Bong
- Yu Intae
- Yu Pei-rong
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabi Alexandre
- Zacharopoulou Anna
- Zahid Sema
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zeinali Maryam
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Liuyao
- Zhang Wenyu
- Zhang Yi
- Zhang Yousen
- Zhang Zhicai
- Zhao Jingzhou
- Zhizhin Ilia
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Ziemons Tim
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zotz Alexander
- Zou David
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Álvarez Fernández Adrian
- Özçelik Özlem
- Publication venue
- Publication date
- 01/01/2021
- Field of study
A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe
Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdalla Hassan
- Abdullin Salavat
- Abercrombie Daniel
- Abreu A.
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamov George
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Aime` Chiara
- Aime‘ C.
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albergo Sebastiano
- Albert Andreas
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Almond John
- Alpana Km
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreassi Guido
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano J.
- Antchev Georgy
- Anthony David
- Antunovic Zeljko
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Araujo Mariana
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Asmuss Paul
- Atakisi Ismail Okan
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
- Avati Valentina
- Avery Paul
- Avila Carlos
- Awais Ali
- Awan Muhammad Imran Malik
- Ayala Edy
- Ayala Gabriel
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M.
- Babaev Anton
- Babounikau Illia
- Bacchetta Nicola
- Bachiller Irene
- Bachtis Michail
- Backhaus Malte
- Baden A.
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakas Georgios
- Bakhshiansohi Hamed
- Bakshi Amandeep Singh
- Baldenegro Barrera Cristian
- Ban Yong
- Band Reyer
- Bandyopadhyay Hirak
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Bargassa Pedrame
- Baringer Philip
- Barnes Virgil E.
- Barney David
- Baron Owen
- Barrio Luna Mar
- Barroso Ferreira Filho Mapse
- Bartek Rachel
- Bartosik Nazar
- Bartók Márton
- Bastos Diogo
- Battilana Carlo
- Baty Austin
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baxter Samuel
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Becerril Gonzalez Hugo
- Bechtel Janek
- Beghin Diego
- Behera Prafulla Kumar
- Behera Subash Chandra
- Behnke Olaf
- Bein Samuel
- Belforte Stefano
- Bell Ken W.
- Bellan Riccardo
- Belloni Alberto
- Bellora Andrea
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benecke Anna
- Benelli Gabriele
- Benitez Jose F.
- Benussi Luigi
- Berenguer Antequera Jorge
- Bergauer Thomas
- Berger Pirmin
- Berger Thomas
- Beri Suman Bala
- Bermúdez Martínez Armando
- Bernardes Cesar Augusto
- Bernet Colin
- Berry Douglas
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- Wei Kai
- Wen Yiwen
- Wertz Sébastien
- West Christopher
- Wezenbeek Liam
- Whitbeck Andrew
- White Robert
- White Sebastian
- Wichmann Katarzyna
- Wickramage Nadeesha
- Wickramarathna D. D. C.
- Wiedenbeck Sebastian
- Wieland Sebastian
- Wiens Lucas
- Wightman Andrew
- Williams Ac
- Williams Justin
- Williams Thomas
- Willmott Carlos
- Wilson Graham
- Wilson Jonathan
- Wimpenny Stephen
- Winer Brian L.
- Winterbottom Daniel
- Wisecarver Andrew
- Wissing Christoph
- Wittich Peter
- Wolf Matthias
- Wolf Roger
- Wolfe Evan
- Wong Kak
- Wong Wing Yan
- Wood Darien
- Wozniak Kinga Anna
- Wozniewski Sebastian
- Wright Douglas
- Wu Hsin-yeh
- Wu Zhenbin
- Wuchterl Sebastian
- Wulz Claudia-Elisabeth
- Wunsch Stefan
- Wyslouch Bolek
- Würthwein Frank
- Xiang Yifan
- Xiao Jie
- Xiao Meng
- Xiao Rui
- Xie Si
- Xie Wei
- Yagil Avraham
- Yalvac Metin
- Yan Furong
- Yan Xuli
- Yang S.
- Yang Shuai
- Yang Unki
- Yang Yu Chul
- Yao Yao
- Yarar Hevjin
- Yates Brent
- Yazgan Efe
- Ye Zhenyu
- Yetkin Elif Asli
- Yi Kai
- Yigitbasi Efe
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Geum Bong
- Yu Intae
- Yu Pei-rong
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S.
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabi Alexandre
- Zacharopoulou Anna
- Zahid Sema
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zeinali Maryam
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Liuyao
- Zhang Sijing
- Zhang Wenyu
- Zhang Yi
- Zhang Yousen
- Zhang Zhicai
- Zhao Jingzhou
- Zhizhin Ilia
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Ziemons Tim Matthias
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Álvarez Fernández Adrian
- Özçelik Özlem
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Abbas Rezaianzadeh
- Abdonas Tamosiunas
- Abdul Basit
- Abdul Hamid Zargar
- Abdullah Alkandari
- Abdullatif Husseini
- Abhijit Sen
- Abla M Sibai
- Abu Am Hanif
- Adela Chirita-Emandi
- Adelheid Weber
- Adetoyeje Y Oyeyemi
- Adewale L Oyeyemi
- Adolfo Rubinstein
- Adoubi Kassi Anicet
- Adroaldo Cesar Araujo Gaya
- Afshin Ostovar
- Agnes L Kadvan
- Agneta Sjöberg
- Agneta Yngve
- Agnès Le Port
- Agustinus Soemantri
- Agustín Perez-Londoño
- Ahmad A Zainuddin
- Ahmad Faudzi Yusoff
- Ahmad Reza Dorosty
- Ahmed A Madar
- Aida Pilav
- Aïcha Soumaré
- Akaninyene Otu
- Akihiro Yoshihara
- Akkumis Salhanova
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Alanna G da Silva
- Albertino Damasceno
- Alberto Barceló
- Alberto Palloni
- Albina A Fakhretdinova
- Alejandro Diaz
- Aleksander Giwercman
- Aleksandra Gomula
- Aleksandra Piwonska
- Alessandro Gialluisi
- Aletta E Schutte
- Alexander D Deev
- Alexandra M Cucu
- Alexandre C Pereira
- Alfonso Siani
- Alfonso Sousa-Poza
- Ali Ahmadi
- Ali Akbar Shayesteh
- Ali Esmaeili
- Ali Ghanbari
- Ali Reza Safarpour
- Alice Bonilla-Vargas
- Alicia Matijasevich
- Alina G Platonova
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline P Batista
- Alireza Ansari-Moghaddam
- Alireza Khosravi
- Alireza Moslem
- Alireza Sadjadi
- Alisha N Wade
- Alison J Hayes
- Alison J Price
- Allan G Hill
- Allan Linneberg
- Almaz Sharman
- Altan Onat
- Aluisio Jd Barros
- Alun Evans
- Amalia De Curtis
- Amanda G Thrift
- Amanda J Cross
- Amaneh Shayanrad
- Ambady Ramachandran
- Amelia C Crampin
- Amina Barkat
- Amir Houshang Mehrparvar
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Barradas-Pires
- Ana Carolina Mgn de Sá
- Ana D González-Alvarez
- Ana Henriques
- Ana I Rito
- Ana Jelaković
- Ana Maria B Menezes
- Ana P Ortiz
- Ana Paula C Cândido
- Anabela Mota-Pinto
- Anar Dushpanova
- Anastasia Markaki
- Anders Grøntved
- Andre L Guimaraes
- Andre P Kengne
- Andrea Gazzinelli
- Andrea Gualtieri
- Andrea Rodriguez-Martinez
- Andrea Rvr Horimoto
- Andrea Schneider
- Andrea Y Rodríguez
- Andrea Zentai
- Andreas Stang
- Andreia N Pizarro
- Andrew Kingston
- Andrew Reynolds
- Andrew Wong
- Andrzej Galbarczyk
- Andrzej Pająk
- Andrzej Więcek
- Anelise Reis Gaya
- Aneta Grajda
- Aneta Weres
- Anette Varbo
- Angel R Gonzalez
- Angela Chetrit
- Angela Döring
- Angela Spinelli
- Angelika Schaffrath Rosario
- Angelique Chan
- Angélica M Ochoa-Avilés
- Anie Marcil
- Anil Poudyal
- Anja L Madsen
- Anja Schienkiewitz
- Anna Bartosiewicz
- Anna Bugge
- Anna Fijalkowska
- Anna Jansson
- Anna V Alieva
- Annamari Lundqvist
- Anne A Bjerregaard
- Anne Chinnock
- Anne Juolevi
- Anne Taylor
- Anne Tjonneland
- Anneke Blokstra
- Annette J Dobson
- Annette Peters
- Annika Rosengren
- Anthony Kafatos
- Antonia Trichopoulou
- Antonio Bernabe-Ortiz
- Antonio Cabrera de León
- Antonio M Silva
- Antonio Mistretta
- Antonio Pedro Graça
- Antonio Prista
- Antonis Zampelas
- Antonisamy Belavendra
- Anu Mishra
- Anwar M Batieha
- Archie W Rayner
- Areti Triantafyllou
- Argyro Karakosta
- Ari Voutilainen
- Aristides M Machado-Rodrigues
- Arnaud Chiolero
- Aroor Bhagyalaxmi
- Arsalan Khaledifar
- Artur Mazur
- Arvind Pandey
- Arwa M Alshangiti
- Aryeh D Stein
- Asher Fawwad
- Attilio Rigotti
- Atul Trivedi
- Augustin F Beybey
- Augustine N Odili
- Augusto Di Castelnuovo
- Aung Soe Htet
- Ausra Petrauskiene
- Avula Laxmaiah
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- Aya Mostafa
- Ayman A Zayed
- Azaliia M Tuliakova
- Azhar Dyussupova
- Azim Nejatizadeh
- Azli Baharudin
- Åsa Ågren
- Badreya Al-Lahou
- Bagher Larijani
- Bahareh Kheiri
- Bahman Cheraghian
- Bakary Jallow
- Baltazar Nunes
- Barbara Heude
- Barbara Thorand
- Barry M Popkin
- Batyrbek Assembekov
- Beatriz D Schaan
- Bee Koon Poh
- Behrooz Hamzeh
- Bekbolat Zholdin
- Belgin Unal
- Belong Cho
- Ben Schöttker
- Benjamin Acosta-Cazares
- Benoit Salanave
- Benson M Kazembe
- Bente Sparboe-Nilsen
- Bernard Maire
- Bernardo L Horta
- Bernhard O Boehm
- Bert-Jan van den Born
- Bettina Bringolf-Isler
- Bharathi Viswanathan
- Bhawesh Koirala
- Bihungum Bista
- Bill Stavreski
- Bin Zhou
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- Birgit Linkohr
- Biruta Velika
- Blanca Sandra Ruiz-Betancourt
- Bo Werner
- Boban Mugoša
- Bogdan Wojtyniak
- Bojan Jelaković
- Bontha V Babu
- Boyd A Swinburn
- Börge Schmidt
- Branimir Leskošek
- Breige A McNulty
- Brian Oldenburg
- Brooklyn Fraser
- Bruna Gonçalves Cordeiro da Silva
- Buthaina M Alkhatib
- Børge G Nordestgaard
- Caleb Ochimana
- Calogero Saieva
- Calvin Ke
- Camilla T Damsgaard
- Carl Lachat
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- Carlo Maria Barbagallo
- Carlos A Aguilar-Salinas
- Carlos O Mendivil
- Carlos P Boissonnet
- Carmen Iñiguez
- Carolina B Tarqui-Mamani
- Caroline H Fall
- Caroline Ramos de Moura Silva
- Carsten O Schmidt
- Cassiano Ricardo Rech
- Catherine Kyobutungi
- Catterina Ferreccio
- Cecilia Björkelund
- Cecily Kelleher
- Cesar G Victora
- Cézane P Reuter
- Chandini Nekkantti
- Chao Qiang Jiang
- Charalambos A Hadjigeorgiou
- Charles Agyemang
- Charles K Mondo
- Charles Lunogelo
- Charles Sossa Jérome
- Charlie Lim
- Charlotte B Ottendahl
- Charmaine A Duante
- Charumathi Sabanayagam
- Chiara Donfrancesco
- Chien-An Sun
- Chien-Jen Chen
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- Chinh Nguyen Huu
- Chinwuba Ijoma
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- Christa Meisinger
- Christian Gieger
- Christina C Dahm
- Christina Howitt
- Christina Mavrogianni
- Christine Cameron
- Christophe Tzourio
- Christopher J Paciorek
- Chung T Nguyen
- Cihangir Erem
- Claes Ohlsson
- Clara Homs
- Claudia M Hormiga
- Cláudia S Minderico
- Clicerio González-Villalpando
- Clive Osmond
- Coimbatore Subramaniam Shanthirani
- Con Burns
- Constance Schultsz
- Constanta Huidumac Petrescu
- Cora L Craig
- Correia Júnior Marco Aurélio de Valois
- Cosmin R Cojocaru
- Cristina P Padez
- Crizian G Saar
- Cynthia M Pérez
- Cyrus Cooper
- Daan Kromhout
- Dalia Luksiene
- Damaskini Valvi
- Damian K Francis
- Dan Zhu
- Daniel Bia
- Daniel Fernández-Bergés
- Daniel Ferrante
- Daniel G Vasques
- Daniel Lemogoum
- Daniel Weghuber
- Daniela Galeone
- Daniela Kállayová
- Daniela Pierannunzio
- Daniela Rodrigues
- Daphne Lai
- Daphne Mirkopoulou
- David A Gonzalez-Chica
- David De Ridder
- David Faeh
- David Goltzman
- Davide Noto
- Davood Khalili
- Deborah C Malta
- Debra S Judge
- Deena Al Asfoor
- Deepak N Amarapurkar
- Delphine De Smedt
- Demetre Labadarios
- Denise Eldemire-Shearer
- Dermot O'Reilly
- Dénes Molnár
- Diana A Santos
- Diane T Meto
- Dianna J Magliano
- Dickman Gareta
- Diego Augusto Santos Silva
- Diego G Christofaro
- Diego Salmerón
- Diego Vanuzzo
- Dimitrios Papandreou
- Dimitrios Poulimeneas
- Dimitrios Trichopoulos
- Dirk De Bacquer
- Dirk Vanderschueren
- Dominique Cottel
- Dominique Hange
- Dong Zhao
- Dongfeng Gu
- Dora Romaguera
- Doris Stöckl
- Dorja Vocanec
- Doroteia A Höfelmann
- Dusko J Bjelica
- Dušan Grafnetter
- Duygu Islek
- Dwi Hapsari Tjandrarini
- E Shyong Tai
- Ebrahim Eftekhar
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- Eduardo Salazar Martinez
- Edward F Fottrell
- Edward Janus
- Edward W Gregg
- Edwige Landais
- Edyta Łuszczki
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- Efthymios Kapantais
- Eha Nurk
- Ei Ei K Nang
- Eiji Oda
- Ekaterina Chikova-Iscener
- Ekaterina Stoyanova
- Elaine Dennison
- Elaine M Murtagh
- Eldridge Ferrer
- Elena Anufrieva
- Elena Bogova
- Elena Pahomova
- Elena Sacchini
- Elena V Skoblina
- Eleonora d'Orsi
- Elias F Gudmundsson
- Elin Kolle
- Elin P Sørgjerd
- Elio Riboli
- Elisabete Ramos
- Elisabetta L Romeo
- Eliza Cinteza
- Eliza Markidou Ioannidou
- Ellina M Iakupova
- Elling Bere
- Ellis Owusu-Dabo
- Ellisiv B Mathiesen
- Elnaz Faramarzi
- Els Clays
- Else Karin Grøholt
- Elvis Oa Wambiya
- Elvynna Leong
- Elysée Claude Bika Lele
- Elzbieta Dziankowska-Zaborszczyk
- Eman Aly
- Emanuel Zitt
- Emanuela Gualdi-Russo
- Emanuela Pettenuzzo
- Emiel Hoogendijk
- Emily B Wong
- Emily Sonestedt
- Emma Ruiz Moreno
- Emmanuel Cohen
- Emmanuella Magriplis
- Eng Joo Tan
- Enguerran Macia
- Enisa Kujundzic
- Enrique Gutiérrez González
- Enzo Manzato
- Erfan Ghasemi
- Eric Monterrubio-Flores
- Erik J Timmermans
- Erik Lykke Mortensen
- Erkin Mirrakhimov
- Ertugrul Celikcan
- Eruke E Egbagbe
- Espen Bjertness
- Esteban Carmuega
- Esther Lopez-Garcia
- Esther M González-Gil
- Ethel Santacruz
- Eugène Sobngwi
- Eunice Ugel
- Eva Corpeleijn
- Eva Gerdts
- Eva Karaglani
- Eva Martos
- Evangelia Tzala
- Ewelina Czenczek-Lewandowska
- Éva Kovács
- Fabian Rohner
- Fabián Méndez
- Fabio Galvano
- Fadi J Charchar
- Fadia AlBuhairan
- Fangfang Chen
- Farahnaz Joukar
- Farhad Moradpour
- Farhad Pourfarzi
- Farhad Zamani
- Fariborz Mansour-Ghanaei
- Farid Najafi
- Farshad Farzadfar
- Farzad Hadaegh
- Fatai A Maruf
- Fatemeh Malekzadeh
- Fatima Zahra Laamiri
- Felicia Cañete
- Felipe F Casanueva
- Felipe V Cureau
- Felix Gutzwiller
- Felix K Assah
- Felix O Kaducu
- Felix P Phiri
- Fereidoun Azizi
- Fernanda Cunha Soares
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- Fernando Rodríguez-Artalejo
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- Francisco de Assis Guedes de Vasconcelos
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- Furusawa Takuro
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- Gabriel M Leung
- Gabriele Eiben
- Gabriele Nagel
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- Geetha R Menon
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- Hana Zamrazilová
- Hanan F Abdul Rahim
- Hanna K Tolonen
- Hanna Nalecz
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- Harald Geiger
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- Harshpal S Sachdev
- Harunobu Nakamura
- Hassan Aguenaou
- Hazzaa M Al-Hazzaa
- Heba M Fouad
- Hedley K Quintana
- Heidi Klakk
- Helen Gonçalves
- Helena Krizan
- Helena Nogueira
- Helle-Mai Loit
- Helmut Schröder
- Heloísa Bettiol
- Henrike Galenkamp
- Henry Völzke
- Herculina S Kruger
- Herman Borghs
- Herman Schargrodsky
- Hermann Brenner
- Hermann Pohlabeln
- Hermine T Mopa
- Hélène Delisle
- Himanshu K Chaturvedi
- Hoang Van Minh
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- Hui Cai
- Huijun Wang
- Hung-Kwan So
- Husam F Alomirah
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- Hynek Pikhart
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- Idowu O Senbanjo
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- Igor Spiroski
- Ildar Fakhradiyev
- Ilona Nenko
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- Ilse Msl Khouw
- Imelda A Agdeppa
- Imperia Brajkovich
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- Irfan Nuhoğlu
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- Isabelle Herter-Aeberli
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- Isti I Fujiati
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- Ivaila Y Ivanova-Pandourska
- Ivan Pećin
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- Jaume Marrugat
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- Jean Ferrieres
- Jean Woo
- Jean-Bernard Ruidavets
- Jean-Michel Gaspoz
- Jean-René M'Buyamba-Kabangu
- Jeannette Klimont
- Jeannette Lee
- Jelena Kos
- Jennifer L Baker
- Jennifer Servais
- Jenny M Kindblom
- Jeonghee Lee
- Jeongseon Kim
- Jeremy M Jacobs
- Jeroen de Bont
- Jerzy Chudek
- Jesus D Melgarejo
- Jesus Vioque
- Jesús Humberto Gómez Gómez
- Jesús Ibarluzea
- Jia Li Duan
- Jianfeng Wu
- Jiang He
- Jie Hao
- Jie Mi
- Jim I Mann
- Jin Soo Moon
- Jing Liu
- Jingli Gao
- Jitendra Jonnagaddala
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- Joana Carvalho
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- Joanne Katz
- Joany Mariño
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- Joaquin Barnoya
- João Breda
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- Juel Jarani
- Juergen Breckenkamp
- Juha Auvinen
- Jukka T Salonen
- Julianne Williams
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- Julie Taylor
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- Jun Hata
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- Jurate Medzioniene
- Jussi Kauhanen
- Justina Vaitkeviciute
- Justyna Godos
- Justyna Leszczak
- Justyna Wyszyńska
- Jutta Stieber
- Juvenal Soares Dias-da-Costa
- Júlio Mello
- Jürgen König
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- Jyrki K Virtanen
- Jytte Halkjær
- Jørgen Meisfjord
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- Łukasz Kryst
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We
estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from
1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods We used data from 3663 population-based studies with 222 million participants that measured height and
weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate
trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children
and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the
individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference)
and obesity (BMI >2 SD above the median).
Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in
11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed
changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and
140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of
underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and
countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior
probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse
was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of
thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a
posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%)
with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and
obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for
both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such
as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged
children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls
in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and
42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents,
the increases in double burden were driven by increases in obesity, and decreases in double burden by declining
underweight or thinness.
Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an
increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy
nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of
underweight while curbing and reversing the increase in obesit
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