On the Kierkegaardian philosophy of culture and its implications in the Chinese and Japanese context (post-1842)

This thesis aims to establish a Kierkegaardian philosophy of culture to address the theoretical problems of modern East Asian philosophy of culture, particularly Chinese New Confucianism and the Kyoto School (represented by Mou Zong-San and Watsuji Tetsuro respectively) who try to formulate their cultural subjectivities for the sake of cultural modernisation. Both schools adopt Hegelian philosophy of culture and therefore inherit the problems of Hegelian dialectics which Kierkegaard criticises. While Kierkegaard himself does not develop a philosophy of culture, this thesis argues that his concepts of culture in terms of the manifestations of passions, community and contemporaneity are useful resources for the formulation of East Asian cultural selves. Firstly, in chapter 1, I argue that there are two tasks of modern East Asian philosophers of culture: how to understand a culture (epistemic task) and how to establish a cultural self (ontological task). Secondly, in chapter 2, I argue that there are three theoretical problems in Mou’s and Watsuji’s Hegelian philosophies of culture, namely, the impossibility of change in cultural value, the lack of empirical method and the neglect of openness of interpretation. Thirdly, in chapter 3, I argue that Kierkegaard’s definition of culture in terms of the manifestations of passions explain East Asian cultural development more consistently than Hegelian dialectics. Fourthly, in chapter 4, I establish a Kierkegaardian philosophy of culture and argue that a cultural self is formulated by the concepts of community and contemporaneity where individuals express their passions according to their free wills. Finally, I argue that Kierkegaardian philosophy of culture fulfils both the ontological and epistemic tasks of East Asian philosophers and solves the theoretical problems they encounter when they adopt Hegelian dialectics

Organization and repair of the trigeminal system in the lamprey using fluorescent double labeling [abstract]

Abstract only availableFaculty Mentor: Andrew McClellan, Biological ScienceIn the CNS, many sensory and motor systems are topologically organized relative to various body structures.  For example, in humans, sensory inputs from the lower, middle, and upper parts of the body are received by the anterior, middle, and posterior somatosensory cortex, respectively.  Following injury in the CNS of higher vertebrates, such as birds and mammals, there is very little regeneration and recovery of function.  In contrast, in lower vertebrates, including lamprey, fish, and certain amphibians, substantial axonal regeneration occurs following CNS injuries, and there is virtually complete recovery of functions.  However, it is not known whether axonal regeneration restores the topological organization that may have existed prior to injury.  The trigeminal system is responsible for transmitting sensory and motor information from the head via axons in the trigeminal cranial nerve.  In the lamprey following injury of the trigeminal nerve, sensory and motor axons regenerate.  The purpose of the present study was to determine whether the trigeminal system of normal lamprey is topologically organized and whether regeneration of axons in injured trigeminal nerve restores this organization.  In normal larval lamprey, Alexa 488 dextran amine (Alexa) and Texas red dextran amine (TRDA), two different anatomical fluorescent tracers, were applied to the medial and lateral parts of the head, respectively.  This resulted in clear labeling of the medial and lateral parts of the trigeminal system in the brain with Alexa and TRDA, respectively.  Thus, in normal lamprey, the trigeminal system appears to be topologically organized.  If following injury of the trigeminal nerve, axonal regeneration restores this topological organization, this will indicate that regeneration in the lamprey is relatively precise and possibly controlled by specific guidance factors.  Identification of these guidance factors would greatly improve our understanding of the mechanisms that regulate axonal regeneration following CNS injury in vertebrate animals, including humans.

Carvedilol in the treatment of elderly patients with chronic heart failure

Chronic heart failure (CHF) is common, and increases in incidence and prevalence with age. There are compelling data demonstrating reduced mortality and hospitalizations with adrenergic blockade in older patients with CHF. Despite this, many older patients remain under-treated. The aim of the present article is to review the potential mechanisms of the benefits of adrenergic blockade in CHF and the clinical data available from the large randomized studies, focusing particularly on older patients

reslife: Residual Lifetime Analysis Tool in R

Mean residual lifetime is an important measure utilized in various fields, including pharmaceutical companies, manufacturing companies, and insurance companies for survival analysis. However, the computation of mean residual lifetime can be laborious and challenging. To address this issue, the R package reslife has been developed, which enables efficient calculation of mean residual lifetime based on closed-form solution in a user-friendly manner. reslife offers the capability to utilize either the results of a flexsurv regression or user-provided parameters to compute mean residual lifetime. Furthermore, there are options to return median and percentile residual lifetime. If the user chooses to use the outputs of a flexsurv regression, there is an option to input a data frame with unobserved data. In this article, we present reslife, explain its underlying mathematical principles, illustrate its functioning, and provide examples on how to utilize the package. The aim is to facilitate the use of mean residual lifetime, making it more accessible and efficient for practitioners in various disciplines, particularly those involved in survival analysis within the pharmaceutical industry

Self-affirmation and self-negation - an analysis on the ontological disagreements between Christianity and Confucianism in Mou Zongsan’s criticism of Kierkegaard = 從牟 宗三對齊克果「否定自我」之批評分析基督教與儒家之存在論分歧

Mou Zongsan rarely discusses Søren Kierkegaard’s philosophy. Nevertheless, in On the Characteristics of Chinese Philosophy, Mou uses Kierkegaard as an example to illustrate the fundamental ontological differences between Christianity and Confucianism. Mou claims that Confucians affirm moral subjectivity, while Christians urge one to deny one’s sinful self and to be integrated into God’s subjectivity. Therefore, Mou believes that Confucianism is characterized by self-affirmation, while Christianity is characterized by self-negation. As a response to this, this article argues that, even if one agrees that Kierkegaard’s philosophy may represent this perspective of Christian ontology, “self-negation” can hardly outline the whole picture of Kierkegaard’s philosophy. By criticizing Mou’s oversimplified dichotomy of self-affirmation and self- negation, this article examines both Mou’s Confucian and Kierkegaard’s Christian perspectives on the ontological question of individual subjectivity, which can provide new insight to Confucian-Christian dialogue

Haemogenic endocardium contributes to transient definitive haematopoiesis.

Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic lineages, it remains unknown whether the mammalian heart tube serves as a haemogenic organ akin to the dorsal aorta. Here we examine the haemogenic activity of the developing endocardium. Mouse heart explants generate myeloid and erythroid colonies in the absence of circulation. Haemogenic activity arises from a subset of endocardial cells in the outflow cushion and atria earlier than in the aorta-gonad-mesonephros region, and is transient and definitive in nature. Interestingly, key cardiac transcription factors, Nkx2-5 and Isl1, are expressed in and required for the haemogenic population of the endocardium. Together, these data suggest that a subset of endocardial/endothelial cells serve as a de novo source for transient definitive haematopoietic progenitors

Cigarette Smoke-Induced Cerebral Cortical Interleukin-6 Elevation is not Mediated Through Oxidative Stress

The author group has previously established an in vivo subchronic cigarette smoke (CS) exposure rat model, in which the systemic oxidative burden as well as the modulation of local anti-oxidative enzymes in the lung has been demonstrated. Oxidative stress has been shown to induce pro-inflammatory cytokine release, including interleukin (IL)-6 in the airways. In this study, we aimed to investigate the changes in IL-6 production, as well as the oxidative/anti-oxidative responses in the cerebral cortex using the same in vivo model. IL-6 was determined by RT-PCR and western-blot analysis. Local oxidative and anti-oxidative responses were determined by measuring cerebral cortical malondialdehyde (MDA) and advanced oxidation protein product (AOPP) levels, superoxide dismutase (SOD) and catalase activities, and the reduced to oxidized glutathione (GSH/GSSG) ratio. Nitrite level was measured by fluorescent spectrophotometry. Our results demonstrated a significant increase in both IL-6 mRNA and protein levels. Reductions of SOD activity and manganese (Mn)SOD protein level were observed together with the increased level of superoxide measured by chemiluminescent signal, after 56 days of CS exposure. There were no significant changes in the cerebral cortical levels of MDA, AOPP, catalase activity, and the GSH/GSSG ratio. Nitrite level was significantly reduced, together with the decreased protein level of nNOS in the cerebral cortex, after 56 days of CS exposure. Our results suggest that exposure to CS induces IL-6 expression in the cerebral cortex, which is not mediated by the oxidative/anti-oxidative imbalance

Seismic tremor reveals slow fracture propagation prior to the 2018 eruption at Sierra Negra volcano, Galápagos

Seismic tremor observed near active volcanoes is an important tool for volcano monitoring as it often appears shortly before eruptions. Although tremor can be generated by a variety of physical processes it is usually interpreted as direct evidence for flowing magma in the sub-surface. These interpretations typically feed into risk assessments for potential eruptions. Using the temporal evolution of tremor amplitude and spectral data from a distributed seismic network that captured the 2018 eruption at Sierra Negra in Galapagos, we determine that tremor is not directly related to sub-surface fluid movement. Instead at Sierra Negra tremor likely indicates a slowly propagating fracture, which is later exploited as a pathway for silent magma flow. Distinct differences in the source migration and the spectral character of pre-eruptive and co-eruptive tremor allow both a location estimate of the future eruption site and a precise timing of the eruption onset

Loline alkaloid effects on gastrointestinal nematodes

Loline, an alkaloid with several derivatives, has suggested antimicrobial and anthelmintic properties. Therefore, loline was investigated as a natural anthelmintic against Trichostrongylus colubriformis, Teladorsagia circumcincta, and Haemonchus contortus. Preliminary in vitro studies had reduced L3 T. circumcincta establishment but no effect on L3 T. colubriformis larvae migration or H. contortus establishment. While loline-treated lambs had lower establishment of L4 and adult T. circumcincta and L4 T. colubriformis, L4 and adult H. contortus appeared unaffected. Following preliminary study, an in vivo experiment examined lambs infected with a mix of L4 T. circumcincta, T. colubriformis, and adult H. contortus. These lambs were treated with either a loline seed extract (LOL, n = 7), nothing (CON, n = 7), or a non-loline seed extract (NIL, n = 2). There were no differences in worm burdens, fecal egg counts, weight gain, or feed intake between treatments. However, an average growth efficiency (kg LWG/kg DM intake) was detected (p = 0.01) in CON (0.18) which was less than LOL (0.24) or NIL (0.23). There was limited evidence to support an in vivo anti-parasitic effect of loline despite in vitro studies indicating potential benefits. Discrepancies between in vivo and in vitro studies results were potentially a result of loline contact time with larvae, mode of ingestion or the forms of loline present