A new surgical technique to facilitate osteochondral autograft transfer in osteochondral defects of the capitellum: A case report

A 17-year-old boy who was engaged in amateur weightlifting and body building presented with complaints of right elbow pain and limitation in elbow range of motion. Plain x-rays and magnetic resonance imaging showed an osteochondral defect in the medial third of the capitellum. At surgery, as a new technique, the lateral collateral ligament was detached from the humeral attachment to provide access to the capitellum with a clear and perpendicular exposure. Following removal of loose fragments within the joint, an osteochondral graft harvested from the lateral femoral condyle was implanted to the defect area of the capitellum. Postoperative radiologic controls showed that the defect was entirely filled by the graft with appropriate graft height. On follow-up examination at 12 months, the patient did not have any complaint about his elbow, and had no limitation of movement compared to the left elbow. Magnetic resonance imaging showed that the graft was successfully adapted to the recipient site without any sign of loosening. At final follow-up 40 months after surgery, the surface of the articular cartilage appeared normal. The range of elbow motion was preserved and the patient had no restriction in daily and sports activities. Considering technical difficulties posed by the narrow and complex structure of the elbow joint, this new technique involving detachment of the lateral collateral ligament facilitates perpendicular implantation of the graft. In our opinion, utilization of this new technique will improve functional and radiological results of osteochondral autograft transfer. © 2010 Turkish Association of Orthopaedics and Traumatology

Optimal Placement of Multiple Interconnected Gateways in Heterogeneous Wireless Sensor Networks

Data c ollec ted b y sensors of ten h av e to b e rem otely d eliv ered th rou g h m u lti- h op w ireless path s to d ata sink s c onnec ted to applic ation ser v ers for inform ation proc essing . T h e position of th ese sink s h as a h u g e im pac t on th e q u ality of th e spec i c W ireless S ensor N etw or k ( W S N ) . Ind eed , it m ay c reate ar ti c ial traf c b ottlenec k s w h ic h affec t th e energ y ef c ienc y and th e W S N lifetim e. T h is paper c onsid ers a h eterog eneou s netw or k sc enar io w h ere w ireless sensors d eliv er d ata to inter m ed iate g atew ay s g eared w ith a d iv erse w ireless tec h nolog y and inter c onnec ted tog eth er and to th e sink . An optim iz ation f ram ew or k b ased on Integ er L inear P rog ram m ing (IL P ) is d ev eloped to loc ate w ireless g atew ay s m inim iz ing th e ov erall installation c ost and th e energ y c onsu m ption in th e W S N , w h ile ac c ou nting for m u lti- h op c ov erag e b etw een sensors and g atew ay s, and c onnec tiv ity am ong w ireless g atew ay s. T h e proposed IL P for m u lations are solv ed to optim ality for m ed iu m -siz e instanc es to analy z e th e q u ality of th e d esig ned netw or k s, and h eu r istic alg or ith m s are also proposed to tac k le larg e-sc ale h eterog eneou s sc enar ios

Mechanical and Tribological Properties of TiN Coatings Produced by PIII&D Technique

The structure, mechanical and tribological properties TiN coatings рroduced with PIII&D by using rectilinear filtered vacuum arc plasma system are present. The results of scratch testing and wear reciprocating testing clearly revealed the positive effect of pulse bias (0.5÷2.5 kV) application on tribological behavior of the TiN coatings in comparison the coatings deposited with DC bias (150 V). Application of pulsed bias potential leads to a significant reduction in the friction coefficient and increasing of coatings wear resistance due to a change in their structure. The orientation of crystal planes parallel to the surface changes from (111) to (220) with the application of pulse bias, which is accompanied by a transition from fibrous grains structure to denser columnar grains. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3518

Performance Evaluation of Gradient Routing Strategies for Wireless Sensor Networks

International audienceWe consider Wireless Sensor Networks (WSN) applications in which sensors have to send data to a unique sink in a multi-hop fashion. Gradient routing protocol is a scalable way to route data in these applications. Many gradient routing protocols exist, they mainly differ in their performances (delay, delivery ratio, etc.). In this paper, we propose an extensive performance evaluation study of some gradient routing protocols in order to give guidelines for WSN developers

Mechanical and Tribological Properties of TiN Coatings Produced by PIII&D Technique

The structure, mechanical and tribological properties TiN coatings рroduced with PIII&D by using rectilinear filtered vacuum arc plasma system are present. The results of scratch testing and wear reciprocating testing clearly revealed the positive effect of pulse bias (0.5÷2.5 kV) application on tribological behavior of the TiN coatings in comparison the coatings deposited with DC bias (150 V). Application of pulsed bias potential leads to a significant reduction in the friction coefficient and increasing of coatings wear resistance due to a change in their structure. The orientation of crystal planes parallel to the surface changes from (111) to (220) with the application of pulse bias, which is accompanied by a transition from fibrous grains structure to denser columnar grains. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3518

The Transient Ultra-luminous X-ray Source, ULX-4, in M51

We present the results of a temporal and spectral analysis of the transient source ULX-4 in the galaxy M51. The data used were drawn from Chandra, XMM-Newton and Swift-XRT archives, spanning the years 2000-2019. The X-ray flux of the source is seen to vary by two orders of magnitudes within a month but a short-term variability was not observed over the time intervals of 100-2000 second in the 0.3-10 keV energy band. We find some evidence for the existence of bi-modality feature in the flux distribution of ULX-4. We identified two optical sources as possible counterparts within an error radius of 0."18 at 95% confidence level for ULX-4 based on the archival HST/ACS and HST/WFC3 data. Blackbody fits of the spectral energy distributions (SEDs) indicate the spectral type to be B-type stars. One of these counterparts exhibits a low-amplitude optical periodicity of 264 days in the F606W filter; if we assume this apparent periodicity is associated with the orbital motion of the donor, then it is more likely that the donor is a red supergiant satisfying the long periodicity and accretion via Roche-lobe overflow. Consequently, the SED would then have to be interpreted as a superposition of emissions from a cold donor and a hot flow component, most likely from an accretion disk. If, on the other hand, the periodicity is super orbital in nature i.e., due to possible interactions of the compact object with a circumstellar disk, the donor could then be a Be/X star hosting a neutron star.Comment: Accepted for publication in MNRAS. 16 pages, 12 figures, 6 table

The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle

For a primary active pump, such as the human ATP-binding-cassette (ABC) transporter ABCB1, coupling of drug-binding by the two transmembrane domains (TMDs) to the ATP catalytic cycle of the two nucleotide-binding domains (NBDs) is fundamental to the transport mechanism, but is poorly understood at the biochemical level. Structure data suggest that signals are transduced through intracellular loops of the TMDs that slot into grooves on the NBDs. At the base of these grooves is the Q loop. We therefore mutated the eponymous glutamine in one or both NBD Q loops and measured the effect on conformation and function by using a conformation-sensitive antibody (UIC2) and a fluorescent drug (Bodipy-verapamil), respectively. We showed that the double mutant is trapped in the inward-open state, which binds the drug, but cannot couple to the ATPase cycle. Our data also describe marked redundancy within the transport mechanism, because single-Q-loop mutants are functional for Bodipy-verapamil transport. This result allowed us to elucidate transduction pathways from twin drug-binding cavities to the Q loops using point mutations to favor one cavity over the other. Together, the data show that the Q loop is the central flexion point where the aspect of the drug-binding cavities is coupled to the ATP catalytic cycle.-Zolnerciks, J. K., Akkaya, B. G., Snippe, M., Chiba, P., Seelig, A., Linton, K. J. The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle

Optimization of distyryl-Bodipy chromophores for efficient panchromatic sensitization in dye sensitized solar cells

Cataloged from PDF version of article.Versatility of Bodipy (4,4-difluoro-4-bora-3a, 4a-diaza-s-indacene) dyes was further expanded in recent dye-sensitized solar cell applications. Here we report a series of derivatives designed to address earlier problems in Bodipy sensitized solar cells. In the best case example, an overall efficiency of a modest 2.46% was achieved, but panchromatic nature of the dyes is quite impressive. This is the best reported efficiency in liquid electrolyte solar cells with Bodipy dyes as photosensitizers

High Molecular Weight Hyaluronan Promotes Corneal Nerve Growth in Severe Dry Eyes

The purpose of this study was to investigate the effect of high molecular weight hyaluronan (HMWHA) eye drops on subbasal corneal nerves in patients suffering from severe dry eye disease (DED) and to evaluate the damage of subbasal corneal nerves associated with severe DED. Designed as an international, multicenter study, 16 patients with symptoms of at least an Ocular Surface Disease Index (OSDI) score of 33, and corneal fluorescein staining (CFS) of at least Oxford grade 3, were included and randomized into two study arms. The control group continued to use their individual optimum artificial tears over the study period of eight weeks; in the verum group, the artificial tears were substituted by eye drops containing 0.15% HMWHA. At the baseline visit, and after eight weeks, the subbasal nerve plexus of 16 patients were assessed by confocal laser scanning microscopy (CSLM). The images were submitted to a masked reading center for evaluation. Results showed a significant increase of total nerve fiber lengths (CNFL) in the HMWHA group (p = 0.030) when compared to the control group, where the total subbasal CNFL did not significantly change from baseline to week 8. We concluded that in severe DED patients, HMWHA from topically applied eye drops could cross the epithelial barrier and reach the subbasal nerve plexus, where it exercised a trophic effect

O-SPIN: an Opportunistic Data Dissemination Protocol for Folk-enabled Information System in Least Developed Countries

International audienceWithout universal access to the Internet, Least Developed Countries are left by the wayside of the digital revolution. Research is underway to overstep the barrier to the development of information technology services in these areas. In this context, the Folk-IS (Folk-enabled Information System) is a new fully decentralized and participatory approach, in which, each individual can transparently perform data management and networking tasks through highly secure, portable, and low-cost storage and computing personal devices, as physically moving, so that global services can finally be delivered by crowd. In this paper we propose Opportunistic SPIN (O-SPIN), an information dissemination protocol that augments the well-known data-centric energy-aware SPIN protocol to enable networking facilities for Folk-nodes, by exploiting opportunistic contacts among users. Performance of the proposed solution has been evaluated through simulations carried out in the OMNeT++ framework under different settings. Achieved results demonstrate its effectiveness and efficiency in the information dissemination process